Details for: MPG

Gene ID: 4350

Symbol: MPG

Ensembl ID: ENSG00000103152

Description: N-methylpurine DNA glycosylase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 236.5228
    Cell Significance Index: -36.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.8354
    Cell Significance Index: -36.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.4015
    Cell Significance Index: -40.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 80.6644
    Cell Significance Index: -20.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.3739
    Cell Significance Index: -39.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.2663
    Cell Significance Index: -40.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.0417
    Cell Significance Index: -36.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.9557
    Cell Significance Index: -39.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.2356
    Cell Significance Index: -40.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8512
    Cell Significance Index: -26.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9632
    Cell Significance Index: -27.5300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.0143
    Cell Significance Index: -17.5400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 5.9311
    Cell Significance Index: 49.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.1345
    Cell Significance Index: 598.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.4913
    Cell Significance Index: 116.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1485
    Cell Significance Index: 138.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1112
    Cell Significance Index: 62.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6151
    Cell Significance Index: 83.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5360
    Cell Significance Index: 210.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3571
    Cell Significance Index: 741.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2334
    Cell Significance Index: 145.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1031
    Cell Significance Index: 30.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0163
    Cell Significance Index: 124.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9964
    Cell Significance Index: 179.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9092
    Cell Significance Index: 12.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8947
    Cell Significance Index: 42.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8014
    Cell Significance Index: 56.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7453
    Cell Significance Index: 329.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7364
    Cell Significance Index: 72.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7319
    Cell Significance Index: 16.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7276
    Cell Significance Index: 50.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6715
    Cell Significance Index: 86.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6558
    Cell Significance Index: 7.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5897
    Cell Significance Index: 43.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5733
    Cell Significance Index: 113.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5023
    Cell Significance Index: 95.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4976
    Cell Significance Index: 10.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4557
    Cell Significance Index: 58.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4128
    Cell Significance Index: 82.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3406
    Cell Significance Index: 7.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3225
    Cell Significance Index: 2.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2265
    Cell Significance Index: 5.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2256
    Cell Significance Index: 11.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2045
    Cell Significance Index: 22.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1871
    Cell Significance Index: 168.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1367
    Cell Significance Index: 3.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1318
    Cell Significance Index: 47.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0955
    Cell Significance Index: 4.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0772
    Cell Significance Index: 53.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0348
    Cell Significance Index: 5.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0229
    Cell Significance Index: 17.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0221
    Cell Significance Index: 0.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0180
    Cell Significance Index: 33.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0109
    Cell Significance Index: 16.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0028
    Cell Significance Index: 5.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0029
    Cell Significance Index: -3.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0052
    Cell Significance Index: -0.1800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0132
    Cell Significance Index: -0.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0137
    Cell Significance Index: -1.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0224
    Cell Significance Index: -16.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0305
    Cell Significance Index: -19.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0317
    Cell Significance Index: -3.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0480
    Cell Significance Index: -35.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0524
    Cell Significance Index: -23.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0633
    Cell Significance Index: -1.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0680
    Cell Significance Index: -38.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0724
    Cell Significance Index: -45.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0775
    Cell Significance Index: -1.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1120
    Cell Significance Index: -32.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1181
    Cell Significance Index: -3.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1244
    Cell Significance Index: -6.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1683
    Cell Significance Index: -4.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1764
    Cell Significance Index: -6.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1774
    Cell Significance Index: -25.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1916
    Cell Significance Index: -5.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1995
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2157
    Cell Significance Index: -45.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2352
    Cell Significance Index: -26.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2433
    Cell Significance Index: -4.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2499
    Cell Significance Index: -15.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2810
    Cell Significance Index: -9.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2906
    Cell Significance Index: -8.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2922
    Cell Significance Index: -5.4000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3054
    Cell Significance Index: -3.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3674
    Cell Significance Index: -38.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4112
    Cell Significance Index: -10.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4187
    Cell Significance Index: -33.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4261
    Cell Significance Index: -28.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4533
    Cell Significance Index: -25.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5069
    Cell Significance Index: -13.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5421
    Cell Significance Index: -9.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5667
    Cell Significance Index: -35.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5973
    Cell Significance Index: -35.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6421
    Cell Significance Index: -28.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6539
    Cell Significance Index: -40.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6547
    Cell Significance Index: -16.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6549
    Cell Significance Index: -19.2900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.6844
    Cell Significance Index: -3.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7487
    Cell Significance Index: -28.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9089
    Cell Significance Index: -31.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Specificity**: MPG is highly specific for N-methylated purines, with a preference for 3-methyladenine and 7-methyladenine. 2. **Mechanism**: MPG recognizes and cleaves the N-glycosidic bond between the damaged base and the sugar moiety of DNA, forming an ap site. 3. **Expression**: MPG is expressed in various cell types, including germ cells, pancreatic acinar cells, and hematopoietic stem cells. 4. **Subcellular localization**: MPG is primarily localized to the cytosol, where it can access damaged DNA. **Pathways and Functions** 1. **Base-excision repair pathway**: MPG is a key enzyme in the base-excision repair pathway, which is responsible for removing damaged bases from DNA. 2. **Resolution of abasic sites**: MPG cleaves ap sites, which can arise from DNA damage, to prevent further damage to the genome. 3. **Depurination**: MPG also participates in the depurination pathway, which involves the removal of purines from DNA. 4. **Ap site formation**: MPG forms ap sites, which can be recognized and repaired by other enzymes in the base-excision repair pathway. **Clinical Significance** 1. **Cancer**: MPG dysfunction has been implicated in various cancers, including bladder cancer, where it can lead to the accumulation of 3-methyladenine and 7-methyladenine. 2. **Neurodegenerative diseases**: MPG dysfunction has also been linked to neurodegenerative diseases, such as Alzheimer's disease, where it can contribute to the accumulation of 3-methyladenine and 7-methyladenine. 3. **Genotoxic stress**: MPG can also be activated in response to genotoxic stress, where it can help to remove damaged bases from DNA. 4. **DNA damage response**: MPG plays a critical role in the DNA damage response, where it can help to maintain genome stability in the face of DNA damage. In conclusion, MPG is a crucial enzyme involved in the base-excision repair pathway, and its dysfunction has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which MPG contributes to disease and to develop therapeutic strategies to target its activity.

