Details for: MX2

Gene ID: 4600

Symbol: MX2

Ensembl ID: ENSG00000183486

Description: MX dynamin like GTPase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.3058
    Cell Significance Index: -13.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.3499
    Cell Significance Index: -12.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.8856
    Cell Significance Index: -13.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.1026
    Cell Significance Index: -13.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 28.1793
    Cell Significance Index: -14.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.0466
    Cell Significance Index: -13.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4795
    Cell Significance Index: -12.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.8404
    Cell Significance Index: -8.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4693
    Cell Significance Index: -13.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.1426
    Cell Significance Index: 39.6000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.8219
    Cell Significance Index: 29.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2738
    Cell Significance Index: 36.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2338
    Cell Significance Index: 64.0900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.0622
    Cell Significance Index: 6.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0307
    Cell Significance Index: 22.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7337
    Cell Significance Index: 14.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.6531
    Cell Significance Index: 22.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6367
    Cell Significance Index: 574.8800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6184
    Cell Significance Index: 10.1900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.5632
    Cell Significance Index: 4.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5618
    Cell Significance Index: 72.0200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.5505
    Cell Significance Index: 6.8100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.5044
    Cell Significance Index: 5.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5028
    Cell Significance Index: 25.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4911
    Cell Significance Index: 7.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4105
    Cell Significance Index: 44.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3869
    Cell Significance Index: 23.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3477
    Cell Significance Index: 69.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3186
    Cell Significance Index: 51.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2218
    Cell Significance Index: 15.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1985
    Cell Significance Index: 19.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1423
    Cell Significance Index: 1.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1223
    Cell Significance Index: 16.7900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1147
    Cell Significance Index: 1.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1100
    Cell Significance Index: 20.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1019
    Cell Significance Index: 2.1700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1006
    Cell Significance Index: 0.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0987
    Cell Significance Index: 2.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0951
    Cell Significance Index: 11.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0834
    Cell Significance Index: 10.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0820
    Cell Significance Index: 5.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0734
    Cell Significance Index: 50.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0470
    Cell Significance Index: 2.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0439
    Cell Significance Index: 7.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0368
    Cell Significance Index: 0.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0241
    Cell Significance Index: 4.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0079
    Cell Significance Index: -0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0088
    Cell Significance Index: -13.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0095
    Cell Significance Index: -5.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0103
    Cell Significance Index: -13.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0130
    Cell Significance Index: -0.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0156
    Cell Significance Index: -6.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0174
    Cell Significance Index: -13.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0179
    Cell Significance Index: -13.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0190
    Cell Significance Index: -12.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0197
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0199
    Cell Significance Index: -14.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0246
    Cell Significance Index: -15.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0248
    Cell Significance Index: -8.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0266
    Cell Significance Index: -15.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0273
    Cell Significance Index: -12.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0284
    Cell Significance Index: -8.1800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0383
    Cell Significance Index: -0.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0540
    Cell Significance Index: -6.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0600
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0647
    Cell Significance Index: -11.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0722
    Cell Significance Index: -15.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0775
    Cell Significance Index: -11.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0873
    Cell Significance Index: -2.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0921
    Cell Significance Index: -2.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0962
    Cell Significance Index: -12.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1124
    Cell Significance Index: -12.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1294
    Cell Significance Index: -13.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1478
    Cell Significance Index: -11.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1598
    Cell Significance Index: -7.5100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1726
    Cell Significance Index: -7.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1756
    Cell Significance Index: -12.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1760
    Cell Significance Index: -13.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1779
    Cell Significance Index: -13.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1945
    Cell Significance Index: -13.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2214
    Cell Significance Index: -13.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2236
    Cell Significance Index: -13.7100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2291
    Cell Significance Index: -3.9500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2402
    Cell Significance Index: -1.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2404
    Cell Significance Index: -7.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2422
    Cell Significance Index: -4.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2526
    Cell Significance Index: -15.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2613
    Cell Significance Index: -14.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2780
    Cell Significance Index: -14.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2807
    Cell Significance Index: -9.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2835
    Cell Significance Index: -13.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2923
    Cell Significance Index: -12.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3317
    Cell Significance Index: -11.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3403
    Cell Significance Index: -12.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3451
    Cell Significance Index: -12.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3518
    Cell Significance Index: -4.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3586
    Cell Significance Index: -9.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3596
    Cell Significance Index: -7.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MX2 is a GTP-binding protein that exhibits high sequence homology with the well-known interferon-stimulated gene protein, Mx1. This suggests that MX2 shares similarities with Mx1 in terms of its antiviral activity and regulation of cellular processes. MX2 is primarily expressed in cells of the immune system, including classical and non-classical monocytes, T cells, and urothelial cells. The gene's expression is induced by interferon-alpha (IFN-α) and is involved in the regulation of cell cycle, nucleocytoplasmic transport, and mRNA transport. **Pathways and Functions:** MX2 is involved in several key pathways, including: 1. **Antiviral Mechanism by IFN-stimulated Genes:** MX2 is a key component of the interferon-stimulated gene (ISG) response, which plays a critical role in defending against viral infections. MX2 works in conjunction with other ISGs to inhibit viral replication and promote antiviral defense. 2. **Cytokine Signaling in Immune System:** MX2 is involved in the regulation of cytokine signaling pathways, including the IFN-α/β signaling pathway. This pathway is essential for the activation of immune cells and the production of cytokines that promote antiviral defense. 3. **Nucleocytoplasmic Transport:** MX2 regulates nucleocytoplasmic transport by interacting with nuclear pore complexes and microtubules. This function is essential for the transport of mRNA and other essential molecules between the nucleus and cytoplasm. 4. **GTPase Activity:** MX2 exhibits GTPase activity, which is involved in the regulation of various cellular processes, including cell cycle progression and antiviral defense. **Clinical Significance:** MX2 plays a crucial role in the immune system's response to viral infections, particularly those caused by influenza and herpesviruses. The gene's expression is significantly elevated in patients with viral infections, suggesting that MX2 is an important component of the innate immune response. Furthermore, MX2 has been implicated in the pathogenesis of various diseases, including cancer and autoimmune disorders, where dysregulation of the interferon response can contribute to disease progression. In conclusion, MX2 is a multifaceted gene that plays a critical role in the immune system's response to viral infections. Its involvement in antiviral defense, cytokine signaling, and nucleocytoplasmic transport highlights its importance in the regulation of cellular processes. Further research is needed to fully understand the mechanisms by which MX2 regulates immune responses and to explore its potential as a therapeutic target for the treatment of viral infections and other diseases.

