Details for: LTBP3

Gene ID: 4054

Symbol: LTBP3

Ensembl ID: ENSG00000168056

Description: latent transforming growth factor beta binding protein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.04
    Marker Score: 7538
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.76
    Marker Score: 59985
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.74
    Marker Score: 4397
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.74
    Marker Score: 3038
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.72
    Marker Score: 1465
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.69
    Marker Score: 390
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.53
    Marker Score: 4013
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.52
    Marker Score: 4083
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.49
    Marker Score: 1425
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.41
    Marker Score: 10511
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.36
    Marker Score: 384
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.35
    Marker Score: 788
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.35
    Marker Score: 28780
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.3
    Marker Score: 923
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.29
    Marker Score: 846
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.28
    Marker Score: 5340
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.27
    Marker Score: 1353
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.26
    Marker Score: 2960
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.25
    Marker Score: 881
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.25
    Marker Score: 687
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.24
    Marker Score: 1291
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.22
    Marker Score: 2350.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.22
    Marker Score: 490
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.19
    Marker Score: 2721
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.18
    Marker Score: 1675
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.18
    Marker Score: 667
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.17
    Marker Score: 339
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.17
    Marker Score: 1013
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.16
    Marker Score: 1918
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.14
    Marker Score: 291
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.14
    Marker Score: 1203
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.14
    Marker Score: 295
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.13
    Marker Score: 12690
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.12
    Marker Score: 68802
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.11
    Marker Score: 4644.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.1
    Marker Score: 1119
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.1
    Marker Score: 459
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.1
    Marker Score: 1007
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.08
    Marker Score: 1150
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.08
    Marker Score: 505
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.07
    Marker Score: 264
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.06
    Marker Score: 333
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.05
    Marker Score: 1205
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.05
    Marker Score: 1128
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.04
    Marker Score: 6788
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.04
    Marker Score: 5454
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.03
    Marker Score: 2067
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16164
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.02
    Marker Score: 329
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.02
    Marker Score: 1573
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.01
    Marker Score: 1383
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1
    Marker Score: 1291
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71657
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47882
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.99
    Marker Score: 577
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.99
    Marker Score: 1519
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.98
    Marker Score: 37291
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30384
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.97
    Marker Score: 1436
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1976
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.97
    Marker Score: 1170
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.97
    Marker Score: 1302
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.97
    Marker Score: 17143
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.96
    Marker Score: 1384
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.96
    Marker Score: 1701
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.96
    Marker Score: 308.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.95
    Marker Score: 302
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.95
    Marker Score: 7293
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.95
    Marker Score: 14219
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.94
    Marker Score: 550
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2391
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.94
    Marker Score: 1161
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.93
    Marker Score: 3304
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.93
    Marker Score: 209
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.92
    Marker Score: 18341
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.92
    Marker Score: 550
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.91
    Marker Score: 3536
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.91
    Marker Score: 881
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.91
    Marker Score: 450
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.9
    Marker Score: 8586
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.9
    Marker Score: 594
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9
    Marker Score: 1896
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.89
    Marker Score: 374
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.89
    Marker Score: 215
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.89
    Marker Score: 331
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.88
    Marker Score: 32614
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.87
    Marker Score: 1086
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.87
    Marker Score: 1047
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.86
    Marker Score: 8636
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.86
    Marker Score: 1405
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.85
    Marker Score: 356
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.84
    Marker Score: 932
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.84
    Marker Score: 375
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.83
    Marker Score: 7196
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.83
    Marker Score: 252

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Other Information

**Key characteristics:** * LTBP3 is a secreted protein that is expressed in high levels in bone and cartilage. * It is a member of the immunoglobulin superfamily. * It is a key regulator of bone mineralization, chondrocyte differentiation, and bone remodeling. * It interacts with the TGF-beta receptor complex and is involved in the regulation of TGF-beta signaling. * It is also involved in the regulation of other signaling pathways, including the MAPK pathway and the Wnt pathway. **Pathways and functions:** * LTBP3 is a key regulator of bone mineralization. It is expressed in cells that are responsible for the formation of new bone tissue. When LTBP3 is bound by TGF-beta, it inhibits the activity of the TGF-beta receptor complex. This prevents the activation of downstream signaling pathways that would otherwise promote bone formation. * LTBP3 is also involved in the regulation of chondrocyte differentiation. It is expressed in cells that are committed to becoming chondrocytes. When LTBP3 is bound by TGF-beta, it inhibits the differentiation of these cells into osteoblasts. * LTBP3 is also involved in the regulation of bone remodeling. It is expressed in cells that are responsible for breaking down old bone tissue. When LTBP3 is bound by TGF-beta, it promotes the formation of new bone tissue. **Clinical significance:** Mutations in the LTBP3 gene have been linked to a number of human diseases, including osteoporosis and rheumatoid arthritis. These diseases are characterized by bone loss, which is often caused by defects in bone mineralization, chondrocyte differentiation, and bone remodeling. **Conclusion:** LTBP3 is a key regulator of bone metabolism. It is involved in the regulation of bone mineralization, chondrocyte differentiation, and bone remodeling. Mutations in the LTBP3 gene have been linked to a number of human diseases, which suggests that LTBP3 is a potential therapeutic target for these diseases.

