NBL1 | ENSG00000158747 | NCBI 4681

Details for: NBL1

Gene ID: 4681

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: NBL1

Ensembl ID: ENSG00000158747

Description: NBL1, DAN family BMP antagonist

Cell Significance Landscape

Display Count:

Associated with

Bmp binding
(GO:0036122)
Determination of dorsal identity
(GO:0048263)
Extracellular space
(GO:0005615)
Identical protein binding
(GO:0042802)
Morphogen activity
(GO:0016015)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of monocyte chemotaxis
(GO:0090027)
Nervous system development
(GO:0007399)
Neuron projection morphogenesis
(GO:0048812)
Positive regulation of neuron differentiation
(GO:0045666)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Sequestering of bmp from receptor via bmp binding
(GO:0038098)
Sequestering of bmp in extracellular matrix
(GO:0035582)
Signal transduction
(GO:0007165)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

bronchus fibroblast of lung CL2000093

CSI 57.93

rCSI 47.07%

PRS 85.25
alveolar type 1 fibroblast cell CL4028004

CSI 40.72

rCSI 44.6%

PRS 87.47
fibroblast of lung CL0002553

CSI 33.62

rCSI 31.29%

PRS 86.76
respiratory basal cell CL0002633

CSI 29.23

rCSI 30.27%

PRS 88.58
transit amplifying cell of colon CL0009011

CSI 28.77

rCSI 33.79%

PRS 86.72
conventional dendritic cell CL0000990

CSI 26.12

rCSI 21.81%

PRS 82.9
alveolar adventitial fibroblast CL4028006

CSI 21.34

rCSI 33.7%

PRS 86.92
CD4-positive helper T cell CL0000492

CSI 18.07

rCSI 13.67%

PRS 95.01
enterocyte CL0000584

CSI 17.37

rCSI 28.01%

PRS 83.52
colon epithelial cell CL0011108

CSI 17.11

rCSI 17.92%

PRS 83.27
colon goblet cell CL0009039

CSI 16.99

rCSI 40.39%

PRS 88.97
stromal cell of ovary CL0002132

CSI 16.59

rCSI 45.59%

PRS 90.2
M cell of gut CL0000682

CSI 16.2

rCSI 17.21%

PRS 89.02
skin fibroblast CL0002620

CSI 15.91

rCSI 13.71%

PRS 85.48
myofibroblast cell CL0000186

CSI 14.89

rCSI 20.62%

PRS 82.23
blood vessel endothelial cell CL0000071

CSI 14.49

rCSI 30.06%

PRS 83.25
colonocyte CL1000347

CSI 14.07

rCSI 20.17%

PRS 85.08
regulatory T cell CL0000815

CSI 13.58

rCSI 15.74%

PRS 83.15
ciliated cell CL0000064

CSI 13.22

rCSI 21.41%

PRS 80.49
interstitial cell of Cajal CL0002088

CSI 12.72

rCSI 16.19%

PRS 90
microcirculation associated smooth muscle cell CL0008035

CSI 11.03

rCSI 31.93%

PRS 84.96
stem cell CL0000034

CSI 10.95

rCSI 10.56%

PRS 80.66
vascular leptomeningeal cell CL4023051

CSI 10.31

rCSI 18.08%

PRS 80.92
BEST4+ enteroycte CL4030026

CSI 9.89

rCSI 12.3%

PRS 86.08
enteric smooth muscle cell CL0002504

CSI 9.45

rCSI 13.49%

PRS 86.3
T-helper 17 cell CL0000899

CSI 9.33

rCSI 7.41%

PRS 97.17
secretory cell CL0000151

CSI 9.25

rCSI 9.65%

PRS 84.93
goblet cell CL0000160

CSI 9.13

rCSI 8.63%

PRS 83.81
perivascular cell CL4033054

CSI 9.12

rCSI 12.46%

PRS 89.6
pancreatic stellate cell CL0002410

CSI 8.66

rCSI 50.38%

PRS 88.16
pancreatic A cell CL0000171

CSI 8.64

rCSI 9.06%

PRS 88.43
sncg GABAergic cortical interneuron CL4023015

CSI 7.88

rCSI 12.68%

PRS 71.37
adventitial cell CL0002503

