MOV10 | ENSG00000155363 | NCBI 4343

Details for: MOV10

Gene ID: 4343

Symbol: MOV10

Ensembl ID: ENSG00000155363

Description: Mov10 RNA helicase

Associated with

Adherens junctions interactions
(R-HSA-418990)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Competing endogenous rnas (cernas) regulate pten translation
(R-HSA-8948700)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Pip3 activates akt signaling
(R-HSA-1257604)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Pten regulation
(R-HSA-6807070)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 mrna translation by micrornas
(R-HSA-9759811)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of mitf-m-dependent genes involved in apoptosis
(R-HSA-9824594)
Regulation of npas4 gene expression
(R-HSA-9768759)
Regulation of npas4 mrna translation
(R-HSA-9768778)
Regulation of pten mrna translation
(R-HSA-8943723)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by tgfbr3
(R-HSA-9839373)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tgfbr3 expression
(R-HSA-9839394)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by npas4
(R-HSA-9634815)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation by ventx
(R-HSA-8853884)
3'-utr-mediated mrna destabilization
(GO:0061158)
5'-3' rna helicase activity
(GO:0032574)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Extracellular space
(GO:0005615)
Mirna-mediated gene silencing by mrna destabilization
(GO:0035279)
Mirna-mediated post-transcriptional gene silencing
(GO:0035195)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
P granule
(GO:0043186)
Positive regulation of mrna catabolic process
(GO:0061014)
Protein binding
(GO:0005515)
Regulation of neuron projection arborization
(GO:0150011)
Regulatory ncrna-mediated post-transcriptional gene silencing
(GO:0035194)
Retrotransposon silencing
(GO:0010526)
Retrotransposon silencing by mrna destabilization
(GO:0141008)
Rna binding
(GO:0003723)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 89.8453
Cell Significance Index: -13.9800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 52.9878
Cell Significance Index: -13.4400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 30.7357
Cell Significance Index: -15.8100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 12.1740
Cell Significance Index: -15.0100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.5098
Cell Significance Index: -14.7600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.8367
Cell Significance Index: -15.1400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.7741
Cell Significance Index: -8.2600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.0957
Cell Significance Index: 144.9300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.0053
Cell Significance Index: 27.3600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.7628
Cell Significance Index: 47.2400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.3901
Cell Significance Index: 1255.1700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1125
Cell Significance Index: 66.7900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0828
Cell Significance Index: 117.7800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9362
Cell Significance Index: 152.2600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8053
Cell Significance Index: 159.8200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7850
Cell Significance Index: 40.7800
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.7738
Cell Significance Index: 6.4000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7261
Cell Significance Index: 15.7300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6469
Cell Significance Index: 18.0800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5869
Cell Significance Index: 16.9100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2785
Cell Significance Index: 15.6300
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.2470
Cell Significance Index: 6.3100
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2370
Cell Significance Index: 5.0700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2320
Cell Significance Index: 22.9500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.2052
Cell Significance Index: 3.0800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2050
Cell Significance Index: 9.5600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1932
Cell Significance Index: 4.8300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1881
Cell Significance Index: 5.1200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1768
Cell Significance Index: 33.6600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1705
Cell Significance Index: 11.0000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1631
Cell Significance Index: 5.7300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1527
Cell Significance Index: 27.5300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1438
Cell Significance Index: 17.6800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1437
Cell Significance Index: 3.0600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1389
Cell Significance Index: 61.4100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1335
Cell Significance Index: 18.3300
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.1279
Cell Significance Index: 1.8400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1263
Cell Significance Index: 69.0000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1132
Cell Significance Index: 22.7100
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1095
Cell Significance Index: 2.8800
Cell Name: peg cell (CL4033014)
Fold Change: 0.1037
Cell Significance Index: 2.4000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0685
Cell Significance Index: 1.4200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0566
Cell Significance Index: 7.2500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0530
Cell Significance Index: 36.6900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0384
Cell Significance Index: 13.7900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0376
Cell Significance Index: 70.7500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0312
Cell Significance Index: 19.8500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0312
Cell Significance Index: 47.9900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0246
Cell Significance Index: 0.2600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0189
Cell Significance Index: 34.9200
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.0141
Cell Significance Index: 0.1800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0032
