Details for: AFDN

Gene ID: 4301

Symbol: AFDN

Ensembl ID: ENSG00000130396

Description: afadin, adherens junction formation factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 248.2597
    Cell Significance Index: -102.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 201.3503
    Cell Significance Index: -81.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 143.6614
    Cell Significance Index: -96.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 85.9289
    Cell Significance Index: -82.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 35.5450
    Cell Significance Index: -95.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.1068
    Cell Significance Index: -67.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.7479
    Cell Significance Index: -43.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 6.3208
    Cell Significance Index: 329.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 5.4597
    Cell Significance Index: 78.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.0202
    Cell Significance Index: 278.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.8550
    Cell Significance Index: 216.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.8513
    Cell Significance Index: 565.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.6474
    Cell Significance Index: 162.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.5788
    Cell Significance Index: 74.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4155
    Cell Significance Index: 866.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3225
    Cell Significance Index: 109.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2308
    Cell Significance Index: 447.5000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 2.2233
    Cell Significance Index: 70.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.6723
    Cell Significance Index: 40.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5867
    Cell Significance Index: 866.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2785
    Cell Significance Index: 34.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2773
    Cell Significance Index: 883.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1436
    Cell Significance Index: 53.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1242
    Cell Significance Index: 75.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9766
    Cell Significance Index: 74.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8418
    Cell Significance Index: 103.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8277
    Cell Significance Index: 149.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6211
    Cell Significance Index: 13.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5821
    Cell Significance Index: 26.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5309
    Cell Significance Index: 86.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4975
    Cell Significance Index: 315.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4962
    Cell Significance Index: 17.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4419
    Cell Significance Index: 10.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4101
    Cell Significance Index: 78.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3999
    Cell Significance Index: 11.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3944
    Cell Significance Index: 8.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3671
    Cell Significance Index: 691.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3617
    Cell Significance Index: 159.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3164
    Cell Significance Index: 430.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2917
    Cell Significance Index: 37.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2893
    Cell Significance Index: 14.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2392
    Cell Significance Index: 368.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2293
    Cell Significance Index: 11.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2207
    Cell Significance Index: 28.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1884
    Cell Significance Index: 347.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1706
    Cell Significance Index: 16.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1551
    Cell Significance Index: 21.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1090
    Cell Significance Index: 98.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0549
    Cell Significance Index: 24.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0031
    Cell Significance Index: 2.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0243
    Cell Significance Index: -0.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0493
    Cell Significance Index: -7.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0745
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0801
    Cell Significance Index: -13.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0950
    Cell Significance Index: -71.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0971
    Cell Significance Index: -71.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1226
    Cell Significance Index: -13.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1568
    Cell Significance Index: -88.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1942
    Cell Significance Index: -121.2900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2360
    Cell Significance Index: -3.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2951
    Cell Significance Index: -84.9000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2959
    Cell Significance Index: -3.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3430
    Cell Significance Index: -25.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3578
    Cell Significance Index: -40.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4181
    Cell Significance Index: -3.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4535
    Cell Significance Index: -20.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4709
    Cell Significance Index: -8.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4742
    Cell Significance Index: -99.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4801
    Cell Significance Index: -13.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5493
    Cell Significance Index: -38.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5498
    Cell Significance Index: -56.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5787
    Cell Significance Index: -67.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6377
    Cell Significance Index: -8.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6742
    Cell Significance Index: -25.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6928
    Cell Significance Index: -22.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.7850
    Cell Significance Index: -92.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7883
    Cell Significance Index: -82.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7951
    Cell Significance Index: -50.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8976
    Cell Significance Index: -47.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9049
    Cell Significance Index: -23.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0045
    Cell Significance Index: -79.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1542
    Cell Significance Index: -17.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.1795
    Cell Significance Index: -23.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2805
    Cell Significance Index: -27.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2946
    Cell Significance Index: -79.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2977
    Cell Significance Index: -41.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3541
    Cell Significance Index: -33.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.3709
    Cell Significance Index: -88.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4148
    Cell Significance Index: -46.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.5932
    Cell Significance Index: -45.6700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.8084
    Cell Significance Index: -22.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.8415
    Cell Significance Index: -63.9900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -1.8706
    Cell Significance Index: -24.0900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.9931
    Cell Significance Index: -40.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.9988
    Cell Significance Index: -81.9000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -2.0698
    Cell Significance Index: -43.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.0761
    Cell Significance Index: -72.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -2.1506
    Cell Significance Index: -56.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.1569
    Cell Significance Index: -79.1800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -2.1979
    Cell Significance Index: -27.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** AFDN is a single copy gene that encodes a cytoplasmic protein, Afadin, which is a member of the cadherin superfamily. Afadin is specifically localized to the plasma membrane and interacts with various proteins, including cadherins, catenins, and the cytoskeleton, to regulate cell-cell adhesion and junction formation. The AFDN gene is highly expressed in epithelial cells, endothelial cells, and muscle cells, and its expression is tightly regulated during development and tissue homeostasis. **Pathways and Functions** AFDN is involved in several key signaling pathways that regulate cell-cell adhesion, junction formation, and tissue organization. The main pathways associated with AFDN include: 1. **Adherens junction formation**: AFDN regulates the formation and maintenance of adherens junctions, which are essential for maintaining tissue structure and function. 2. **Cadherin binding**: AFDN interacts with cadherins to regulate cell-cell adhesion and junction formation. 3. **Cell-cell adhesion mediated by cadherin**: AFDN regulates the activity of cadherin-mediated cell-cell adhesion. 4. **Cell-cell signaling**: AFDN regulates the signaling pathways that coordinate cell-cell communication and tissue organization. 5. **Cell junction organization**: AFDN regulates the organization and dynamics of cell junctions, including adherens junctions, tight junctions, and gap junctions. AFDN also regulates various cellular processes, including: 1. **Protein localization**: AFDN regulates the localization of proteins to specific cellular compartments, including the plasma membrane and cytoskeleton. 2. **Gene expression**: AFDN regulates the expression of genes involved in cell-cell adhesion, signaling, and tissue organization. 3. **Cell migration**: AFDN regulates the migration of cells, including epithelial and endothelial cells. **Clinical Significance** Dysregulation of AFDN has been implicated in various diseases, including: 1. **Cancer**: AFDN dysregulation has been observed in various types of cancer, including breast cancer, lung cancer, and colon cancer. 2. **Cardiovascular disease**: AFDN dysregulation has been implicated in cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 3. **Neurological disorders**: AFDN dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Endothelial dysfunction**: AFDN dysregulation has been implicated in endothelial dysfunction, which is a key feature of cardiovascular disease. In conclusion, the AFDN gene plays a critical role in regulating cell-cell adhesion, signaling, and organization, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which AFDN regulates cell-cell adhesion and junction formation, and to develop therapeutic strategies to target AFDN dysregulation in disease.

