Details for: MYH10

Gene ID: 4628

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: MYH10

Ensembl ID: ENSG00000133026

Description: myosin heavy chain 10

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pvalb GABAergic cortical interneuron CL4023018
    CSI 41.29
    rCSI 51.36%
    PRS 62.32
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 31.4
    rCSI 52.7%
    PRS 64.5
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 26.25
    rCSI 63.79%
    PRS 62.43
  • alveolar type 1 fibroblast cell CL4028004
    CSI 23.69
    rCSI 25.94%
    PRS 83.82
  • fibroblast of lung CL0002553
    CSI 23.66
    rCSI 22.02%
    PRS 82.75
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 21.86
    rCSI 38.61%
    PRS 63.97
  • sncg GABAergic cortical interneuron CL4023015
    CSI 21.67
    rCSI 34.85%
    PRS 65.96
  • L6b glutamatergic cortical neuron CL4023038
    CSI 20.59
    rCSI 64.33%
    PRS 66.17
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 20.02
    rCSI 23.12%
    PRS 74.17
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 19.48
    rCSI 60.94%
    PRS 68.42
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 18.17
    rCSI 65.38%
    PRS 62.42
  • retinal ganglion cell CL0000740
    CSI 17.67
    rCSI 39.03%
    PRS 68.12
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 17.32
    rCSI 37.57%
    PRS 69.58
  • neuron CL0000540
    CSI 16.48
    rCSI 43.88%
    PRS 69.4
  • retinal rod cell CL0000604
    CSI 16.42
    rCSI 28.94%
    PRS 77.24
  • VIP GABAergic cortical interneuron CL4023016
    CSI 15.72
    rCSI 18.77%
    PRS 64.61
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 15.2
    rCSI 57.45%
    PRS 65.03
  • sst GABAergic cortical interneuron CL4023017
    CSI 15.17
    rCSI 19.55%
    PRS 65.62
  • erythrocyte CL0000232
    CSI 15.13
    rCSI 34.33%
    PRS 82.17
  • ependymal cell CL0000065
    CSI 15.11
    rCSI 30.67%
    PRS 60.83
  • retinal bipolar neuron CL0000748
    CSI 14.18
    rCSI 26.56%
    PRS 70.6
  • GABAergic amacrine cell CL4030027
    CSI 14.12
    rCSI 48.36%
    PRS 68.15
  • ciliated cell CL0000064
    CSI 13.48
    rCSI 21.85%
    PRS 76.76
  • neural crest cell CL0011012
    CSI 13.32
    rCSI 10.53%
    PRS 71.31
  • neural cell CL0002319
    CSI 12.9
    rCSI 48.67%
    PRS 65.42
  • Schwann cell CL0002573
    CSI 12.45
    rCSI 35.39%
    PRS 77.52
  • Mueller cell CL0000636
    CSI 12.34
    rCSI 28.16%
    PRS 73.56
  • radial glial cell CL0000681
    CSI 12.23
    rCSI 16.99%
    PRS 80.32
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 11.42
    rCSI 27.31%
    PRS 68.96
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 10.9
    rCSI 9.84%
    PRS 80.1
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 10.61
    rCSI 62.47%
    PRS 65.09
  • myofibroblast cell CL0000186
    CSI 10.48
    rCSI 14.52%
    PRS 78.89
  • mesodermal cell CL0000222
    CSI 9.95
    rCSI 11.94%
    PRS 79.97
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 9.89
    rCSI 12.69%
    PRS 78.04
  • interneuron CL0000099
    CSI 9.79
    rCSI 19.65%
    PRS 72.7
  • stem cell CL0000034
    CSI 9.74
    rCSI 9.39%
    PRS 75.7
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 9.59
    rCSI 31.51%
    PRS 67.84
  • bronchus fibroblast of lung CL2000093
    CSI 9.4
    rCSI 7.63%
    PRS 81.31