CSI 7.84

rCSI 18.73%

PRS 88.65
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 7.42

rCSI 8.99%

PRS 66.18
smooth muscle cell CL0000192

CSI 6.91

rCSI 16.47%

PRS 81.11
intestine goblet cell CL0019031

CSI 6.76

rCSI 6%

PRS 83.3
sst GABAergic cortical interneuron CL4023017

CSI 6.65

rCSI 8.57%

PRS 71.15
vascular associated smooth muscle cell CL0000359

CSI 6.5

rCSI 21.09%

PRS 83.84
epithelial cell CL0000066

CSI 6.4

rCSI 9.83%

PRS 74.5
respiratory suprabasal cell CL4033048

CSI 6.28

rCSI 8.06%

PRS 88.3
transit amplifying cell CL0009010

CSI 6.16

rCSI 9.43%

PRS 91.02
innate lymphoid cell CL0001065

CSI 6.13

rCSI 12.66%

PRS 81.25
transit amplifying cell of small intestine CL0009012

CSI 6

rCSI 26.33%

PRS 91.01
stromal cell CL0000499

CSI 5.96

rCSI 16.78%

PRS 81.15
multi-ciliated epithelial cell CL0005012

CSI 5.79

rCSI 5.78%

PRS 80.03
retinal bipolar neuron CL0000748

CSI 5.73

rCSI 10.73%

PRS 75.73
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 5.71

rCSI 13.01%

PRS 79.09
retinal blood vessel endothelial cell CL0002585

CSI 5.55

rCSI 8.87%

PRS 89.02
lung pericyte CL0009089

CSI 5.46

rCSI 14.41%

PRS 90.84
melanocyte CL0000148

CSI 5.39

rCSI 3.99%

PRS 80.67
conjunctival epithelial cell CL1000432

CSI 5.27

rCSI 8.06%

PRS 85.59
CD8-positive, alpha-beta memory T cell CL0000909

CSI 5.25

rCSI 5.49%

PRS 94.33
respiratory hillock cell CL4030023

CSI 5.23

rCSI 9.33%

PRS 91.53
peripheral nervous system neuron CL2000032

CSI 5.11

rCSI 6.97%

PRS 78.41
mononuclear phagocyte CL0000113

CSI 5.1

rCSI 11.23%

PRS 88.76
pancreatic PP cell CL0002275

CSI 5.09

rCSI 20.27%

PRS 90.73
fallopian tube secretory epithelial cell CL4030006

CSI 5.03

rCSI 4.84%

PRS 84.9
ON-bipolar cell CL0000749

CSI 4.94

rCSI 7.35%

PRS 85.24
Hofbauer cell CL3000001

CSI 4.71

rCSI 8.89%

PRS 91.99
group 3 innate lymphoid cell CL0001071

CSI 4.69

rCSI 3.52%

PRS 90.31
enteroendocrine cell CL0000164

CSI 4.45

rCSI 6.08%

PRS 84.79
intestinal crypt stem cell of colon CL0009043

CSI 4.41

rCSI 33.1%

PRS 92.39
hematopoietic stem cell CL0000037

CSI 4.27

rCSI 2.84%

PRS 87.69
cerebral cortex neuron CL0010012

CSI 4.25

rCSI 17.3%

PRS 77.89
tracheobronchial smooth muscle cell CL0019019

CSI 4.21

rCSI 7.43%

PRS 89.51
basal cell of prostate epithelium CL0002341

CSI 4.18

rCSI 12.08%

PRS 90.06
ciliated epithelial cell CL0000067

CSI 4.12

rCSI 3.63%

PRS 76.08
pvalb GABAergic cortical interneuron CL4023018

CSI 4.03

rCSI 5.02%

PRS 67.87
inhibitory interneuron CL0000498

CSI 3.87

rCSI 8.92%

PRS 75.15
cardiac endothelial cell CL0010008

CSI 3.83

rCSI 15.45%

PRS 86.26
helper T cell CL0000912

CSI 3.68

rCSI 5.21%

PRS 83.03
luminal cell of prostate epithelium CL0002340

CSI 3.64

rCSI 19.57%

PRS 91.52
squamous epithelial cell CL0000076

CSI 3.54

rCSI 8.41%

PRS 84.49
cytotoxic T cell CL0000910

CSI 3.42

rCSI 19.61%

PRS 86.97
pancreatic D cell CL0000173

CSI 3.35

rCSI 3.29%

PRS 87.67
intestinal epithelial cell CL0002563

CSI 3.34

rCSI 3.49%

PRS 83.22
intestinal crypt stem cell of small intestine CL0009017

CSI 3.26

