Details for: NBL1

Gene ID: 4681

Symbol: NBL1

Ensembl ID: ENSG00000158747

Description: NBL1, DAN family BMP antagonist

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 305.1203
    Cell Significance Index: -47.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.4251
    Cell Significance Index: -45.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 100.6942
    Cell Significance Index: -47.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 96.0475
    Cell Significance Index: -39.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.7963
    Cell Significance Index: -38.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.6591
    Cell Significance Index: -47.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.4062
    Cell Significance Index: -43.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.0855
    Cell Significance Index: -47.6900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 8.5132
    Cell Significance Index: 50.0200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.8227
    Cell Significance Index: 23.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.5789
    Cell Significance Index: 48.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.1564
    Cell Significance Index: 2849.9700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.7700
    Cell Significance Index: 6.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6858
    Cell Significance Index: 76.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.4811
    Cell Significance Index: 43.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.2808
    Cell Significance Index: 47.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0500
    Cell Significance Index: 281.5200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.9935
    Cell Significance Index: 20.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5264
    Cell Significance Index: 69.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3247
    Cell Significance Index: 19.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0090
    Cell Significance Index: 29.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8292
    Cell Significance Index: 366.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7911
    Cell Significance Index: 58.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6956
    Cell Significance Index: 68.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5738
    Cell Significance Index: 34.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5329
    Cell Significance Index: 106.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4860
    Cell Significance Index: 16.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4856
    Cell Significance Index: 174.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4274
    Cell Significance Index: 233.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3754
    Cell Significance Index: 19.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3090
    Cell Significance Index: 14.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2832
    Cell Significance Index: 36.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2738
    Cell Significance Index: 18.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2662
    Cell Significance Index: 7.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2396
    Cell Significance Index: 29.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2121
    Cell Significance Index: 40.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1872
    Cell Significance Index: 13.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1777
    Cell Significance Index: 2.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1435
    Cell Significance Index: 1.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1312
    Cell Significance Index: 4.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1045
    Cell Significance Index: 18.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0821
    Cell Significance Index: 2.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0673
    Cell Significance Index: 8.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0373
    Cell Significance Index: 70.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0147
    Cell Significance Index: 10.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0179
    Cell Significance Index: -1.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0334
    Cell Significance Index: -61.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0347
    Cell Significance Index: -1.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0417
    Cell Significance Index: -64.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0494
    Cell Significance Index: -67.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0538
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0569
    Cell Significance Index: -42.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0576
    Cell Significance Index: -42.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0626
    Cell Significance Index: -47.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0825
    Cell Significance Index: -37.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0885
    Cell Significance Index: -49.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0911
    Cell Significance Index: -56.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0990
    Cell Significance Index: -6.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1386
    Cell Significance Index: -39.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1532
    Cell Significance Index: -3.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2077
    Cell Significance Index: -4.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2119
    Cell Significance Index: -24.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2270
    Cell Significance Index: -45.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2429
    Cell Significance Index: -27.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2735
    Cell Significance Index: -57.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3047
    Cell Significance Index: -44.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3083
    Cell Significance Index: -31.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3083
    Cell Significance Index: -52.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3573
    Cell Significance Index: -18.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3702
    Cell Significance Index: -3.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4149
    Cell Significance Index: -25.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4153
    Cell Significance Index: -48.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4171
    Cell Significance Index: -25.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4191
    Cell Significance Index: -43.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4319
    Cell Significance Index: -27.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4322
    Cell Significance Index: -9.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4504
    Cell Significance Index: -12.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5480
    Cell Significance Index: -43.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5689
    Cell Significance Index: -14.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6010
    Cell Significance Index: -46.1200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.6266
    Cell Significance Index: -4.8300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6463
    Cell Significance Index: -5.2700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6623
    Cell Significance Index: -7.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7218
    Cell Significance Index: -46.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7549
    Cell Significance Index: -42.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7751
    Cell Significance Index: -22.1200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.8431
    Cell Significance Index: -11.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8665
    Cell Significance Index: -43.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8766
    Cell Significance Index: -40.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9099
    Cell Significance Index: -26.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9286
    Cell Significance Index: -23.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9475
    Cell Significance Index: -41.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9945
    Cell Significance Index: -19.4100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.0002
    Cell Significance Index: -43.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0722
    Cell Significance Index: -39.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.1105
    Cell Significance Index: -42.0500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.1409
    Cell Significance Index: -18.8000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.1497
    Cell Significance Index: -7.7900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -1.1895
    Cell Significance Index: -10.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NBL1 is a secreted protein belonging to the DAN family, which is characterized by its ability to sequester BMPs from their receptors, thereby inhibiting BMP signaling. This antagonistic activity is mediated through the interaction of NBL1 with BMPs, leading to the suppression of BMP-induced responses. NBL1 is highly expressed in various tissues, including lung, prostate, and mammary gland fibroblasts, as well as in the nervous system and immune cells. **Pathways and Functions:** NBL1's primary function is to regulate BMP signaling, which is involved in a wide range of biological processes, including: 1. **Animal organ morphogenesis**: BMPs play a crucial role in the development of various organs, including the nervous system, and NBL1's antagonistic activity helps to fine-tune this process. 2. **Determination of dorsal identity**: BMPs are involved in the specification of dorsal-ventral axes during embryonic development, and NBL1's regulation of BMP signaling is essential for maintaining proper patterning. 3. **Morphogen activity**: BMPs are classified as morphogens due to their ability to diffuse and induce cellular responses over long distances. NBL1's sequestration of BMPs helps to limit their range and prevent excessive morphogen activity. 4. **Negative regulation of BMP signaling pathway**: By sequestering BMPs, NBL1 inhibits the activation of BMP receptors, thereby reducing the downstream effects of BMP signaling. 5. **Regulation of immune responses**: NBL1's expression in immune cells, such as fibroblasts and decidual cells, suggests a role in modulating immune responses, including the regulation of monocyte chemotaxis. **Clinical Significance:** NBL1's dysregulation has been implicated in various diseases, including: 1. **Cancer**: Alterations in BMP signaling, mediated by NBL1, have been associated with cancer development and progression. 2. **Autoimmune diseases**: NBL1's role in regulating immune responses suggests that dysregulation of this protein may contribute to autoimmune diseases, such as rheumatoid arthritis. 3. **Neurological disorders**: NBL1's expression in the nervous system and its involvement in neuron differentiation and morphogenesis imply a potential role in neurological disorders, such as Alzheimer's disease. In conclusion, NBL1 is a critical regulator of BMP signaling, and its dysregulation has significant implications for various diseases. Further research is needed to fully elucidate the mechanisms by which NBL1 modulates immune responses and tissue development, and to explore the therapeutic potential of targeting this protein in disease contexts.

Genular Protein ID: 678218699

Symbol: A0A087WTY6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WTY6

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 215
  • Mass: 23239
  • Checksum: 6F601C269975E270
  • Sequence:
    • MCSLALQQLI SMDLFWRLFF VCGQEGLRAL EATGMMLRVL VGAVLPAMLL AAPPPINKLA 
LFPDKSAWCE AKNITQIVGH SGCEAKSIQN RACLGQCFSY SVPNTFPQST ESLVHCDSCM 
PAQSMWEIVT LECPGHEEVP RVDKLVEKIL HCSCQACGKE PSHEGLSVYV QGEDGPGSQP 
GTHPHPHPHP HPGGQTPEPE DPPGAPHTEE EGAED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.