Genular Protein ID: 4272740507

Symbol: MX2_HUMAN

Name: Interferon-induced GTP-binding protein Mx2

UniProtKB Accession Codes:

P20592 B7Z5D3 D3DSI7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 5 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2481229

Title: cDNA structures and regulation of two interferon-induced human Mx proteins.

PubMed ID: 2481229

DOI: 10.1128/mcb.9.11.5062-5072.1989

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2154602

Title: Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter.

PubMed ID: 2154602

DOI: 10.1128/jvi.64.3.1171-1181.1990

PubMed ID: 15184662

Title: Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB.

PubMed ID: 15184662

DOI: 10.1073/pnas.0403167101

PubMed ID: 18062906

Title: The Mx GTPase family of interferon-induced antiviral proteins.

PubMed ID: 18062906

DOI: 10.1016/j.micinf.2007.09.010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24139395

Title: Dynamins are forever: MxB inhibits HIV-1.

PubMed ID: 24139395

DOI: 10.1016/j.chom.2013.10.002

PubMed ID: 24055605

Title: The interferon-inducible MxB protein inhibits HIV-1 infection.

PubMed ID: 24055605

DOI: 10.1016/j.chom.2013.08.015

PubMed ID: 24048477

Title: Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.

PubMed ID: 24048477

DOI: 10.1038/nature12542

PubMed ID: 24121441

Title: MX2 is an interferon-induced inhibitor of HIV-1 infection.

PubMed ID: 24121441

DOI: 10.1038/nature12653

Sequence Information:

  • Length: 715
  • Mass: 82089
  • Checksum: 1AE4B80157545344
  • Sequence:
    • MSKAHKPWPY RRRSQFSSRK YLKKEMNSFQ QQPPPFGTVP PQMMFPPNWQ GAEKDAAFLA 
KDFNFLTLNN QPPPGNRSQP RAMGPENNLY SQYEQKVRPC IDLIDSLRAL GVEQDLALPA 
IAVIGDQSSG KSSVLEALSG VALPRGSGIV TRCPLVLKLK KQPCEAWAGR ISYRNTELEL 
QDPGQVEKEI HKAQNVMAGN GRGISHELIS LEITSPEVPD LTIIDLPGIT RVAVDNQPRD 
IGLQIKALIK KYIQRQQTIN LVVVPCNVDI ATTEALSMAH EVDPEGDRTI GILTKPDLMD 
RGTEKSVMNV VRNLTYPLKK GYMIVKCRGQ QEITNRLSLA EATKKEITFF QTHPYFRVLL 
EEGSATVPRL AERLTTELIM HIQKSLPLLE GQIRESHQKA TEELRRCGAD IPSQEADKMF 
FLIEKIKMFN QDIEKLVEGE EVVRENETRL YNKIREDFKN WVGILATNTQ KVKNIIHEEV 
EKYEKQYRGK ELLGFVNYKT FEIIVHQYIQ QLVEPALSML QKAMEIIQQA FINVAKKHFG 
EFFNLNQTVQ STIEDIKVKH TAKAENMIQL QFRMEQMVFC QDQIYSVVLK KVREEIFNPL 
GTPSQNMKLN SHFPSNESSV SSFTEIGIHL NAYFLETSKR LANQIPFIIQ YFMLRENGDS 
LQKAMMQILQ EKNRYSWLLQ EQSETATKRR ILKERIYRLT QARHALCQFS SKEIH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.