Details for: LY9

Gene ID: 4063

Symbol: LY9

Ensembl ID: ENSG00000122224

Description: lymphocyte antigen 9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.13
    Marker Score: 3707
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1154
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.49
    Marker Score: 1330.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.48
    Marker Score: 4161
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.47
    Marker Score: 885
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.44
    Marker Score: 1090
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.43
    Marker Score: 506
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.39
    Marker Score: 2921
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.38
    Marker Score: 1362
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.36
    Marker Score: 4029
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.35
    Marker Score: 1345.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.31
    Marker Score: 644
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.26
    Marker Score: 291
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.25
    Marker Score: 1358
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 843
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.19
    Marker Score: 5101
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.17
    Marker Score: 3692
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.15
    Marker Score: 478
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4786
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.13
    Marker Score: 59772
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.11
    Marker Score: 2178
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.03
    Marker Score: 995
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48014
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.99
    Marker Score: 594
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.96
    Marker Score: 1366
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.96
    Marker Score: 2335
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.95
    Marker Score: 812
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5239
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.89
    Marker Score: 671
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.88
    Marker Score: 210
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.88
    Marker Score: 783
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.86
    Marker Score: 396
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.85
    Marker Score: 9906
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.85
    Marker Score: 800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.84
    Marker Score: 8347
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.84
    Marker Score: 784
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.82
    Marker Score: 411
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.81
    Marker Score: 397
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.8
    Marker Score: 244
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.8
    Marker Score: 248
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.8
    Marker Score: 1371
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.79
    Marker Score: 754
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.78
    Marker Score: 573
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 589
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1251
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.75
    Marker Score: 170
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.75
    Marker Score: 439
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.73
    Marker Score: 452
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.73
    Marker Score: 443
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 454
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.7
    Marker Score: 618
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.68
    Marker Score: 1004
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.68
    Marker Score: 499
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.67
    Marker Score: 1196
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.64
    Marker Score: 696
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.64
    Marker Score: 541
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.63
    Marker Score: 357
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.62
    Marker Score: 453
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.62
    Marker Score: 511
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.61
    Marker Score: 515
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.61
    Marker Score: 197
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.6
    Marker Score: 143
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.59
    Marker Score: 133
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.57
    Marker Score: 788
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.57
    Marker Score: 244
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.56
    Marker Score: 372
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.56
    Marker Score: 195
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.55
    Marker Score: 1045
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.55
    Marker Score: 320
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.54
    Marker Score: 350
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.53
    Marker Score: 271
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.52
    Marker Score: 302
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.5
    Marker Score: 175
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.49
    Marker Score: 541
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.48
    Marker Score: 486
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.48
    Marker Score: 324
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.48
    Marker Score: 348
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.48
    Marker Score: 375
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.46
    Marker Score: 501
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.45
    Marker Score: 115
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.44
    Marker Score: 588
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.43
    Marker Score: 478
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.41
    Marker Score: 675
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.41
    Marker Score: 359
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.39
    Marker Score: 212
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.39
    Marker Score: 217

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Other Information

## Summary The LY9 gene encodes a cell surface protein that is expressed on B cells and some other immune cells. LY9 is involved in the regulation of the immune response, and it is important for the development of memory B cells. ## Key characteristics * LY9 is a cell adhesion molecule that is expressed on B cells and some other immune cells. * It is a member of the immunoglobulin superfamily IgV. * LY9 is a key regulator of the immune response, and it is important for the development of memory B cells. * It is involved in the regulation of T-cell activation and the production of cytokines. * LY9 is also involved in the regulation of inflammation. ## Pathways and functions * LY9 is expressed on B cells and some other immune cells. * It is involved in the regulation of the immune response. * LY9 is a key regulator of the development of memory B cells. * It is involved in the regulation of T-cell activation and the production of cytokines. * LY9 is also involved in the regulation of inflammation. ## Clinical significance * Mutations in the LY9 gene have been linked to a number of human diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. * LY9 is a potential target for cancer immunotherapy. * LY9 inhibitors are being investigated as a treatment for cancer and other diseases that are characterized by inflammation. ## Additional notes * LY9 is a highly conserved protein, with a similar sequence found in mice, rats, and humans. * The LY9 gene is located on chromosome 15q21.1. * LY9 is a relatively new protein, with the first sequence being identified in 1996.