Genular Protein ID: 3263400600

Symbol: AFAD_HUMAN

Name: Afadin

UniProtKB Accession Codes:

P55196 O75087 O75088 O75089 Q59FP0 Q5TIG6 Q5TIG7 Q9NSN7 Q9NU92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 5 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 10 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8242616

Title: Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation.

PubMed ID: 8242616

PubMed ID: 9679199

Title: Complete genomic structure, DNA polymorphisms, and alternative splicing of the human AF-6 gene.

PubMed ID: 9679199

DOI: 10.1093/dnares/5.2.115

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11024295

Title: Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin.

PubMed ID: 11024295

DOI: 10.1016/s0378-1119(00)00316-4

PubMed ID: 12456712

Title: Nectin and afadin: novel organizers of intercellular junctions.

PubMed ID: 12456712

DOI: 10.1242/jcs.00167

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30463011

Title: A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote alpha-Toxin Cytotoxicity.

PubMed ID: 30463011

DOI: 10.1016/j.celrep.2018.10.088

PubMed ID: 15684424

Title: Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr.

PubMed ID: 15684424

DOI: 10.1074/jbc.m411065200

PubMed ID: 16671149

Title: Discovery of low-molecular-weight ligands for the AF6 PDZ domain.

PubMed ID: 16671149

DOI: 10.1002/anie.200503965

Sequence Information:

  • Length: 1824
  • Mass: 206804
  • Checksum: 51486232F183A3BA
  • Sequence:
    • MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK AAGNFATKCI 
RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG ERRLDIDEKP LVVQLNWNKD 
DREGRFVLKN ENDAIPPKKA QSNGPEKQEK EGVIQNFKRT LSKKEKKEKK KREKEALRQA 
SDKDDRPFQG EDVENSRLAA EVYKDMPETS FTRTISNPEV VMKRRRQQKL EKRMQEFRSS 
DGRPDSGGTL RIYADSLKPN IPYKTILLST TDPADFAVAE ALEKYGLEKE NPKDYCIARV 
MLPPGAQHSD EKGAKEIILD DDECPLQIFR EWPSDKGILV FQLKRRPPDH IPKKTKKHLE 
GKTPKGKERA DGSGYGSTLP PEKLPYLVEL SPGRRNHFAY YNYHTYEDGS DSRDKPKLYR 
LQLSVTEVGT EKLDDNSIQL FGPGIQPHHC DLTNMDGVVT VTPRSMDAET YVEGQRISET 
TMLQSGMKVQ FGASHVFKFV DPSQDHALAK RSVDGGLMVK GPRHKPGIVQ ETTFDLGGDI 
HSGTALPTSK STTRLDSDRV SSASSTAERG MVKPMIRVEQ QPDYRRQESR TQDASGPELI 
LPASIEFRES SEDSFLSAII NYTNSSTVHF KLSPTYVLYM ACRYVLSNQY RPDISPTERT 
HKVIAVVNKM VSMMEGVIQK QKNIAGALAF WMANASELLN FIKQDRDLSR ITLDAQDVLA 
HLVQMAFKYL VHCLQSELNN YMPAFLDDPE ENSLQRPKID DVLHTLTGAM SLLRRCRVNA 
ALTIQLFSQL FHFINMWLFN RLVTDPDSGL CSHYWGAIIR QQLGHIEAWA EKQGLELAAD 
CHLSRIVQAT TLLTMDKYAP DDIPNINSTC FKLNSLQLQA LLQNYHCAPD EPFIPTDLIE 
NVVTVAENTA DELARSDGRE VQLEEDPDLQ LPFLLPEDGY SCDVVRNIPN GLQEFLDPLC 
QRGFCRLIPH TRSPGTWTIY FEGADYESHL LRENTELAQP LRKEPEIITV TLKKQNGMGL 
SIVAAKGAGQ DKLGIYVKSV VKGGAADVDG RLAAGDQLLS VDGRSLVGLS QERAAELMTR 
TSSVVTLEVA KQGAIYHGLA TLLNQPSPMM QRISDRRGSG KPRPKSEGFE LYNNSTQNGS 
PESPQLPWAE YSEPKKLPGD DRLMKNRADH RSSPNVANQP PSPGGKSAYA SGTTAKITSV 
STGNLCTEEQ TPPPRPEAYP IPTQTYTREY FTFPASKSQD RMAPPQNQWP NYEEKPHMHT 
DSNHSSIAIQ RVTRSQEELR EDKAYQLERH RIEAAMDRKS DSDMWINQSS SLDSSTSSQE 
HLNHSSKSVT PASTLTKSGP GRWKTPAAIP ATPVAVSQPI RTDLPPPPPP PPVHYAGDFD 
GMSMDLPLPP PPSANQIGLP SAQVAAAERR KREEHQRWYE KEKARLEEER ERKRREQERK 
LGQMRTQSLN PAPFSPLTAQ QMKPEKPSTL QRPQETVIRE LQPQQQPRTI ERRDLQYITV 
SKEELSSGDS LSPDPWKRDA KEKLEKQQQM HIVDMLSKEI QELQSKPDRS AEESDRLRKL 
MLEWQFQKRL QESKQKDEDD EEEEDDDVDT MLIMQRLEAE RRARLQDEER RRQQQLEEMR 
KREAEDRARQ EEERRRQEEE RTKRDAEEKR RQEEGYYSRL EAERRRQHDE AARRLLEPEA 
PGLCRPPLPR DYEPPSPSPA PGAPPPPPQR NASYLKTQVL SPDSLFTAKF VAYNEEEEEE 
DCSLAGPNSY PGSTGAAVGA HDACRDAKEK RSKSQDADSP GSSGAPENLT FKERQRLFSQ 
GQDVSNKVKA SRKLTELENE LNTK