rCSI 8.79%

PRS 88.91
keratinocyte CL0000312

CSI 3.26

rCSI 2.73%

PRS 87.55
mesodermal cell CL0000222

CSI 3.08

rCSI 3.69%

PRS 84.03
ionocyte CL0005006

CSI 2.95

rCSI 3.16%

PRS 87.72
VIP GABAergic cortical interneuron CL4023016

CSI 2.9

rCSI 3.46%

PRS 70.14
myeloid leukocyte CL0000766

CSI 2.88

rCSI 2.66%

PRS 86.96
chondrocyte CL0000138

CSI 2.85

rCSI 4.53%

PRS 79.88
choroid plexus epithelial cell CL0000706

CSI 2.81

rCSI 4.61%

PRS 76.91
fibroblast of breast CL4006000

CSI 2.8

rCSI 11.79%

PRS 88.84
mesenchymal cell CL0008019

CSI 2.75

rCSI 6.99%

PRS 79.7
tendon cell CL0000388

CSI 2.73

rCSI 7.08%

PRS 90.31
retina horizontal cell CL0000745

CSI 2.66

rCSI 4.06%

PRS 82.86
mucous neck cell CL0000651

CSI 2.48

rCSI 3.58%

PRS 90.21
OFF-bipolar cell CL0000750

CSI 2.36

rCSI 3.22%

PRS 86.08
foveolar cell of stomach CL0002179

CSI 2.32

rCSI 4.95%

PRS 89.56
dopaminergic neuron CL0000700

CSI 2.32

rCSI 13.13%

PRS 73.4
basal cell of epidermis CL0002187

CSI 2.29

rCSI 4.05%

PRS 55.41
duct epithelial cell CL0000068

CSI 2.24

rCSI 3.28%

PRS 89.83
enterocyte of epithelium of small intestine CL1000334

CSI 2.13

rCSI 32.98%

PRS 90.64
pancreatic ductal cell CL0002079

CSI 2.08

rCSI 4.05%

PRS 88.31
ependymal cell CL0000065

CSI 2.06

rCSI 4.19%

PRS 66.18
bronchiolar smooth muscle cell CL4033017

CSI 1.99

rCSI 29.9%

PRS 91.63
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.94

rCSI 3.43%

PRS 69.55
lung ciliated cell CL1000271

CSI 1.92

rCSI 2.22%

PRS 79.26

hair follicular keratinocyte CL2000092

CSI 0.3

rCSI 5.6%

PRS 91.6%
prostate gland microvascular endothelial cell CL2000059

CSI 0.4

rCSI 8.8%

PRS 91.3%
epithelial cell of esophagus CL0002252

CSI 0.4

rCSI 4.2%

PRS 87.4%
podocyte CL0000653

CSI 0.5

rCSI 2.3%

PRS 86.5%
blood vessel smooth muscle cell CL0019018

CSI 0.6

rCSI 4.5%

PRS 81.4%
kidney interstitial cell CL1000500

CSI 0.6

rCSI 9.6%

PRS 88.1%
epithelial cell of urethra CL1000296

CSI 0.7

rCSI 16.9%

PRS 90.4%
bronchial goblet cell CL1000312

CSI 0.9

rCSI 3.6%

PRS 90.6%
keratocyte CL0002363

CSI 1.2

rCSI 2.8%

PRS 87.6%
vein endothelial cell of respiratory system CL4033008

CSI 1.2

rCSI 8.5%

PRS 90.2%
type L enteroendocrine cell CL0002279

CSI 1.2

rCSI 2.3%

PRS 89.5%
endothelial cell of uterus CL0009095

CSI 1.3

rCSI 9.5%

PRS 91.4%
smooth muscle cell of prostate CL1000487

CSI 1.3

rCSI 7.9%

PRS 89.7%
endocardial cell CL0002350

CSI 1.4

rCSI 6.7%

PRS 81.9%
enteroendocrine cell of colon CL0009042

CSI 1.5

rCSI 7.0%

PRS 90.3%
deuterosomal cell CL4033044

CSI 1.5

rCSI 5.0%

PRS 81.7%
mammary gland epithelial cell CL0002327

CSI 1.5

rCSI 5.3%

PRS 91.4%
enterocyte of epithelium of large intestine CL0002071

CSI 1.5

rCSI 8.1%

PRS 89.0%
club cell CL0000158

CSI 1.6

rCSI 2.3%

PRS 80.8%
small intestine goblet cell CL1000495

CSI 1.7

rCSI 3.6%

PRS 89.5%
paneth cell of colon CL0009009

CSI 1.7

rCSI 16.8%

PRS 91.1%
T-helper 1 cell CL0000545

CSI 1.8

rCSI 3.2%

PRS 95.8%
paneth cell of epithelium of small intestine CL1000343

CSI 1.9

rCSI 5.3%

PRS 90.4%
lung ciliated cell CL1000271