Genular Protein ID: 3637231047

Symbol: LY9_HUMAN

Name: T-lymphocyte surface antigen Ly-9

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10970093

Title: Gene structure of the mouse leukocyte cell surface molecule Ly9.

PubMed ID: 10970093

DOI: 10.1007/s002510000209

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8537117

Title: Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9.

PubMed ID: 8537117

DOI: 10.1007/bf00186599

PubMed ID: 11389028

Title: Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.

PubMed ID: 11389028

DOI: 10.1182/blood.v97.12.3867

PubMed ID: 12458214

Title: Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors.

PubMed ID: 12458214

DOI: 10.1074/jbc.m206649200

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 22989874

Title: CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORgammat recruitment to the IL17A promoter in human T lymphocytes.

PubMed ID: 22989874

DOI: 10.1074/jbc.m112.415067

PubMed ID: 22184727

Title: Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation.

PubMed ID: 22184727

DOI: 10.4049/jimmunol.1102773

PubMed ID: 26221972

Title: A polymorphism in a phosphotyrosine signalling motif of CD229 (Ly9, SLAMF3) alters SH2 domain binding and T-cell activation.

PubMed ID: 26221972

DOI: 10.1111/imm.12513

Sequence Information:

  • Length: 655
  • Mass: 72139
  • Checksum: 84ABA3056D69E80A
  • Sequence:
  • MVAPKSHTDD WAPGPFSSKP QRSQLQIFSS VLQTSLLFLL MGLRASGKDS APTVVSGILG 
    GSVTLPLNIS VDTEIENVIW IGPKNALAFA RPKENVTIMV KSYLGRLDIT KWSYSLCISN 
    LTLNDAGSYK AQINQRNFEV TTEEEFTLFV YEQLQEPQVT MKSVKVSENF SCNITLMCSV 
    KGAEKSVLYS WTPREPHASE SNGGSILTVS RTPCDPDLPY ICTAQNPVSQ RSSLPVHVGQ 
    FCTDPGASRG GTTGETVVGV LGEPVTLPLA LPACRDTEKV VWLFNTSIIS KEREEAATAD 
    PLIKSRDPYK NRVWVSSQDC SLKISQLKIE DAGPYHAYVC SEASSVTSMT HVTLLIYRRL 
    RKPKITWSLR HSEDGICRIS LTCSVEDGGN TVMYTWTPLQ KEAVVSQGES HLNVSWRSSE 
    NHPNLTCTAS NPVSRSSHQF LSENICSGPE RNTKLWIGLF LMVCLLCVGI FSWCIWKRKG 
    RCSVPAFCSS QAEAPADTPE PTAGHTLYSV LSQGYEKLDT PLRPARQQPT PTSDSSSDSN 
    LTTEEDEDRP EVHKPISGRY EVFDQVTQEG AGHDPAPEGQ ADYDPVTPYV TEVESVVGEN 
    TMYAQVFNLQ GKTPVSQKEE SSATIYCSIR KPQVVPPPQQ NDLEIPESPT YENFT

Genular Protein ID: 3804815413

Symbol: Q05CA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 405
  • Mass: 44402
  • Checksum: D739607D6CB18F21
  • Sequence:
  • MKSVKVSENF SCNITLMCSV KGAEKSVLYS WTPREPHASE SNGGSILTVS RTPCDPDLPY 
    ICTAQNPVSQ RSSLPVHVGQ FCTDPGASRG GTTGETVVGV LGEPVTLPLA LPACRDTEKV 
    VWLFNTSIIS KEREEAATAD PLIKSRDPYK NRVWVSSQDC SLKISQLKIE DAGPYHAYVC 
    SEASSVTSMT HVTLLIYRPE RNTKLWIGLF LMVCLLCVGI FSWCIWKRKG RCSVPAFCSS 
    QAEAPADTPE PTAGHTLYSV LSQGYEKLDT PLRPARQQPT PTSDSSSDSN LTTEEDEDRP 
    EVHKPISGRY EVFDQVTQEG AGHDPAPEGQ ADYDPVTPYV TEVESVVGEN TVYAQVFNLQ 
    GKTPVSQKEE SSATIYCSIR KPQVVPPPQQ NDLEIPESPT YENFT