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 9.35
    rCSI 17%
    PRS 73.71
  • enteric smooth muscle cell CL0002504
    CSI 9.2
    rCSI 13.13%
    PRS 82.67
  • kidney connecting tubule epithelial cell CL1000768
    CSI 9.04
    rCSI 22.93%
    PRS 72.63
  • blood vessel endothelial cell CL0000071
    CSI 9.01
    rCSI 18.7%
    PRS 78.78
  • glioblast CL0000030
    CSI 8.93
    rCSI 14.25%
    PRS 73.55
  • retinal cone cell CL0000573
    CSI 8.75
    rCSI 14.09%
    PRS 72.32
  • interstitial cell of Cajal CL0002088
    CSI 8.37
    rCSI 10.65%
    PRS 86.72
  • pancreatic A cell CL0000171
    CSI 8.16
    rCSI 8.55%
    PRS 85
  • inhibitory interneuron CL0000498
    CSI 7.97
    rCSI 18.4%
    PRS 70.17
  • renal principal cell CL0005009
    CSI 7.8
    rCSI 20.26%
    PRS 82.23
  • hepatic stellate cell CL0000632
    CSI 7.74
    rCSI 29.01%
    PRS 74.69
  • adipocyte CL0000136
    CSI 7.67
    rCSI 9.84%
    PRS 72.32
  • placental villous trophoblast CL2000060
    CSI 7.66
    rCSI 11.83%
    PRS 81
  • extravillous trophoblast CL0008036
    CSI 7.6
    rCSI 9.4%
    PRS 80.17
  • vascular leptomeningeal cell CL4023051
    CSI 7.36
    rCSI 12.91%
    PRS 76.17
  • melanocyte CL0000148
    CSI 7.35
    rCSI 5.45%
    PRS 75.68
  • skin fibroblast CL0002620
    CSI 7.26
    rCSI 6.26%
    PRS 82.62
  • macroglial cell CL0000126
    CSI 7.24
    rCSI 18.62%
    PRS 78.55
  • central nervous system neuron CL2000029
    CSI 7.22
    rCSI 53.06%
    PRS 69.73
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 7.01
    rCSI 18.28%
    PRS 82.97
  • brush cell of tracheobronchial tree CL0002075
    CSI 7
    rCSI 20.76%
    PRS 89.78
  • cerebral cortex endothelial cell CL1001602
    CSI 6.92
    rCSI 11.98%
    PRS 73.89
  • epithelial cell of proximal tubule CL0002306
    CSI 6.91
    rCSI 16.88%
    PRS 74.38
  • dopaminergic neuron CL0000700
    CSI 6.85
    rCSI 38.68%
    PRS 68.23
  • basal cell of epidermis CL0002187
    CSI 6.65
    rCSI 11.79%
    PRS 51
  • rod bipolar cell CL0000751
    CSI 6.22
    rCSI 11.17%
    PRS 75.44
  • vascular associated smooth muscle cell CL0000359
    CSI 6.06
    rCSI 19.66%
    PRS 80
  • ciliated epithelial cell CL0000067
    CSI 6.05
    rCSI 5.32%
    PRS 71.42
  • epithelial cell of lower respiratory tract CL0002632
    CSI 5.75
    rCSI 4.46%
    PRS 85.52
  • erythroblast CL0000765
    CSI 5.67
    rCSI 15.04%
    PRS 86.72
  • glutamatergic neuron CL0000679
    CSI 5.34
    rCSI 10.98%
    PRS 69.3
  • retina horizontal cell CL0000745
    CSI 5.3
    rCSI 8.08%
    PRS 78.69
  • midbrain dopaminergic neuron CL2000097
    CSI 5.3
    rCSI 33.92%
    PRS 77.81
  • mesenchymal cell CL0008019
    CSI 5.07
    rCSI 12.86%
    PRS 75.61
  • astrocyte of the cerebral cortex CL0002605
    CSI 5
    rCSI 11.21%
    PRS 65.3
  • smooth muscle cell CL0000192
    CSI 4.94
    rCSI 11.77%
    PRS 77.86
  • kidney collecting duct principal cell CL1001431
    CSI 4.8
    rCSI 24.15%
    PRS 79.31
  • tracheobronchial smooth muscle cell CL0019019
    CSI 4.79
    rCSI 8.45%
    PRS 86.63
  • enteroendocrine cell CL0000164
    CSI 4.78
    rCSI 6.54%
    PRS 81.56
  • choroid plexus epithelial cell CL0000706
    CSI 4.76
    rCSI 7.79%
    PRS 71.73
  • stromal cell CL0000499
    CSI 4.72
    rCSI 13.27%
    PRS 77.05
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 4.67
