Details for: LRPAP1

Gene ID: 4043

Symbol: LRPAP1

Ensembl ID: ENSG00000163956

Description: LDL receptor related protein associated protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.86
    Marker Score: 6524
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.58
    Marker Score: 11145
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.56
    Marker Score: 88700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.55
    Marker Score: 65368
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.53
    Marker Score: 28500.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.41
    Marker Score: 6082.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.31
    Marker Score: 2785
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.27
    Marker Score: 8904.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.18
    Marker Score: 1856.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.15
    Marker Score: 25021
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.13
    Marker Score: 3135
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.09
    Marker Score: 836
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.06
    Marker Score: 5391
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.02
    Marker Score: 1803.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.01
    Marker Score: 3786
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.01
    Marker Score: 2295
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.98
    Marker Score: 826
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.98
    Marker Score: 5309
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.97
    Marker Score: 110416
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.96
    Marker Score: 2819
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.95
    Marker Score: 787
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.94
    Marker Score: 65857
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.93
    Marker Score: 720.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.91
    Marker Score: 890
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.9
    Marker Score: 902
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.88
    Marker Score: 1602
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.88
    Marker Score: 1255
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.88
    Marker Score: 1903
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.87
    Marker Score: 2977
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.87
    Marker Score: 3638
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.86
    Marker Score: 3092
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.86
    Marker Score: 429
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.86
    Marker Score: 4640
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.85
    Marker Score: 3035
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.85
    Marker Score: 2458
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.85
    Marker Score: 2614
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.84
    Marker Score: 2531
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.83
    Marker Score: 1157
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.83
    Marker Score: 4468
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.81
    Marker Score: 11022
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.8
    Marker Score: 445.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.8
    Marker Score: 13425
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.8
    Marker Score: 406
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.79
    Marker Score: 749
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.79
    Marker Score: 1787
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.78
    Marker Score: 426
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.78
    Marker Score: 6601.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.78
    Marker Score: 6863.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.78
    Marker Score: 503
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.77
    Marker Score: 913
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.77
    Marker Score: 4019
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.75
    Marker Score: 10369.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.75
    Marker Score: 3644
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.73
    Marker Score: 3524
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.73
    Marker Score: 549
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.72
    Marker Score: 947
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.71
    Marker Score: 977
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.7
    Marker Score: 8179.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.7
    Marker Score: 546
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.7
    Marker Score: 2215.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.7
    Marker Score: 1761
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.69
    Marker Score: 1114
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.69
    Marker Score: 421
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.69
    Marker Score: 488
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.69
    Marker Score: 1786
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.69
    Marker Score: 2177
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.68
    Marker Score: 14609
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.68
    Marker Score: 421
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.66
    Marker Score: 10814
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.65
    Marker Score: 387
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.65
    Marker Score: 717
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.64
    Marker Score: 1735
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.63
    Marker Score: 845
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.63
    Marker Score: 1742
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.62
    Marker Score: 1902
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.62
    Marker Score: 1278
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6
    Marker Score: 1680
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.59
    Marker Score: 16005
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.58
    Marker Score: 1850
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.57
    Marker Score: 416
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.56
    Marker Score: 858
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.55
    Marker Score: 4221.5
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 1.55
    Marker Score: 440
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.55
    Marker Score: 2486.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.55
    Marker Score: 407
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.55
    Marker Score: 382
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.54
    Marker Score: 534
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.54
    Marker Score: 5298
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.54
    Marker Score: 900
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.54
    Marker Score: 2229
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.54
    Marker Score: 1899
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.54
    Marker Score: 5462
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.54
    Marker Score: 2806
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.53
    Marker Score: 535
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.53
    Marker Score: 1651.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.53
    Marker Score: 3055.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.53
    Marker Score: 6370.5
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.53
    Marker Score: 532
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.52
    Marker Score: 4210
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.52
    Marker Score: 1906

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Other Information

**Key characteristics:** * LRPAP1 is a transmembrane protein that is expressed in the endoplasmic reticulum. * It is a member of the LDL receptor-related protein family. * It is a negative regulator of protein binding and receptor internalization. * It is significantly expressed in cells of the salivary gland, decidual cells, and immune cells. **Pathways and functions:** * LRPAP1 is a negative regulator of protein binding and receptor internalization. It does this by binding to the LDL receptor and preventing it from interacting with its ligands. This prevents the receptor from being internalized into the cell. * LRPAP1 is also a negative regulator of very-low-density lipoprotein (VLDL) particle clearance. It does this by binding to VLDL particles and promoting their clearance from the bloodstream. * In addition to its role in protein binding and receptor internalization, LRPAP1 is also involved in the regulation of cell migration and invasion. **Clinical significance:** LRPAP1 is a potential therapeutic target for a variety of diseases. For example, it is a target for the treatment of amyloidosis, a rare disease that is characterized by the deposition of amyloid plaques in the brain and other organs. LRPAP1 is also a target for the treatment of cancer. It is a protein that is expressed on the surface of cancer cells, and it is known to promote cancer cell growth and survival.

