Details for: NBR1

Gene ID: 4077

Symbol: NBR1

Ensembl ID: ENSG00000188554

Description: NBR1 autophagy cargo receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 307.2418
    Cell Significance Index: -47.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 196.2598
    Cell Significance Index: -49.7800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 134.0704
    Cell Significance Index: -55.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.6370
    Cell Significance Index: -51.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 99.9613
    Cell Significance Index: -40.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 91.7600
    Cell Significance Index: -47.2000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 76.4654
    Cell Significance Index: -51.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.7864
    Cell Significance Index: -40.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.2472
    Cell Significance Index: -48.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.4011
    Cell Significance Index: -46.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.9813
    Cell Significance Index: -51.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.1841
    Cell Significance Index: -31.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.5815
    Cell Significance Index: -20.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4773
    Cell Significance Index: 293.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3265
    Cell Significance Index: 239.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2149
    Cell Significance Index: 63.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0327
    Cell Significance Index: 126.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9846
    Cell Significance Index: 197.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9252
    Cell Significance Index: 639.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7895
    Cell Significance Index: 54.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7635
    Cell Significance Index: 16.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7453
    Cell Significance Index: 672.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7280
    Cell Significance Index: 20.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7089
    Cell Significance Index: 77.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6241
    Cell Significance Index: 29.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5981
    Cell Significance Index: 27.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5050
    Cell Significance Index: 10.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5024
    Cell Significance Index: 64.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4940
    Cell Significance Index: 177.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4726
    Cell Significance Index: 258.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4335
    Cell Significance Index: 59.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4270
    Cell Significance Index: 26.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3711
    Cell Significance Index: 28.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3707
    Cell Significance Index: 163.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3494
    Cell Significance Index: 18.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3203
    Cell Significance Index: 60.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2866
    Cell Significance Index: 8.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2256
    Cell Significance Index: 6.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1389
    Cell Significance Index: 6.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1101
    Cell Significance Index: 18.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0545
    Cell Significance Index: 0.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0466
    Cell Significance Index: 87.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0443
    Cell Significance Index: 3.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0282
    Cell Significance Index: 0.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0128
    Cell Significance Index: 8.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0079
    Cell Significance Index: 14.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0064
    Cell Significance Index: 2.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0005
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0082
    Cell Significance Index: -6.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0159
    Cell Significance Index: -11.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0170
    Cell Significance Index: -23.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0260
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0319
    Cell Significance Index: -19.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0470
    Cell Significance Index: -1.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0480
    Cell Significance Index: -36.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0619
    Cell Significance Index: -34.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0763
    Cell Significance Index: -9.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0892
    Cell Significance Index: -1.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0912
    Cell Significance Index: -5.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1034
    Cell Significance Index: -13.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1071
    Cell Significance Index: -10.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1140
    Cell Significance Index: -8.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1311
    Cell Significance Index: -27.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1461
    Cell Significance Index: -42.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1525
    Cell Significance Index: -3.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1920
    Cell Significance Index: -5.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1925
    Cell Significance Index: -27.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1955
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2194
    Cell Significance Index: -25.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2326
    Cell Significance Index: -4.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2410
    Cell Significance Index: -28.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2461
    Cell Significance Index: -28.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2605
    Cell Significance Index: -4.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2799
    Cell Significance Index: -7.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2936
    Cell Significance Index: -7.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3098
    Cell Significance Index: -20.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3232
    Cell Significance Index: -8.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3249
    Cell Significance Index: -10.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3632
    Cell Significance Index: -19.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4233
    Cell Significance Index: -44.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4331
    Cell Significance Index: -19.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4633
    Cell Significance Index: -36.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5117
    Cell Significance Index: -33.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5412
    Cell Significance Index: -8.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5580
    Cell Significance Index: -19.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5702
    Cell Significance Index: -7.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5939
    Cell Significance Index: -22.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6345
    Cell Significance Index: -14.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6483
    Cell Significance Index: -13.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6799
    Cell Significance Index: -19.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7084
    Cell Significance Index: -43.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8061
    Cell Significance Index: -40.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8159
    Cell Significance Index: -15.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8727
    Cell Significance Index: -25.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0844
    Cell Significance Index: -31.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1382
    Cell Significance Index: -37.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1422
    Cell Significance Index: -41.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1479
    Cell Significance Index: -36.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.1481
    Cell Significance Index: -27.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NBR1 is a ubiquitin-binding protein that forms a complex with ubiquitin, enabling the recognition and targeting of specific substrates for degradation. Its unique structure, comprising a RING finger domain and a ubiquitin-binding motif, allows for the interaction with ubiquitinated proteins. NBR1 is predominantly expressed in cells with high energy demands, such as neurons, endothelial cells, and epithelial cells, where it plays a critical role in maintaining cellular homeostasis. **Pathways and Functions:** NBR1 is integral to the autophagy process, which is a vital cellular mechanism for the degradation and recycling of damaged or dysfunctional cellular components. By binding to ubiquitinated proteins, NBR1 recruits them to the phagophore assembly site (PAS), where they are engulfed by autophagosomes and eventually degraded by lysosomes. NBR1 also participates in the regulation of stress-activated mitogen-activated protein kinase (MAPK) cascades, which are crucial for cellular responses to stress and damage. Additionally, NBR1 has been implicated in the regulation of bone mineralization and osteoblast differentiation, highlighting its role in maintaining cellular homeostasis in the bone. **Clinical Significance:** Dysregulation of NBR1 has been linked to various diseases, including neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease, where impaired autophagy and protein quality control contribute to disease progression. Additionally, NBR1 has been implicated in the pathogenesis of cancer, where its dysregulation can lead to the accumulation of damaged cellular components and the development of cancerous cells. Furthermore, NBR1 has been shown to play a role in the regulation of bone metabolism, making it a potential target for the treatment of bone-related disorders. In conclusion, NBR1 is a critical gene that plays a pivotal role in the regulation of autophagy and cellular homeostasis. Its dysregulation has been linked to various diseases, highlighting the importance of NBR1 in maintaining cellular health and preventing disease. Further research is needed to fully elucidate the functions and mechanisms of NBR1, but its significance in the regulation of autophagy and cellular homeostasis is clear. **Signaling Pathways:** 1. Autophagosome formation and degradation 2. Stress-activated MAPK cascade 3. Regulation of bone mineralization and osteoblast differentiation 4. Phagophore assembly site (PAS) formation 5. Ubiquitin binding and protein degradation 6. Lysosome-mediated degradation of autophagic substrates **Cell Types:** 1. Squamous epithelial cell 2. Luminal epithelial cell of mammary gland 3. Lung endothelial cell 4. Ciliated cell 5. Ciliated columnar cell of tracheobronchial tree 6. Conjunctival epithelial cell 7. Bladder urothelial cell 8. Dopaminergic neuron 9. L6b glutamatergic cortical neuron 10. Ependymal cell **Proteins:** 1. NBR1_HUMAN (Next to BRCA1 gene 1 protein) 2. B7Z5R6_HUMAN

