Details for: MGST2

Gene ID: 4258

Symbol: MGST2

Ensembl ID: ENSG00000085871

Description: microsomal glutathione S-transferase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 214.3428
    Cell Significance Index: -33.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 87.6822
    Cell Significance Index: -22.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 86.5585
    Cell Significance Index: -35.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 76.5963
    Cell Significance Index: -39.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 59.2529
    Cell Significance Index: -39.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.1671
    Cell Significance Index: -35.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.3904
    Cell Significance Index: -37.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0694
    Cell Significance Index: -37.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.8576
    Cell Significance Index: -28.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.0404
    Cell Significance Index: -33.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.9492
    Cell Significance Index: -39.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.5467
    Cell Significance Index: 236.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.3424
    Cell Significance Index: 100.3300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.2923
    Cell Significance Index: 75.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.1766
    Cell Significance Index: 113.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9832
    Cell Significance Index: 592.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.9635
    Cell Significance Index: 27.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.7385
    Cell Significance Index: 127.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.5747
    Cell Significance Index: 29.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.3741
    Cell Significance Index: 63.6200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.2250
    Cell Significance Index: 15.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9278
    Cell Significance Index: 347.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.8374
    Cell Significance Index: 51.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.7726
    Cell Significance Index: 92.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6761
    Cell Significance Index: 75.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5161
    Cell Significance Index: 39.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4876
    Cell Significance Index: 812.4200
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 1.3630
    Cell Significance Index: 5.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2348
    Cell Significance Index: 122.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1905
    Cell Significance Index: 34.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1529
    Cell Significance Index: 141.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0351
    Cell Significance Index: 15.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8040
    Cell Significance Index: 61.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7584
    Cell Significance Index: 56.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7325
    Cell Significance Index: 262.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6938
    Cell Significance Index: 306.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6662
    Cell Significance Index: 133.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6489
    Cell Significance Index: 41.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5989
    Cell Significance Index: 16.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5598
    Cell Significance Index: 72.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5499
    Cell Significance Index: 38.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5474
    Cell Significance Index: 104.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5096
    Cell Significance Index: 36.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3238
    Cell Significance Index: 15.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3077
    Cell Significance Index: 39.4400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2944
    Cell Significance Index: 2.9700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2913
    Cell Significance Index: 1.7600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2630
    Cell Significance Index: 4.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2330
    Cell Significance Index: 39.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2088
    Cell Significance Index: 33.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1124
    Cell Significance Index: 3.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1010
    Cell Significance Index: 13.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0680
    Cell Significance Index: 2.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0536
    Cell Significance Index: 40.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0454
    Cell Significance Index: 0.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0307
    Cell Significance Index: 56.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0304
    Cell Significance Index: 57.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0286
    Cell Significance Index: 0.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0231
    Cell Significance Index: 35.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0091
    Cell Significance Index: 6.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0080
    Cell Significance Index: -5.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0084
    Cell Significance Index: -3.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0088
    Cell Significance Index: -11.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0142
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0156
    Cell Significance Index: -11.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0176
    Cell Significance Index: -0.5700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0200
    Cell Significance Index: -0.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0223
    Cell Significance Index: -14.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0265
    Cell Significance Index: -18.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0463
    Cell Significance Index: -26.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0767
    Cell Significance Index: -16.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0910
    Cell Significance Index: -10.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1110
    Cell Significance Index: -31.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1121
    Cell Significance Index: -1.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1582
    Cell Significance Index: -23.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1662
    Cell Significance Index: -19.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1695
    Cell Significance Index: -4.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1718
    Cell Significance Index: -20.0200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1798
    Cell Significance Index: -2.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1997
    Cell Significance Index: -13.4300
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.2060
    Cell Significance Index: -1.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2114
    Cell Significance Index: -4.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2521
    Cell Significance Index: -4.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2801
    Cell Significance Index: -2.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2844
    Cell Significance Index: -32.4700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3011
    Cell Significance Index: -4.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3088
    Cell Significance Index: -9.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3111
    Cell Significance Index: -10.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3119
    Cell Significance Index: -32.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3700
    Cell Significance Index: -22.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3785
    Cell Significance Index: -21.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4196
    Cell Significance Index: -33.2300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4643
    Cell Significance Index: -3.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4661
    Cell Significance Index: -7.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5144
    Cell Significance Index: -27.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5213
    Cell Significance Index: -13.0300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.5982
    Cell Significance Index: -5.3100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6003
    Cell Significance Index: -8.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6425
    Cell Significance Index: -39.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6481
    Cell Significance Index: -40.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MGST2 is a cytosolic enzyme that belongs to the glutathione S-transferase family. It is characterized by its ability to conjugate glutathione with a wide range of substrates, including xenobiotics, reactive oxygen species (ROS), and lipid peroxides. MGST2 is also involved in the regulation of inflammatory responses and the response to lipopolysaccharide (LPS). **Pathways and Functions:** MGST2 is involved in several key pathways, including: 1. **Glutathione Conjugation:** MGST2 conjugates glutathione with a variety of substrates, including xenobiotics, ROS, and lipid peroxides, resulting in the formation of glutathione conjugates that can be excreted from the body. 2. **Antioxidant Defense:** MGST2 plays a role in protecting cells against oxidative stress by conjugating glutathione with ROS and lipid peroxides, thereby neutralizing their harmful effects. 3. **Detoxification:** MGST2 is involved in the detoxification of various toxins and xenobiotics, including aflatoxins, by conjugating them with glutathione, making them more water-soluble and easier to excrete. 4. **Inflammation Regulation:** MGST2 regulates inflammatory responses by modulating the activity of inflammatory signaling pathways, such as the NF-κB pathway. **Clinical Significance:** MGST2 has been implicated in various diseases, including: 1. **Cancer:** Elevated levels of MGST2 have been observed in various types of cancer, including lung, breast, and colon cancer, suggesting its potential role in cancer development and progression. 2. **Neurodegenerative Diseases:** MGST2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where oxidative stress and inflammation play a key role. 3. **Inflammatory Diseases:** MGST2 has been shown to regulate inflammatory responses in various diseases, including atherosclerosis, arthritis, and asthma. 4. **Toxicity:** MGST2 has been implicated in the toxicity of various chemicals, including aflatoxins, pesticides, and heavy metals, suggesting its potential role in protecting against chemical-induced toxicity. In conclusion, MGST2 plays a crucial role in glutathione metabolism and detoxification, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms of MGST2 and its potential therapeutic applications.