    rCSI 13.78%
    PRS 82.69
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 4.65
    rCSI 12.02%
    PRS 77.49
  • fallopian tube secretory epithelial cell CL4030006
    CSI 4.64
    rCSI 4.47%
    PRS 81.29
  • peripheral nervous system neuron CL2000032
    CSI 4.54
    rCSI 6.18%
    PRS 73.78
  • blood vessel smooth muscle cell CL0019018
    CSI 4.54
    rCSI 36.91%
    PRS 76.54
  • ON parasol ganglion cell CL4033052
    CSI 4.46
    rCSI 63.26%
    PRS 73.25
  • alveolar adventitial fibroblast CL4028006
    CSI 4.4
    rCSI 6.95%
    PRS 83.34
  • chondrocyte CL0000138
    CSI 4.33
    rCSI 6.88%
    PRS 75.25
  • cerebral cortex neuron CL0010012
    CSI 4.32
    rCSI 17.61%
    PRS 73.94
  • cardiac endothelial cell CL0010008
    CSI 4.32
    rCSI 17.42%
    PRS 81.9
  • medium spiny neuron CL1001474
    CSI 4.25
    rCSI 36.61%
    PRS 70.19
  • intestinal epithelial cell CL0002563
    CSI 4.24
    rCSI 4.43%
    PRS 79.51
  • epithelial cell of lung CL0000082
    CSI 4.16
    rCSI 3.45%
    PRS 82.83
  • endothelial cell of vascular tree CL0002139
    CSI 3.83
    rCSI 20.95%
    PRS 78.3
  • regular ventricular cardiac myocyte CL0002131
    CSI 3.76
    rCSI 23.48%
    PRS 73.83
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 3.72
    rCSI 17.05%
    PRS 85.87
  • endocardial cell CL0002350
    CSI 3.65
    rCSI 17.5%
    PRS 78.35
  • adventitial cell CL0002503
    CSI 3.59
    rCSI 8.56%
    PRS 85.53
  • fibroblast of cardiac tissue CL0002548
    CSI 3.57
    rCSI 17.09%
    PRS 81.92
  • cerebellar granule cell CL0001031
    CSI 3.56
    rCSI 5.23%
    PRS 74.95
  • Bergmann glial cell CL0000644
    CSI 3.47
    rCSI 4.75%
    PRS 73.27
  • eye photoreceptor cell CL0000287
    CSI 0.4
    rCSI 4.8%
    PRS 88.9%
  • pancreatic PP cell CL0002275
    CSI 0.7
    rCSI 2.7%
    PRS 88.3%
  • fibroblast of breast CL4006000
    CSI 0.7
    rCSI 3.0%
    PRS 86.3%
  • flat midget bipolar cell CL4033033
    CSI 0.8
    rCSI 5.5%
    PRS 72.6%
  • diffuse bipolar 2 cell CL4033028
    CSI 0.8
    rCSI 6.0%
    PRS 75.6%
  • erythroid progenitor cell CL0000038
    CSI 0.8
    rCSI 4.5%
    PRS 86.6%
  • neural progenitor cell CL0011020
    CSI 0.8
    rCSI 3.6%
    PRS 70.5%
  • deuterosomal cell CL4033044
    CSI 0.9
    rCSI 2.9%
    PRS 78.9%
  • parietal epithelial cell CL1000452
    CSI 0.9
    rCSI 2.3%
    PRS 74.1%
  • glial cell CL0000125
    CSI 0.9
    rCSI 3.4%
    PRS 73.2%
  • H1 horizontal cell CL0004217
    CSI 0.9
    rCSI 3.6%
    PRS 76.8%
  • pancreatic ductal cell CL0002079
    CSI 0.9
    rCSI 1.8%
    PRS 84.8%
  • podocyte CL0000653
    CSI 1.0
    rCSI 4.4%
    PRS 82.4%
  • invaginating midget bipolar cell CL4033034
    CSI 1.0
    rCSI 5.9%
    PRS 73.3%
  • diffuse bipolar 1 cell CL4033027
    CSI 1.0
    rCSI 7.8%
    PRS 72.0%
  • endothelial cell of placenta CL0009092
    CSI 1.1
    rCSI 5.6%
    PRS 88.7%
  • H2 horizontal cell CL0004218
    CSI 1.2
    rCSI 5.8%
    PRS 76.6%
  • regular atrial cardiac myocyte CL0002129
    CSI 1.2
    rCSI 4.0%
    PRS 78.7%
  • cerebellar neuron CL1001611
    CSI 1.3
    rCSI 11.3%
    PRS 70.1%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 1.3
    rCSI 2.3%
    PRS 90.8%
  • diffuse bipolar 6 cell CL4033032
    CSI 1.3
    rCSI 6.8%
    PRS 72.6%
  • diffuse bipolar 3b cell CL4033030
