Details for: MYB

Gene ID: 4602

Symbol: MYB

Ensembl ID: ENSG00000118513

Description: MYB proto-oncogene, transcription factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 18.7727
    Cell Significance Index: -2.9200
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 17.4350
    Cell Significance Index: 7.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.1536
    Cell Significance Index: -5.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 9.9699
    Cell Significance Index: -6.6900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 6.8644
    Cell Significance Index: 43.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.9283
    Cell Significance Index: -5.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.9661
    Cell Significance Index: -4.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.2271
    Cell Significance Index: 208.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 3.1779
    Cell Significance Index: 81.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.8165
    Cell Significance Index: 75.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5109
    Cell Significance Index: 140.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.3976
    Cell Significance Index: 237.1800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.2535
    Cell Significance Index: 14.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8694
    Cell Significance Index: 112.2300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.8051
    Cell Significance Index: 18.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.4952
    Cell Significance Index: -5.9000
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.4746
    Cell Significance Index: 10.6000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.4608
    Cell Significance Index: 8.9900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.3727
    Cell Significance Index: 19.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2699
    Cell Significance Index: 206.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.2502
    Cell Significance Index: -3.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1587
    Cell Significance Index: 33.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9267
    Cell Significance Index: 42.0100
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.8374
    Cell Significance Index: 6.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7753
    Cell Significance Index: 53.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5792
    Cell Significance Index: 18.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5643
    Cell Significance Index: 509.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5623
    Cell Significance Index: 107.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4983
    Cell Significance Index: 10.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4814
    Cell Significance Index: 18.2300
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.4789
    Cell Significance Index: 5.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4412
    Cell Significance Index: 32.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4210
    Cell Significance Index: 18.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3924
    Cell Significance Index: 5.8800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.3603
    Cell Significance Index: 4.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2656
    Cell Significance Index: 6.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2529
    Cell Significance Index: 5.4800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2334
    Cell Significance Index: 2.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2206
    Cell Significance Index: 120.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2183
    Cell Significance Index: 6.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2112
    Cell Significance Index: 3.0300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1716
    Cell Significance Index: 1.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1554
    Cell Significance Index: 2.1200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1520
    Cell Significance Index: 1.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1222
    Cell Significance Index: 3.2800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1153
    Cell Significance Index: 1.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0925
    Cell Significance Index: 1.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0818
    Cell Significance Index: 2.8800
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.0806
    Cell Significance Index: 0.6800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.0767
    Cell Significance Index: 0.5400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0702
    Cell Significance Index: 1.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0504
    Cell Significance Index: 3.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0340
    Cell Significance Index: 15.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0333
    Cell Significance Index: 11.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0277
    Cell Significance Index: 0.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0161
    Cell Significance Index: 3.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0144
    Cell Significance Index: 2.8900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.0092
    Cell Significance Index: 0.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0076
    Cell Significance Index: 0.1300
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0055
    Cell Significance Index: 0.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0022
    Cell Significance Index: 0.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0019
    Cell Significance Index: 0.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0009
    Cell Significance Index: -0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0023
    Cell Significance Index: -0.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0024
    Cell Significance Index: -1.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0029
    Cell Significance Index: -5.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.7000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0044
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0048
    Cell Significance Index: -6.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0063
    Cell Significance Index: -0.7700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0065
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0087
    Cell Significance Index: -6.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0094
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0114
    Cell Significance Index: -7.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0123
    Cell Significance Index: -6.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0134
    Cell Significance Index: -6.0600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0144
    Cell Significance Index: -0.2000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0177
    Cell Significance Index: -0.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0198
    Cell Significance Index: -5.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0239
    Cell Significance Index: -3.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0299
    Cell Significance Index: -0.3100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0300
    Cell Significance Index: -0.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0303
    Cell Significance Index: -1.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0318
    Cell Significance Index: -5.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0335
    Cell Significance Index: -7.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0342
    Cell Significance Index: -4.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0363
    Cell Significance Index: -4.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0396
    Cell Significance Index: -5.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0445
    Cell Significance Index: -0.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0524
    Cell Significance Index: -5.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0545
    Cell Significance Index: -6.2400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0554
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: -0.0560
    Cell Significance Index: -0.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0563
    Cell Significance Index: -0.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0601
    Cell Significance Index: -4.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0617
    Cell Significance Index: -6.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0627
    Cell Significance Index: -2.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0728
    Cell Significance Index: -1.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Activator:** MYB is a transcription factor that activates the expression of target genes by binding to specific DNA sequences. 2. **Hematopoietic Specificity:** MYB is significantly expressed in hematopoietic precursor cells, indicating its role in regulating hematopoiesis. 3. **Cell Cycle Regulation:** MYB regulates the cell cycle, particularly during the G1 phase, by controlling the expression of genes involved in cell growth and proliferation. 4. **Developmental Biology:** MYB is involved in developmental processes, including gastrulation, specification of the neural plate border, and erythrocyte differentiation. 5. **Diverse Cellular Expression:** MYB is expressed in various cell types, including T-helper 17 cells, neuroendocrine cells, and erythroid progenitor cells. **Pathways and Functions:** 1. **Cellular Response to Hydrogen Peroxide:** MYB regulates the expression of genes involved in cellular response to oxidative stress, protecting cells from damage. 2. **Cellular Response to Retinoic Acid:** MYB modulates the expression of genes involved in retinoic acid signaling, regulating cell growth and differentiation. 3. **Cytosol and Nucleus:** MYB regulates the expression of genes involved in cytosol and nuclear functions, including protein binding and transcriptional regulation. 4. **Developmental Biology:** MYB regulates the expression of genes involved in developmental processes, including gastrulation, specification of the neural plate border, and erythrocyte differentiation. 5. **Hematopoiesis:** MYB regulates the expression of genes involved in hematopoiesis, including the differentiation of hematopoietic precursor cells. **Clinical Significance:** 1. **Hematological Disorders:** MYB dysregulation has been implicated in various hematological disorders, including acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL). 2. **Cancer:** MYB overexpression has been observed in various types of cancer, including breast cancer, lung cancer, and colon cancer. 3. **Neurological Disorders:** MYB dysregulation has been implicated in neurological disorders, including schizophrenia and autism spectrum disorder. 4. **Cardiovascular Diseases:** MYB regulates the expression of genes involved in cardiovascular disease, including hypertension and atherosclerosis. In conclusion, the MYB proto-oncogene is a transcriptional regulator that plays a critical role in regulating hematopoiesis, cell cycle, and developmental biology. Its dysregulation has been implicated in various diseases, including hematological disorders, cancer, neurological disorders, and cardiovascular diseases. Further research is needed to fully understand the mechanisms by which MYB regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 3884217785

