Details for: SMAD9

Gene ID: 4093

Symbol: SMAD9

Ensembl ID: ENSG00000120693

Description: SMAD family member 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.9609
    Cell Significance Index: -29.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.0496
    Cell Significance Index: -29.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.5823
    Cell Significance Index: -29.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.7974
    Cell Significance Index: -14.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.3918
    Cell Significance Index: 61.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6917
    Cell Significance Index: 94.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1974
    Cell Significance Index: 118.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0447
    Cell Significance Index: 943.2700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8327
    Cell Significance Index: 13.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7839
    Cell Significance Index: 16.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7368
    Cell Significance Index: 49.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6538
    Cell Significance Index: 106.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6507
    Cell Significance Index: 30.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6208
    Cell Significance Index: 67.5200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5693
    Cell Significance Index: 8.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4517
    Cell Significance Index: 27.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4056
    Cell Significance Index: 77.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3896
    Cell Significance Index: 9.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3803
    Cell Significance Index: 48.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3154
    Cell Significance Index: 21.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3153
    Cell Significance Index: 63.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2699
    Cell Significance Index: 96.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2260
    Cell Significance Index: 7.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1691
    Cell Significance Index: 76.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1659
    Cell Significance Index: 114.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1303
    Cell Significance Index: 17.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1290
    Cell Significance Index: 198.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1077
    Cell Significance Index: 21.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0774
    Cell Significance Index: 34.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0420
    Cell Significance Index: 57.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0401
    Cell Significance Index: 75.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0307
    Cell Significance Index: 1.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0078
    Cell Significance Index: 4.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0035
    Cell Significance Index: 0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0005
    Cell Significance Index: 0.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0045
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0070
    Cell Significance Index: -4.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0079
    Cell Significance Index: -0.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0096
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0130
    Cell Significance Index: -9.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0266
    Cell Significance Index: -4.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0317
    Cell Significance Index: -17.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0343
    Cell Significance Index: -25.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0354
    Cell Significance Index: -25.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0448
    Cell Significance Index: -24.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0556
    Cell Significance Index: -0.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0627
    Cell Significance Index: -9.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0651
    Cell Significance Index: -1.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0760
    Cell Significance Index: -9.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0843
    Cell Significance Index: -14.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0876
    Cell Significance Index: -4.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0878
    Cell Significance Index: -25.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1005
    Cell Significance Index: -21.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1424
    Cell Significance Index: -14.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1708
    Cell Significance Index: -19.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1808
    Cell Significance Index: -12.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2155
    Cell Significance Index: -22.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2188
    Cell Significance Index: -28.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2248
    Cell Significance Index: -6.1200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2261
    Cell Significance Index: -2.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2336
    Cell Significance Index: -17.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2370
    Cell Significance Index: -7.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2436
    Cell Significance Index: -27.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2473
    Cell Significance Index: -2.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2492
    Cell Significance Index: -29.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2572
    Cell Significance Index: -29.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2800
    Cell Significance Index: -5.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3283
    Cell Significance Index: -14.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3504
    Cell Significance Index: -27.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3539
    Cell Significance Index: -13.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3648
    Cell Significance Index: -23.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3763
    Cell Significance Index: -23.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3815
    Cell Significance Index: -7.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3879
    Cell Significance Index: -24.4500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.3888
    Cell Significance Index: -4.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3925
    Cell Significance Index: -29.2500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3985
    Cell Significance Index: -5.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4047
    Cell Significance Index: -2.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4305
    Cell Significance Index: -22.4300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4651
    Cell Significance Index: -2.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4985
    Cell Significance Index: -10.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5095
    Cell Significance Index: -14.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5110
    Cell Significance Index: -14.2800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5243
    Cell Significance Index: -5.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5396
    Cell Significance Index: -25.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5421
    Cell Significance Index: -11.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5519
    Cell Significance Index: -13.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5636
    Cell Significance Index: -17.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5867
    Cell Significance Index: -12.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6015
    Cell Significance Index: -21.0700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.6088
    Cell Significance Index: -6.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6504
    Cell Significance Index: -19.1600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.6557
    Cell Significance Index: -10.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6634
    Cell Significance Index: -21.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6780
    Cell Significance Index: -34.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7385
    Cell Significance Index: -21.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7464
    Cell Significance Index: -32.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7467
    Cell Significance Index: -12.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7625
    Cell Significance Index: -27.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7669
    Cell Significance Index: -16.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **SMAD family member**: SMAD9 belongs to the SMAD family, a group of proteins that interact with TGF-β and BMP receptors to regulate signaling pathways. 2. **DNA-binding transcription factor**: SMAD9 possesses DNA-binding capabilities, allowing it to regulate gene expression by interacting with specific DNA sequences. 3. **Heteromeric complex formation**: SMAD9 can form heteromeric complexes with other SMAD proteins, such as SMAD1 and SMAD5, to modulate signaling outcomes. 4. **Regulation of transcription**: SMAD9 acts as a transcriptional activator, promoting the expression of target genes in response to TGF-β and BMP ligands. **Pathways and Functions:** 1. **TGF-β signaling pathway**: SMAD9 mediates the transcriptional activation of target genes in response to TGF-β ligands, regulating cellular processes such as proliferation, differentiation, and apoptosis. 2. **BMP signaling pathway**: SMAD9 also participates in BMP signaling, influencing cellular processes like morphogenesis, differentiation, and cell fate determination. 3. **Anatomical structure morphogenesis**: SMAD9 is involved in the regulation of tissue development and morphogenesis, particularly in the development of the cerebral cortex and smooth muscle cells. 4. **Cell differentiation**: SMAD9 plays a role in regulating cellular differentiation, particularly in the development of neural progenitor cells and smooth muscle cells. **Clinical Significance:** 1. **Cancer progression**: Aberrant SMAD9 expression has been linked to cancer progression, with SMAD9 acting as a tumor suppressor in various cancers, including breast, lung, and colon cancer. 2. **Cardiovascular disease**: SMAD9 is involved in the regulation of vascular smooth muscle cell function, and its dysregulation may contribute to cardiovascular disease. 3. **Neurological disorders**: SMAD9 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to neuronal dysfunction and degeneration. 4. **Regenerative medicine**: SMAD9's role in tissue development and morphogenesis makes it a potential target for regenerative medicine applications, such as wound healing and tissue engineering. In conclusion, SMAD9 is a critical regulator of cellular processes, including morphogenesis, differentiation, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying SMAD9's functions and its potential therapeutic applications.