    CSI 1.3
    rCSI 8.7%
    PRS 76.4%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 1.3
    rCSI 3.8%
    PRS 81.3%
  • starburst amacrine cell CL0004232
    CSI 1.3
    rCSI 11.0%
    PRS 69.9%
  • stromal cell of ovary CL0002132
    CSI 1.3
    rCSI 3.7%
    PRS 88.0%
  • syncytiotrophoblast cell CL0000525
    CSI 1.4
    rCSI 3.9%
    PRS 87.2%
  • OFFx cell CL4033036
    CSI 1.4
    rCSI 6.5%
    PRS 73.3%
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI 1.4
    rCSI 10.7%
    PRS 83.3%
  • cerebral cortex pyramidal neuron CL4023111
    CSI 1.5
    rCSI 8.9%
    PRS 86.2%
  • bronchiolar smooth muscle cell CL4033017
    CSI 1.5
    rCSI 21.8%
    PRS 89.4%
  • pluripotent stem cell CL0002248
    CSI 1.5
    rCSI 44.2%
    PRS 91.0%
  • type EC enteroendocrine cell CL0000577
    CSI 1.5
    rCSI 5.3%
    PRS 85.6%
  • Cajal-Retzius cell CL0000695
    CSI 1.6
    rCSI 12.4%
    PRS 86.4%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.7
    rCSI 18.2%
    PRS 78.0%
  • retinal pigment epithelial cell CL0002586
    CSI 1.7
    rCSI 3.4%
    PRS 77.8%
  • progenitor cell CL0011026
    CSI 1.8
    rCSI 3.7%
    PRS 75.9%
  • diffuse bipolar 3a cell CL4033029
    CSI 1.8
    rCSI 11.9%
    PRS 74.4%
  • neuroplacodal cell CL0000032
    CSI 1.9
    rCSI 17.1%
    PRS 82.3%
  • keratocyte CL0002363
    CSI 1.9
    rCSI 4.5%
    PRS 84.6%
  • tendon cell CL0000388
    CSI 1.9
    rCSI 4.8%
    PRS 88.1%
  • lung ciliated cell CL1000271
    CSI 1.9
    rCSI 2.2%
    PRS 74.5%
  • type B pancreatic cell CL0000169
    CSI 1.9
    rCSI 4.2%
    PRS 81.4%
  • forebrain radial glial cell CL0013000
    CSI 1.9
    rCSI 6.1%
    PRS 83.3%
  • serotonergic neuron CL0000850
    CSI 2.0
    rCSI 9.1%
    PRS 66.1%
  • primitive red blood cell CL0002355
    CSI 2.0
    rCSI 11.0%
    PRS 87.3%
  • myeloid leukocyte CL0000766
    CSI 2.1
    rCSI 1.9%
    PRS 83.4%
  • lung secretory cell CL1000272
    CSI 2.1
    rCSI 5.2%
    PRS 81.9%
  • renal interstitial pericyte CL1001318
    CSI 2.1
    rCSI 5.8%
    PRS 77.3%
  • hepatocyte CL0000182
    CSI 2.1
    rCSI 3.8%
    PRS 81.2%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.1
    rCSI 3.0%
    PRS 78.7%
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 2.2
    rCSI 6.6%
    PRS 85.9%
  • neuroendocrine cell CL0000165
    CSI 2.2
    rCSI 8.4%
    PRS 89.4%
  • GABAergic neuron CL0000617
    CSI 2.3
    rCSI 7.8%
    PRS 66.0%
  • lung neuroendocrine cell CL1000223
    CSI 2.4
    rCSI 3.5%
    PRS 85.5%
  • cardiac muscle cell CL0000746
    CSI 2.4
    rCSI 3.4%
    PRS 72.0%
  • pancreatic D cell CL0000173
    CSI 2.4
    rCSI 2.3%
    PRS 84.3%
  • multi-ciliated epithelial cell CL0005012
    CSI 2.5
    rCSI 2.5%
    PRS 75.9%
  • basket cell CL0000118
    CSI 2.6
    rCSI 16.3%
    PRS 61.9%
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.7
    rCSI 65.5%
    PRS 63.1%
  • direct pathway medium spiny neuron CL4023026
    CSI 2.7
    rCSI 65.7%
    PRS 62.5%
  • S cone cell CL0003050
    CSI 2.8
    rCSI 12.1%
    PRS 76.5%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 2.8
    rCSI 24.1%
    PRS 76.3%
  • mesothelial cell CL0000077
    CSI 2.8
    rCSI 11.0%
    PRS 60.7%
  • amacrine cell CL0000561
    CSI 2.9
    rCSI 8.3%
    PRS 71.7%
  • GABAergic interneuron CL0011005
    CSI 3.0
    rCSI 46.8%