Genular Protein ID: 2075334458

Symbol: Q0VAI0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 405
  • Mass: 44303
  • Checksum: 7328727CBABCE8F6
  • Sequence:
  • MKSVKVSENF SCNITLMCSV KGAEKSVLYS WTPREPHASE SNGGSILTVS GTPCDPDLPY 
    ICTAQNPVSQ RSSLPVHVGQ FCTDPGASRG GTTGETVVGV LGEPVTLPLA LPACRDTEKV 
    VWLFNTSIIS KEREEAATAD PLIKSRDPYK NRVWVSSQDC SLKISQLKIE DAGPYHAYVC 
    SEASSVTSMT HVTLLIYRPE RNTKLWIGLF LMVCLLCVGI FSWCIWKRKG RCSVPAFCSS 
    QAEAPADTPE PTAGHTLYSV LSQGYEKLDT PLRPARQQPT PTSDSSSDSN LTTEEDEDRP 
    EVHKPISGRY EVFDQVTQEG AGHDPAPEGQ ADYDPVTPYV TEVESVVGEN TVYAQVFNLQ 
    GKTPVSQKEE SSATIYCSIR KPQVVPPPQQ NDLEIPESPT YENFT

Genular Protein ID: 1531412087

Symbol: Q5VYH9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 565
  • Mass: 62113
  • Checksum: 833D30A2797B2EBF
  • Sequence:
  • MVAPKSHTDD WAPGPFSSKP QRSQLQIFSS VLQTSLLFLL MGLRASGKDS APTVVSGILG 
    GSVTLPLNIS VDTEIENVIW IGPKNALAFA RPKENVTIMV KSYLGRLDIT KWSYSLCISN 
    LTLNDAGSYK AQINQRNFEV TTEEEFTLFV YEQLQEPQVT MKSVKVSENF SCNITLMCSV 
    KGAEKSVLYS WTPREPHASE SNGGSILTVS RTPCDPDLPY ICTAQNPVSQ RSSLPVHVGQ 
    FCTDPGASRG GTTGETVVGV LGEPVTLPLA LPACRDTEKV VWLFNTSIIS KEREEAATAD 
    PLIKSRDPYK NRVWVSSQDC SLKISQLKIE DAGPYHAYVC SEASSVTSMT HVTLLIYRPE 
    RNTKLWIGLF LMVCLLCVGI FSWCIWKRKG RCSVPAFCSS QAEAPADTPE PTAGHTLYSV 
    LSQGYEKLDT PLRPARQQPT PTSDSSSDSN LTTEEDEDRP EVHKPISGRY EVFDQVTQEG 
    AGHDPAPEGQ ADYDPVTPYV TEVESVVGEN TMYAQVFNLQ GKTPVSQKEE SSATIYCSIR 
    KPQVVPPPQQ NDLEIPESPT YENFT

Genular Protein ID: 1185610984

Symbol: A0A0C4DFU4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 193
  • Mass: 21169
  • Checksum: D9552BB4293C5B00
  • Sequence:
  • MVAPKSHTDD WAPGPFSSKP QRSQLQIFSS VLQTSLLFLL MGLRASGKDS APTVVSGILG 
    GSVTLPLNIS VDTEIENVIW IGPKNALAFA RPKENVTIMV KSYLGRLDIT KWSYSLCISN 
    LTLNDAGSYK AQINQRNFEV TTEEEFTLFV YAPFIEKLSV HVIEGDHRTL LEGSGLESII 
    STLAEPRVSV REG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.