Details for: MLLT1

Gene ID: 4298

Symbol: MLLT1

Ensembl ID: ENSG00000130382

Description: MLLT1 super elongation complex subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 147.9313
    Cell Significance Index: -23.0100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 53.9389
    Cell Significance Index: -22.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.3214
    Cell Significance Index: -24.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.1314
    Cell Significance Index: -19.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.6650
    Cell Significance Index: -22.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.0633
    Cell Significance Index: -20.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.9301
    Cell Significance Index: -23.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 7.3524
    Cell Significance Index: 196.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.1502
    Cell Significance Index: -18.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9325
    Cell Significance Index: -23.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3544
    Cell Significance Index: -9.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1193
    Cell Significance Index: 28.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3162
    Cell Significance Index: 91.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0663
    Cell Significance Index: 55.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0050
    Cell Significance Index: 907.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9664
    Cell Significance Index: 112.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7505
    Cell Significance Index: 81.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7324
    Cell Significance Index: 119.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6329
    Cell Significance Index: 126.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5602
    Cell Significance Index: 29.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5520
    Cell Significance Index: 109.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5468
    Cell Significance Index: 98.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3887
    Cell Significance Index: 139.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3619
    Cell Significance Index: 49.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3262
    Cell Significance Index: 8.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3114
    Cell Significance Index: 38.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2951
    Cell Significance Index: 161.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2930
    Cell Significance Index: 13.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2727
    Cell Significance Index: 7.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2699
    Cell Significance Index: 34.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1900
    Cell Significance Index: 18.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1821
    Cell Significance Index: 80.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1736
    Cell Significance Index: 7.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1611
    Cell Significance Index: 3.4900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1079
    Cell Significance Index: 0.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1077
    Cell Significance Index: 6.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1030
    Cell Significance Index: 17.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0883
    Cell Significance Index: 0.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0811
    Cell Significance Index: 4.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0803
    Cell Significance Index: 15.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0796
    Cell Significance Index: 4.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0697
    Cell Significance Index: 1.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0680
    Cell Significance Index: 1.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0646
    Cell Significance Index: 2.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0589
    Cell Significance Index: 40.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0320
    Cell Significance Index: 49.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0179
    Cell Significance Index: 33.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0076
    Cell Significance Index: 0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0066
    Cell Significance Index: 12.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0027
    Cell Significance Index: 2.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0016
    Cell Significance Index: 0.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0042
    Cell Significance Index: -0.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -3.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0069
    Cell Significance Index: -5.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0071
    Cell Significance Index: -4.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0083
    Cell Significance Index: -11.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0101
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0123
    Cell Significance Index: -9.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0168
    Cell Significance Index: -10.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0240
    Cell Significance Index: -1.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0244
    Cell Significance Index: -13.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0277
    Cell Significance Index: -3.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0340
    Cell Significance Index: -4.9400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0359
    Cell Significance Index: -0.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0465
    Cell Significance Index: -0.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0496
    Cell Significance Index: -3.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0595
    Cell Significance Index: -2.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0637
    Cell Significance Index: -18.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0659
    Cell Significance Index: -13.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0752
    Cell Significance Index: -2.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0764
    Cell Significance Index: -2.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0770
    Cell Significance Index: -5.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0825
    Cell Significance Index: -10.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1037
    Cell Significance Index: -11.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1064
    Cell Significance Index: -10.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1190
    Cell Significance Index: -2.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1234
    Cell Significance Index: -14.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1390
    Cell Significance Index: -6.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1501
    Cell Significance Index: -5.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1899
    Cell Significance Index: -5.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1948
    Cell Significance Index: -4.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1949
    Cell Significance Index: -5.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1996
    Cell Significance Index: -20.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2230
    Cell Significance Index: -17.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2337
    Cell Significance Index: -8.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2675
    Cell Significance Index: -5.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2696
    Cell Significance Index: -3.9800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2748
    Cell Significance Index: -2.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3137
    Cell Significance Index: -19.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3202
    Cell Significance Index: -4.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3405
    Cell Significance Index: -8.1700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3435
    Cell Significance Index: -3.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3806
    Cell Significance Index: -10.1800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4299
    Cell Significance Index: -6.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4467
    Cell Significance Index: -11.7500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4763
    Cell Significance Index: -6.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4792
    Cell Significance Index: -17.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4818
    Cell Significance Index: -14.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5183
    Cell Significance Index: -13.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5330
    Cell Significance Index: -17.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MLLT1 is a human gene that codes for a subunit of the super elongation complex, a multi-protein complex involved in the regulation of gene expression. The gene is highly expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, placental villous trophoblasts, and cardiac muscle myoblasts. MLLT1 has been shown to interact with various proteins, including ENL, a protein essential for the formation of the super elongation complex. **Pathways and Functions:** The MLLT1 gene is involved in several key pathways, including: 1. **Chromatin binding**: MLLT1 interacts with histones to regulate chromatin structure and facilitate gene expression. 2. **Gene expression (transcription)**: MLLT1 is involved in the regulation of transcription by interacting with RNAPII and other transcription factors. 3. **Formation of RNA polymerase II elongation complex**: MLLT1 is essential for the formation of the RNAPII elongation complex, which is responsible for the elongation of RNA synthesis. 4. **Positive regulation of DNA-templated transcription**: MLLT1 regulates the transcription of genes by interacting with transcription factors and other regulatory proteins. **Clinical Significance:** Dysregulation of MLLT1 has been implicated in various diseases, including cancer and autoimmune disorders. For example, mutations in the MLLT1 gene have been associated with T-cell acute lymphoblastic leukemia (T-ALL) and other types of leukemia. Additionally, MLLT1 has been shown to play a role in the regulation of immune responses, making it a potential target for the treatment of autoimmune diseases. **Proteins Associated with MLLT1:** The primary protein associated with MLLT1 is ENL, a protein essential for the formation of the super elongation complex. ENL has been shown to interact with MLLT1 and other proteins to regulate gene expression and transcription. **Significantly Expressed Cells:** MLLT1 is highly expressed in various cell types, including: 1. Kidney proximal convoluted tubule epithelial cells 2. Placental villous trophoblasts 3. Tracheal goblet cells 4. Kidney capillary endothelial cells 5. Immature innate lymphoid cells 6. Kidney proximal straight tubule epithelial cells 7. Cardiac muscle myoblasts 8. Extravillous trophoblasts 9. Respiratory epithelial cells 10. Kidney collecting duct principal cells In conclusion, MLLT1 plays a crucial role in regulating gene expression and transcription by interacting with various proteins and pathways. Its dysregulation has been implicated in various diseases, making it a potential target for the treatment of cancer and autoimmune disorders. Further research is needed to fully understand the role of MLLT1 in human disease.

