Details for: LTA4H

Gene ID: 4048

Symbol: LTA4H

Ensembl ID: ENSG00000111144

Description: leukotriene A4 hydrolase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 223.0862
    Cell Significance Index: -34.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.6384
    Cell Significance Index: -36.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.1474
    Cell Significance Index: -40.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.8599
    Cell Significance Index: -40.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.9979
    Cell Significance Index: -19.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.0129
    Cell Significance Index: -40.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.8898
    Cell Significance Index: -36.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.5631
    Cell Significance Index: -36.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.8562
    Cell Significance Index: -34.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5412
    Cell Significance Index: -37.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1976
    Cell Significance Index: -28.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7121
    Cell Significance Index: -14.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.4216
    Cell Significance Index: 63.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.5628
    Cell Significance Index: 16.9900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.5476
    Cell Significance Index: 19.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3214
    Cell Significance Index: 27.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1670
    Cell Significance Index: 637.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9275
    Cell Significance Index: 184.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8533
    Cell Significance Index: 171.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7641
    Cell Significance Index: 20.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7459
    Cell Significance Index: 96.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7357
    Cell Significance Index: 90.4600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6763
    Cell Significance Index: 5.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6501
    Cell Significance Index: 44.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6261
    Cell Significance Index: 15.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5991
    Cell Significance Index: 70.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5787
    Cell Significance Index: 104.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.5721
    Cell Significance Index: 9.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5351
    Cell Significance Index: 236.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5256
    Cell Significance Index: 13.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5134
    Cell Significance Index: 6.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5111
    Cell Significance Index: 14.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4871
    Cell Significance Index: 14.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4497
    Cell Significance Index: 61.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3941
    Cell Significance Index: 18.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3646
    Cell Significance Index: 130.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3582
    Cell Significance Index: 25.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3453
    Cell Significance Index: 44.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3306
    Cell Significance Index: 9.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3074
    Cell Significance Index: 6.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2776
    Cell Significance Index: 30.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2760
    Cell Significance Index: 27.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2603
    Cell Significance Index: 44.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2450
    Cell Significance Index: 221.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2441
    Cell Significance Index: 3.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2322
    Cell Significance Index: 8.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1933
    Cell Significance Index: 14.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1879
    Cell Significance Index: 1.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1757
    Cell Significance Index: 121.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1749
    Cell Significance Index: 11.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1730
    Cell Significance Index: 8.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1698
    Cell Significance Index: 32.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1560
    Cell Significance Index: 4.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1546
    Cell Significance Index: 7.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1324
    Cell Significance Index: 21.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1136
    Cell Significance Index: 213.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0984
    Cell Significance Index: 74.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0496
    Cell Significance Index: 2.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0250
    Cell Significance Index: 46.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0235
    Cell Significance Index: 14.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0226
    Cell Significance Index: 34.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0111
    Cell Significance Index: 0.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0049
    Cell Significance Index: -0.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0050
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0109
    Cell Significance Index: -6.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0137
    Cell Significance Index: -18.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0141
    Cell Significance Index: -10.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0155
    Cell Significance Index: -0.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0193
    Cell Significance Index: -14.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0306
    Cell Significance Index: -4.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0428
    Cell Significance Index: -24.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0611
    Cell Significance Index: -1.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0851
    Cell Significance Index: -2.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0895
    Cell Significance Index: -5.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0955
    Cell Significance Index: -20.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1000
    Cell Significance Index: -5.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1012
    Cell Significance Index: -3.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1085
    Cell Significance Index: -31.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1104
    Cell Significance Index: -6.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1222
    Cell Significance Index: -6.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1225
    Cell Significance Index: -14.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1243
    Cell Significance Index: -3.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1278
    Cell Significance Index: -2.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1414
    Cell Significance Index: -16.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1562
    Cell Significance Index: -11.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1573
    Cell Significance Index: -4.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1695
    Cell Significance Index: -4.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1917
    Cell Significance Index: -12.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2595
    Cell Significance Index: -29.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2719
    Cell Significance Index: -28.3100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.3135
    Cell Significance Index: -2.0800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3209
    Cell Significance Index: -3.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3681
    Cell Significance Index: -16.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4010
    Cell Significance Index: -31.7600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4410
    Cell Significance Index: -4.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4510
    Cell Significance Index: -17.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5405
    Cell Significance Index: -33.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5592
    Cell Significance Index: -16.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6373
    Cell Significance Index: -7.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7401
    Cell Significance Index: -27.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LTA4H is a metalloaminopeptidase enzyme that belongs to the M12 family of metalloproteases. It is a secreted enzyme that is primarily expressed in cells of the innate immune system, including classical and non-classical monocytes, macrophages, and epithelial cells. The enzyme is characterized by its ability to hydrolyze LTA4 into leukotriene E4 (LTE4), a less potent anti-inflammatory mediator. LTA4H is also involved in the regulation of other inflammatory mediators, such as prostaglandins and thromboxanes. **Pathways and Functions** The primary function of LTA4H is to regulate the levels of LTA4 and LTE4 in the inflammatory response. LTA4H hydrolyzes LTA4 into LTE4, which has anti-inflammatory properties and promotes the resolution of inflammation. The enzyme also plays a role in the regulation of other inflammatory mediators, such as prostaglandins and thromboxanes, which are involved in the initiation and maintenance of inflammation. In addition to its role in inflammation, LTA4H is also involved in the regulation of cell signaling pathways, including the NF-κB and MAPK pathways. These pathways are critical in the regulation of immune responses and inflammation. **Clinical Significance** Dysregulation of LTA4H has been implicated in various inflammatory and immune-related disorders, including asthma, chronic obstructive pulmonary disease (COPD), and cancer. Overexpression of LTA4H has been observed in these conditions, leading to an imbalance in the levels of LTA4 and LTE4, which can exacerbate inflammation and tissue damage. Furthermore, LTA4H has been shown to play a role in the regulation of immune responses to infections, including viral and bacterial infections. The enzyme is involved in the production of anti-inflammatory mediators, such as LTE4, which can help to resolve inflammation and prevent tissue damage. In conclusion, LTA4H is an important enzyme involved in the regulation of inflammation and immune responses. Its dysregulation has been implicated in various inflammatory and immune-related disorders, highlighting the potential for therapeutic targeting of this enzyme in the treatment of these conditions. **Significantly Expressed Cells** LTA4H is expressed in various cell types, including: * CD14-positive, CD16-negative classical monocytes * CD14-positive monocyte * Blood cell * CD14-positive, CD16-positive monocyte * Non-classical monocyte * Type II pneumocyte * Epithelial cell of esophagus * Pneumocyte * Myelocyte These cells are involved in the innate immune response and are critical in the regulation of inflammation and immune responses. **Proteins** The LTA4H protein is a metalloaminopeptidase enzyme that belongs to the M12 family of metalloproteases. It has a molecular weight of approximately 40 kDa and is secreted from the cell surface. The protein has a high degree of specificity for LTA4, and its activity is inhibited by zinc ions.