Genular Protein ID: 2352280297

Symbol: 3MG_HUMAN

Name: DNA-3-methyladenine glycosylase

UniProtKB Accession Codes:

P29372 G5E9E2 Q13770 Q15275 Q15961 Q5J9I4 Q96BZ6 Q96S33 Q9NNX5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 14 EMDB 3 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1924375

Title: Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16.

PubMed ID: 1924375

DOI: 10.1073/pnas.88.20.9127

PubMed ID: 8475094

Title: Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere.

PubMed ID: 8475094

DOI: 10.1073/pnas.90.8.3437

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1874728

Title: Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase.

PubMed ID: 1874728

DOI: 10.1016/s0021-9258(18)98467-x

PubMed ID: 1645538

Title: Human cDNA expressing a functional DNA glycosylase excising 3-methyladenine and 7-methylguanine.

PubMed ID: 1645538

DOI: 10.1016/0006-291x(91)90408-y

PubMed ID: 8318735

Title: Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse.

PubMed ID: 8318735

DOI: 10.1007/bf00357090

PubMed ID: 14555760

Title: Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin.

PubMed ID: 14555760

DOI: 10.1073/pnas.2131819100

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23290262

Title: Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB).

PubMed ID: 23290262

DOI: 10.1016/j.dnarep.2012.11.009

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 9790531

Title: Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision.

PubMed ID: 9790531

DOI: 10.1016/s0092-8674(00)81755-9

Sequence Information:

  • Length: 298
  • Mass: 32869
  • Checksum: BEA8C4CB250D572B
  • Sequence:
    • MVTPALQMKK PKQFCRRMGQ KKQRPARAGQ PHSSSDAAQA PAEQPHSSSD AAQAPCPRER 
CLGPPTTPGP YRSIYFSSPK GHLTRLGLEF FDQPAVPLAR AFLGQVLVRR LPNGTELRGR 
IVETEAYLGP EDEAAHSRGG RQTPRNRGMF MKPGTLYVYI IYGMYFCMNI SSQGDGACVL 
LRALEPLEGL ETMRQLRSTL RKGTASRVLK DRELCSGPSK LCQALAINKS FDQRDLAQDE 
AVWLERGPLE PSEPAVVAAA RVGVGHAGEW ARKPLRFYVR GSPWVSVVDR VAEQDTQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.