    PRS 83.0%
  • mesangial cell CL0000650
    CSI 3.0
    rCSI 12.2%
    PRS 89.8%
  • lung pericyte CL0009089
    CSI 3.0
    rCSI 7.9%
    PRS 88.0%
  • ON-bipolar cell CL0000749
    CSI 3.0
    rCSI 4.5%
    PRS 81.6%
  • mesenchymal stem cell CL0000134
    CSI 3.0
    rCSI 33.3%
    PRS 86.6%
  • ionocyte CL0005006
    CSI 3.1
    rCSI 3.3%
    PRS 83.3%
  • OFF midget ganglion cell CL4033047
    CSI 3.1
    rCSI 63.6%
    PRS 73.0%
  • glycinergic amacrine cell CL4030028
    CSI 3.1
    rCSI 8.2%
    PRS 76.4%
  • retinal blood vessel endothelial cell CL0002585
    CSI 3.2
    rCSI 5.1%
    PRS 85.4%
  • ON midget ganglion cell CL4033046
    CSI 3.2
    rCSI 64.5%
    PRS 71.9%
  • myoepithelial cell CL0000185
    CSI 3.2
    rCSI 8.0%
    PRS 86.4%
  • renal beta-intercalated cell CL0002201
    CSI 3.3
    rCSI 8.0%
    PRS 81.9%
  • Bergmann glial cell CL0000644
    CSI 3.5
    rCSI 4.8%
    PRS 73.3%
  • cerebellar granule cell CL0001031
    CSI 3.6
    rCSI 5.2%
    PRS 75.0%
  • fibroblast of cardiac tissue CL0002548
    CSI 3.6
    rCSI 17.1%
    PRS 81.9%
  • adventitial cell CL0002503
    CSI 3.6
    rCSI 8.6%
    PRS 85.5%
  • endocardial cell CL0002350
    CSI 3.7
    rCSI 17.5%
    PRS 78.4%
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 3.7
    rCSI 17.1%
    PRS 85.9%
  • regular ventricular cardiac myocyte CL0002131
    CSI 3.8
    rCSI 23.5%
    PRS 73.8%
  • endothelial cell of vascular tree CL0002139
    CSI 3.8
    rCSI 21.0%
    PRS 78.3%
  • epithelial cell of lung CL0000082
    CSI 4.2
    rCSI 3.5%
    PRS 82.8%
  • intestinal epithelial cell CL0002563
    CSI 4.2
    rCSI 4.4%
    PRS 79.5%
  • medium spiny neuron CL1001474
    CSI 4.3
    rCSI 36.6%
    PRS 70.2%
  • cardiac endothelial cell CL0010008
    CSI 4.3
    rCSI 17.4%
    PRS 81.9%
  • cerebral cortex neuron CL0010012
    CSI 4.3
    rCSI 17.6%
    PRS 73.9%
  • chondrocyte CL0000138
    CSI 4.3
    rCSI 6.9%
    PRS 75.3%
  • alveolar adventitial fibroblast CL4028006
    CSI 4.4
    rCSI 7.0%
    PRS 83.3%
  • ON parasol ganglion cell CL4033052
    CSI 4.5
    rCSI 63.3%
    PRS 73.3%
  • blood vessel smooth muscle cell CL0019018
    CSI 4.5
    rCSI 36.9%
    PRS 76.5%
  • peripheral nervous system neuron CL2000032
    CSI 4.5
    rCSI 6.2%
    PRS 73.8%
  • fallopian tube secretory epithelial cell CL4030006
    CSI 4.6
    rCSI 4.5%
    PRS 81.3%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 4.7
    rCSI 12.0%
    PRS 77.5%
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 4.7
    rCSI 13.8%
    PRS 82.7%
  • stromal cell CL0000499
    CSI 4.7
    rCSI 13.3%
    PRS 77.1%
  • choroid plexus epithelial cell CL0000706
    CSI 4.8
    rCSI 7.8%
    PRS 71.7%
  • enteroendocrine cell CL0000164
    CSI 4.8
    rCSI 6.5%
    PRS 81.6%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MYH10](/details-gene/4628), or Myosin Heavy Chain 10, encodes a nonmuscle myosin II heavy chain-B (NMHC-IIB) protein. This protein is a fundamental component of the cellular cytoskeleton, functioning as an ATP-dependent motor protein that generates mechanical force through interaction with actin filaments. Its primary roles involve regulating cell shape, adhesion, and motility. **Overall**, expression data reveals that [MYH10](/details-gene/4628) shows particularly high significance in a wide