Details for: MLLT3

Gene ID: 4300

Symbol: MLLT3

Ensembl ID: ENSG00000171843

Description: MLLT3 super elongation complex subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 365.3600
    Cell Significance Index: -56.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 222.4777
    Cell Significance Index: -56.4300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 143.8532
    Cell Significance Index: -59.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 139.2011
    Cell Significance Index: -65.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 128.6870
    Cell Significance Index: -52.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 98.0892
    Cell Significance Index: -65.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.0465
    Cell Significance Index: -53.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.0294
    Cell Significance Index: -64.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.9706
    Cell Significance Index: -61.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.5352
    Cell Significance Index: -56.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.8244
    Cell Significance Index: -66.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.4718
    Cell Significance Index: -36.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 5.0320
    Cell Significance Index: 120.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.5349
    Cell Significance Index: 304.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 4.3627
    Cell Significance Index: 268.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.2761
    Cell Significance Index: 189.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.2214
    Cell Significance Index: 159.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.9139
    Cell Significance Index: 111.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.6511
    Cell Significance Index: 1309.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.3726
    Cell Significance Index: 189.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8836
    Cell Significance Index: 578.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.4321
    Cell Significance Index: 41.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.0153
    Cell Significance Index: 1393.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5409
    Cell Significance Index: 152.4300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2549
    Cell Significance Index: 15.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0327
    Cell Significance Index: 28.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0031
    Cell Significance Index: 76.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7797
    Cell Significance Index: 84.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7071
    Cell Significance Index: 32.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5651
    Cell Significance Index: 11.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4642
    Cell Significance Index: 210.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4601
    Cell Significance Index: 292.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4553
    Cell Significance Index: 700.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4371
    Cell Significance Index: 823.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4231
    Cell Significance Index: 780.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3434
    Cell Significance Index: 61.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3012
    Cell Significance Index: 18.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2833
    Cell Significance Index: 13.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2787
    Cell Significance Index: 251.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2407
    Cell Significance Index: 327.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2272
    Cell Significance Index: 15.7100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1930
    Cell Significance Index: 4.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1920
    Cell Significance Index: 4.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1289
    Cell Significance Index: 15.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1287
    Cell Significance Index: 70.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1243
    Cell Significance Index: 54.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0974
    Cell Significance Index: 18.5400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0746
    Cell Significance Index: 0.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0073
    Cell Significance Index: 0.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0134
    Cell Significance Index: -2.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0203
    Cell Significance Index: -1.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0293
    Cell Significance Index: -4.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0355
    Cell Significance Index: -0.7700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0420
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0435
    Cell Significance Index: -32.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0574
    Cell Significance Index: -42.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0644
    Cell Significance Index: -36.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0664
    Cell Significance Index: -41.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0752
    Cell Significance Index: -56.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1913
    Cell Significance Index: -27.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1979
    Cell Significance Index: -56.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2081
    Cell Significance Index: -43.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2189
    Cell Significance Index: -37.3700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2213
    Cell Significance Index: -2.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2280
    Cell Significance Index: -8.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3312
    Cell Significance Index: -33.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3524
    Cell Significance Index: -41.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4114
    Cell Significance Index: -47.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4119
    Cell Significance Index: -53.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4140
    Cell Significance Index: -12.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4256
    Cell Significance Index: -22.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4462
    Cell Significance Index: -9.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4464
    Cell Significance Index: -46.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4613
    Cell Significance Index: -59.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4794
    Cell Significance Index: -35.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4918
    Cell Significance Index: -58.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5132
    Cell Significance Index: -58.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5147
    Cell Significance Index: -16.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5937
    Cell Significance Index: -31.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6084
    Cell Significance Index: -19.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6374
    Cell Significance Index: -20.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6508
    Cell Significance Index: -13.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6521
    Cell Significance Index: -13.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6542
    Cell Significance Index: -42.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6710
    Cell Significance Index: -31.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7004
    Cell Significance Index: -10.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7135
    Cell Significance Index: -56.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7290
    Cell Significance Index: -51.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7644
    Cell Significance Index: -16.2800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.7733
    Cell Significance Index: -11.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7987
    Cell Significance Index: -48.9700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.8074
    Cell Significance Index: -10.7700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.8102
    Cell Significance Index: -11.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8216
    Cell Significance Index: -16.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8504
    Cell Significance Index: -21.8600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.8755
    Cell Significance Index: -9.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.9004
    Cell Significance Index: -9.8100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.0275
    Cell Significance Index: -14.7600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.0678
    Cell Significance Index: -10.1600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.0826
    Cell Significance Index: -15.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MLLT3 is a member of the YEATS (YBX and AT-rich sequence-binding protein) domain-containing protein family, which is characterized by the presence of a YEATS domain. This domain is essential for the interaction with histone proteins and the regulation of chromatin structure. MLLT3 is specifically expressed in cells that require precise regulation of gene expression, such as neurons, where it plays a crucial role in the development and maintenance of neuronal function. **Pathways and Functions:** MLLT3 is involved in various cellular processes, including: 1. **Transcription Elongation**: MLLT3 forms part of the SEC, which regulates the transition from the initiation to the elongation stage of RNAPII transcription. This complex ensures the accurate and efficient elongation of transcripts, preventing aberrant transcription and promoting gene expression. 2. **Chromatin Regulation**: MLLT3 interacts with histone proteins, modulating chromatin structure and facilitating the recruitment of transcription factors and other regulatory proteins. 3. **Gene Expression**: MLLT3 plays a crucial role in the regulation of gene expression, particularly in cells that require precise control of transcription, such as neurons and hematopoietic stem cells. 4. **Stem Cell Differentiation**: MLLT3 is involved in the regulation of stem cell differentiation, particularly in the development of hematopoietic stem cells and neurons. 5. **Cancer**: MLLT3 has been implicated in cancer, where its dysregulation can lead to aberrant transcription and tumorigenesis. **Clinical Significance:** Dysregulation of MLLT3 has been implicated in various diseases, including: 1. **Neurological Disorders**: MLLT3 mutations have been associated with neurological disorders, such as epilepsy and schizophrenia, highlighting its importance in neuronal function and development. 2. **Cancer**: MLLT3 dysregulation has been implicated in various types of cancer, including leukemia and lymphoma, where it can promote tumorigenesis and progression. 3. **Hematological Disorders**: MLLT3 mutations have been associated with hematological disorders, such as leukemia and lymphoma, where it can disrupt normal hematopoiesis. In conclusion, MLLT3 is a crucial regulator of gene expression, playing a key role in the development and maintenance of various cell types, including neurons and hematopoietic stem cells. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of MLLT3 and its potential therapeutic applications.