CSI 1.9

rCSI 2.2%

PRS 79.3%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.9

rCSI 3.4%

PRS 69.6%
bronchiolar smooth muscle cell CL4033017

CSI 2.0

rCSI 29.9%

PRS 91.6%
ependymal cell CL0000065

CSI 2.1

rCSI 4.2%

PRS 66.2%
pancreatic ductal cell CL0002079

CSI 2.1

rCSI 4.1%

PRS 88.3%
enterocyte of epithelium of small intestine CL1000334

CSI 2.1

rCSI 33.0%

PRS 90.6%
duct epithelial cell CL0000068

CSI 2.2

rCSI 3.3%

PRS 89.8%
basal cell of epidermis CL0002187

CSI 2.3

rCSI 4.1%

PRS 55.4%
dopaminergic neuron CL0000700

CSI 2.3

rCSI 13.1%

PRS 73.4%
foveolar cell of stomach CL0002179

CSI 2.3

rCSI 5.0%

PRS 89.6%
OFF-bipolar cell CL0000750

CSI 2.4

rCSI 3.2%

PRS 86.1%
mucous neck cell CL0000651

CSI 2.5

rCSI 3.6%

PRS 90.2%
retina horizontal cell CL0000745

CSI 2.7

rCSI 4.1%

PRS 82.9%
tendon cell CL0000388

CSI 2.7

rCSI 7.1%

PRS 90.3%
mesenchymal cell CL0008019

CSI 2.8

rCSI 7.0%

PRS 79.7%
fibroblast of breast CL4006000

CSI 2.8

rCSI 11.8%

PRS 88.8%
choroid plexus epithelial cell CL0000706

CSI 2.8

rCSI 4.6%

PRS 76.9%
chondrocyte CL0000138

CSI 2.9

rCSI 4.5%

PRS 79.9%
myeloid leukocyte CL0000766

CSI 2.9

rCSI 2.7%

PRS 87.0%
VIP GABAergic cortical interneuron CL4023016

CSI 2.9

rCSI 3.5%

PRS 70.1%
ionocyte CL0005006

CSI 3.0

rCSI 3.2%

PRS 87.7%
mesodermal cell CL0000222

CSI 3.1

rCSI 3.7%

PRS 84.0%
keratinocyte CL0000312

CSI 3.3

rCSI 2.7%

PRS 87.6%
intestinal crypt stem cell of small intestine CL0009017

CSI 3.3

rCSI 8.8%

PRS 88.9%
intestinal epithelial cell CL0002563

CSI 3.3

rCSI 3.5%

PRS 83.2%
pancreatic D cell CL0000173

CSI 3.4

rCSI 3.3%

PRS 87.7%
cytotoxic T cell CL0000910

CSI 3.4

rCSI 19.6%

PRS 87.0%
squamous epithelial cell CL0000076

CSI 3.5

rCSI 8.4%

PRS 84.5%
luminal cell of prostate epithelium CL0002340

CSI 3.6

rCSI 19.6%

PRS 91.5%
helper T cell CL0000912

CSI 3.7

rCSI 5.2%

PRS 83.0%
cardiac endothelial cell CL0010008

CSI 3.8

rCSI 15.5%

PRS 86.3%
inhibitory interneuron CL0000498

CSI 3.9

rCSI 8.9%

PRS 75.2%
pvalb GABAergic cortical interneuron CL4023018

CSI 4.0

rCSI 5.0%

PRS 67.9%
ciliated epithelial cell CL0000067

CSI 4.1

rCSI 3.6%

PRS 76.1%
basal cell of prostate epithelium CL0002341

CSI 4.2

rCSI 12.1%

PRS 90.1%
tracheobronchial smooth muscle cell CL0019019

CSI 4.2

rCSI 7.4%

PRS 89.5%
cerebral cortex neuron CL0010012

CSI 4.3

rCSI 17.3%

PRS 77.9%
hematopoietic stem cell CL0000037

CSI 4.3

rCSI 2.8%

PRS 87.7%
intestinal crypt stem cell of colon CL0009043

CSI 4.4

rCSI 33.1%

PRS 92.4%
enteroendocrine cell CL0000164

CSI 4.5

rCSI 6.1%

PRS 84.8%
group 3 innate lymphoid cell CL0001071

CSI 4.7

rCSI 3.5%

PRS 90.3%
Hofbauer cell CL3000001

CSI 4.7

rCSI 8.9%

PRS 92.0%
ON-bipolar cell CL0000749

CSI 4.9

rCSI 7.4%

PRS 85.2%
fallopian tube secretory epithelial cell CL4030006

CSI 5.0

rCSI 4.8%

PRS 84.9%
pancreatic PP cell CL0002275

CSI 5.1

rCSI 20.3%

PRS 90.7%
mononuclear phagocyte CL0000113

CSI 5.1

rCSI 11.2%

PRS 88.8%
peripheral nervous system neuron CL2000032

CSI 5.1

rCSI 7.0%

PRS 78.4%
respiratory hillock cell CL4030023