Cell Significance Index: 1.4400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0029
Cell Significance Index: 3.9000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0024
Cell Significance Index: -0.0700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0081
Cell Significance Index: -1.3900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0126
Cell Significance Index: -9.5500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0127
Cell Significance Index: -1.8400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0143
Cell Significance Index: -10.5000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0172
Cell Significance Index: -12.7100
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0181
Cell Significance Index: -0.3100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0257
Cell Significance Index: -14.5200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0269
Cell Significance Index: -16.7700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0323
Cell Significance Index: -1.4300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0332
Cell Significance Index: -3.3900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0335
Cell Significance Index: -1.2700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0359
Cell Significance Index: -2.5400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0363
Cell Significance Index: -0.7600
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0380
Cell Significance Index: -0.3100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0463
Cell Significance Index: -13.3200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0475
Cell Significance Index: -0.8000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0489
Cell Significance Index: -3.2900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0514
Cell Significance Index: -6.6400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0590
Cell Significance Index: -1.8900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0622
Cell Significance Index: -4.7800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0632
Cell Significance Index: -2.9700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0699
Cell Significance Index: -8.0100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0726
Cell Significance Index: -8.5600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0771
Cell Significance Index: -16.2300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0792
Cell Significance Index: -9.2300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0884
Cell Significance Index: -6.5900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0951
Cell Significance Index: -4.3100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1000
Cell Significance Index: -2.6800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1089
Cell Significance Index: -5.5100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1186
Cell Significance Index: -12.3500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1204
Cell Significance Index: -4.1900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1323
Cell Significance Index: -3.7800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1878
Cell Significance Index: -14.8700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1891
Cell Significance Index: -5.4200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1915
Cell Significance Index: -3.5400
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.1971
Cell Significance Index: -1.2900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2032
Cell Significance Index: -12.4600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2040
Cell Significance Index: -12.5400
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.2412
Cell Significance Index: -3.5600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2497
Cell Significance Index: -15.7400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2607
Cell Significance Index: -7.6800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2666
Cell Significance Index: -14.0000
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2675
Cell Significance Index: -5.2200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2690
Cell Significance Index: -7.9000
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2748
Cell Significance Index: -1.6600
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.2796
Cell Significance Index: -3.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** MOV10 exhibits several key characteristics that distinguish it from other RNA helicases: 1. **Unique molecular structure**: MOV10's eight transmembrane domains and long N-terminal tail confer it a distinct molecular architecture, allowing it to interact with multiple partners and regulate various cellular processes. 2. **RNA unwinding activity**: MOV10's helicase activity enables it to unwind RNA structures, including those involved in gene regulation and immune response. 3. **mRNA destabilization**: MOV10 has been shown to regulate mRNA stability, influencing gene expression and immune response. 4. **Cellular localization**: MOV10 is predominantly found in cells of the immune system, suggesting a critical role in immune regulation. **Pathways and Functions** MOV10 is involved in multiple signaling pathways and cellular processes, including: 1. **Immune regulation**: MOV10 regulates immune response by controlling mRNA stability and expression of immune-related genes. 2. **Gene expression**: MOV10 influences gene expression by unwinding RNA structures and regulating mRNA stability. 3. **Cell-cell communication**: MOV10 interacts with Notch and Wnt signaling pathways, modulating cell-cell communication and immune response. 4. **Stress granule formation**: MOV10 is involved in the formation of stress granules, a critical response to cellular stress. **Clinical Significance** MOV10's dysregulation has been implicated in various human diseases, including: 1. **Autoimmune disorders**: MOV10's role in immune regulation and gene expression has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: MOV10's involvement in cell-cell communication and immune response has been implicated in cancer development and progression. 3. **Neurological disorders**: MOV10's expression in neurons has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, MOV10 is a complex RNA helicase that plays a critical role in immune regulation, gene expression, and disease pathogenesis. Further research is necessary to fully elucidate the molecular mechanisms underlying MOV10's function and its implications in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Moloney leukemia virus 10 protein
Q5JR04_HUMAN

