Details for: MCM3

Gene ID: 4172

Symbol: MCM3

Ensembl ID: ENSG00000112118

Description: minichromosome maintenance complex component 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.1468
    Cell Significance Index: -9.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.6259
    Cell Significance Index: -12.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.3439
    Cell Significance Index: -21.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.1192
    Cell Significance Index: -18.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.2835
    Cell Significance Index: -21.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.6070
    Cell Significance Index: -21.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.1157
    Cell Significance Index: -19.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.0399
    Cell Significance Index: -16.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5524
    Cell Significance Index: -21.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.4116
    Cell Significance Index: -13.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 4.0422
    Cell Significance Index: 103.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1390
    Cell Significance Index: -6.8700
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 2.6570
    Cell Significance Index: 1.2100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.4832
    Cell Significance Index: 18.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.3459
    Cell Significance Index: 81.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.8837
    Cell Significance Index: 31.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.8251
    Cell Significance Index: 48.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6732
    Cell Significance Index: 18.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6506
    Cell Significance Index: 99.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3618
    Cell Significance Index: 160.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3389
    Cell Significance Index: 145.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1563
    Cell Significance Index: 188.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0633
    Cell Significance Index: 8.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0577
    Cell Significance Index: 9.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8487
    Cell Significance Index: 168.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8308
    Cell Significance Index: 43.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7779
    Cell Significance Index: 20.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7196
    Cell Significance Index: 88.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7004
    Cell Significance Index: 14.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6655
    Cell Significance Index: 7.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6572
    Cell Significance Index: 42.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6442
    Cell Significance Index: 116.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5775
    Cell Significance Index: 32.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5375
    Cell Significance Index: 485.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5052
    Cell Significance Index: 14.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4906
    Cell Significance Index: 12.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4515
    Cell Significance Index: 31.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4024
    Cell Significance Index: 55.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3981
    Cell Significance Index: 217.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3662
    Cell Significance Index: 161.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2924
    Cell Significance Index: 7.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2869
    Cell Significance Index: 7.8100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2592
    Cell Significance Index: 3.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2256
    Cell Significance Index: 14.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2253
    Cell Significance Index: 22.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2101
    Cell Significance Index: 14.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1935
    Cell Significance Index: 24.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1822
    Cell Significance Index: 34.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1673
    Cell Significance Index: 4.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1412
    Cell Significance Index: 3.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1053
    Cell Significance Index: 65.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0783
    Cell Significance Index: 2.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0692
    Cell Significance Index: 5.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0631
    Cell Significance Index: 12.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0505
    Cell Significance Index: 2.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0164
    Cell Significance Index: 0.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0077
    Cell Significance Index: 0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0017
    Cell Significance Index: 0.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0016
    Cell Significance Index: 0.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0011
    Cell Significance Index: -0.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0037
    Cell Significance Index: -1.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0042
    Cell Significance Index: -3.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0044
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0050
    Cell Significance Index: -9.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0104
