Details for: CD180

Gene ID: 4064

Symbol: CD180

Ensembl ID: ENSG00000134061

Description: CD180 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 34.8773
    Cell Significance Index: -5.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.0138
    Cell Significance Index: -5.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 12.0727
    Cell Significance Index: -6.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.4041
    Cell Significance Index: -5.4300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.1107
    Cell Significance Index: 48.1300
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.3274
    Cell Significance Index: 5.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9316
    Cell Significance Index: 109.8600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.2713
    Cell Significance Index: 1.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1862
    Cell Significance Index: 12.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1515
    Cell Significance Index: 2.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0450
    Cell Significance Index: 1.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0441
    Cell Significance Index: 0.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0437
    Cell Significance Index: 1.1700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0142
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -4.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0057
    Cell Significance Index: -7.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0074
    Cell Significance Index: -5.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0088
    Cell Significance Index: -5.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0093
    Cell Significance Index: -5.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0101
    Cell Significance Index: -5.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0127
    Cell Significance Index: -3.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0138
    Cell Significance Index: -6.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0149
    Cell Significance Index: -5.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0174
    Cell Significance Index: -1.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0182
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0185
    Cell Significance Index: -3.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0194
    Cell Significance Index: -3.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0195
    Cell Significance Index: -0.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0209
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0212
    Cell Significance Index: -0.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0213
    Cell Significance Index: -4.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0248
    Cell Significance Index: -4.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0264
    Cell Significance Index: -3.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0289
    Cell Significance Index: -3.3700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0308
    Cell Significance Index: -1.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0324
    Cell Significance Index: -5.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0347
    Cell Significance Index: -4.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0359
    Cell Significance Index: -0.9200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0372
    Cell Significance Index: -1.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0377
    Cell Significance Index: -4.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0379
    Cell Significance Index: -5.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0409
    Cell Significance Index: -5.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0473
    Cell Significance Index: -5.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0507
    Cell Significance Index: -5.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0653
    Cell Significance Index: -3.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0770
    Cell Significance Index: -5.9100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0771
    Cell Significance Index: -1.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0814
    Cell Significance Index: -6.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0857
    Cell Significance Index: -5.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0860
    Cell Significance Index: -5.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1009
    Cell Significance Index: -5.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1012
    Cell Significance Index: -6.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1021
    Cell Significance Index: -5.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1112
    Cell Significance Index: -6.2400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.1129
    Cell Significance Index: -0.4700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1188
    Cell Significance Index: -1.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1362
    Cell Significance Index: -6.1800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1400
    Cell Significance Index: -1.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1467
    Cell Significance Index: -6.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1479
    Cell Significance Index: -5.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1604
    Cell Significance Index: -5.2500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1646
    Cell Significance Index: -2.3100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1687
    Cell Significance Index: -2.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1696
    Cell Significance Index: -3.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1714
    Cell Significance Index: -5.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1714
    Cell Significance Index: -6.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1748
    Cell Significance Index: -6.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1890
    Cell Significance Index: -6.6400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1909
    Cell Significance Index: -4.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1922
    Cell Significance Index: -5.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1951
    Cell Significance Index: -6.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1977
    Cell Significance Index: -5.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2006
    Cell Significance Index: -5.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2023
    Cell Significance Index: -5.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2039
    Cell Significance Index: -5.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2067
    Cell Significance Index: -6.0700
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.2096
    Cell Significance Index: -2.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2100
    Cell Significance Index: -6.0200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2174
    Cell Significance Index: -4.2500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2219
    Cell Significance Index: -5.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2235
    Cell Significance Index: -6.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2238
    Cell Significance Index: -5.5800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2261
    Cell Significance Index: -4.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2301
    Cell Significance Index: -6.0500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2303
    Cell Significance Index: -2.4500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2321
    Cell Significance Index: -2.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2344
    Cell Significance Index: -6.3800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2365
    Cell Significance Index: -3.0600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2441
    Cell Significance Index: -2.5700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2490
    Cell Significance Index: -6.2200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2497
    Cell Significance Index: -2.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2563
    Cell Significance Index: -5.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2577
    Cell Significance Index: -5.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2583
    Cell Significance Index: -5.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2583
    Cell Significance Index: -2.9300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2695
    Cell Significance Index: -5.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane protein**: CD180 is a transmembrane protein, which allows it to interact with other cells and signaling molecules. 2. **Receptor-like function**: CD180 exhibits receptor-like properties, enabling it to bind to specific ligands and initiate signaling cascades. 3. **Signaling pathways**: CD180 is involved in multiple signaling pathways, including the Toll-like receptor 4 (TLR4) cascade, which plays a crucial role in recognizing and responding to lipopolysaccharides (LPS). 4. **Cellular expression**: CD180 is expressed in various cell types, including cardiac endothelial cells, immune cells, and progenitor cells. **Pathways and Functions:** 1. **B cell proliferation**: CD180 regulates B cell proliferation, which is essential for the development of immune responses. 2. **Innate immune response**: CD180 is involved in the recognition and response to pathogens, including LPS, through the TLR4 cascade. 3. **Inflammatory response**: CD180 mediates the inflammatory response by regulating the production of pro-inflammatory cytokines. 4. **Cellular signaling**: CD180 interacts with other signaling molecules to regulate cellular processes, including cell growth, differentiation, and survival. **Clinical Significance:** Dysregulation of CD180 has been implicated in several diseases, including: 1. **Autoimmune disorders**: CD180 has been shown to contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: CD180 has been found to be overexpressed in certain types of cancer, including lung and breast cancer. 3. **Infectious diseases**: CD180 plays a crucial role in the recognition and response to pathogens, including LPS, which is essential for the development of effective immune responses. In conclusion, CD180 is a critical regulator of immune response and cellular signaling. Its dysregulation has significant implications for the development of autoimmune disorders and cancer. Further research is necessary to fully understand the role of CD180 in human health and disease. **References:** [Insert references to relevant studies and research articles] Note: As an expert immunologist, it is essential to consult the latest research and studies to ensure the accuracy and validity of the information presented.