range of neuronal subtypes, including both GABAergic and glutamatergic cortical neurons, as well as in fibroblasts. This expression pattern, combined with its functional annotations, suggests a critical role in neurodevelopment, particularly in processes like axon guidance, and in the structural dynamics of connective tissue cells. Clinical associations with this gene are noted under OMIM entry [160776](https://omim.org/entry/160776). ## Cellular Roles and Expression Landscape The expression profile of [MYH10](/details-gene/4628) highlights its specialized importance within the central nervous system and in structural cell types. **Overall**, the gene exhibits its highest significance in diverse neuronal populations. It is a top marker in `pvalb GABAergic cortical interneuron` ([CL4023018](/details-cell/CL4023018)), `lamp5 GABAergic cortical interneuron` ([CL4023011](/details-cell/CL4023011)), and various `L2/3-6 intratelencephalic projecting glutamatergic neuron` ([CL4023040](/details-cell/CL4023040)), indicating a broad and essential function across both inhibitory and excitatory neuronal circuits. Its high significance extends to `retinal ganglion cell` ([CL0000740](/details-cell/CL0000740)) and `retinal rod cell` ([CL0000604](/details-cell/CL0000604)), underscoring a key role in the visual system. Beyond the nervous system, [MYH10](/details-gene/4628) is also highly significant in mesenchymal-derived cells, such as `alveolar type 1 fibroblast cell` ([CL4028004](/details-cell/CL4028004)) and `fibroblast of lung` ([CL0002553](/details-cell/CL0002553)). This suggests a role in maintaining tissue architecture, wound healing, and extracellular matrix remodeling, consistent with the contractile functions of nonmuscle myosin. Early work identified human nonmuscle myosin heavy chains as being encoded by two distinct genes [Link](https://pubmed.ncbi.nlm.nih.gov/1860190/). The neuronal expression of specific isoforms of nonmuscle myosin heavy chain II-B has also been previously characterized [Link](https://doi.org/10.1074/jbc.270.24.14533). ## Pathways and Molecular Function The molecular functions of [MYH10](/details-gene/4628) are centered on its role as a cytoskeletal motor protein. Gene Ontology annotations confirm its involvement in `Microfilament motor activity` ([GO:0000146](https://www.ebi.ac.uk/QuickGO/term/GO:0000146)), `Actin filament binding` ([GO:0051015](https://www.ebi.ac.uk/QuickGO/term/GO:0051015)), and `Atp binding` ([GO:0005524](https://www.ebi.ac.uk/QuickGO/term/GO:0005524)). These molecular activities drive larger biological processes such as `Actin filament-based movement` ([GO:0030048](https://www.ebi.ac.uk/QuickGO/term/GO:0030048)), `Regulation of cell shape` ([GO:0008360](https://www.ebi.ac.uk/QuickGO/term/GO:0008360)), and `Mitotic cytokinesis` ([GO:0000281](https://www.ebi.ac.uk/QuickGO/term/GO:0000281)), where it is a key component of the contractile ring at the `Cleavage furrow` ([GO:0032154](https://www.ebi.ac.uk/QuickGO/term/GO:0032154)). The Reactome pathway analysis strongly aligns with the gene's prominent neuronal expression. [MYH10](/details-gene/4628) is a participant in `Nervous system development` ([R-HSA-9675108](https://reactome.org/content/detail/R-HSA-9675108)), particularly in pathways governing neuronal wiring such as `Axon