Details for: MFAP1

Gene ID: 4236

Symbol: MFAP1

Ensembl ID: ENSG00000140259

Description: microfibril associated protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 174.6116
    Cell Significance Index: -27.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 109.5633
    Cell Significance Index: -27.7900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 72.4364
    Cell Significance Index: -29.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.0499
    Cell Significance Index: -32.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.6389
    Cell Significance Index: -26.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.6305
    Cell Significance Index: -26.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.2077
    Cell Significance Index: -31.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9296
    Cell Significance Index: -26.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0992
    Cell Significance Index: -31.9600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2474
    Cell Significance Index: -22.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7186
    Cell Significance Index: 46.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5553
    Cell Significance Index: 93.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4237
    Cell Significance Index: 38.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3665
    Cell Significance Index: 148.6300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.3072
    Cell Significance Index: 10.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1109
    Cell Significance Index: 136.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0789
    Cell Significance Index: 68.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0103
    Cell Significance Index: 182.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8016
    Cell Significance Index: 41.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7896
    Cell Significance Index: 27.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7372
    Cell Significance Index: 402.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7118
    Cell Significance Index: 49.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6922
    Cell Significance Index: 95.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5698
    Cell Significance Index: 251.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5185
    Cell Significance Index: 4.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5150
    Cell Significance Index: 10.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5059
    Cell Significance Index: 22.9300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4995
    Cell Significance Index: 4.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4736
    Cell Significance Index: 55.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4267
    Cell Significance Index: 69.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4226
    Cell Significance Index: 19.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4175
    Cell Significance Index: 83.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4040
    Cell Significance Index: 10.1000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3743
    Cell Significance Index: 2.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3613
    Cell Significance Index: 71.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3518
    Cell Significance Index: 9.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3176
    Cell Significance Index: 22.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3161
    Cell Significance Index: 40.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3037
    Cell Significance Index: 14.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2690
    Cell Significance Index: 7.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2390
    Cell Significance Index: 17.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1748
    Cell Significance Index: 1.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1707
    Cell Significance Index: 8.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1650
    Cell Significance Index: 59.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1226
    Cell Significance Index: 84.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1133
    Cell Significance Index: 11.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1091
    Cell Significance Index: 2.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1056
    Cell Significance Index: 1.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0802
    Cell Significance Index: 10.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0753
    Cell Significance Index: 3.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0425
    Cell Significance Index: 0.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0379
    Cell Significance Index: 2.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0182
    Cell Significance Index: 0.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0119
    Cell Significance Index: 8.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0044
    Cell Significance Index: 0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0063
    Cell Significance Index: -8.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0065
    Cell Significance Index: -9.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0115
    Cell Significance Index: -21.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0153
    Cell Significance Index: -0.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0156
    Cell Significance Index: -11.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0214
    Cell Significance Index: -13.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0235
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0371
    Cell Significance Index: -27.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0385
    Cell Significance Index: -17.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0467
    Cell Significance Index: -4.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0525
    Cell Significance Index: -29.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0562
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0581
    Cell Significance Index: -36.3000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0621
    Cell Significance Index: -0.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0662
    Cell Significance Index: -0.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0675
    Cell Significance Index: -5.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0853
    Cell Significance Index: -24.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0900
    Cell Significance Index: -13.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0996
    Cell Significance Index: -17.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1004
    Cell Significance Index: -11.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1209
    Cell Significance Index: -3.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1209
    Cell Significance Index: -3.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1374
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1570
    Cell Significance Index: -17.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1580
    Cell Significance Index: -3.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1669
    Cell Significance Index: -2.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1725
    Cell Significance Index: -36.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1777
    Cell Significance Index: -1.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1796
    Cell Significance Index: -2.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2192
    Cell Significance Index: -6.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2329
    Cell Significance Index: -5.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2622
    Cell Significance Index: -20.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2827
    Cell Significance Index: -19.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3003
    Cell Significance Index: -4.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3012
    Cell Significance Index: -31.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3303
    Cell Significance Index: -20.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3567
    Cell Significance Index: -10.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3686
    Cell Significance Index: -4.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3766
    Cell Significance Index: -9.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4026
    Cell Significance Index: -12.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4379
    Cell Significance Index: -19.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4389
    Cell Significance Index: -26.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5125
    Cell Significance Index: -13.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5321
    Cell Significance Index: -20.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MFAP1 is a protein that interacts with microfibrils, which are essential components of the extracellular matrix. It is also involved in RNA processing, particularly in the splicing of pre-mRNA, and exhibits binding affinity for various proteins and RNAs. These characteristics suggest that MFAP1 is a versatile protein that contributes to the structural integrity and function of cells. **Pathways and Functions:** MFAP1 is implicated in several cellular pathways, including: 1. **Microfibril formation**: MFAP1 interacts with microfibrils, which are crucial for maintaining tissue structure and function. 2. **RNA processing**: MFAP1 is involved in the splicing of pre-mRNA via the U2-type spliceosome, a complex that plays a central role in RNA processing. 3. **Protein binding**: MFAP1 exhibits binding affinity for various proteins, including those involved in microfibril formation and RNA processing. 4. **Cell signaling**: MFAP1 may participate in cell signaling pathways, influencing cell growth, differentiation, and survival. These pathways and functions highlight the importance of MFAP1 in maintaining cellular homeostasis and tissue integrity. **Clinical Significance:** MFAP1 is significantly expressed in various cell types and tissues, including: 1. **Neural progenitor cells**: MFAP1 is essential for the development and maintenance of neural cells. 2. **Placental villous trophoblasts**: MFAP1 plays a crucial role in placental development and function. 3. **Male germ cells**: MFAP1 is involved in spermatogenesis and male fertility. 4. **Kidney epithelial cells**: MFAP1 contributes to renal function and disease. 5. **Skeletal muscle satellite stem cells**: MFAP1 is essential for muscle development and regeneration. Dysregulation of MFAP1 expression has been linked to various diseases, including cancer, cardiovascular disease, and neurological disorders. Further research is needed to elucidate the specific mechanisms by which MFAP1 contributes to disease pathogenesis and to identify potential therapeutic targets. In conclusion, MFAP1 is a multifunctional protein that plays a crucial role in various cellular processes, including microfibril formation, RNA processing, and protein binding. Its significant expression in different cell types and tissues highlights its importance in maintaining cellular homeostasis and tissue integrity. Further research is needed to fully elucidate the clinical significance of MFAP1 and its potential role in disease pathogenesis.