Genular Protein ID: 3024797889

Symbol: SMAD9_HUMAN

Name: Mothers against decapentaplegic homolog 9

UniProtKB Accession Codes:

O15198 A2A2Y6 O14989 Q5TBA1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9205116

Title: Cloning and characterization of a novel member of the human Mad gene family (MADH6).

PubMed ID: 9205116

DOI: 10.1006/geno.1997.4753

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9759503

Title: TGF-beta signal transduction.

PubMed ID: 9759503

DOI: 10.1146/annurev.biochem.67.1.753

PubMed ID: 10647776

Title: Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.

PubMed ID: 10647776

DOI: 10.1016/s1359-6101(99)00012-x

PubMed ID: 10708948

Title: The Smad pathway.

PubMed ID: 10708948

DOI: 10.1016/s1359-6101(99)00024-6

PubMed ID: 10708949

Title: TGF-beta signaling by Smad proteins.

PubMed ID: 10708949

DOI: 10.1016/s1359-6101(99)00025-8

PubMed ID: 25755279

Title: Nuclear export of Smads by RanBP3L regulates bone morphogenetic protein signaling and mesenchymal stem cell differentiation.

PubMed ID: 25755279

DOI: 10.1128/mcb.00121-15

PubMed ID: 21898662

Title: Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension.

PubMed ID: 21898662

DOI: 10.1002/humu.21605

Sequence Information:

  • Length: 467
  • Mass: 52493
  • Checksum: CFC8F982945BC6DD
  • Sequence:
    • MHSTTPISSL FSFTSPAVKR LLGWKQGDEE EKWAEKAVDS LVKKLKKKKG AMDELERALS 
CPGQPSKCVT IPRSLDGRLQ VSHRKGLPHV IYCRVWRWPD LQSHHELKPL ECCEFPFGSK 
QKEVCINPYH YRRVETPVLP PVLVPRHSEY NPQLSLLAKF RSASLHSEPL MPHNATYPDS 
FQQPPCSALP PSPSHAFSQS PCTASYPHSP GSPSEPESPY QHSVDTPPLP YHATEASETQ 
SGQPVDATAD RHVVLSIPNG DFRPVCYEEP QHWCSVAYYE LNNRVGETFQ ASSRSVLIDG 
FTDPSNNRNR FCLGLLSNVN RNSTIENTRR HIGKGVHLYY VGGEVYAECV SDSSIFVQSR 
NCNYQHGFHP ATVCKIPSGC SLKVFNNQLF AQLLAQSVHH GFEVVYELTK MCTIRMSFVK 
GWGAEYHRQD VTSTPCWIEI HLHGPLQWLD KVLTQMGSPH NPISSVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.