guidance` ([R-HSA-422475](https://reactome.org/content/detail/R-HSA-422475)) and `Epha-mediated growth cone collapse` ([R-HSA-3928663](https://reactome.org/content/detail/R-HSA-3928663)). Its function is further contextualized by its role as an effector in `Signaling by rho gtpases` ([R-HSA-194315](https://reactome.org/content/detail/R-HSA-194315)), a central signaling hub that links extracellular cues to cytoskeletal reorganization. This positions [MYH10](/details-gene/4628) as a critical downstream component that executes the physical changes in cell morphology required for neuronal migration and synapse formation. ## Research Directions The specific and high-level expression of [MYH10](/details-gene/4628) in diverse neuronal subtypes and its deep integration into neurodevelopmental pathways present several avenues for future research. **Proposed Hypotheses:** 1. Given its high expression across multiple cortical neuron types and its role in `Axon guidance` ([R-HSA-422475](https://reactome.org/content/detail/R-HSA-422475)), [MYH10](/details-gene/4628) may function as a master regulator of growth cone motility and directional sensing. Its activity is likely fine-tuned by local signaling to control the precise pathfinding of distinct neuronal subtypes during the formation of cortical circuits. 2. The high significance of [MYH10](/details-gene/4628) in lung fibroblasts suggests it is a key driver of fibroblast-mediated tissue contraction and matrix deposition. Therefore, aberrant regulation or overexpression of [MYH10](/details-gene/4628) in these cells could be a pathogenic factor in the development of pulmonary fibrosis by promoting excessive tissue stiffening. **Experimental Approach:** To test the hypothesis regarding [MYH10](/details-gene/4628)'s role in neuronal circuit formation, one could utilize an *in vitro* model with human iPSC-derived cortical neurons. CRISPR interference (CRISPRi) could be used to achieve a titratable knockdown of [MYH10](/details-gene/4628). These neurons could then be cultured on micropatterned surfaces coated with guidance cues (e.g., Ephrin-A5, Semaphorin-3A). High-resolution live-cell imaging would be employed to quantify key parameters such as neurite extension rate, growth cone morphology, cytoskeletal dynamics (visualized by fluorescent actin reporters), and the fidelity of axon pathfinding in response to the cues. This would directly assess the necessity of [MYH10](/details-gene/4628) in translating guidance signals into directed growth. **Therapeutic Potential:** As an intracellular motor protein essential for fundamental processes like cytokinesis, [MYH10](/details-gene/4628) presents a challenging therapeutic target due to the high risk of on-target toxicity in healthy dividing cells. However, its role in cell migration and division could be exploited in oncology. **Inhibition** of [MYH10](/details-gene/4628) activity with a small molecule inhibitor could be a viable strategy for cancers that are highly dependent on this specific myosin isoform for proliferation or invasion, such as glioblastoma or other neuroectodermal tumors. A targeted approach would be necessary to mitigate systemic side effects, potentially through advanced drug delivery systems or by identifying therapeutic windows where tumor cells are uniquely vulnerable to [MYH10](/details-gene/4628) inhibition.

