Details for: MAFG

Gene ID: 4097

Symbol: MAFG

Ensembl ID: ENSG00000197063

Description: MAF bZIP transcription factor G

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 169.1469
    Cell Significance Index: -26.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 110.4701
    Cell Significance Index: -28.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.7925
    Cell Significance Index: -30.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.0636
    Cell Significance Index: -24.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.3865
    Cell Significance Index: -28.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 45.6021
    Cell Significance Index: -30.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.6404
    Cell Significance Index: -24.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.5856
    Cell Significance Index: -29.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.0308
    Cell Significance Index: -29.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.6330
    Cell Significance Index: -30.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5739
    Cell Significance Index: -17.1200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 4.3603
    Cell Significance Index: 31.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3544
    Cell Significance Index: -9.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.8269
    Cell Significance Index: 109.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7558
    Cell Significance Index: 75.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7878
    Cell Significance Index: 92.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6652
    Cell Significance Index: 22.7200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.4999
    Cell Significance Index: 26.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4130
    Cell Significance Index: 229.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2849
    Cell Significance Index: 37.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2080
    Cell Significance Index: 26.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1029
    Cell Significance Index: 49.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9784
    Cell Significance Index: 72.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8438
    Cell Significance Index: 54.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8246
    Cell Significance Index: 106.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7266
    Cell Significance Index: 656.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6613
    Cell Significance Index: 132.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6311
    Cell Significance Index: 29.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6072
    Cell Significance Index: 66.0400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.5565
    Cell Significance Index: 8.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5362
    Cell Significance Index: 27.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4811
    Cell Significance Index: 59.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4168
    Cell Significance Index: 82.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4046
    Cell Significance Index: 72.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3298
    Cell Significance Index: 45.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3277
    Cell Significance Index: 8.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3268
    Cell Significance Index: 117.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2637
    Cell Significance Index: 144.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2624
    Cell Significance Index: 49.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2596
    Cell Significance Index: 114.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2088
    Cell Significance Index: 5.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2016
    Cell Significance Index: 15.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2003
    Cell Significance Index: 19.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1682
    Cell Significance Index: 116.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1570
    Cell Significance Index: 17.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1178
    Cell Significance Index: 15.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1121
    Cell Significance Index: 3.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1015
    Cell Significance Index: 7.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0648
    Cell Significance Index: 1.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0633
    Cell Significance Index: 1.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0622
    Cell Significance Index: 2.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0587
    Cell Significance Index: 1.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0543
    Cell Significance Index: 3.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0260
    Cell Significance Index: 4.4400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0222
    Cell Significance Index: 0.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0194
    Cell Significance Index: 0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0159
    Cell Significance Index: 21.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -4.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0041
    Cell Significance Index: -2.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -6.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0186
    Cell Significance Index: -13.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0192
    Cell Significance Index: -12.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0219
    Cell Significance Index: -12.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0227
    Cell Significance Index: -0.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0245
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0250
    Cell Significance Index: -18.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0311
    Cell Significance Index: -14.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0564
    Cell Significance Index: -11.8700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0593
    Cell Significance Index: -0.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0638
    Cell Significance Index: -6.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0675
    Cell Significance Index: -7.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0838
    Cell Significance Index: -24.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0887
    Cell Significance Index: -10.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1131
    Cell Significance Index: -2.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1306
    Cell Significance Index: -8.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1366
    Cell Significance Index: -19.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1458
    Cell Significance Index: -17.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1851
    Cell Significance Index: -9.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2062
    Cell Significance Index: -11.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2164
    Cell Significance Index: -13.3000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2299
    Cell Significance Index: -5.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2722
    Cell Significance Index: -28.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2768
    Cell Significance Index: -9.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3062
    Cell Significance Index: -20.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3097
    Cell Significance Index: -4.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3141
    Cell Significance Index: -24.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3283
    Cell Significance Index: -20.1300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3583
    Cell Significance Index: -2.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3592
    Cell Significance Index: -18.8600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3821
    Cell Significance Index: -15.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4236
    Cell Significance Index: -7.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4640
    Cell Significance Index: -14.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4878
    Cell Significance Index: -8.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5031
    Cell Significance Index: -10.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5380
    Cell Significance Index: -14.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5544
    Cell Significance Index: -20.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5644
    Cell Significance Index: -14.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** MAFG is a transcription factor that regulates gene expression by binding to specific DNA sequences, thereby modulating the transcription of target genes. 2. **Cellular Localization:** MAFG is predominantly localized to the nucleus, where it interacts with other transcriptional regulators to control gene expression. 3. **Expression Pattern:** MAFG is highly expressed in fibroblasts, endothelial cells, and epithelial cells, as well as in cells involved in hemostasis, such as platelets and megakaryocytes. 4. **Pathway Involvement:** MAFG is implicated in various signaling pathways, including the Keap1-NFE2L2 pathway, which regulates cellular responses to oxidative stress and DNA damage. **Pathways and Functions:** 1. **Hemostasis:** MAFG plays a critical role in regulating the expression of genes involved in platelet production and function, thereby influencing hemostasis. 2. **Cellular Stress Response:** MAFG is involved in the regulation of cellular responses to oxidative stress and DNA damage, mediated through the Keap1-NFE2L2 pathway. 3. **Embryonic Development:** MAFG is required for normal embryonic development, particularly in the regulation of gene expression during in utero development. 4. **Cell Proliferation and Differentiation:** MAFG regulates cell proliferation and differentiation in various cell types, including fibroblasts and epithelial cells. **Clinical Significance:** Dysregulation of MAFG expression has been implicated in various diseases, including: 1. **Cancer:** Altered MAFG expression has been observed in various types of cancer, including prostate cancer, suggesting a role in tumorigenesis. 2. **Hemostatic Disorders:** MAFG deficiency or dysfunction may contribute to bleeding disorders, such as hemophilia. 3. **Neurological Disorders:** MAFG has been implicated in the regulation of gene expression in neurons, and dysregulation may contribute to neurological disorders, such as Alzheimer's disease. In conclusion, the MAFG gene plays a critical role in regulating cellular processes, including hemostasis, cellular stress response, and embryonic development. Further research is necessary to fully elucidate the mechanisms by which MAFG regulates gene expression and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 2300329389

