Details for: MAP3K3

Gene ID: 4215

Symbol: MAP3K3

Ensembl ID: ENSG00000198909

Description: mitogen-activated protein kinase kinase kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 232.5369
    Cell Significance Index: -36.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 139.5266
    Cell Significance Index: -35.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 77.5010
    Cell Significance Index: -36.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 72.5403
    Cell Significance Index: -29.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.2842
    Cell Significance Index: -34.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.8669
    Cell Significance Index: -29.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.5307
    Cell Significance Index: -36.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.8432
    Cell Significance Index: -34.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.8348
    Cell Significance Index: -28.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.2548
    Cell Significance Index: -36.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7534
    Cell Significance Index: 351.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3286
    Cell Significance Index: 101.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1698
    Cell Significance Index: 222.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0119
    Cell Significance Index: 362.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8756
    Cell Significance Index: 17.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8033
    Cell Significance Index: 555.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7528
    Cell Significance Index: 149.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7120
    Cell Significance Index: 70.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6796
    Cell Significance Index: 30.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6288
    Cell Significance Index: 23.8100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6119
    Cell Significance Index: 8.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5590
    Cell Significance Index: 31.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3709
    Cell Significance Index: 60.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2456
    Cell Significance Index: 44.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2332
    Cell Significance Index: 28.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2232
    Cell Significance Index: 24.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1603
    Cell Significance Index: 9.8500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1595
    Cell Significance Index: 2.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1432
    Cell Significance Index: 3.5800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1286
    Cell Significance Index: 1.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1132
    Cell Significance Index: 71.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1009
    Cell Significance Index: 6.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0789
    Cell Significance Index: 10.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0770
    Cell Significance Index: 1.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0695
    Cell Significance Index: 0.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0615
    Cell Significance Index: 55.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0599
    Cell Significance Index: 92.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0574
    Cell Significance Index: 107.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0439
    Cell Significance Index: 19.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0422
    Cell Significance Index: 77.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0412
    Cell Significance Index: 22.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0359
    Cell Significance Index: 16.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0330
    Cell Significance Index: 44.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0208
    Cell Significance Index: 0.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0168
    Cell Significance Index: -1.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0174
    Cell Significance Index: -12.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0283
    Cell Significance Index: -4.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0380
    Cell Significance Index: -2.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0401
    Cell Significance Index: -30.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0431
    Cell Significance Index: -31.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0577
    Cell Significance Index: -3.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0605
    Cell Significance Index: -2.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0614
    Cell Significance Index: -34.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0660
    Cell Significance Index: -41.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0677
    Cell Significance Index: -11.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0744
    Cell Significance Index: -3.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0759
    Cell Significance Index: -2.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0771
    Cell Significance Index: -2.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0856
    Cell Significance Index: -9.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1078
    Cell Significance Index: -31.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1242
    Cell Significance Index: -12.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1514
    Cell Significance Index: -3.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1569
    Cell Significance Index: -20.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1801
    Cell Significance Index: -21.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1902
    Cell Significance Index: -21.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1902
    Cell Significance Index: -40.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1982
    Cell Significance Index: -25.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2039
    Cell Significance Index: -3.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2621
    Cell Significance Index: -12.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2681
    Cell Significance Index: -27.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2726
    Cell Significance Index: -16.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3042
    Cell Significance Index: -6.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3086
    Cell Significance Index: -7.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3167
    Cell Significance Index: -8.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3338
    Cell Significance Index: -6.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3366
    Cell Significance Index: -17.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3487
    Cell Significance Index: -24.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3632
    Cell Significance Index: -22.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3669
    Cell Significance Index: -29.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3693
    Cell Significance Index: -27.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3914
    Cell Significance Index: -20.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3918
    Cell Significance Index: -11.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4172
    Cell Significance Index: -11.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4532
    Cell Significance Index: -14.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5145
    Cell Significance Index: -10.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5188
    Cell Significance Index: -27.2400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5237
    Cell Significance Index: -6.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5275
    Cell Significance Index: -16.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5582
    Cell Significance Index: -16.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5611
    Cell Significance Index: -18.3700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5953
    Cell Significance Index: -12.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6297
    Cell Significance Index: -31.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6452
    Cell Significance Index: -13.7400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6560
    Cell Significance Index: -8.2800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6585
    Cell Significance Index: -9.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6737
    Cell Significance Index: -13.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7095
    Cell Significance Index: -14.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7113
    Cell Significance Index: -30.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7176
    Cell Significance Index: -25.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7471
    Cell Significance Index: -20.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAP3K3 is a serine/threonine kinase that belongs to the TAK1 family of kinases. It is characterized by its ability to phosphorylate and activate downstream targets, including MAP2Ks, MAPKs, and other transcription factors. MAP3K3 is highly expressed in various tissues, including the cerebral cortex, where it is involved in regulating neuronal signaling and synaptic plasticity. **Pathways and Functions:** MAP3K3 is involved in multiple signaling pathways, including: 1. **Cytokine signaling in the immune system**: MAP3K3 is activated by cytokines, such as TNF-α and IL-1β, and plays a key role in regulating the production of pro-inflammatory cytokines and chemokines. 2. **Intracellular signal transduction**: MAP3K3 phosphorylates and activates downstream targets, including MAPKs and NF-κB, to regulate various cellular processes, including cell migration, proliferation, and survival. 3. **MAPK cascade**: MAP3K3 phosphorylates and activates MAP2Ks, which in turn phosphorylate and activate MAPKs, leading to the activation of downstream targets. 4. **Positive regulation of canonical NF-κB signaling**: MAP3K3 phosphorylates and activates IκB kinase (IKK), which in turn phosphorylates and activates NF-κB, a transcription factor involved in regulating immune responses and inflammation. **Clinical Significance:** MAP3K3 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: MAP3K3 has been shown to play a role in regulating the production of pro-inflammatory cytokines and chemokines in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Inflammatory bowel disease**: MAP3K3 has been implicated in the regulation of inflammation and immune responses in inflammatory bowel disease (IBD). 3. **Cancer**: MAP3K3 has been shown to play a role in regulating cell proliferation and survival in various types of cancer, including lung cancer and breast cancer. 4. **Neurological disorders**: MAP3K3 has been implicated in the regulation of neuronal signaling and synaptic plasticity in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, MAP3K3 is a critical component of the MAPK signaling pathway, playing a pivotal role in regulating various cellular processes, including immune responses, cell migration, proliferation, and survival. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of MAP3K3 in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 641661570