Genular Protein ID: 3598542681

Symbol: LKHA4_HUMAN

Name: Leukotriene A-4 hydrolase

UniProtKB Accession Codes:

P09960 B4DNQ9 F8VV40 Q6IAT6 Q9UCT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 2 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 22 DrugCentral 1 EC 2 EMBL 29 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 76 PDBsum 76 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 7 RefSeq 4 Rhea 6 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3654641

Title: Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase. Complete primary structure of an enzyme involved in eicosanoid synthesis.

PubMed ID: 3654641

DOI: 10.1016/s0021-9258(18)47872-6

PubMed ID: 2821541

Title: Molecular cloning and amino acid sequence of leukotriene A4 hydrolase.

PubMed ID: 2821541

DOI: 10.1073/pnas.84.19.6677

PubMed ID: 7628486

Title: Cloning and characterization of the human leukotriene A4 hydrolase gene.

PubMed ID: 7628486

DOI: 10.1111/j.1432-1033.1995.tb20671.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1897988

Title: Leukotriene A4 hydrolase in the human B-lymphocytic cell line Raji: indications of catalytically divergent forms of the enzyme.

PubMed ID: 1897988

DOI: 10.1016/0003-9861(91)90402-5

PubMed ID: 6490615

Title: Leukotriene A4 hydrolase in human leukocytes. Purification and properties.

PubMed ID: 6490615

DOI: 10.1016/s0021-9258(18)90750-7

PubMed ID: 7667299

Title: Leukotriene A4 hydrolase: mapping of a henicosapeptide involved in mechanism-based inactivation.