Genular Protein ID: 2379055163

Symbol: LTBP3_HUMAN

Name: Latent-transforming growth factor beta-binding protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12154076

Title: Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta.

PubMed ID: 12154076

DOI: 10.1242/jcs.115.17.3457

PubMed ID: 9620332

Title: Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region.

PubMed ID: 9620332

DOI: 10.1002/hep.510270619

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10930463

Title: Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.

PubMed ID: 10930463

DOI: 10.1091/mbc.11.8.2691

PubMed ID: 10743502

Title: Latent transforming growth factor-beta binding proteins (LTBPs) -- structural extracellular matrix proteins for targeting TGF-beta action.

PubMed ID: 10743502

DOI: 10.1016/s1359-6101(99)00010-6

PubMed ID: 11104663

Title: The latent transforming growth factor beta binding protein (LTBP) family.

PubMed ID: 11104663

DOI: 10.1042/bj3520601

PubMed ID: 16157329

Title: Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts.

PubMed ID: 16157329

DOI: 10.1016/j.yexcr.2005.08.008

PubMed ID: 27339457

Title: Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.

PubMed ID: 27339457

DOI: 10.1016/j.matbio.2016.06.003

PubMed ID: 19344874

Title: Oligodontia is caused by mutation in LTBP3, the gene encoding latent TGF-beta binding protein 3.

PubMed ID: 19344874

DOI: 10.1016/j.ajhg.2009.03.007

PubMed ID: 27068007

Title: Mutations in LTBP3 cause acromicric dysplasia and geleophysic dysplasia.

PubMed ID: 27068007

DOI: 10.1136/jmedgenet-2015-103647

Sequence Information:

  • Length: 1303
  • Mass: 139359
  • Checksum: 3BC6B1EE19198414
  • Sequence:
  • MPGPRGAAGG LAPEMRGAGA AGLLALLLLL LLLLLGLGGR VEGGPAGERG AGGGGALARE 
    RFKVVFAPVI CKRTCLKGQC RDSCQQGSNM TLIGENGHST DTLTGSGFRV VVCPLPCMNG 
    GQCSSRNQCL CPPDFTGRFC QVPAGGAGGG TGGSGPGLSR TGALSTGALP PLAPEGDSVA 
    SKHAIYAVQV IADPPGPGEG PPAQHAAFLV PLGPGQISAE VQAPPPVVNV RVHHPPEASV 
    QVHRIESSNA ESAAPSQHLL PHPKPSHPRP PTQKPLGRCF QDTLPKQPCG SNPLPGLTKQ 
    EDCCGSIGTA WGQSKCHKCP QLQYTGVQKP GPVRGEVGAD CPQGYKRLNS THCQDINECA 
    MPGVCRHGDC LNNPGSYRCV CPPGHSLGPS RTQCIADKPE EKSLCFRLVS PEHQCQHPLT 
    TRLTRQLCCC SVGKAWGARC QRCPTDGTAA FKEICPAGKG YHILTSHQTL TIQGESDFSL 
    FLHPDGPPKP QQLPESPSQA PPPEDTEEER GVTTDSPVSE ERSVQQSHPT ATTTPARPYP 
    ELISRPSPPT MRWFLPDLPP SRSAVEIAPT QVTETDECRL NQNICGHGEC VPGPPDYSCH 
    CNPGYRSHPQ HRYCVDVNEC EAEPCGPGRG ICMNTGGSYN CHCNRGYRLH VGAGGRSCVD 
    LNECAKPHLC GDGGFCINFP GHYKCNCYPG YRLKASRPPV CEDIDECRDP SSCPDGKCEN 
    KPGSFKCIAC QPGYRSQGGG ACRDVNECAE GSPCSPGWCE NLPGSFRCTC AQGYAPAPDG 
    RSCLDVDECE AGDVCDNGIC SNTPGSFQCQ CLSGYHLSRD RSHCEDIDEC DFPAACIGGD 
    CINTNGSYRC LCPQGHRLVG GRKCQDIDEC SQDPSLCLPH GACKNLQGSY VCVCDEGFTP 
    TQDQHGCEEV EQPHHKKECY LNFDDTVFCD SVLATNVTQQ ECCCSLGAGW GDHCEIYPCP 
    VYSSAEFHSL CPDGKGYTQD NNIVNYGIPA HRDIDECMLF GSEICKEGKC VNTQPGYECY 
    CKQGFYYDGN LLECVDVDEC LDESNCRNGV CENTRGGYRC ACTPPAEYSP AQRQCLSPEE 
    MDVDECQDPA ACRPGRCVNL PGSYRCECRP PWVPGPSGRD CQLPESPAER APERRDVCWS 
    QRGEDGMCAG PLAGPALTFD DCCCRQGRGW GAQCRPCPPR GAGSHCPTSQ SESNSFWDTS 
    PLLLGKPPRD EDSSEEDSDE CRCVSGRCVP RPGGAVCECP GGFQLDASRA RCVDIDECRE 
    LNQRGLLCKS ERCVNTSGSF RCVCKAGFAR SRPHGACVPQ RRR