Symbol: M3K3_HUMAN

Name: Mitogen-activated protein kinase kinase kinase 3

UniProtKB Accession Codes:

Q99759 B2RCW2 D3DU15 Q5BKZ6 Q8N3I9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 4 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9006902

Title: Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein kinase/ERK kinase kinase 3 (MEKK) derivative.

PubMed ID: 9006902

DOI: 10.1074/jbc.272.5.2668

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12761204

Title: Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum- and glucocorticoid-induced kinase 1.

PubMed ID: 12761204

DOI: 10.1093/jb/mvg010

PubMed ID: 12912994

Title: PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway.

PubMed ID: 12912994

DOI: 10.1074/jbc.c300313200

PubMed ID: 14661019

Title: Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3.

PubMed ID: 14661019

DOI: 10.1038/ni1014

PubMed ID: 14743216

Title: A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.

PubMed ID: 14743216

DOI: 10.1038/ncb1086

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 626
  • Mass: 70898
  • Checksum: 28129168A57571DD
  • Sequence:
    • MDEQEALNSI MNDLVALQMN RRHRMPGYET MKNKDTGHSN RQSDVRIKFE HNGERRIIAF 
SRPVKYEDVE HKVTTVFGQP LDLHYMNNEL SILLKNQDDL DKAIDILDRS SSMKSLRILL 
LSQDRNHNSS SPHSGVSRQV RIKASQSAGD INTIYQPPEP RSRHLSVSSQ NPGRSSPPPG 
YVPERQQHIA RQGSYTSINS EGEFIPETSE QCMLDPLSSA ENSLSGSCQS LDRSADSPSF 
RKSRMSRAQS FPDNRQEYSD RETQLYDKGV KGGTYPRRYH VSVHHKDYSD GRRTFPRIRR 
HQGNLFTLVP SSRSLSTNGE NMGLAVQYLD PRGRLRSADS ENALSVQERN VPTKSPSAPI 
NWRRGKLLGQ GAFGRVYLCY DVDTGRELAS KQVQFDPDSP ETSKEVSALE CEIQLLKNLQ 
HERIVQYYGC LRDRAEKTLT IFMEYMPGGS VKDQLKAYGA LTESVTRKYT RQILEGMSYL 
HSNMIVHRDI KGANILRDSA GNVKLGDFGA SKRLQTICMS GTGMRSVTGT PYWMSPEVIS 
GEGYGRKADV WSLGCTVVEM LTEKPPWAEY EAMAAIFKIA TQPTNPQLPS HISEHGRDFL 
RRIFVEARQR PSAEELLTHH FAQLMY