Symbol: MYB_HUMAN

Name: Transcriptional activator Myb

UniProtKB Accession Codes:

P10242 E9PI07 E9PLZ5 E9PNA4 E9PNL6 E9PRS2 P78391 P78392 P78525 P78526 Q14023 Q14024 Q708E4 Q708E7 Q9UE83

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 25 Ensembl 15 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 Pumba 1 RNAct 1 Reactome 5 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3540945

Title: Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus.

PubMed ID: 3540945

DOI: 10.1073/pnas.83.24.9636

PubMed ID: 2202948

Title: Alternative splicing of the human c-myb gene.

PubMed ID: 2202948

PubMed ID: 15169551

Title: Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults.

PubMed ID: 15169551

DOI: 10.1186/1471-2164-5-33

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8302584

Title: Identification of a second promoter in the human c-myb proto-oncogene.

PubMed ID: 8302584

PubMed ID: 1944282

Title: Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene.

PubMed ID: 1944282

DOI: 10.1128/mcb.11.12.6166-6176.1991

PubMed ID: 3014652

Title: Studies of the human c-myb gene and its product in human acute leukemias.

PubMed ID: 3014652

DOI: 10.1126/science.3014652

PubMed ID: 2687764

Title: Identification of alternatively spliced transcripts for human c-myb: molecular cloning and sequence analysis of human c-myb exon 9A sequences.

PubMed ID: 2687764

PubMed ID: 2189102

Title: Transcriptional activation by human c-myb and v-myb genes.

PubMed ID: 2189102

PubMed ID: 10747903

Title: p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3.

PubMed ID: 10747903

DOI: 10.1074/jbc.m000372200

PubMed ID: 19646965

Title: HIPK1 interacts with c-Myb and modulates its activity through phosphorylation.

PubMed ID: 19646965

DOI: 10.1016/j.bbrc.2009.07.139

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23166356

Title: BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.

PubMed ID: 23166356

DOI: 10.1084/jem.20121387

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 640
  • Mass: 72341
  • Checksum: FD5E6694020426ED
  • Sequence:
    • MARRPRHSIY SSDEDDEDFE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK LKKLVEQNGT 
DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED QRVIELVQKY GPKRWSVIAK 
HLKGRIGKQC RERWHNHLNP EVKKTSWTEE EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA 
IKNHWNSTMR RKVEQEGYLQ ESSKASQPAV ATSFQKNSHL MGFAQAPPTA QLPATGQPTV 
NNDYSYYHIS EAQNVSSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL 
LLMSTENELK GQQVLPTQNH TCSYPGWHST TIADHTRPHG DSAPVSCLGE HHSTPSLPAD 
PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID SFLNTSSNHE NSDLEMPSLT 
STPLIGHKLT VTTPFHRDQT VKTQKENTVF RTPAIKRSIL ESSPRTPTPF KHALAAQEIK 
YGPLKMLPQT PSHLVEDLQD VIKQESDESG IVAEFQENGP PLLKKIKQEV ESPTDKSGNF 
FCSHHWEGDS LNTQLFTQTS PVADAPNILT SSVLMAPASE DEDNVLKAFT VPKNRSLASP 
LQPCSSTWEP ASCGKMEEQM TSSSQARKYV NAFSARTLVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.