Genular Protein ID: 1714195955

Symbol: AMRP_HUMAN

Name: Low density lipoprotein receptor-related protein-associated protein 1

UniProtKB Accession Codes:

P30533 D3DVR9 Q2M310 Q53HQ3 Q53HS6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 9 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1712782

Title: Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen.

PubMed ID: 1712782

DOI: 10.1016/s0021-9258(18)98848-4

PubMed ID: 9782079

Title: Analysis of the human LRPAP1 gene coding for the lipoprotein receptor-associated protein: identification of 22 polymorphisms and one mutation.

PubMed ID: 9782079

DOI: 10.1006/geno.1998.5413

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7789983

Title: Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein.

PubMed ID: 7789983

DOI: 10.1016/0888-7543(95)80050-v

PubMed ID: 1400426

Title: The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330.

PubMed ID: 1400426

DOI: 10.1016/s0021-9258(19)36811-5

PubMed ID: 7774585

Title: 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein.

PubMed ID: 7774585

DOI: 10.1002/j.1460-2075.1995.tb07221.x

PubMed ID: 8940146

Title: Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein.

PubMed ID: 8940146

DOI: 10.1074/jbc.271.49.31379

PubMed ID: 11294867

Title: Activation and functional characterization of the mosaic receptor SorLA/LR11.

PubMed ID: 11294867

DOI: 10.1074/jbc.m100857200

PubMed ID: 11384978

Title: The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.

PubMed ID: 11384978

DOI: 10.1074/jbc.m102727200

PubMed ID: 12530537

Title: Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA.

PubMed ID: 12530537

DOI: 10.1515/bc.2002.193

PubMed ID: 15053742

Title: The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.

PubMed ID: 15053742

DOI: 10.1042/bj20040149

PubMed ID: 15364913

Title: Functional organization of the sortilin Vps10p domain.

PubMed ID: 15364913

DOI: 10.1074/jbc.m408873200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23830514

Title: Mutations in LRPAP1 are associated with severe myopia in humans.

PubMed ID: 23830514

DOI: 10.1016/j.ajhg.2013.06.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26858303

Title: Cytokine-like factor 1, an essential facilitator of cardiotrophin-like cytokine:ciliary neurotrophic factor receptor alpha signaling and sorLA-mediated turnover.

PubMed ID: 26858303

DOI: 10.1128/mcb.00917-15

PubMed ID: 32296178

Title: LRP1 is a master regulator of tau uptake and spread.

PubMed ID: 32296178

DOI: 10.1038/s41586-020-2156-5

PubMed ID: 9207124

Title: The solution structure of the N-terminal domain of alpha2-macroglobulin receptor-associated protein.

PubMed ID: 9207124

DOI: 10.1073/pnas.94.14.7521

PubMed ID: 12766414

Title: 1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein.

PubMed ID: 12766414

DOI: 10.1023/a:1023534107920

PubMed ID: 16938309

Title: Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif.

PubMed ID: 16938309

DOI: 10.1016/j.jmb.2006.07.013

PubMed ID: 16630895

Title: Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors.

PubMed ID: 16630895

DOI: 10.1016/j.molcel.2006.02.021

PubMed ID: 16678114

Title: RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi.

PubMed ID: 16678114

DOI: 10.1016/j.molcel.2006.04.011

Sequence Information:

  • Length: 357
  • Mass: 41466
  • Checksum: D56A7DA754125CFA
  • Sequence:
    • MAPRRVRSFL RGLPALLLLL LFLGPWPAAS HGGKYSREKN QPKPSPKRES GEEFRMEKLN 
QLWEKAQRLH LPPVRLAELH ADLKIQERDE LAWKKLKLDG LDEDGEKEAR LIRNLNVILA 
KYGLDGKKDA RQVTSNSLSG TQEDGLDDPR LEKLWHKAKT SGKFSGEELD KLWREFLHHK 
EKVHEYNVLL ETLSRTEEIH ENVISPSDLS DIKGSVLHSR HTELKEKLRS INQGLDRLRR 
VSHQGYSTEA EFEEPRVIDL WDLAQSANLT DKELEAFREE LKHFEAKIEK HNHYQKQLEI 
AHEKLRHAES VGDGERVSRS REKHALLEGR TKELGYTVKK HLQDLSGRIS RARHNEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.