Genular Protein ID: 3440031313

Symbol: ENL_HUMAN

Name: Protein ENL

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1423624

Title: Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.

PubMed ID: 1423624

DOI: 10.1016/0092-8674(92)90602-9

PubMed ID: 8378076

Title: Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia.

PubMed ID: 8378076

PubMed ID: 8080983

Title: ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells.

PubMed ID: 8080983

PubMed ID: 12665591

Title: Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.

PubMed ID: 12665591

DOI: 10.1128/mcb.23.8.2942-2952.2003

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20159561

Title: AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

PubMed ID: 20159561

DOI: 10.1016/j.molcel.2010.01.026

PubMed ID: 20471948

Title: HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.

PubMed ID: 20471948

DOI: 10.1016/j.molcel.2010.04.013

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22195968

Title: The little elongation complex regulates small nuclear RNA transcription.

PubMed ID: 22195968

DOI: 10.1016/j.molcel.2011.12.008

PubMed ID: 23145062

Title: Human ALKBH4 interacts with proteins associated with transcription.

PubMed ID: 23145062

DOI: 10.1371/journal.pone.0049045

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27105114

Title: Molecular coupling of histone crotonylation and active transcription by AF9 YEATS domain.

PubMed ID: 27105114

DOI: 10.1016/j.molcel.2016.03.028

PubMed ID: 28241139

Title: Transcription control by the ENL YEATS domain in acute leukaemia.

PubMed ID: 28241139

DOI: 10.1038/nature21688

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30374167

Title: Structure-guided development of YEATS domain inhibitors by targeting pi-pi-pi stacking.

PubMed ID: 30374167

DOI: 10.1038/s41589-018-0144-y

PubMed ID: 28241141

Title: ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia.

PubMed ID: 28241141

DOI: 10.1038/nature21687

Sequence Information:

  • Length: 559
  • Mass: 62056
  • Checksum: A8480BA0F8742173
  • Sequence:
  • MDNQCTVQVR LELGHRAQLR KKPTTEGFTH DWMVFVRGPE QCDIQHFVEK VVFWLHDSFP 
    KPRRVCKEPP YKVEESGYAG FIMPIEVHFK NKEEPRKVCF TYDLFLNLEG NPPVNHLRCE 
    KLTFNNPTTE FRYKLLRAGG VMVMPEGADT VSRPSPDYPM LPTIPLSAFS DPKKTKPSHG 
    SKDANKESSK TSKPHKVTKE HRERPRKDSE SKSSSKELER EQAKSSKDTS RKLGEGRLPK 
    EEKAPPPKAA FKEPKMALKE TKLESTSPKG GPPPPPPPPP RASSKRPATA DSPKPSAKKQ 
    KKSSSKGSRS APGTSPRTSS SSSFSDKKPA KDKSSTRGEK VKAESEPREA KKALEVEESN 
    SEDEASFKSE SAQSSPSNSS SSSDSSSDSD FEPSQNHSQG PLRSMVEDLQ SEESDEDDSS 
    SGEEAAGKTN PGRDSRLSFS DSESDNSADS SLPSREPPPP QKPPPPNSKV SGRRSPESCS 
    KPEKILKKGT YDKAYTDELV ELHRRLMALR ERNVLQQIVN LIEETGHFNV TNTTFDFDLF 
    SLDETTVRKL QSCLEAVAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.