CSI 5.2

rCSI 9.3%

PRS 91.5%
CD8-positive, alpha-beta memory T cell CL0000909

CSI 5.3

rCSI 5.5%

PRS 94.3%
conjunctival epithelial cell CL1000432

CSI 5.3

rCSI 8.1%

PRS 85.6%
melanocyte CL0000148

CSI 5.4

rCSI 4.0%

PRS 80.7%
lung pericyte CL0009089

CSI 5.5

rCSI 14.4%

PRS 90.8%
retinal blood vessel endothelial cell CL0002585

CSI 5.6

rCSI 8.9%

PRS 89.0%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 5.7

rCSI 13.0%

PRS 79.1%
retinal bipolar neuron CL0000748

CSI 5.7

rCSI 10.7%

PRS 75.7%
multi-ciliated epithelial cell CL0005012

CSI 5.8

rCSI 5.8%

PRS 80.0%
stromal cell CL0000499

CSI 6.0

rCSI 16.8%

PRS 81.2%
transit amplifying cell of small intestine CL0009012

CSI 6.0

rCSI 26.3%

PRS 91.0%
innate lymphoid cell CL0001065

CSI 6.1

rCSI 12.7%

PRS 81.3%
transit amplifying cell CL0009010

CSI 6.2

rCSI 9.4%

PRS 91.0%
respiratory suprabasal cell CL4033048

CSI 6.3

rCSI 8.1%

PRS 88.3%
epithelial cell CL0000066

CSI 6.4

rCSI 9.8%

PRS 74.5%
vascular associated smooth muscle cell CL0000359

CSI 6.5

rCSI 21.1%

PRS 83.8%
sst GABAergic cortical interneuron CL4023017

CSI 6.7

rCSI 8.6%

PRS 71.2%
intestine goblet cell CL0019031

CSI 6.8

rCSI 6.0%

PRS 83.3%
smooth muscle cell CL0000192

CSI 6.9

rCSI 16.5%

PRS 81.1%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 7.4

rCSI 9.0%

PRS 66.2%
adventitial cell CL0002503

CSI 7.8

rCSI 18.7%

PRS 88.7%
sncg GABAergic cortical interneuron CL4023015

CSI 7.9

rCSI 12.7%

PRS 71.4%
pancreatic A cell CL0000171

CSI 8.6

rCSI 9.1%

PRS 88.4%
pancreatic stellate cell CL0002410

CSI 8.7

rCSI 50.4%

PRS 88.2%
perivascular cell CL4033054

CSI 9.1

rCSI 12.5%

PRS 89.6%
goblet cell CL0000160

CSI 9.1

rCSI 8.6%

PRS 83.8%
secretory cell CL0000151

CSI 9.3

rCSI 9.7%

PRS 84.9%
T-helper 17 cell CL0000899

CSI 9.3

rCSI 7.4%

PRS 97.2%
enteric smooth muscle cell CL0002504

CSI 9.5

rCSI 13.5%

PRS 86.3%
BEST4+ enteroycte CL4030026

CSI 9.9

rCSI 12.3%

PRS 86.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [NBL1](/details-gene/4681) (Neuroblastoma 1, DAN family BMP antagonist) is a protein-coding gene located on chromosome 1p36.13. As a member of the DAN family, it functions as a secreted antagonist of Bone Morphogenetic Proteins (BMPs). By binding to BMPs in the extracellular space, [NBL1](/details-gene/4681) negatively regulates BMP signaling pathways, which are critical for a wide range of developmental and homeostatic processes, including nervous system development and cell differentiation. Expression data indicates that [NBL1](/details-gene/4681) is most prominently active in various fibroblast populations, particularly within the lung, as well as in epithelial and certain immune cell types, suggesting a key role in tissue maintenance, remodeling, and local immune modulation. A clinical association with this gene has been noted ([Link](https://omim.org/entry/600613)). ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [NBL1](/details-gene/4681) highlights its significant role in stromal and structural cells, particularly fibroblasts. The gene shows its highest significance in lung-resident fibroblasts, including [bronchus fibroblast of lung](/details-cell/CL2000093) (CSI: 57.93), [alveolar type 1 fibroblast cell](/details-cell/CL4028004) (CSI: 40.72), and [fibroblast of lung](/details-cell/CL0002553) (CSI: 33.62), as well as [skin fibroblast](/details-cell/CL0002620) and [myofibroblast cell](/details-cell/CL0000186). This pattern is consistent with a crucial function in maintaining the structural integrity and homeostatic balance of connective tissues, likely through the modulation of extracellular matrix dynamics. Beyond its primary association with fibroblasts, [NBL1](/details-gene/4681) is also significantly expressed in several epithelial and progenitor cell populations. These include [respiratory basal cell](/details-cell/CL0002633) (CSI: 29.23) in the lung and various cells of the gastrointestinal tract, such as [transit amplifying cell of colon](/details-cell/CL0009011) (CSI: 28.77), [enterocyte](/details-cell/CL0000584) (CSI: 17.37), and [colon epithelial cell](/details-cell/CL0011108) (CSI: 17.11). This suggests a role in regulating epithelial cell proliferation and differentiation at mucosal barriers. Furthermore, [NBL1](/details-gene/4681) shows notable expression in immune cells, including [conventional dendritic cell](/details-cell/CL0000990) (CSI: 26.12) and [CD4-positive helper T cell](/details-cell/CL0000492) (CSI: 18.07). This expression pattern points towards a potential immunomodulatory function, where [NBL1](/details-gene/4681) secreted by immune or stromal cells may influence local immune cell trafficking and responses. ## Pathways and Molecular Function The functional annotations for [NBL1](/details-gene/4681) confirm its role as an extracellular regulator of cell signaling. Its primary molecular function is to act as a BMP antagonist through direct [Bmp binding](/details-gene/GO:0036122) in the [extracellular space](/details-gene/GO:0005615). This activity leads to the [negative regulation of bmp signaling pathway](/details-gene/GO:0030514) by sequestering these growth factors and preventing them from interacting with their cell surface receptors. This mechanism underlies its involvement in several key biological processes. Its role in development is highlighted by its association with [nervous system development](/details-gene/GO:0007399) and the [positive regulation of neuron differentiation](/details-gene/GO:0045666). The high expression in fibroblasts and epithelial cells aligns with its function in modulating tissue homeostasis. Furthermore, its annotated role in the [negative regulation of monocyte chemotaxis](/details-gene/GO:0090027) is consistent with its expression in immune cells and suggests a mechanism by which it could shape the inflammatory milieu within tissues. ## Research Directions The specific expression pattern and established anti-BMP function of [NBL1](/details-gene/4681) lead to several testable hypotheses regarding its role in health and disease. 