Gene CD180 - ENSG00000134061 | NCBI Gene ID: 4064

Details for: CD180

Gene ID: 4064

Symbol: CD180

Ensembl ID: ENSG00000134061

Description: CD180 molecule

Associated with

Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
B cell proliferation involved in immune response
(GO:0002322)
Cellular response to lipopolysaccharide
(GO:0071222)
Extracellular matrix
(GO:0031012)
Extracellular space
(GO:0005615)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Mitotic spindle
(GO:0072686)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Positive regulation of lipopolysaccharide-mediated signaling pathway
(GO:0031666)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 2.33
Marker Score: 4416
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.7
Marker Score: 3466
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.56
Marker Score: 857
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.29
Marker Score: 777
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.24
Marker Score: 19355
Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.14
Marker Score: 693
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.06
Marker Score: 3147
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 1.04
Marker Score: 1251
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251802.5
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71820
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48045
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.99
Marker Score: 229
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.99
Marker Score: 928
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5308
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2737
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.89
Marker Score: 1557
Cell Name: naive B cell (CL0000788)
Fold Change: 0.88
Marker Score: 783.5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5283
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.86
Marker Score: 862.5
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.82
Marker Score: 625.5
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.79
Marker Score: 379
Cell Name: memory B cell (CL0000787)
Fold Change: 0.78
Marker Score: 591
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 706
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.75
Marker Score: 263
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.75
Marker Score: 241
Cell Name: centroblast (CL0009112)
Fold Change: 0.71
Marker Score: 349
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.65
Marker Score: 286
Cell Name: plasmablast (CL0000980)
Fold Change: 0.64
Marker Score: 856
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.61
Marker Score: 168
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.6
Marker Score: 612
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.59
Marker Score: 155
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.58
Marker Score: 340
Cell Name: blood cell (CL0000081)
Fold Change: 0.57
Marker Score: 6618
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: B cell (CL0000236)
Fold Change: 0.53
Marker Score: 506
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.53
Marker Score: 1444
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.52
Marker Score: 1096
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.51
Marker Score: 586
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.5
Marker Score: 178
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.49
Marker Score: 1019
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.49
Marker Score: 593
Cell Name: immature B cell (CL0000816)
Fold Change: 0.49
Marker Score: 324
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.48
Marker Score: 114
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.48
Marker Score: 2894
Cell Name: centrocyte (CL0009111)
Fold Change: 0.46
Marker Score: 110
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.46
Marker Score: 275
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.42
Marker Score: 679
Cell Name: microglial cell (CL0000129)
Fold Change: 0.41
Marker Score: 755
Cell Name: mature B cell (CL0000785)
Fold Change: 0.4
Marker Score: 294
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.4
Marker Score: 144
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.39
Marker Score: 397
Cell Name: pre-conventional dendritic cell (CL0002010)
Fold Change: 0.39
Marker Score: 115
Cell Name: thymocyte (CL0000893)
Fold Change: 0.38
Marker Score: 402
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.36
Marker Score: 149
Cell Name: promonocyte (CL0000559)
Fold Change: 0.36
Marker Score: 235
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.36
Marker Score: 91
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.36
Marker Score: 238
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.36
Marker Score: 927
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.35
Marker Score: 92
Cell Name: goblet cell (CL0000160)
Fold Change: 0.35
Marker Score: 2302
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.34
Marker Score: 363
Cell Name: macrophage (CL0000235)
Fold Change: 0.33
Marker Score: 370
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.33
Marker Score: 87
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.33
Marker Score: 144
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.32
Marker Score: 112
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.32
Marker Score: 800
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.31
Marker Score: 196
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.31
Marker Score: 17255
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.31
Marker Score: 151
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.3
Marker Score: 301
Cell Name: podocyte (CL0000653)
Fold Change: 0.29
Marker Score: 109
Cell Name: plasma cell (CL0000786)
Fold Change: 0.29
Marker Score: 328
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.29
Marker Score: 280
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.27
Marker Score: 113
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.27
Marker Score: 229
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.26
Marker Score: 2636
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.26
Marker Score: 154
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.26
Marker Score: 93
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.25
Marker Score: 492
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.24
Marker Score: 135
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.24
Marker Score: 99
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.23
Marker Score: 158
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.22
Marker Score: 120
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.22
Marker Score: 903
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.21
Marker Score: 208
Cell Name: leukocyte (CL0000738)
Fold Change: 0.21
Marker Score: 119
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.2
Marker Score: 100
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.2
Marker Score: 70
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.2
Marker Score: 460
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.19
Marker Score: 133
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.19
Marker Score: 125.5
Cell Name: monocyte (CL0000576)
Fold Change: 0.18
Marker Score: 240
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.18
Marker Score: 181.5
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.18
Marker Score: 220
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.17
Marker Score: 86

Hover over a box to see details here...