    Cell Significance Index: -19.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0107
    Cell Significance Index: -7.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0148
    Cell Significance Index: -22.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0194
    Cell Significance Index: -12.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0200
    Cell Significance Index: -27.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0201
    Cell Significance Index: -5.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0212
    Cell Significance Index: -11.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0311
    Cell Significance Index: -0.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0348
    Cell Significance Index: -15.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0394
    Cell Significance Index: -4.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0459
    Cell Significance Index: -1.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0525
    Cell Significance Index: -2.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0558
    Cell Significance Index: -11.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0581
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0607
    Cell Significance Index: -6.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0626
    Cell Significance Index: -2.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0677
    Cell Significance Index: -7.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0699
    Cell Significance Index: -10.1600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0702
    Cell Significance Index: -0.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1424
    Cell Significance Index: -7.4200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1495
    Cell Significance Index: -2.2700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1549
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1662
    Cell Significance Index: -18.9700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1718
    Cell Significance Index: -2.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1788
    Cell Significance Index: -4.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2066
    Cell Significance Index: -21.5100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.2068
    Cell Significance Index: -1.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2075
    Cell Significance Index: -15.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2185
    Cell Significance Index: -13.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2226
    Cell Significance Index: -17.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2340
    Cell Significance Index: -4.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2437
    Cell Significance Index: -14.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2482
    Cell Significance Index: -3.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2861
    Cell Significance Index: -19.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3042
    Cell Significance Index: -8.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Highly Conserved**: MCM3 is highly conserved across species, suggesting its essential role in DNA replication and cell cycle progression. 2. **DNA Binding**: MCM3 binds to specific DNA sequences, facilitating the assembly of the pre-replicative complex and the initiation of DNA replication. 3. **Cell Cycle Regulation**: MCM3 is involved in the regulation of cell cycle progression, particularly during the G1/S transition and the G2/M checkpoint. 4. **DNA Replication Initiation**: MCM3 plays a critical role in the initiation of DNA replication, working in conjunction with other components of the MCMC to facilitate the unwinding of DNA and the assembly of the replication machinery. **Pathways and Functions:** 1. **Activation of ATR in Response to Replication Stress**: MCM3 interacts with the ATM/ATR protein kinase complex to activate the ATR kinase, which responds to replication stress by inducing cell cycle arrest and DNA repair. 2. **Assembly of the Pre-replicative Complex**: MCM3 binds to specific DNA sequences, facilitating the assembly of the pre-replicative complex and the initiation of DNA replication. 3. **Alpha DNA Polymerase: Primase Complex**: MCM3 interacts with the alpha DNA polymerase:primase complex to facilitate the synthesis of primers and the initiation of DNA replication. 4. **DNA Unwinding and Elongation**: MCM3 plays a critical role in the unwinding of DNA and the elongation of the replication fork, working in conjunction with other components of the MCMC to facilitate the progression of DNA replication. **Clinical Significance:** 1. **Cancer**: Abnormal expression of MCM3 has been observed in various types of cancer, including breast, lung, and colon cancer. Its overexpression may contribute to cancer progression and tumorigenesis. 2. **Genetic Disorders**: Mutations in the MCM3 gene have been associated with genetic disorders, including Fanconi anemia and Bloom syndrome, which are characterized by impaired DNA repair and cell cycle regulation. 3. **Reproductive Health**: MCM3 is essential for the proper development and function of oogonial cells, and its dysregulation may contribute to infertility and reproductive disorders. 4. **Cellular Senescence**: MCM3 plays a role in the regulation of cellular senescence, a state of permanent cell cycle arrest that occurs in response to DNA damage or other forms of cellular stress. In conclusion, the MCM3 gene is a critical regulator of DNA replication and cell cycle progression, and its dysregulation may contribute to various diseases, including cancer, genetic disorders, and reproductive health disorders. Further research is needed to fully understand the mechanisms by which MCM3 regulates DNA replication and cell cycle progression, and to explore its therapeutic potential in the treatment of these diseases.

Genular Protein ID: 3734382581

Symbol: MCM3_HUMAN

Name: DNA polymerase alpha holoenzyme-associated protein P1

UniProtKB Accession Codes:

P25205 B4DWW4 Q92660 Q9BTR3 Q9NUE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 EMDB 6 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8265339

Title: The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.

PubMed ID: 8265339

DOI: 10.1093/nar/21.23.5289-a

PubMed ID: 7758114

Title: Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor.

PubMed ID: 7758114

DOI: 10.1016/0092-8674(95)90081-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1549468

Title: Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein.

PubMed ID: 1549468

DOI: 10.1093/nar/20.5.1069

PubMed ID: 9712829

Title: Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization.

PubMed ID: 9712829

DOI: 10.1074/jbc.273.35.22177

PubMed ID: 11258703

Title: MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3.

PubMed ID: 11258703

DOI: 10.1093/embo-reports/kve026

PubMed ID: 12226073

Title: The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3.

PubMed ID: 12226073

DOI: 10.1074/jbc.c200442200

PubMed ID: 15210935

Title: Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.

PubMed ID: 15210935

DOI: 10.1073/pnas.0403410101

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16899510

Title: Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.

PubMed ID: 16899510

DOI: 10.1091/mbc.e06-03-0241

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17296731

Title: Identification and characterization of a novel component of the human minichromosome maintenance complex.

PubMed ID: 17296731

DOI: 10.1128/mcb.02384-06

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22967762

Title: Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.

PubMed ID: 22967762

DOI: 10.1016/j.bbagen.2012.08.024

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23711367

Title: A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.

PubMed ID: 23711367

DOI: 10.1016/j.febslet.2013.05.037

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 35585232

Title: Fast and efficient DNA replication with purified human proteins.

PubMed ID: 35585232

DOI: 10.1038/s41586-022-04759-1

PubMed ID: 32453425

Title: CryoEM structures of human CMG-ATPgammaS-DNA and CMG-AND-1 complexes.

PubMed ID: 32453425

DOI: 10.1093/nar/gkaa429

PubMed ID: 34700328

Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.

PubMed ID: 34700328

DOI: 10.1038/s41586-021-04145-3

PubMed ID: 34694004

Title: Structure of a human replisome shows the organisation and interactions of a DNA replication machine.

PubMed ID: 34694004

DOI: 10.15252/embj.2021108819

Sequence Information:

  • Length: 808
  • Mass: 90981
  • Checksum: C967C068B7090558
  • Sequence:
    • MAGTVVLDDV ELREAQRDYL DFLDDEEDQG IYQSKVRELI SDNQYRLIVN VNDLRRKNEK 
RANRLLNNAF EELVAFQRAL KDFVASIDAT YAKQYEEFYV GLEGSFGSKH VSPRTLTSCF 
LSCVVCVEGI VTKCSLVRPK VVRSVHYCPA TKKTIERRYS DLTTLVAFPS SSVYPTKDEE 
NNPLETEYGL SVYKDHQTIT IQEMPEKAPA GQLPRSVDVI LDDDLVDKAK PGDRVQVVGT 
YRCLPGKKGG YTSGTFRTVL IACNVKQMSK DAQPSFSAED IAKIKKFSKT RSKDIFDQLA 
KSLAPSIHGH DYVKKAILCL LLGGVERDLE NGSHIRGDIN ILLIGDPSVA KSQLLRYVLC 
TAPRAIPTTG RGSSGVGLTA AVTTDQETGE RRLEAGAMVL ADRGVVCIDE FDKMSDMDRT 
AIHEVMEQGR VTIAKAGIHA RLNARCSVLA AANPVYGRYD QYKTPMENIG LQDSLLSRFD 
LLFIMLDQMD PEQDREISDH VLRMHRYRAP GEQDGDAMPL GSAVDILATD DPNFSQEDQQ 
DTQIYEKHDN LLHGTKKKKE KMVSAAFMKK YIHVAKIIKP VLTQESATYI AEEYSRLRSQ 
DSMSSDTART SPVTARTLET LIRLATAHAK ARMSKTVDLQ DAEEAVELVQ YAYFKKVLEK 
EKKRKKRSED ESETEDEEEK SQEDQEQKRK RRKTRQPDAK DGDSYDPYDF SDTEEEMPQV 
HTPKTADSQE TKESQKVELS ESRLKAFKVA LLDVFREAHA QSIGMNRLTE SINRDSEEPF 
SSVEIQAALS KMQDDNQVMV SEGIIFLI

Genular Protein ID: 2507085561

Symbol: A0A499FHX9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A499FHX9

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 4 GeneTree 1 HGNC 1 InterPro 9 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 2 RuleBase 2 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 818
  • Mass: 91930
  • Checksum: 7D37CF485B41255C
  • Sequence:
    • MLICSQGPRL FLEVTFGGGK SSEVFAPGWS HPGNLHATLV EVVLWQRAWR VPWCWTMWSC 
GRLREITWTS WTTRLLNNAF EELVAFQRAL KDFVASIDAT YAKQYEEFYV GLEGSFGSKH 
VSPRTLTSCF LSCVVCVEGI VTKCSLVRPK VVRSVHYCPA TKKTIERRYS DLTTLVAFPS 
SSVYPTKDEE NNPLETEYGL SVYKDHQTIT IQEMPEKAPA GQLPRSVDVI LDDDLVDKAK 
PGDRVQVVGT YRCLPGKKGG YTSGTFRTVL IACNVKQMSK DAQPSFSAED IAKIKKFSKT 
RSKDIFDQLA KSLAPSIHGH DYVKKAILCL LLGGVERDLE NGSHIRGDIN ILLIGDPSVA 
KSQLLRYVLC TAPRAIPTTG RGSSGVGLTA AVTTDQETGE RRLEAGAMVL ADRGVVCIDE 
FDKMSDMDRT AIHEVMEQGR VTIAKAGIHA RLNARCSVLA AANPVYGRYD QYKTPMENIG 
LQDSLLSRFD LLFIMLDQMD PEQDREISDH VLRMHRYRAP GEQDGDAMPL GSAVDILATD 
DPNFSQEDQQ DTQIYEKHDN LLHGTKKKKE KMVSAAFMKK YIHVAKIIKP VLTQESATYI 
AEEYSRLRSQ DSMSSDTART SPVTARTLET LIRLATAHAK ARMSKTVDLQ DAEEAVELVQ 
YAYFKKVLEK EKKRKKRSED ESETEDEEEK SQEDQEQKRK RRKTRQPDAK DGDSYDPYDF 
SDTEEEMPQV HTPKTADSQE TKESQKVELS ESRLKAFKVA LLDVFREAHA QSIGMNRLTE 
SINRDSEEPF SSVEIQAALS KMQDDNQVMV SEGIIFLI

Genular Protein ID: 193584095

Symbol: B4DUQ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DUQ9

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 10 Gene3D 4 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 3 RefSeq 1 Rhea 2 RuleBase 2 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 762
  • Mass: 85639
  • Checksum: E2700E5A0E167AA9
  • Sequence:
    • MWSYGRLREI TWTSWTTRLL NNAFEELVAF QRALKDFVAS IDATYAKQYE EFYVGLEGSF 
GSKHVSPRTL TSCFLSCVVC VEGIVTKCSL VRPKVVRSVH YCPATKKTIE RRYSDLTTLV 
AFPSSSVYPT KDEENNPLET EYGLSVYKDH QTITIQEMPE KAPAGQLPRS VDVILDDDLV 
DKAKPGDRVQ VVGTYRCLPG KKGGYTSGTF RTVLIACNVK QMSKDAQPSF SAEDIAKIKK 
FSKTRSKDIF DQLAKSLAPS IHGHDYVKKA ILCLLLGGVE RDLENGSHIR GDINILLIGD 
PSVAKSQLLR YVLCTAPRAI PTTGRGSSGV GLTAAVTTDQ ETGERRLEAG AMVLADRGVV 
CIDEFDKMSD MDRTAIHEVM EQGRVTIAKA GIHARLNARC SVLAAANPVY GRYDQYKTPM 
ENIGLQDSLL SRFDLLFIML DQMDPEQDRE ISDHVLRMHR YRAPGEQDGD AMPLGSAVDI 
LATDDPNFSQ EDQQDTQIYE KHDNLLHGTK KKKEKMVGAA FMKKYIHVAK IIKPVLTQES 
ATYIAEEYSR LRSQDSMSSD TARTSPVTAR TLETLIRLAT AHAKARMSKT VDLQDAEEAV 
ELVQYAYFKK VLEKEKKRKK RSEDESETED EEEKSQEDQE QKRKRRKTRQ PDAKDGDSYD 
PYDFSDTEEE MPQVHTPKTA DSQETKESQK VELSESRLKA FKVALLDVFR EAHAQSIGMN 
RLTESINRDS EEPFSSVEIQ AALSKMQDDN QVMVSEGIIF LI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.