Genular Protein ID: 2015954640

Symbol: AF9_HUMAN

Name: YEATS domain-containing protein 3

UniProtKB Accession Codes:

P42568 B1AMQ2 B2R7B3 B7Z755 D3DRJ8 Q8IVB0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 21 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8506309

Title: Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

PubMed ID: 8506309

DOI: 10.1073/pnas.90.10.4631

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10898795

Title: BCoR, a novel corepressor involved in BCL-6 repression.

PubMed ID: 10898795

PubMed ID: 10861294

Title: DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis.

PubMed ID: 10861294

DOI: 10.1093/hmg/9.11.1671

PubMed ID: 11313972

Title: The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3.

PubMed ID: 11313972

DOI: 10.1038/sj.onc.1204108

PubMed ID: 16001262

Title: Loss-of-function mutation of the AF9/MLLT3 gene in a girl with neuromotor development delay, cerebellar ataxia, and epilepsy.

PubMed ID: 16001262

DOI: 10.1007/s00439-005-0004-1

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20471948

Title: HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.

PubMed ID: 20471948

DOI: 10.1016/j.molcel.2010.04.013

PubMed ID: 20159561

Title: AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

PubMed ID: 20159561

DOI: 10.1016/j.molcel.2010.01.026

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22195968

Title: The little elongation complex regulates small nuclear RNA transcription.

PubMed ID: 22195968

DOI: 10.1016/j.molcel.2011.12.008

PubMed ID: 22936661

Title: Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

PubMed ID: 22936661

DOI: 10.1182/blood-2012-05-429274

PubMed ID: 22895430

Title: The super elongation complex (SEC) family in transcriptional control.

PubMed ID: 22895430

DOI: 10.1038/nrm3417

PubMed ID: 23145062

Title: Human ALKBH4 interacts with proteins associated with transcription.

PubMed ID: 23145062

DOI: 10.1371/journal.pone.0049045

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25305204

Title: The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.

PubMed ID: 25305204

DOI: 10.1182/blood-2014-01-550079

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31776511

Title: MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment.

PubMed ID: 31776511

DOI: 10.1038/s41586-019-1790-2

PubMed ID: 30134174

Title: Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.

PubMed ID: 30134174

DOI: 10.1016/j.celrep.2018.07.064

PubMed ID: 23260655

Title: Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.

PubMed ID: 23260655

DOI: 10.1016/j.str.2012.11.011

PubMed ID: 25417107

Title: AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation.

PubMed ID: 25417107

DOI: 10.1016/j.cell.2014.09.049

PubMed ID: 27105114

Title: Molecular coupling of histone crotonylation and active transcription by AF9 YEATS domain.

PubMed ID: 27105114

DOI: 10.1016/j.molcel.2016.03.028

PubMed ID: 27545619

Title: Structural insights into histone crotonyl-lysine recognition by the AF9 YEATS domain.

PubMed ID: 27545619

DOI: 10.1016/j.str.2016.05.023

PubMed ID: 30374167

Title: Structure-guided development of YEATS domain inhibitors by targeting pi-pi-pi stacking.

PubMed ID: 30374167

DOI: 10.1038/s41589-018-0144-y

PubMed ID: 30385749

Title: Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain.

PubMed ID: 30385749

DOI: 10.1038/s41467-018-07072-6

Sequence Information:

  • Length: 568
  • Mass: 63351
  • Checksum: 0A020B7FB34132F9
  • Sequence:
    • MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK VVFHLHESFP 
RPKRVCKDPP YKVEESGYAG FILPIEVYFK NKEEPRKVRF DYDLFLHLEG HPPVNHLRCE 
KLTFNNPTED FRRKLLKAGG DPNRSIHTSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS 
SSSSSSSSSS TSFSKPHKLM KEHKEKPSKD SREHKSAFKE PSRDHNKSSK ESSKKPKENK 
PLKEEKIVPK MAFKEPKPMS KEPKPDSNLL TITSGQDKKA PSKRPPISDS EELSAKKRKK 
SSSEALFKSF SSAPPLILTC SADKKQIKDK SHVKMGKVKI ESETSEKKKS TLPPFDDIVD 
PNDSDVEENI SSKSDSEQPS PASSSSSSSS SFTPSQTRQQ GPLRSIMKDL HSDDNEEESD 
EVEDNDNDSE MERPVNRGGS RSRRVSLSDG SDSESSSASS PLHHEPPPPL LKTNNNQILE 
VKSPIKQSKS DKQIKNGECD KAYLDELVEL HRRLMTLRER HILQQIVNLI EETGHFHITN 
TTFDFDLCSL DKTTVRKLQS YLETSGTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.