Genular Protein ID: 3247713793

Symbol: NBR1_HUMAN

Name: Next to BRCA1 gene 1 protein

UniProtKB Accession Codes:

Q14596 Q13173 Q15026 Q5J7Q8 Q96GB6 Q9NRF7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8069304

Title: A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1.

PubMed ID: 8069304

DOI: 10.1093/hmg/3.4.589

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11179671

Title: Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes.

PubMed ID: 11179671

DOI: 10.1016/s0378-1119(00)00549-7

PubMed ID: 7581362

Title: Comparison of the positional cloning methods used to isolate the BRCA1 gene.

PubMed ID: 7581362

DOI: 10.1093/hmg/4.8.1259

PubMed ID: 12813044

Title: Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.

PubMed ID: 12813044

DOI: 10.1074/jbc.m303221200

PubMed ID: 15802564

Title: The kinase domain of titin controls muscle gene expression and protein turnover.

PubMed ID: 15802564

DOI: 10.1126/science.1110463

PubMed ID: 24331465

Title: The globally disseminated M1T1 clone of group A Streptococcus evades autophagy for intracellular replication.

PubMed ID: 24331465

DOI: 10.1016/j.chom.2013.11.003

PubMed ID: 19427866

Title: Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover.

PubMed ID: 19427866

DOI: 10.1016/j.febslet.2009.04.049

PubMed ID: 19250911

Title: A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

PubMed ID: 19250911

DOI: 10.1016/j.molcel.2009.01.020

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24879152

Title: Phosphorylation of NBR1 by GSK3 modulates protein aggregation.

PubMed ID: 24879152

DOI: 10.4161/auto.28479

PubMed ID: 33226137

Title: Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

PubMed ID: 33226137

DOI: 10.15252/embj.2020104948

PubMed ID: 34471133

Title: Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation.

PubMed ID: 34471133

DOI: 10.1038/s41467-021-25572-w

PubMed ID: 33577621

Title: The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation.

PubMed ID: 33577621

DOI: 10.1371/journal.ppat.1009300

PubMed ID: 35914352

Title: NBR1 mediates autophagic degradation of IRF3 to negatively regulate type I interferon production.

PubMed ID: 35914352

DOI: 10.1016/j.bbrc.2022.07.043

PubMed ID: 16376336

Title: Crystal structure of the PB1 domain of NBR1.

