Details for: LTA4H

Gene ID: 4048

Symbol: LTA4H

Ensembl ID: ENSG00000111144

Description: leukotriene A4 hydrolase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.78
    Marker Score: 155406
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.67
    Marker Score: 68446
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.53
    Marker Score: 6291
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.49
    Marker Score: 29002
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.37
    Marker Score: 4611
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.23
    Marker Score: 5380
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.1
    Marker Score: 13705
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.97
    Marker Score: 16981
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.92
    Marker Score: 3093
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.91
    Marker Score: 827
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.86
    Marker Score: 1026
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.85
    Marker Score: 11232
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.81
    Marker Score: 9491
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.8
    Marker Score: 7488
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.79
    Marker Score: 11666
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.7
    Marker Score: 1597
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.67
    Marker Score: 4536
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.66
    Marker Score: 57465
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.65
    Marker Score: 868
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.59
    Marker Score: 1149
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.59
    Marker Score: 1324
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.57
    Marker Score: 2745
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.57
    Marker Score: 3296
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.57
    Marker Score: 6411
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.56
    Marker Score: 12219.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.56
    Marker Score: 1662
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.55
    Marker Score: 3229
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.54
    Marker Score: 1416
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.53
    Marker Score: 2436.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.51
    Marker Score: 1593
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.49
    Marker Score: 997
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.46
    Marker Score: 14666.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.45
    Marker Score: 3424
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166038
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.45
    Marker Score: 506
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.44
    Marker Score: 3425
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.44
    Marker Score: 23152
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.41
    Marker Score: 18564
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.39
    Marker Score: 2363.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.36
    Marker Score: 1588
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.35
    Marker Score: 1207
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.34
    Marker Score: 5626
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.34
    Marker Score: 1534.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.34
    Marker Score: 1363
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.33
    Marker Score: 1337
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.32
    Marker Score: 423
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.31
    Marker Score: 2148
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.3
    Marker Score: 543
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.3
    Marker Score: 2372
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.29
    Marker Score: 1216
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.29
    Marker Score: 303
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.28
    Marker Score: 1890
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.28
    Marker Score: 1540.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.28
    Marker Score: 481
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.27
    Marker Score: 368
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.27
    Marker Score: 1360.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.27
    Marker Score: 1534.5
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.24
    Marker Score: 377
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.2
    Marker Score: 1183
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.2
    Marker Score: 588
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.19
    Marker Score: 2117
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.19
    Marker Score: 1286
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.18
    Marker Score: 271
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.17
    Marker Score: 299
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.17
    Marker Score: 735
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.17
    Marker Score: 7476
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.17
    Marker Score: 293
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.16
    Marker Score: 1092
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.16
    Marker Score: 404
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.15
    Marker Score: 820
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.14
    Marker Score: 3102.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.14
    Marker Score: 1428
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.14
    Marker Score: 272
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.14
    Marker Score: 1476
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.13
    Marker Score: 2560
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.12
    Marker Score: 684
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.12
    Marker Score: 11543
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.11
    Marker Score: 652
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.11
    Marker Score: 269
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.11
    Marker Score: 383
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.1
    Marker Score: 833
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.09
    Marker Score: 1951
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.09
    Marker Score: 533
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.09
    Marker Score: 982
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.09
    Marker Score: 537
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.09
    Marker Score: 819
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.08
    Marker Score: 2646.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.08
    Marker Score: 66370
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.08
    Marker Score: 734
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.08
    Marker Score: 3194
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.08
    Marker Score: 519
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.07
    Marker Score: 209
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.07
    Marker Score: 1146
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.06
    Marker Score: 2086
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.06
    Marker Score: 447
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.06
    Marker Score: 433
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.06
    Marker Score: 476
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.06
    Marker Score: 1365
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.06
    Marker Score: 14185.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.05
    Marker Score: 5063

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Other Information

**Key characteristics** * The LTA4H gene is located on chromosome 15q23.1. * It is a large gene with a length of approximately 13.6 kb. * The protein encoded by LTA4H is a transmembrane protein with a molecular weight of approximately 92 kDa. * It is expressed in a variety of cell types, including monocytes, macrophages, and endothelial cells. **Pathways and functions** * LTA4H is involved in the synthesis of eicosanoids, which are lipid mediators that play a role in inflammation, pain, and blood clotting. * Eicosanoids are produced by a variety of cell types, including monocytes, macrophages, and endothelial cells. * They are released into the extracellular environment, where they can bind to receptors on target cells, triggering a variety of cellular responses. * Leukotrienes have a number of important roles in inflammation, including promoting neutrophil degranulation, activating platelets, and suppressing inflammation. **Clinical significance** * Mutations in the LTA4H gene have been linked to a number of inflammatory diseases, including asthma, rheumatoid arthritis, and lupus. * These mutations can lead to the production of excessive leukotrienes, which can contribute to inflammation and tissue damage. * Therefore, LTA4H is a potential target for the treatment of inflammatory diseases. **Additional information** * The LTA4H gene is also involved in the regulation of inflammation in the airways. * It is upregulated in asthma and chronic obstructive pulmonary disease (COPD). * LTA4H is a promising target for the treatment of inflammatory diseases.

Genular Protein ID: 3598542681

Symbol: LKHA4_HUMAN

Name: Leukotriene A-4 hydrolase

UniProtKB Accession Codes:

P09960 B4DNQ9 F8VV40 Q6IAT6 Q9UCT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 2 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 22 DrugCentral 1 EC 2 EMBL 29 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 70 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 7 RefSeq 4 Rhea 6 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3654641

Title: Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase. Complete primary structure of an enzyme involved in eicosanoid synthesis.