Genular Protein ID: 3441012051

Symbol: MGST2_HUMAN

Name: Microsomal glutathione S-transferase 2

UniProtKB Accession Codes:

Q99735 D6RBB5 Q7Z5B8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 3 EMBL 7 Ensembl 4 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 Rhea 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8703034

Title: Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase.

PubMed ID: 8703034

DOI: 10.1074/jbc.271.36.22203

PubMed ID: 9278457

Title: Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities.

PubMed ID: 9278457

DOI: 10.1074/jbc.272.36.22934

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11322876

Title: Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor.

PubMed ID: 11322876

DOI: 10.1046/j.1432-1327.2001.02142.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23409838

Title: Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps.

PubMed ID: 23409838

DOI: 10.1021/bi3014104

PubMed ID: 26066610

Title: Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.

PubMed ID: 26066610

DOI: 10.1016/j.bbapap.2015.06.003

PubMed ID: 26656251

Title: Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage.

PubMed ID: 26656251

DOI: 10.1038/ncomms10112

Sequence Information:

  • Length: 147
  • Mass: 16621
  • Checksum: D0E89B46885D16EF
  • Sequence:
    • MAGNSILLAA VSILSACQQS YFALQVGKAR LKYKVTPPAV TGSPEFERVF RAQQNCVEFY 
PIFIITLWMA GWYFNQVFAT CLGLVYIYGR HLYFWGYSEA AKKRITGFRL SLGILALLTL 
LGALGIANSF LDEYLDLNIA KKLRRQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.