PubMed ID: 16376336

DOI: 10.1016/j.febslet.2005.12.021

PubMed ID: 24692539

Title: Solution structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin.

PubMed ID: 24692539

DOI: 10.1074/jbc.m114.555441

Sequence Information:

  • Length: 966
  • Mass: 107413
  • Checksum: 6A057E67947838EF
  • Sequence:
    • MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD EENEEVSINS 
QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK RLAARAGKKP LAHYSSLVRV 
LGSDMKTPED PAVQSFPLVP CDTDQPQDKP PDWFTSYLET FREQVVNETV EKLEQKLHEK 
LVLQNPSLGS CPSEVSMPTS EETLFLPENQ FSWHIACNNC QRRIVGVRYQ CSLCPSYNIC 
EDCEAGPYGH DTNHVLLKLR RPVVGSSEPF CHSKYSTPRL PAALEQVRLQ KQVDKNFLKA 
EKQRLRAEKK QRKAEVKELK KQLKLHRKIH LWNSIHGLQS PKSPLGRPES LLQSNTLMLP 
LQPCTSVMPM LSAAFVDENL PDGTHLQPGT KFIKHWRMKN TGNVKWSADT KLKFMWGNLT 
LASTEKKDVL VPCLKAGHVG VVSVEFIAPA LEGTYTSHWR LSHKGQQFGP RVWCSIIVDP 
FPSEESPDNI EKGMISSSKT DDLTCQQEET FLLAKEERQL GEVTEQTEGT AACIPQKAKN 
VASERELYIP SVDLLTAQDL LSFELLDINI VQELERVPHN TPVDVTPCMS PLPHDSPLIE 
KPGLGQIEEE NEGAGFKALP DSMVSVKRKA ENIASVEEAE EDLSGTQFVC ETVIRSLTLD 
AAPDHNPPCR QKSLQMTFAL PEGPLGNEKE EIIHIAEEEA VMEEEEDEED EEEEDELKDE 
VQSQSSASSE DYIIILPECF DTSRPLGDSM YSSALSQPGL ERGAEGKPGV EAGQEPAEAG 
ERLPGGENQP QEHSISDILT TSQTLETVPL IPEVVELPPS LPRSSPCVHH HGSPGVDLPV 
TIPEVSSVPD QIRGEPRGSS GLVNSRQKSY DHSRHHHGSS IAGGLVKGAL SVAASAYKAL 
FAGPPVTAQP IISEDQTAAL MAHLFEMGFC DRQLNLRLLK KHNYNILQVV TELLQLNNND 
WYSQRY

Genular Protein ID: 3607493342

Symbol: B7Z5R6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z5R6

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 837
  • Mass: 92949
  • Checksum: 7943A8DC7F810B32
  • Sequence:
    • MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVSINSQ GEYEEALKMA VKQGNQLQMQ 
VHEGHHVVDE APPPVVGAKR LAARAGKKPL AHYSSLVRVL GSDMKTPEDP AVQSFPLVPC 
DTDQPQDKPP DWFTSYLETF REQVVNETVE KLEQKLHEKL VLQNPSLGSC PSEVSMPTSE 
ETLFLPENQF SWHIACNNCQ RRIVGVRYQC SLCPSYNICE DCEAGPYGHD TNHVLLKLRR 
PVVGSSEPFC HSKYSTPRLP AALEQVRLQK QVDKNFLKAE KQRLRAEKKQ RKAEVKELKK 
QLKLHRKIHL WNSIHGLQSP KSPLGRPESL LQSNTLMLPL QPCTSVMPML SAAFVDENLP 
DGTHLQPGTK FIKHWRMKNT GNVKWSADTK LKFMWGNLTL ASTEKKDVLV PCLKAGHVGV 
VSVEFIAPAL EGTYTSHWRL SHKGQQFGPR VWCSIIVDPF PSEESPDNIE KGMISSSKTD 
DLTCQQEETF LLAKEERQLG EVTEQTEGTA ACIPQKAKNV ASERELYIPS VDLLTAQDLL 
SFELLDINIV QELERVPHNT PVDVTPCMSP LPHDSPLIEK PGLGQIEEEN EGAGFKALPD 
SMVSVKRKAE NIASVEEAEE DLSGTQFVCE TVIRSLTLDA APDHNPPCRQ KSLQMTFALP 
EGPLGNEKEE IIHIAEEEAV MEEEEDEEDE EEEDELKDEV QSQSSASSED YIIILPECFD 
TSRPLGDSMY SSALSQPGLE RGAEGKPGVE AGQEPAEAGE RLPGGENQPQ EHSISDILTT 
SQTLETVPLI PEVVELPPSL PRSSPCVHHH GSPGVDLPVT IPEVSSVPDQ IRGANNF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.