PubMed ID: 7667299

DOI: 10.1073/pnas.92.18.8383

PubMed ID: 8615763

Title: The human leukotriene A4 hydrolase gene is expressed in two alternatively spliced mRNA forms.

PubMed ID: 8615763

DOI: 10.1042/bj3140733

PubMed ID: 1975494

Title: Molecular evolution and zinc ion binding motif of leukotriene A4 hydrolase.

PubMed ID: 1975494

DOI: 10.1016/0006-291x(90)91379-7

PubMed ID: 2244921

Title: Leukotriene A4 hydrolase: a zinc metalloenzyme.

PubMed ID: 2244921

DOI: 10.1016/0006-291x(90)91540-9

PubMed ID: 1881903

Title: Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis.

PubMed ID: 1881903

DOI: 10.1073/pnas.88.17.7620

PubMed ID: 1516710

Title: Leukotriene A4 hydrolase, a bifunctional enzyme. Distinction of leukotriene A4 hydrolase and aminopeptidase activities by site-directed mutagenesis at Glu-297.

PubMed ID: 1516710

DOI: 10.1016/0014-5793(92)80806-r

PubMed ID: 1357660

Title: Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296.

PubMed ID: 1357660

DOI: 10.1073/pnas.89.19.9141

PubMed ID: 9395533

Title: Regulation of leukotriene A4 hydrolase activity in endothelial cells by phosphorylation.

PubMed ID: 9395533

DOI: 10.1074/jbc.272.50.31865

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20813919

Title: A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.

PubMed ID: 20813919

DOI: 10.1126/science.1190594

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21206090

Title: Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.

PubMed ID: 21206090

DOI: 10.1172/jci42545

PubMed ID: 11175901

Title: Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.

PubMed ID: 11175901

DOI: 10.1038/84117

PubMed ID: 12207002

Title: Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors.

PubMed ID: 12207002

DOI: 10.1096/fj.01-1017fje

PubMed ID: 11675384

Title: Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms.

PubMed ID: 11675384

DOI: 10.1074/jbc.m106577200

PubMed ID: 11917124

Title: Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375.

PubMed ID: 11917124

DOI: 10.1073/pnas.072090099

PubMed ID: 15078870

Title: Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates.

PubMed ID: 15078870

DOI: 10.1074/jbc.m401031200

PubMed ID: 18804029

Title: Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design.

PubMed ID: 18804029

DOI: 10.1016/j.chembiol.2008.07.018

PubMed ID: 19618939

Title: Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.

PubMed ID: 19618939

DOI: 10.1021/jm900259h

PubMed ID: 24591641

Title: Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.

PubMed ID: 24591641

DOI: 10.1073/pnas.1402136111

Sequence Information:

  • Length: 611
  • Mass: 69285
  • Checksum: 329BF6D04D4A06E1
  • Sequence:
    • MPEIVDTCSL ASPASVCRTK HLHLRCSVDF TRRTLTGTAA LTVQSQEDNL RSLVLDTKDL 
TIEKVVINGQ EVKYALGERQ SYKGSPMEIS LPIALSKNQE IVIEISFETS PKSSALQWLT 
PEQTSGKEHP YLFSQCQAIH CRAILPCQDT PSVKLTYTAE VSVPKELVAL MSAIRDGETP 
DPEDPSRKIY KFIQKVPIPC YLIALVVGAL ESRQIGPRTL VWSEKEQVEK SAYEFSETES 
MLKIAEDLGG PYVWGQYDLL VLPPSFPYGG MENPCLTFVT PTLLAGDKSL SNVIAHEISH 
SWTGNLVTNK TWDHFWLNEG HTVYLERHIC GRLFGEKFRH FNALGGWGEL QNSVKTFGET 
HPFTKLVVDL TDIDPDVAYS SVPYEKGFAL LFYLEQLLGG PEIFLGFLKA YVEKFSYKSI 
TTDDWKDFLY SYFKDKVDVL NQVDWNAWLY SPGLPPIKPN YDMTLTNACI ALSQRWITAK 
EDDLNSFNAT DLKDLSSHQL NEFLAQTLQR APLPLGHIKR MQEVYNFNAI NNSEIRFRWL 
RLCIQSKWED AIPLALKMAT EQGRMKFTRP LFKDLAAFDK SHDQAVRTYQ EHKASMHPVT 
AMLVGKDLKV D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.