Details for: MLLT1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 147.9313
Cell Significance Index: -23.0100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 53.9389
Cell Significance Index: -22.2200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 51.3214
Cell Significance Index: -24.2300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 49.1314
Cell Significance Index: -19.9600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 44.6650
Cell Significance Index: -22.9800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 21.0633
Cell Significance Index: -20.1100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.9301
Cell Significance Index: -23.3400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 7.3524
Cell Significance Index: 196.3200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.1502
Cell Significance Index: -18.8900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.9325
Cell Significance Index: -23.4100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.3544
Cell Significance Index: -9.5300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.1193
Cell Significance Index: 28.9200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.3162
Cell Significance Index: 91.0200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.0663
Cell Significance Index: 55.5400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0050
Cell Significance Index: 907.4700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.9664
Cell Significance Index: 112.6200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7505
Cell Significance Index: 81.6300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7324
Cell Significance Index: 119.1300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6329
Cell Significance Index: 126.9500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5602
Cell Significance Index: 29.1000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5520
Cell Significance Index: 109.5500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5468
Cell Significance Index: 98.5700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3887
Cell Significance Index: 139.4300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3619
Cell Significance Index: 49.7000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3262
Cell Significance Index: 8.8800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3114
Cell Significance Index: 38.2900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2951
Cell Significance Index: 161.1800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2930
Cell Significance Index: 13.6600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2727
Cell Significance Index: 7.6200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2699
Cell Significance Index: 34.6000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1900
Cell Significance Index: 18.8000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1821
Cell Significance Index: 80.5100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1736
Cell Significance Index: 7.8700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1611
Cell Significance Index: 3.4900 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.1079
Cell Significance Index: 0.8800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1077
Cell Significance Index: 6.7900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1030
Cell Significance Index: 17.5800 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.0883
Cell Significance Index: 0.7100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0811
Cell Significance Index: 4.5500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0803
Cell Significance Index: 15.2900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0796
Cell Significance Index: 4.8900 - Cell Name: peg cell (CL4033014)
Fold Change: 0.0697
Cell Significance Index: 1.6100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0680
Cell Significance Index: 1.9600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0646
Cell Significance Index: 2.2700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0589
Cell Significance Index: 40.7400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0320
Cell Significance Index: 49.2800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0179
Cell Significance Index: 33.7500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0076
Cell Significance Index: 0.1900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0066
Cell Significance Index: 12.1500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0027
Cell Significance Index: 2.0300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0016
Cell Significance Index: 0.1100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0042
Cell Significance Index: -0.2800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0066
Cell Significance Index: -3.0100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0069
Cell Significance Index: -5.0800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0071
Cell Significance Index: -4.5000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0083
Cell Significance Index: -11.2200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0101
Cell Significance Index: -0.5300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0123
Cell Significance Index: -9.0900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0168
Cell Significance Index: -10.5100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0240
Cell Significance Index: -1.8500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0244
Cell Significance Index: -13.7700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0277
Cell Significance Index: -3.1600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0340
Cell Significance Index: -4.9400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0359
Cell Significance Index: -0.6000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0465
Cell Significance Index: -0.9900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0496
Cell Significance Index: -3.5100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0595
Cell Significance Index: -2.8000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0637
Cell Significance Index: -18.3400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0659
Cell Significance Index: -13.8900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0752
Cell Significance Index: -2.4100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0764
Cell Significance Index: -2.1900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0770
Cell Significance Index: -5.7400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0825
Cell Significance Index: -10.6600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1037
Cell Significance Index: -11.8800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1064
Cell Significance Index: -10.8700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1190
Cell Significance Index: -2.0400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1234
Cell Significance Index: -14.5500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1390
Cell Significance Index: -6.1500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1501
Cell Significance Index: -5.2200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1899
Cell Significance Index: -5.4200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1948
Cell Significance Index: -4.0400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1949
Cell Significance Index: -5.0100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1996
Cell Significance Index: -20.7800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2230
Cell Significance Index: -17.6700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2337
Cell Significance Index: -8.8500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2675
Cell Significance Index: -5.6000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.2696
Cell Significance Index: -3.9800 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.2748
Cell Significance Index: -2.6100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3137
Cell Significance Index: -19.2300 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3202
Cell Significance Index: -4.5900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3405
Cell Significance Index: -8.1700 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.3435
Cell Significance Index: -3.6500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3806
Cell Significance Index: -10.1800 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.4299
Cell Significance Index: -6.8200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4467
Cell Significance Index: -11.7500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.4763
Cell Significance Index: -6.8500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4792
Cell Significance Index: -17.5900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4818
Cell Significance Index: -14.1900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5183
Cell Significance Index: -13.2400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5330
Cell Significance Index: -17.4500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3440031313
Symbol: ENL_HUMAN
Name: Protein ENL
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1423624
Title: Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.
PubMed ID: 1423624
PubMed ID: 8378076
Title: Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia.
PubMed ID: 8378076
PubMed ID: 8080983
Title: ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells.
PubMed ID: 8080983
PubMed ID: 12665591
Title: Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.
PubMed ID: 12665591
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20159561
Title: AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.
PubMed ID: 20159561
PubMed ID: 20471948
Title: HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.
PubMed ID: 20471948
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 22195968
Title: The little elongation complex regulates small nuclear RNA transcription.
PubMed ID: 22195968
PubMed ID: 23145062
Title: Human ALKBH4 interacts with proteins associated with transcription.
PubMed ID: 23145062
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 27105114
Title: Molecular coupling of histone crotonylation and active transcription by AF9 YEATS domain.
PubMed ID: 27105114
PubMed ID: 28241139
Title: Transcription control by the ENL YEATS domain in acute leukaemia.
PubMed ID: 28241139
DOI: 10.1038/nature21688
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 30374167
Title: Structure-guided development of YEATS domain inhibitors by targeting pi-pi-pi stacking.
PubMed ID: 30374167
PubMed ID: 28241141
Title: ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia.
PubMed ID: 28241141
DOI: 10.1038/nature21687
Sequence Information:
- Length: 559
- Mass: 62056
- Checksum: A8480BA0F8742173
- Sequence:
MDNQCTVQVR LELGHRAQLR KKPTTEGFTH DWMVFVRGPE QCDIQHFVEK VVFWLHDSFP KPRRVCKEPP YKVEESGYAG FIMPIEVHFK NKEEPRKVCF TYDLFLNLEG NPPVNHLRCE KLTFNNPTTE FRYKLLRAGG VMVMPEGADT VSRPSPDYPM LPTIPLSAFS DPKKTKPSHG SKDANKESSK TSKPHKVTKE HRERPRKDSE SKSSSKELER EQAKSSKDTS RKLGEGRLPK EEKAPPPKAA FKEPKMALKE TKLESTSPKG GPPPPPPPPP RASSKRPATA DSPKPSAKKQ KKSSSKGSRS APGTSPRTSS SSSFSDKKPA KDKSSTRGEK VKAESEPREA KKALEVEESN SEDEASFKSE SAQSSPSNSS SSSDSSSDSD FEPSQNHSQG PLRSMVEDLQ SEESDEDDSS SGEEAAGKTN PGRDSRLSFS DSESDNSADS SLPSREPPPP QKPPPPNSKV SGRRSPESCS KPEKILKKGT YDKAYTDELV ELHRRLMALR ERNVLQQIVN LIEETGHFNV TNTTFDFDLF SLDETTVRKL QSCLEAVAT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.