1. **Hypothesis on Tissue Fibrosis:** Given its high expression in various fibroblast populations and its function as a BMP antagonist, [NBL1](/details-gene/4681) may function as a key negative regulator of fibrosis. Since some BMPs are pro-fibrotic, it is hypothesized that locally secreted [NBL1](/details-gene/4681) protects tissues like the lung from excessive fibroblast-to-myofibroblast differentiation and extracellular matrix deposition. A downregulation of [NBL1](/details-gene/4681) could therefore be a contributing factor to the pathogenesis of fibrotic diseases such as idiopathic pulmonary fibrosis (IPF). 2. **Hypothesis on Immune Homeostasis:** The expression of [NBL1](/details-gene/4681) in [conventional dendritic cells](/details-cell/CL0000990) and its documented role in negatively regulating monocyte chemotaxis suggest it contributes to immune quiescence at barrier tissues. We hypothesize that [NBL1](/details-gene/4681) secreted in the gut and lung microenvironments helps to limit the influx of inflammatory monocytes under homeostatic conditions, thereby preventing inappropriate inflammation. ### Proposed Experiment To test the hypothesis that [NBL1](/details-gene/4681) has an anti-fibrotic role (Hypothesis 1), a well-defined *in vitro* model could be employed. Primary human lung fibroblasts would be cultured and stimulated with a pro-fibrotic agent like TGF-beta1 to induce myofibroblast differentiation. The role of [NBL1](/details-gene/4681) could be investigated through loss-of-function and gain-of-function experiments. Knockdown of [NBL1](/details-gene/4681) using siRNA would be expected to potentiate the pro-fibrotic effects of TGF-beta1, leading to increased expression of alpha-smooth muscle actin (α-SMA) and collagen type I, as measured by western blot and qPCR. Conversely, treatment with recombinant human [NBL1](/details-gene/4681) protein would be expected to antagonize TGF-beta1-induced differentiation, thus attenuating the fibrotic response. ### Therapeutic Potential As a secreted protein that antagonizes a critical signaling pathway, [NBL1](/details-gene/4681) has significant therapeutic potential. In diseases characterized by excessive BMP signaling, such as certain fibrotic conditions or cancers, administration of recombinant [NBL1](/details-gene/4681) could serve as a biologic therapy to restore signaling balance. This represents a strategy of *activation* or supplementation. The high expression in fibroblasts suggests that targeting the regulation of endogenous [NBL1](/details-gene/4681) in these cells could also be a viable approach to modulate tissue remodeling and disease progression.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

A0A087WTY6_HUMAN

Genular Protein ID: 678218699

Symbol: A0A087WTY6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WTY6

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

Length: 215
Mass: 23239
Checksum: 6F601C269975E270
Sequence:

MCSLALQQLI SMDLFWRLFF VCGQEGLRAL EATGMMLRVL VGAVLPAMLL AAPPPINKLA 
LFPDKSAWCE AKNITQIVGH SGCEAKSIQN RACLGQCFSY SVPNTFPQST ESLVHCDSCM 
PAQSMWEIVT LECPGHEEVP RVDKLVEKIL HCSCQACGKE PSHEGLSVYV QGEDGPGSQP 
GTHPHPHPHP HPGGQTPEPE DPPGAPHTEE EGAED