Symbol: MAFG_HUMAN

Name: Transcription factor MafG

UniProtKB Accession Codes:

O15525

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9195958

Title: hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2.

PubMed ID: 9195958

DOI: 10.1074/jbc.272.26.16490

PubMed ID: 9166829

Title: Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression.

PubMed ID: 9166829

PubMed ID: 9286713

Title: Molecular characterization and localization of the human MAFG gene.

PubMed ID: 9286713

DOI: 10.1006/geno.1997.4847

PubMed ID: 9150357

Title: Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif.

PubMed ID: 9150357

DOI: 10.1038/sj.onc.1201024

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8932385

Title: Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1.

PubMed ID: 8932385

DOI: 10.1093/nar/24.21.4289

PubMed ID: 9421508

Title: Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription.

PubMed ID: 9421508

DOI: 10.1093/nar/26.2.512

PubMed ID: 11154691

Title: Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation.

PubMed ID: 11154691

DOI: 10.1074/jbc.m007846200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 162
  • Mass: 17850
  • Checksum: E49F1FBA230F8D30
  • Sequence:
    • MTTPNKGNKA LKVKREPGEN GTSLTDEELV TMSVRELNQH LRGLSKEEIV QLKQRRRTLK 
NRGYAASCRV KRVTQKEELE KQKAELQQEV EKLASENASM KLELDALRSK YEALQTFART 
VARSPVAPAR GPLAAGLGPL VPGKVAATSV ITIVKSKTDA RS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.