PubMed ID: 3654641

DOI: 10.1016/s0021-9258(18)47872-6

PubMed ID: 2821541

Title: Molecular cloning and amino acid sequence of leukotriene A4 hydrolase.

PubMed ID: 2821541

DOI: 10.1073/pnas.84.19.6677

PubMed ID: 7628486

Title: Cloning and characterization of the human leukotriene A4 hydrolase gene.

PubMed ID: 7628486

DOI: 10.1111/j.1432-1033.1995.tb20671.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1897988

Title: Leukotriene A4 hydrolase in the human B-lymphocytic cell line Raji: indications of catalytically divergent forms of the enzyme.

PubMed ID: 1897988

DOI: 10.1016/0003-9861(91)90402-5

PubMed ID: 6490615

Title: Leukotriene A4 hydrolase in human leukocytes. Purification and properties.

PubMed ID: 6490615

DOI: 10.1016/s0021-9258(18)90750-7

PubMed ID: 7667299

Title: Leukotriene A4 hydrolase: mapping of a henicosapeptide involved in mechanism-based inactivation.

PubMed ID: 7667299

DOI: 10.1073/pnas.92.18.8383

PubMed ID: 8615763

Title: The human leukotriene A4 hydrolase gene is expressed in two alternatively spliced mRNA forms.

PubMed ID: 8615763

DOI: 10.1042/bj3140733

PubMed ID: 1975494

Title: Molecular evolution and zinc ion binding motif of leukotriene A4 hydrolase.

PubMed ID: 1975494

DOI: 10.1016/0006-291x(90)91379-7

PubMed ID: 2244921

Title: Leukotriene A4 hydrolase: a zinc metalloenzyme.

PubMed ID: 2244921

DOI: 10.1016/0006-291x(90)91540-9

PubMed ID: 1881903

Title: Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis.

PubMed ID: 1881903

DOI: 10.1073/pnas.88.17.7620

PubMed ID: 1516710

Title: Leukotriene A4 hydrolase, a bifunctional enzyme. Distinction of leukotriene A4 hydrolase and aminopeptidase activities by site-directed mutagenesis at Glu-297.

PubMed ID: 1516710

DOI: 10.1016/0014-5793(92)80806-r

PubMed ID: 1357660

Title: Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296.

PubMed ID: 1357660

DOI: 10.1073/pnas.89.19.9141

PubMed ID: 9395533

Title: Regulation of leukotriene A4 hydrolase activity in endothelial cells by phosphorylation.

PubMed ID: 9395533

DOI: 10.1074/jbc.272.50.31865

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20813919

Title: A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.

PubMed ID: 20813919

DOI: 10.1126/science.1190594

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21206090

Title: Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.

PubMed ID: 21206090

DOI: 10.1172/jci42545

PubMed ID: 11175901

Title: Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.

PubMed ID: 11175901

DOI: 10.1038/84117

PubMed ID: 12207002

Title: Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors.

PubMed ID: 12207002

DOI: 10.1096/fj.01-1017fje

PubMed ID: 11675384

Title: Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms.

PubMed ID: 11675384

DOI: 10.1074/jbc.m106577200

PubMed ID: 11917124

Title: Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375.

PubMed ID: 11917124

DOI: 10.1073/pnas.072090099

PubMed ID: 15078870

Title: Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates.

PubMed ID: 15078870

DOI: 10.1074/jbc.m401031200

PubMed ID: 18804029

Title: Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design.

PubMed ID: 18804029

DOI: 10.1016/j.chembiol.2008.07.018

PubMed ID: 19618939

Title: Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.

PubMed ID: 19618939

DOI: 10.1021/jm900259h

PubMed ID: 24591641

Title: Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.

PubMed ID: 24591641

DOI: 10.1073/pnas.1402136111

Sequence Information:

  • Length: 611
  • Mass: 69285
  • Checksum: 329BF6D04D4A06E1
  • Sequence:
    • MPEIVDTCSL ASPASVCRTK HLHLRCSVDF TRRTLTGTAA LTVQSQEDNL RSLVLDTKDL 
TIEKVVINGQ EVKYALGERQ SYKGSPMEIS LPIALSKNQE IVIEISFETS PKSSALQWLT 
PEQTSGKEHP YLFSQCQAIH CRAILPCQDT PSVKLTYTAE VSVPKELVAL MSAIRDGETP 
DPEDPSRKIY KFIQKVPIPC YLIALVVGAL ESRQIGPRTL VWSEKEQVEK SAYEFSETES 
MLKIAEDLGG PYVWGQYDLL VLPPSFPYGG MENPCLTFVT PTLLAGDKSL SNVIAHEISH 
SWTGNLVTNK TWDHFWLNEG HTVYLERHIC GRLFGEKFRH FNALGGWGEL QNSVKTFGET 
HPFTKLVVDL TDIDPDVAYS SVPYEKGFAL LFYLEQLLGG PEIFLGFLKA YVEKFSYKSI 
TTDDWKDFLY SYFKDKVDVL NQVDWNAWLY SPGLPPIKPN YDMTLTNACI ALSQRWITAK 
EDDLNSFNAT DLKDLSSHQL NEFLAQTLQR APLPLGHIKR MQEVYNFNAI NNSEIRFRWL 
RLCIQSKWED AIPLALKMAT EQGRMKFTRP LFKDLAAFDK SHDQAVRTYQ EHKASMHPVT 
AMLVGKDLKV D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.