Genular Protein ID: 2817416807

Symbol: MYH10_HUMAN

Name: Myosin-10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7499478

Title: Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies.

PubMed ID: 7499478

DOI: 10.1007/bf00114503

PubMed ID: 8690889

Title: Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles.

PubMed ID: 8690889

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1860190

Title: Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes.

PubMed ID: 1860190

DOI: 10.1161/01.res.69.2.530

PubMed ID: 7782316

Title: Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B.

PubMed ID: 7782316

DOI: 10.1074/jbc.270.24.14533

PubMed ID: 7916668

Title: Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis.

PubMed ID: 7916668

DOI: 10.1161/01.res.73.6.1000

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16721066

Title: A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis.

PubMed ID: 16721066

DOI: 10.4161/cc.5.11.2815

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20682791

Title: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.

PubMed ID: 20682791

DOI: 10.1074/jbc.m110.154120

PubMed ID: 20603131

Title: Nonmuscle myosin-dependent synthesis of type I collagen.

PubMed ID: 20603131

DOI: 10.1016/j.jmb.2010.06.057

PubMed ID: 20052411

Title: Myosin II motor proteins with different functions determine the fate of lamellipodia extension during cell spreading.

PubMed ID: 20052411

DOI: 10.1371/journal.pone.0008560

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22480440

Title: The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells.

PubMed ID: 22480440

DOI: 10.1016/j.bbamcr.2012.03.011

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28345668

Title: C9ORF135 encodes a membrane protein whose expression is related to pluripotency in human embryonic stem cells.

PubMed ID: 28345668

DOI: 10.1038/srep45311

PubMed ID: 25003005

Title: A human de novo mutation in MYH10 phenocopies the loss of function mutation in mice.

PubMed ID: 25003005

DOI: 10.4161/rdis.26144

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

Sequence Information:

  • Length: 1976
  • Mass: 228999
  • Checksum: A7C91944EBC2368F
  • Sequence:
  • MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 
    ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 
    FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES 
    GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS 
    RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL 
    LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS 
    FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA 
    VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN 
    EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW 
    FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN 
    DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF RTVGQLYKES 
    LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR CNGVLEGIRI CRQGFPNRIV 
    FQEFRQRYEI LTPNAIPKGF MDGKQACERM IRALELDPNL YRIGQSKIFF RAGVLAHLEE 
    ERDLKITDII IFFQAVCRGY LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK 
    VKPLLQVTRQ EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET 
    ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA HIQDLEEQLD 
    EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE KKLMEDRIAE CSSQLAEEEE 
    KAKNLAKIRN KQEVMISDLE ERLKKEEKTR QELEKAKRKL DGETTDLQDQ IAELQAQIDE 
    LKLQLAKKEE ELQGALARGD DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ 
    KRDLSEELEA LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR 
    HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES EHKRKKLDAQ 
    VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE KKGIKFAKDA ASLESQLQDT 
    QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE QQEEEEEARK NLEKQVLALQ SQLADTKKKV 
    DDDLGTIESL EEAKKKLLKD AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR 
    QVASNLEKKQ KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE 
    EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE LEDELQATED 
    AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE LEAELEDERK QRALAVASKK 
    KMEIDLKDLE AQIEAANKAR DEVIKQLRKL QAQMKDYQRE LEEARASRDE IFAQSKESEK 
    KLKSLEAEIL QLQEELASSE RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ 
    LEEELEEEQS NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK 
    LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK LKEIFMQVED 
    ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR RKLQRELDDA TEANEGLSRE 
    VSTLKNRLRR GGPISFSSSR SGRRQLHLEG ASLELSDDDT ESKTSDVNET QPPQSE

Genular Protein ID: 1862833226

Symbol: G1UI33_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

Sequence Information:

  • Length: 180
  • Mass: 20795
  • Checksum: 13B6A7D616FF3F07
  • Sequence:
  • MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 
    ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 
    FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES