Details for: CD46

Gene ID: 4179

Symbol: CD46

Ensembl ID: ENSG00000117335

Description: CD46 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 497.1223
    Cell Significance Index: -77.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 311.2638
    Cell Significance Index: -78.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 177.1044
    Cell Significance Index: -83.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 173.7570
    Cell Significance Index: -70.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 155.6227
    Cell Significance Index: -80.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 124.8468
    Cell Significance Index: -83.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 74.0932
    Cell Significance Index: -70.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 66.0689
    Cell Significance Index: -81.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 27.8962
    Cell Significance Index: -74.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.8918
    Cell Significance Index: -82.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.8715
    Cell Significance Index: -51.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.8732
    Cell Significance Index: -34.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 7.3576
    Cell Significance Index: 196.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.8756
    Cell Significance Index: 180.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.2470
    Cell Significance Index: 87.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.9416
    Cell Significance Index: 530.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.8815
    Cell Significance Index: 26.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.8489
    Cell Significance Index: 65.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.8296
    Cell Significance Index: 561.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6981
    Cell Significance Index: 140.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.6101
    Cell Significance Index: 320.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.1012
    Cell Significance Index: 58.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9786
    Cell Significance Index: 1080.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9636
    Cell Significance Index: 319.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8121
    Cell Significance Index: 49.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6927
    Cell Significance Index: 339.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5490
    Cell Significance Index: 72.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5271
    Cell Significance Index: 44.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5002
    Cell Significance Index: 92.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3197
    Cell Significance Index: 74.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1450
    Cell Significance Index: 410.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1124
    Cell Significance Index: 50.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8603
    Cell Significance Index: 16.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8465
    Cell Significance Index: 59.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7567
    Cell Significance Index: 103.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7469
    Cell Significance Index: 330.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6360
    Cell Significance Index: 47.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5771
    Cell Significance Index: 62.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5125
    Cell Significance Index: 50.7000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4663
    Cell Significance Index: 2.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4094
    Cell Significance Index: 14.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3973
    Cell Significance Index: 50.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3786
    Cell Significance Index: 64.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3281
    Cell Significance Index: 25.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2949
    Cell Significance Index: 38.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2760
    Cell Significance Index: 190.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2434
    Cell Significance Index: 15.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1256
    Cell Significance Index: 236.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1149
    Cell Significance Index: 1.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1105
    Cell Significance Index: 70.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0941
    Cell Significance Index: 69.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0860
    Cell Significance Index: 132.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0845
    Cell Significance Index: 155.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0575
    Cell Significance Index: 10.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0548
    Cell Significance Index: 41.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0294
    Cell Significance Index: 0.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0064
    Cell Significance Index: 8.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0034
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0299
    Cell Significance Index: -22.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0489
    Cell Significance Index: -30.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0654
    Cell Significance Index: -4.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0951
    Cell Significance Index: -53.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1054
    Cell Significance Index: -10.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1716
    Cell Significance Index: -11.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1821
    Cell Significance Index: -38.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1894
    Cell Significance Index: -22.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1918
    Cell Significance Index: -4.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2477
    Cell Significance Index: -71.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2622
    Cell Significance Index: -38.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2851
    Cell Significance Index: -3.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2872
    Cell Significance Index: -19.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3450
    Cell Significance Index: -17.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3731
    Cell Significance Index: -42.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4700
    Cell Significance Index: -54.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5326
    Cell Significance Index: -23.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5682
    Cell Significance Index: -12.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5710
    Cell Significance Index: -3.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5757
    Cell Significance Index: -65.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6417
    Cell Significance Index: -11.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6794
    Cell Significance Index: -70.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7061
    Cell Significance Index: -26.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7277
    Cell Significance Index: -13.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7648
    Cell Significance Index: -20.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7708
    Cell Significance Index: -12.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8635
    Cell Significance Index: -14.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8802
    Cell Significance Index: -69.7100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.9164
    Cell Significance Index: -13.1800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.9364
    Cell Significance Index: -9.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9511
    Cell Significance Index: -23.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9635
    Cell Significance Index: -33.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9843
    Cell Significance Index: -51.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9967
    Cell Significance Index: -25.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1451
    Cell Significance Index: -32.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2131
    Cell Significance Index: -38.8500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.2351
    Cell Significance Index: -18.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.2632
    Cell Significance Index: -37.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2927
    Cell Significance Index: -27.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3290
    Cell Significance Index: -81.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.5471
    Cell Significance Index: -44.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.6716
    Cell Significance Index: -34.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Protein:** CD46 is a transmembrane protein, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. 2. **Complement Activation Regulation:** CD46 acts as a negative regulator of the classical complement pathway by binding to C4b and C3b, thereby preventing their deposition on the surface of cells. 3. **Cell Surface Expression:** CD46 is expressed on various cell types, including cortical cells of the adrenal gland, renal interstitial pericytes, and conjunctival epithelial cells. 4. **Protein Binding:** CD46 exhibits high affinity for complement components C4b and C3b, allowing it to regulate their activity. **Pathways and Functions:** 1. **Adaptive Immune Response:** CD46 plays a crucial role in regulating the adaptive immune response by modulating the activity of T cells and regulatory T cells. 2. **Complement Activation:** CD46 negatively regulates the classical complement pathway, preventing excessive activation and tissue damage. 3. **Innate Immune Response:** CD46 is also involved in the innate immune response, influencing the activity of complement components and the production of cytokines. 4. **Signaling Pathways:** CD46 interacts with various signaling pathways, including the Notch signaling pathway and the regulation of interleukin-10 production. **Clinical Significance:** 1. **Autoimmune Diseases:** CD46 dysregulation has been implicated in various autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 2. **Inflammation:** CD46 plays a crucial role in regulating inflammation, which is a hallmark of many diseases, including cancer and cardiovascular disease. 3. **Transplantation:** CD46 has been identified as a potential target for modulating the immune response in transplantation, reducing the risk of rejection. 4. **Viral Infections:** CD46 has been shown to interact with viruses, such as HIV and herpes simplex virus, influencing their entry into host cells. In conclusion, CD46 is a multifaceted gene that plays a critical role in regulating the immune response and complement activation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its function and potential therapeutic applications. Further research is needed to elucidate the complex interactions of CD46 and its role in maintaining immune homeostasis.

Genular Protein ID: 3981109789

Symbol: MCP_HUMAN

Name: Membrane cofactor protein

UniProtKB Accession Codes:

P15529 A0T1T0 A0T1T1 A0T1T2 Q15429 Q53GV9 Q5HY94 Q5VWS6 Q5VWS7 Q5VWS8 Q5VWS9 Q5VWT0 Q5VWT1 Q5VWT2 Q6N0A1 Q7Z3R5 Q9NNW2 Q9NNW3 Q9NNW4 Q9UCJ4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 9 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 30 EMDB 1 Ensembl 10 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 4 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 16 Pumba 1 RNAct 1 Reactome 1 RefSeq 13 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3260937

Title: Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins.

PubMed ID: 3260937

DOI: 10.1084/jem.168.1.181

PubMed ID: 2050389

Title: Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation.

PubMed ID: 2050389

DOI: 10.1007/bf00216692

PubMed ID: 1711570

Title: Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype.

PubMed ID: 1711570

DOI: 10.1084/jem.174.1.93

PubMed ID: 8418811

Title: Characterization of a cDNA clone coding for human testis membrane cofactor protein (MCP, CD46).

PubMed ID: 8418811

DOI: 10.1002/mrd.1080340117

PubMed ID: 9659228

Title: Post-translational modification and intracellular localization of a splice product of CD46 cloned from human testis: role of the intracellular domains in O-glycosylation.

PubMed ID: 9659228

DOI: 10.1046/j.1365-2567.1998.00455.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10751138

Title: Analysis of measles virus binding sites of the CD46 gene in patients with subacute sclerosing panencephalitis.

PubMed ID: 10751138

DOI: 10.1086/315386

PubMed ID: 7691939

Title: Characterization of the promoter region of the membrane cofactor protein (CD46) gene of the human complement system and comparison to a membrane cofactor protein-like genetic element.

PubMed ID: 7691939

PubMed ID: 1479546

Title: Homology of an acrosome-reacted sperm-specific antigen to CD46.

PubMed ID: 1479546

DOI: 10.1248/bpb1978.15.455

PubMed ID: 2298462

Title: Human non-lineage antigen, CD46 (HuLy-m5): purification and partial sequencing demonstrates structural homology with complement-regulating glycoproteins.

PubMed ID: 2298462

DOI: 10.1007/bf00702485

PubMed ID: 8371352

Title: Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus.

PubMed ID: 8371352

DOI: 10.1128/jvi.67.10.6025-6032.1993

PubMed ID: 1717583

Title: Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity.

PubMed ID: 1717583

PubMed ID: 1601037

Title: Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing.

PubMed ID: 1601037

DOI: 10.1002/eji.1830220625

PubMed ID: 8402913

Title: The human CD46 molecule is a receptor for measles virus (Edmonston strain).

PubMed ID: 8402913

DOI: 10.1016/0092-8674(93)80071-l

PubMed ID: 7534417

Title: Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46).

PubMed ID: 7534417

DOI: 10.1073/pnas.92.6.2303

PubMed ID: 7708671

Title: Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus.

PubMed ID: 7708671

DOI: 10.1073/pnas.92.7.2489

PubMed ID: 7884872

Title: Physical association of moesin and CD46 as a receptor complex for measles virus.

PubMed ID: 7884872

DOI: 10.1128/jvi.69.4.2248-2256.1995

PubMed ID: 8764003

Title: The N-glycan of the SCR 2 region is essential for membrane cofactor protein (CD46) to function as a measles virus receptor.

PubMed ID: 8764003

DOI: 10.1128/jvi.70.8.4973-4977.1996

PubMed ID: 9379894

Title: Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria.

PubMed ID: 9379894

DOI: 10.1046/j.1365-2958.1997.4841857.x

PubMed ID: 9759896

Title: Membrane cofactor protein: importance of N- and O-glycosylation for complement regulatory function.

PubMed ID: 9759896

PubMed ID: 10619434

Title: CD46 is a cellular receptor for human herpesvirus 6.

PubMed ID: 10619434

DOI: 10.1016/s0092-8674(00)81678-5

PubMed ID: 10657632

Title: Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation.

PubMed ID: 10657632

DOI: 10.4049/jimmunol.164.4.1839

PubMed ID: 10843656

Title: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation.

PubMed ID: 10843656

DOI: 10.4049/jimmunol.164.12.6091

PubMed ID: 10972291

Title: SLAM (CDw150) is a cellular receptor for measles virus.

PubMed ID: 10972291

DOI: 10.1038/35022579

PubMed ID: 11260136

Title: Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherence.

PubMed ID: 11260136

DOI: 10.1046/j.1462-5822.2001.00095.x

PubMed ID: 12171934

Title: Human Herpesvirus 6 and Measles Virus employ distinct CD46 domains for receptor function.

PubMed ID: 12171934

DOI: 10.1074/jbc.m206488200

PubMed ID: 11901164

Title: CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae.

PubMed ID: 11901164

DOI: 10.1083/jcb.200109005

PubMed ID: 11971006

Title: Identification of the streptococcal M protein binding site on membrane cofactor protein (CD46).

PubMed ID: 11971006

DOI: 10.4049/jimmunol.168.9.4585

PubMed ID: 12112588

Title: Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa.

PubMed ID: 12112588

DOI: 10.1002/mrd.10144

PubMed ID: 12724329

Title: Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46.

PubMed ID: 12724329

DOI: 10.1074/jbc.m302373200

PubMed ID: 14597734

Title: Down-regulation of CD46 by piliated Neisseria gonorrhoeae.

PubMed ID: 14597734

DOI: 10.1084/jem.20031159

PubMed ID: 12663806

Title: Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46.

PubMed ID: 12663806

DOI: 10.1128/jvi.77.8.4992-4999.2003

PubMed ID: 12915534

Title: Adenovirus type 11 uses CD46 as a cellular receptor.

PubMed ID: 12915534

DOI: 10.1128/jvi.77.17.9183-9191.2003

PubMed ID: 14615110

Title: Familial haemolytic uraemic syndrome and an MCP mutation.

PubMed ID: 14615110

DOI: 10.1016/s0140-6736(03)14742-3

PubMed ID: 12540904

Title: Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype.

PubMed ID: 12540904

DOI: 10.1038/nature01315

PubMed ID: 14566335

Title: CD46 is a cellular receptor for group B adenoviruses.

PubMed ID: 14566335

DOI: 10.1038/nm952

PubMed ID: 15307194

Title: Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form.

PubMed ID: 15307194

DOI: 10.1002/eji.200424969

PubMed ID: 15047806

Title: Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis.

PubMed ID: 15047806

DOI: 10.1128/jvi.78.8.3897-3905.2004

PubMed ID: 15078926

Title: The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3.

PubMed ID: 15078926

DOI: 10.1128/jvi.78.9.4454-4462.2004

PubMed ID: 15919905

Title: Localization of regions in CD46 that interact with adenovirus.

PubMed ID: 15919905

DOI: 10.1128/jvi.79.12.7503-7513.2005

PubMed ID: 16254377

Title: CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7.

PubMed ID: 16254377

DOI: 10.1128/jvi.79.22.14429-14436.2005

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10357804

Title: Crystal structure of two CD46 domains reveals an extended measles virus-binding surface.

PubMed ID: 10357804

DOI: 10.1093/emboj/18.11.2911

PubMed ID: 14566051

Title: Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome.

PubMed ID: 14566051

DOI: 10.1073/pnas.2135497100

PubMed ID: 16621965

Title: Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome.

PubMed ID: 16621965

DOI: 10.1182/blood-2005-10-007252

PubMed ID: 16386793

Title: Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree.

PubMed ID: 16386793

DOI: 10.1016/j.molimm.2005.11.008

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 20513133

Title: Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.

PubMed ID: 20513133

DOI: 10.1002/humu.21256

Sequence Information:

  • Length: 392
  • Mass: 43747
  • Checksum: 85FE0CF100EA703E
  • Sequence:
    • MEPPGRRECP FPSWRFPGLL LAAMVLLLYS FSDACEEPPT FEAMELIGKP KPYYEIGERV 
DYKCKKGYFY IPPLATHTIC DRNHTWLPVS DDACYRETCP YIRDPLNGQA VPANGTYEFG 
YQMHFICNEG YYLIGEEILY CELKGSVAIW SGKPPICEKV LCTPPPKIKN GKHTFSEVEV 
FEYLDAVTYS CDPAPGPDPF SLIGESTIYC GDNSVWSRAA PECKVVKCRF PVVENGKQIS 
GFGKKFYYKA TVMFECDKGF YLDGSDTIVC DSNSTWDPPV PKCLKVLPPS STKPPALSHS 
VSTSSTTKSP ASSASGPRPT YKPPVSNYPG YPKPEEGILD SLDVWVIAVI VIAIVVGVAV 
ICVVPYRYLQ RRKKKGTYLT DETHREVKFT SL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.