Genular Protein ID: 2494862363

Symbol: CD180_HUMAN

Name: CD180 antigen

UniProtKB Accession Codes:

Q99467 B2R7Z7 Q32MM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8975706

Title: Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64).

PubMed ID: 8975706

DOI: 10.1006/geno.1996.0632

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9763566

Title: RP105 is associated with MD-1 and transmits an activation signal in human B cells.

PubMed ID: 9763566

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21959264

Title: Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family.

PubMed ID: 21959264

DOI: 10.1016/j.jmb.2011.09.020

Sequence Information:

  • Length: 661
  • Mass: 74179
  • Checksum: 93DE3178594B3383
  • Sequence:
    • MAFDVSCFFW VVLFSAGCKV ITSWDQMCIE KEANKTYNCE NLGLSEIPDT LPNTTEFLEF 
SFNFLPTIHN RTFSRLMNLT FLDLTRCQIN WIHEDTFQSH HQLSTLVLTG NPLIFMAETS 
LNGPKSLKHL FLIQTGISNL EFIPVHNLEN LESLYLGSNH ISSIKFPKDF PARNLKVLDF 
QNNAIHYISR EDMRSLEQAI NLSLNFNGNN VKGIELGAFD STIFQSLNFG GTPNLSVIFN 
GLQNSTTQSL WLGTFEDIDD EDISSAMLKG LCEMSVESLN LQEHRFSDIS STTFQCFTQL 
QELDLTATHL KGLPSGMKGL NLLKKLVLSV NHFDQLCQIS AANFPSLTHL YIRGNVKKLH 
LGVGCLEKLG NLQTLDLSHN DIEASDCCSL QLKNLSHLQT LNLSHNEPLG LQSQAFKECP 
QLELLDLAFT RLHINAPQSP FQNLHFLQVL NLTYCFLDTS NQHLLAGLPV LRHLNLKGNH 
FQDGTITKTN LLQTVGSLEV LILSSCGLLS IDQQAFHSLG KMSHVDLSHN SLTCDSIDSL 
SHLKGIYLNL AANSINIISP RLLPILSQQS TINLSHNPLD CTCSNIHFLT WYKENLHKLE 
GSEETTCANP PSLRGVKLSD VKLSCGITAI GIFFLIVFLL LLAILLFFAV KYLLRWKYQH 
I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.