Genular Protein ID: 1395992318

Symbol: MOV10_HUMAN

Name: Moloney leukemia virus 10 protein

UniProtKB Accession Codes:

Q9HCE1 Q5JR03 Q8TEF0 Q9BSY3 Q9BUJ9

Database IDs:

Citations:

PubMed ID: 10997877

Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10997877

DOI: 10.1093/dnares/7.4.271

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16289642

Title: Identification of novel argonaute-associated proteins.

PubMed ID: 16289642

DOI: 10.1016/j.cub.2005.10.048

PubMed ID: 17507929

Title: MicroRNA silencing through RISC recruitment of eIF6.

PubMed ID: 17507929

DOI: 10.1038/nature05841

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18552826

Title: Capped small RNAs and MOV10 in human hepatitis delta virus replication.

PubMed ID: 18552826

DOI: 10.1038/nsmb.1440

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20215113

Title: Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication.

PubMed ID: 20215113

DOI: 10.1074/jbc.m110.109314

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22791714

Title: APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10.

PubMed ID: 22791714

DOI: 10.1074/jbc.m112.354001

PubMed ID: 23093941

Title: MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells.

PubMed ID: 23093941

DOI: 10.1371/journal.pgen.1002941

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23125361

Title: The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.

PubMed ID: 23125361

DOI: 10.1093/nar/gks1032

PubMed ID: 25220460

Title: The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.

PubMed ID: 25220460

DOI: 10.1016/j.celrep.2014.08.020

PubMed ID: 25464849

Title: MOV10 and FMRP regulate AGO2 association with microRNA recognition elements.

PubMed ID: 25464849

DOI: 10.1016/j.celrep.2014.10.054

PubMed ID: 24726324

Title: MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.

PubMed ID: 24726324

DOI: 10.1016/j.molcel.2014.03.017

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27974568

Title: IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral Activity against Dengue Virus, Interacts with MOV10.

PubMed ID: 27974568

DOI: 10.1128/jvi.01606-16

PubMed ID: 30122351

Title: Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.

PubMed ID: 30122351

DOI: 10.1016/j.cell.2018.07.022

PubMed ID: 27016603

Title: MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction.

PubMed ID: 27016603

DOI: 10.4049/jimmunol.1501359

PubMed ID: 29258557

Title: Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif-mediated ubiquitin-proteasome pathway.

PubMed ID: 29258557

DOI: 10.1186/s12977-017-0382-1

PubMed ID: 31722967

Title: The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription.

PubMed ID: 31722967

DOI: 10.1074/jbc.ra119.009435

PubMed ID: 34065512

Title: CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation.

PubMed ID: 34065512

DOI: 10.3390/ijms22105394

PubMed ID: 35157734

Title: Host MOV10 is induced to restrict herpes simplex virus 1 lytic infection by promoting type I interferon response.

PubMed ID: 35157734

DOI: 10.1371/journal.ppat.1010301

Sequence Information:

Length: 1003
Mass: 113671
Checksum: 28A8B3BF9B5B54FC
Sequence:

MPSKFSCRQL REAGQCFESF LVVRGLDMET DRERLRTIYN RDFKISFGTP APGFSSMLYG 
MKIANLAYVT KTRVRFFRLD RWADVRFPEK RRMKLGSDIS KHHKSLLAKI FYDRAEYLHG 
KHGVDVEVQG PHEARDGQLL IRLDLNRKEV LTLRLRNGGT QSVTLTHLFP LCRTPQFAFY 
NEDQELPCPL GPGECYELHV HCKTSFVGYF PATVLWELLG PGESGSEGAG TFYIARFLAA 
VAHSPLAAQL KPMTPFKRTR ITGNPVVTNR IEEGERPDRA KGYDLELSMA LGTYYPPPRL 
RQLLPMLLQG TSIFTAPKEI AEIKAQLETA LKWRNYEVKL RLLLHLEELQ MEHDIRHYDL 
ESVPMTWDPV DQNPRLLTLE VPGVTESRPS VLRGDHLFAL LSSETHQEDP ITYKGFVHKV 
ELDRVKLSFS MSLLSRFVDG LTFKVNFTFN RQPLRVQHRA LELTGRWLLW PMLFPVAPRD 
VPLLPSDVKL KLYDRSLESN PEQLQAMRHI VTGTTRPAPY IIFGPPGTGK TVTLVEAIKQ 
VVKHLPKAHI LACAPSNSGA DLLCQRLRVH LPSSIYRLLA PSRDIRMVPE DIKPCCNWDA 
KKGEYVFPAK KKLQEYRVLI TTLITAGRLV SAQFPIDHFT HIFIDEAGHC MEPESLVAIA 
GLMEVKETGD PGGQLVLAGD PRQLGPVLRS PLTQKHGLGY SLLERLLTYN SLYKKGPDGY 
DPQFITKLLR NYRSHPTILD IPNQLYYEGE LQACADVVDR ERFCRWAGLP RQGFPIIFHG 
VMGKDEREGN SPSFFNPEEA ATVTSYLKLL LAPSSKKGKA RLSPRSVGVI SPYRKQVEKI 
RYCITKLDRE LRGLDDIKDL KVGSVEEFQG QERSVILIST VRSSQSFVQL DLDFNLGFLK 
NPKRFNVAVT RAKALLIIVG NPLLLGHDPD WKVFLEFCKE NGGYTGCPFP AKLDLQQGQN 
LLQGLSKLSP STSGPHSHDY LPQEREGEGG LSLQVEPEWR NEL

Genular Protein ID: 1753957150

Symbol: Q5JR04_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5JR04

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 947
Mass: 107210
Checksum: BC32EF734FEA100C
Sequence:

MLYGMKIANL AYVTKTRVRF FRLDRWADVR FPEKRRMKLG SDISKHHKSL LAKIFYDRAE 
YLHGKHGVDV EVQGPHEARD GQLLIRLDLN RKEVLTLRLR NGGTQSVTLT HLFPLCRTPQ 
FAFYNEDQEL PCPLGPGECY ELHVHCKTSF VGYFPATVLW ELLGPGESGS EGAGTFYIAR 
FLAAVAHSPL AAQLKPMTPF KRTRITGNPV VTNRIEEGER PDRAKGYDLE LSMALGTYYP 
PPRLRQLLPM LLQGTSIFTA PKEIAEIKAQ LETALKWRNY EVKLRLLLHL EELQMEHDIR 
HYDLESVPMT WDPVDQNPRL LTLEVPGVTE SRPSVLRGDH LFALLSSETH QEDPITYKGF 
VHKVELDRVK LSFSMSLLSR FVDGLTFKVN FTFNRQPLRV QHRALELTGR WLLWPMLFPV 
APRDVPLLPS DVKLKLYDRS LESNPEQLQA MRHIVTGTTR PAPYIIFGPP GTGKTVTLVE 
AIKQVVKHLP KAHILACAPS NSGADLLCQR LRVHLPSSIY RLLAPSRDIR MVPEDIKPCC 
NWDAKKGEYV FPAKKKLQEY RVLITTLITA GRLVSAQFPI DHFTHIFIDE AGHCMEPESL 
VAIAGLMEVK ETGDPGGQLV LAGDPRQLGP VLRSPLTQKH GLGYSLLERL LTYNSLYKKG 
PDGYDPQFIT KLLRNYRSHP TILDIPNQLY YEGELQACAD VVDRERFCRW AGLPRQGFPI 
IFHGVMGKDE REGNSPSFFN PEEAATVTSY LKLLLAPSSK KGKARLSPRS VGVISPYRKQ 
VEKIRYCITK LDRELRGLDD IKDLKVGSVE EFQGQERSVI LISTVRSSQS FVQLDLDFNL 
GFLKNPKRFN VAVTRAKALL IIVGNPLLLG HDPDWKVFLE FCKENGGYTG CPFPAKLDLQ 
QGQNLLQGLS KLSPSTSGPH SHDYLPQERE GEGGLSLQVE PEWRNEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MOV10

Associated with

Cells (max top 100)

Other Information

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10997877

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of novel argonaute-associated proteins. PubMed ID: 16289642

MicroRNA silencing through RISC recruitment of eIF6. PubMed ID: 17507929

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Capped small RNAs and MOV10 in human hepatitis delta virus replication. PubMed ID: 18552826

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication. PubMed ID: 20215113

Initial characterization of the human central proteome. PubMed ID: 21269460

APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10. PubMed ID: 22791714

MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells. PubMed ID: 23093941

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. PubMed ID: 23125361

The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex. PubMed ID: 25220460

MOV10 and FMRP regulate AGO2 association with microRNA recognition elements. PubMed ID: 25464849

MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. PubMed ID: 24726324

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral Activity against Dengue Virus, Interacts with MOV10. PubMed ID: 27974568

Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s. PubMed ID: 30122351

MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction. PubMed ID: 27016603

Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif-mediated ubiquitin-proteasome pathway. PubMed ID: 29258557

The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription. PubMed ID: 31722967

CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation. PubMed ID: 34065512

Host MOV10 is induced to restrict herpes simplex virus 1 lytic infection by promoting type I interferon response. PubMed ID: 35157734

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The sequence of the human genome. PubMed ID: 11181995

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Database document:

PubMed ID: 10997877

PubMed ID: 12168954

PubMed ID: 17974005

PubMed ID: 16710414

PubMed ID: 15489334

PubMed ID: 16289642

PubMed ID: 17507929

PubMed ID: 17525332

PubMed ID: 18552826

PubMed ID: 18669648

PubMed ID: 19608861

PubMed ID: 20068231

PubMed ID: 20215113

PubMed ID: 21269460

PubMed ID: 22791714

PubMed ID: 23093941

PubMed ID: 23186163

PubMed ID: 23125361

PubMed ID: 25220460

PubMed ID: 25464849

PubMed ID: 24726324

PubMed ID: 24275569

PubMed ID: 27974568

PubMed ID: 30122351

PubMed ID: 27016603

PubMed ID: 29258557

PubMed ID: 31722967

PubMed ID: 34065512

PubMed ID: 35157734

PubMed ID: 11237011

PubMed ID: 11181995

PubMed ID: 15496913

PubMed ID: 16710414

PubMed ID: 17525332

PubMed ID: 18669648

PubMed ID: 19608861

PubMed ID: 20068231

PubMed ID: 21269460

PubMed ID: 23186163

PubMed ID: 24275569