Genular Protein ID: 3722165805

Symbol: MFAP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7835894

Title: Structure of the human gene encoding the associated microfibrillar protein (MFAP1) and localization to chromosome 15q15-q21.

PubMed ID: 7835894

DOI: 10.1006/geno.1994.1521

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 26673105

Title: Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome.

PubMed ID: 26673105

DOI: 10.1261/rna.054296.115

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 27773687

Title: Scaffolding in the Spliceosome via Single alpha Helices.

PubMed ID: 27773687

DOI: 10.1016/j.str.2016.09.007

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

Sequence Information:

  • Length: 439
  • Mass: 51958
  • Checksum: 0EF6F4F091C05A88
  • Sequence:
  • MSVPSALMKQ PPIQSTAGAV PVRNEKGEIS MEKVKVKRYV SGKRPDYAPM ESSDEEDEEF 
    QFIKKAKEQE AEPEEQEEDS SSDPRLRRLQ NRISEDVEER LARHRKIVEP EVVGESDSEV 
    EGDAWRMERE DSSEEEEEEI DDEEIERRRG MMRQRAQERK NEEMEVMEVE DEGRSGEESE 
    SESEYEEYTD SEDEMEPRLK PVFIRKKDRV TVQEREAEAL KQKELEQEAK RMAEERRKYT 
    LKIVEEETKK ELEENKRSLA ALDALNTDDE NDEEEYEAWK VRELKRIKRD REDREALEKE 
    KAEIERMRNL TEEERRAELR ANGKVITNKA VKGKYKFLQK YYHRGAFFMD EDEEVYKRDF 
    SAPTLEDHFN KTILPKVMQV KNFGRSGRTK YTHLVDQDTT SFDSAWGQES AQNTKFFKQK 
    AAGVRDVFER PSAKKRKTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.