Genular Protein ID: 2619537679

Symbol: Q96HN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96HN9

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 Google 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 594
  • Mass: 67092
  • Checksum: F493865DB2F8CC3D
  • Sequence:
    • NKDTGHSNRQ SDVRIKFEHN GERRIIAFSR PVKYEDVEHK VTTVFGQPLD LHYMNNELSI 
LLKNQDDLDK AIDILDRSSS MKSLRILLLS QDRNHNSSSP HSGVSRQVRI KASQSAGDIN 
TIYQPPEPRS RHLSVSSQNP GRSSPPPGYV PERQQHIARQ GSYTSINSEG EFIPETSEQC 
MLDPLSSAEN SLSGSCQSLD RSADSPSFRK SRMSRAQSFP DNRQEYSDRE TQLYDKGVKG 
GTYPRRYHVS VHHKDYSDGR RTFPRIRRHQ GNLFTLVPSS RSLSTNGENM GLAVQYLDPR 
GRLRSADSEN ALSVQERNVP TKSPSAPINW RRGKLLGQGA FGRVYLCYDV DTGRELASKQ 
VQFDPDSPET SKEVSALECE IQLLKNLQHE RIVQYYGCLR DRAEKTLTIF MEYMPGGSVK 
DQLKAYGALT ESVTRKYTRQ ILEGMSYLHS NMIVHRDIKG ANILRDSAGN VKLGDFGASK 
RLQTICMSGT GMRSVTGTPY WMSPEVISGE GYGRKADVWS LGCTVVEMLT EKPPWAEYEA 
MAAIFKIATQ PTNPQLPSHI SEHGRDFLRR IFVEARQRPS AEELLTHHFA QLMY

Genular Protein ID: 2576693582

Symbol: J3KRN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KRN4

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 622
  • Mass: 70468
  • Checksum: B0CC703710CFC461
  • Sequence:
    • MDEQEALNSI MNDLVALQMN RRHRMPGYET MKNKDTGHSN RQSDVRIKFE HNGERRIIAF 
SRPVKYEDVE HKVTTVFGQP LDLHYMNNEL SILLKNQDDL DKAIDILDRS SSMKSLRILL 
LSQDRNHNSS SPHSGVSRQV RIKASQSAGD INTIYQPPEP RSRHLSVSSQ NPGRSSPPPG 
YVPERQQHIA RQGSYTSINS EGEFIPETSE QCMLDPLSSA ENSLSGSCQS LDSPSFRKSR 
MSRAQSFPDN RQEYSDRETQ LYDKGVKGGT YPRRYHVSVH HKDYSDGRRT FPRIRRHQGN 
LFTLVPSSRS LSTNGENMGL AVQYLDPRGR LRSADSENAL SVQERNVPTK SPSAPINWRR 
GKLLGQGAFG RVYLCYDVDT GRELASKQVQ FDPDSPETSK EVSALECEIQ LLKNLQHERI 
VQYYGCLRDR AEKTLTIFME YMPGGSVKDQ LKAYGALTES VTRKYTRQIL EGMSYLHSNM 
IVHRDIKGAN ILRDSAGNVK LGDFGASKRL QTICMSGTGM RSVTGTPYWM SPEVISGEGY 
GRKADVWSLG CTVVEMLTEK PPWAEYEAMA AIFKIATQPT NPQLPSHISE HGRDFLRRIF 
VEARQRPSAE ELLTHHFAQL MY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.