Genular Protein ID: 608373297

Symbol: A8MQ02_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MQ02

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneTree 1 HGNC 1 IntAct 1 InterPro 9 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 4 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.M700120-MCP200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1781
  • Mass: 201806
  • Checksum: F68F525A0822AD73
  • Sequence:
    • MRFYFQDKAA GNFATKCIRV SSTATTQDVI ETLAEKFRPD MRMLSSPKYS LYEVHVSGEE 
RRLDIDEKPL VVQLNWNKDD REGRFVLKNE NDAIPPKKAQ SNGPEKQEKE GVIQNFKRTL 
SKKEKKEKKK REKEALRQAS DKDDRPFQGE DVENSRLAAE VYKDMPETSF TRTISNPEVV 
MKRRRQQKLE KRMQEFRSSD GRPDSGGTLR IYADSLKPNI PYKTILLSTT DPADFAVAEA 
LEKYGLEKEN PKDYCIARVM LPPGAQHSDE KGAKEIILDD DECPLQIFRE WPSDKGILVF 
QLKRRPPDHI PKKTKKHLEG KTPKGKERAD GSGYGSTLPP EKLPYLVELS PGRRNHFAYY 
NYHTYEDGSD SRDKPKLYRL QLSVTEVGTE KLDDNSIQLF GPGIQPHHCD LTNMDGVVTV 
TPRSMDAETY VEGQRISETT MLQSGMKVQF GASHVFKFVD PSQDHALAKR SVDGGLMVKG 
PRHKPGIVQE TTFDLGGDIH SGTALPTSKS TTRLDSDRVS SASSTAERGM VKPMIRVEQQ 
PDYRRQESRT QDASGPELIL PASIEFRESS EDSFLSAIIN YTNSSTVHFK LSPTYVLYMA 
CRYVLSNQYR PDISPTERTH KVIAVVNKMV SMMEGVIQKQ KNIAGALAFW MANASELLNF 
IKQDRDLSRI TLDAQDVLAH LVQMAFKYLV HCLQSELNNY MPAFLDDPEE NSLQRPKIDD 
VLHTLTGAMS LLRRCRVNAA LTIQLFSQLF HFINMWLFNR LVTDPDSGLC SHYWGAIIRQ 
QLGHIEAWAE KQGLELAADC HLSRIVQATT LLTMDKYAPD DIPNINSTCF KLNSLQLQAL 
LQNYHCAPDE PFIPTDLIEN VVTVAENTAD ELARSDGREV QLEEDPDLQL PFLLPEDGYS 
CDVVRNIPNG LQEFLDPLCQ RGFCRLIPHT RSPGTWTIYF EGADYESHLL RENTELAQPL 
RKEPEIITVT LKKQNGMGLS IVAAKGAGQD KLGIYVKSVV KGGAADVDGR LAAGDQLLSV 
DGRSLVGLSQ ERAAELMTRT SSVVTLEVAK QGAIYHGLAT LLNQPSPMMQ RISDRRGSGK 
PRPKSEGFEL YNNSTQNGSP ESPQLPWAEY SEPKKLPGDD RLMKNRADHR SSPNVANQPP 
SPGGKSAYAS GTTAKITSVS TGNLCTEEQT PPPRPEAYPI PTQTYTREYF TFPASKSQDR 
MAPPQNQWPN YEEKPHMHTD SNHSSIAIQR VTRSQEELRE DKAYQLERHR IEAAMDRKSD 
SDMWINQSSS LDSSTSSQEH LNHSSKSVTP ASTLTKSGPG RWKTPAAIPA TPVAVSQPIR 
TDLPPPPPPP PVHYAGDFDG MSMDLPLPPP PSANQIGLPS AQVAAAERRK REEHQRWYEK 
EKARLEEERE RKRREQERKL GQMRTQSLNP APFSPLTAQQ MKPEKPSTLQ RPQETVIREL 
QPQQQPRTIE RRDLQYITVS KEELSSGDSL SPDPWKRDAK EKLEKQQQMH IVDMLSKEIQ 
ELQSKPDRSA EESDRLRKLM LEWQFQKRLQ ESKQKDEDDE EEEDDDVDTM LIMQRLEAER 
RARDEERRRQ QQLEEMRKRE AEDRARQEEE RRRQEEERTK RDAEEKRRQE EGYYSRLEAE 
RRRQHDEAAR RLLEPEAPGL CRPPLPRDYE PPSPSPAPGA PPPPPQRNAS YLKTQVLSPD 
SLFTAKFVAY NEEEEEEDCS LAGPNSYPGS TGAAVGAHDA CRDAKEKRSK SQDADSPGSS 
GAPENLTFKE RQRLFSQGQD VSNKVKASRK LTELENELNT K

Genular Protein ID: 407376350

Symbol: G1UI22_HUMAN

Name: N/A

UniProtKB Accession Codes:

G1UI22

Database IDs:

ARBA 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 1 SMART 4 SUPFAM 3

Citations:

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

Sequence Information:

  • Length: 1781
  • Mass: 201820
  • Checksum: AE2DCEA8AB004B2F
  • Sequence:
    • MRFYFQDKAA GNFATKCIRV SSTATTQDVI ETLAEKFRPD MRMLSSPKYS LYEVHVSGEE 
RRLDIDEKPL VVQLNWNKDD REGRFVLKNE NDAIPPKKAQ SNGPEKQEKE GVIQNFKRTL 
SKKEKKEKKK REKEALRQAS DKDDRPFQGE DVENSRLAAE VYKDMPETSF TRTISNPEVV 
MKRRRQQKLE KRMQEFRSSD GRPDSGGTLR IYADSLKPNI PYKTILLSTT DPADFAVAEA 
LEKYGLEKEN PKDYCIARVM LPPGAQHSDE KGAKEIILDD DECPLQIFRE WPSDKGILVF 
QLKRRPPDHI PKKTKKHLEG KTPKGKERAD GSGYGSTLPP EKLPYLVELS PGRRNHFAYY 
NYHTYEDGSD SRDKPKLYRL QLSVTEVGTE KLDDNSIQLF GPGIQPHHCD LTNMDGVVTV 
TPRSMDAETY VEGQRISETT MLQSGMKVQF GASHVFKFVD PSQDHALAKR SVDGGLMVKG 
PRHKPGIVQE TTFDLGGDIH SGTALPTSKS TTRLDSDRVS SASSTAERGM VKPMIRVEQQ 
PDYRRQESRT QDASGPELIL PASIEFRESS EDSFLSAIIN YTNSSTVHFK LSPTYVLYMA 
CRYVLSNQYR PDISPTERTH KVIAVVNKMV SMMEGVIQKQ KNIAGALAFW MANASELLNF 
IKQDRDLSRI TLDAQDVLAH LVQMAFKYLV HCLQSELNNY MPAFLDDPEE NSLQRPKIDD 
VLHTLTGAMS LLRRCRVNAA LTIQLFSQLF HFINMWLFNR LVTDPDSGLC SHYWGAIIRQ 
QLGHIEAWAE KQGLELAADC HLSRIVQATT LLTMDKYAPD DIPNINSTCF KLNSLQLQAL 
LQNYHCAPDE PFIPTDLIEN LVTVAENTAD ELARSDGREV QLEEDPDLQL PFLLPEDGYS 
CDVVRNIPNG LQEFLDPLCQ RGFCRLIPHT RSPGTWTIYF EGADYESHLL RENTELAQPL 
RKEPEIITVT LKKQNGMGLS IVAAKGAGQD KLGIYVKSVV KGGAADVDGR LAAGDQLLSV 
DGRSLVGLSQ ERAAELMTRT SSVVTLEVAK QGAIYHGLAT LLNQPSPMMQ RISDRRGSGK 
PRPKSEGFEL YNNSTQNGSP ESPQLPWAEY SEPKKLPGDD RLMKNRADHR SSPNVANQPP 
SPGGKSAYAS GTTAKITSVS TGNLCTEEQT PPPRPEAYPI PTQTYTREYF TFPASKSQDR 
MAPPQNQWPN YEEKPHMHTD SNHSSIAIQR VTRSQEELRE DKAYQLERHR IEAAMDRKSD 
SDMWINQSSS LDSSTSSQEH LNHSSKSVTP ASTLTKSGPG RWKTPAAIPA TPVAVSQPIR 
TDLPPPPPPP PVHYAGDFDG MSMDLPLPPP PSANQIGLPS AQVAAAERRK REEHQRWYEK 
EKARLEEERE RKRREQERKL GQMRTQSLNP APFSPLTAQQ MKPEKPSTLQ RPQETVIREL 
QPQQQPRTIE RRDLQYITVS KEELSSGDSL SPDPWKRDAK EKLEKQQQMH IVDMLSKEIQ 
ELQSKPDRSA EESDRLRKLM LEWQFQKRLQ ESKQKDEDDE EEEDDDVDTM LIMQRLEAER 
RARDEERRRQ QQLEEMRKRE AEDRARQEEE RRRQEEERTK RDAEEKRRQE EGYYSRLEAE 
RRRQHDEAAR RLLEPEAPGL CRPPLPRDYE PPSPSPAPGA PPPPPQRNAS YLKTQVLSPD 
SLFTAKFVAY NEEEEEEDCS LAGPNSYPGS TGAAVGAHDA CRDAKEKRSK SQDADSPGSS 
GAPENLTFKE RQRLFSQGQD VSNKVKASRK LTELENELNT K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.