**Key characteristics:** - CD180 is a glycoprotein with a molecular weight of approximately 120 kDa. - It is a transmembrane protein that is expressed on the surface of immune cells. - CD180 is a member of the immunoglobulin superfamily. - It is involved in the regulation of the immune response by interacting with Toll-like receptors (TLRs). **Pathways and functions:** - CD180 is involved in the B cell proliferation process. - It is expressed on immature B cells, which are required for the generation of plasma cells. - CD180 signaling is essential for the activation of naive B cells, promoting the differentiation of pre-B cells into plasma cells. - It also plays a role in the activation of mature B cells, promoting the development of plasma cells. - CD180 is also involved in the regulation of the activation of macrophages and dendritic cells. **Clinical significance:** - Mutations in CD180 have been linked to several human diseases, including systemic sclerosis, rheumatoid arthritis, and inflammatory bowel disease. - Targeting CD180 has been explored as a therapeutic strategy for these diseases, but it has not been successful due to the lack of specific and effective antibodies. - However, research is ongoing to develop novel CD180-targeting therapies that may be effective for these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CD180 antigen

Genular Protein ID: 2494862363

Symbol: CD180_HUMAN

Name: CD180 antigen

UniProtKB Accession Codes:

Q99467 B2R7Z7 Q32MM5

Database IDs:

Citations:

PubMed ID: 8975706

Title: Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64).

PubMed ID: 8975706

DOI: 10.1006/geno.1996.0632

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9763566

Title: RP105 is associated with MD-1 and transmits an activation signal in human B cells.

PubMed ID: 9763566

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21959264

Title: Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family.

PubMed ID: 21959264

DOI: 10.1016/j.jmb.2011.09.020

Sequence Information:

Length: 661
Mass: 74179
Checksum: 93DE3178594B3383
Sequence:

MAFDVSCFFW VVLFSAGCKV ITSWDQMCIE KEANKTYNCE NLGLSEIPDT LPNTTEFLEF 
SFNFLPTIHN RTFSRLMNLT FLDLTRCQIN WIHEDTFQSH HQLSTLVLTG NPLIFMAETS 
LNGPKSLKHL FLIQTGISNL EFIPVHNLEN LESLYLGSNH ISSIKFPKDF PARNLKVLDF 
QNNAIHYISR EDMRSLEQAI NLSLNFNGNN VKGIELGAFD STIFQSLNFG GTPNLSVIFN 
GLQNSTTQSL WLGTFEDIDD EDISSAMLKG LCEMSVESLN LQEHRFSDIS STTFQCFTQL 
QELDLTATHL KGLPSGMKGL NLLKKLVLSV NHFDQLCQIS AANFPSLTHL YIRGNVKKLH 
LGVGCLEKLG NLQTLDLSHN DIEASDCCSL QLKNLSHLQT LNLSHNEPLG LQSQAFKECP 
QLELLDLAFT RLHINAPQSP FQNLHFLQVL NLTYCFLDTS NQHLLAGLPV LRHLNLKGNH 
FQDGTITKTN LLQTVGSLEV LILSSCGLLS IDQQAFHSLG KMSHVDLSHN SLTCDSIDSL 
SHLKGIYLNL AANSINIISP RLLPILSQQS TINLSHNPLD CTCSNIHFLT WYKENLHKLE 
GSEETTCANP PSLRGVKLSD VKLSCGITAI GIFFLIVFLL LLAILLFFAV KYLLRWKYQH 
I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CD180

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). PubMed ID: 8975706

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

RP105 is associated with MD-1 and transmits an activation signal in human B cells. PubMed ID: 9763566

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family. PubMed ID: 21959264