Genular Protein ID: 2236646199

Symbol: Q8WYU6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 263
  • Mass: 28251
  • Checksum: 636CFA1C2AEC701D
  • Sequence:
  • MLFGSEICKE GKCVNTQPGY ECYCKQGFYY DGNLLECVDV DECLDESNCR NGVCENTRGG 
    YRCACTPPAE YSPAQRQSLS PEEMDVDECQ DPAACRPGRC VNLPGSYRCE CRPPWVPGPS 
    GRDCQLPESP AERAPERRDV CWSQRGEDGM CAGPLAGPAL TFDDCCCRQG RGWGAQCRPC 
    PPRGAGSHCP TSQSESNSFW DTSPLLLGKP PRDEDSSEED SDECRCVSAA ACRGRAAPCA 
    SVPAASSSTP PAPAAWISTS AES

Genular Protein ID: 1853100906

Symbol: B9EG76_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1139
  • Mass: 122596
  • Checksum: 50EEDCB507224080
  • Sequence:
  • MNGGQCSSRN QCLCPPDFTG RFCQVPAGGA GGGTGGSGPG LSRTGALSTG ALPPLAPEGD 
    SVASKHAIYA VQVIADPPGP GEGPPAQHAA FLVPLGPGQI SAEVQAPPPV VNVRVHHPPE 
    ASVQVHRIES SNAESAAPSQ HLLPHPKPSH PRPPTQKPLG RCFQDTLPKQ PCGSNPLPGL 
    TKQEDCCGSI GTAWGQSKCH KCPQLQYTGV QKPGPVRGEV GADCPQGYKR LNSTHCQDIN 
    ECAMPGVCRH GDCLNNPGSY RCVCPPGHSL GPSRTQCIAD KPEEKSLCFR LVSPEHQCQH 
    PLTTRLTRQL CCCSVGKAWG ARCQRCPTDG TAAFKEICPA GKGYHILTSH QTLTIQGESD 
    FSLFLHPDGP PKPQQLPESP SQAPPPEDTE EERGVTTDSP VSEERSVQQS HPTATTTPAR 
    PYPELISRPS PPTMRWFLPD LPPSRSAVEI APTQVTETDE CRLNQNICGH GECVPGPPDY 
    SCHCNPGYRS HPQHRYCVDV NECEAEPCGP GRGICMNTGG SYNCHCNRGY RLHVGAGGRS 
    CVDLNECAKP HLCGDGGFCI NFPGHYKCNC YPGYRLKASR PPVCEDIDEC RDPSSCPDGK 
    CENKPGSFKC IACQPGYRSQ GGGACRDVNE CAEGSPCSPG WCENLPGSFR CTCAQGYAPA 
    PDGRSCLDVD ECEAGDVCDN GICSNTPGSF QCQCLSGYHL SRDRSHCEDI DECDFPAACI 
    GGDCINTNGS YRCLCPQGHR LVGGRKCQDI DECSQDPSLC LPHGACKNLQ GSYVCVCDEG 
    FTPTQDQHGC EEVEQPHHKK ECYLNFDDTV FCDSVLATNV TQQECCCSLG AGWGDHCEIY 
    PCPVYSSAEF HSLCPDGKGY TQDNNIVNYG IPAHRDIDEC MLFGSEICKE GKCVNTQPGY 
    ECYCKQGFYY DGNLLECVDV DECLDESNCR NGVCENTRGG YRCACTPPAE YSPAQRQCLS 
    PEEMERAPER RDVCWSQRGE DGMCAGPLAG PALTFDDCCC RQGRGWGAQC RPCPPRGAGS 
    HCPTSQSESN SFWDTSPLLL GKPPRDEDSS EEDSDECRCV SGRCVPRPGG AVCECPGGFQ 
    LDASRARCVD IDECRELNQR GLLCKSERCV NTSGSFRCVC KAGFARSRPH GACVPQRRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.