NCK1 | ENSG00000158092 | NCBI 4690

Details for: NCK1

Gene ID: 4690

Symbol: NCK1

Ensembl ID: ENSG00000158092

Description: NCK adaptor protein 1

Associated with

Activation of rac1
(R-HSA-428540)
Adaptive immune system
(R-HSA-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Axon guidance
(R-HSA-422475)
Cell-cell communication
(R-HSA-1500931)
Cytokine signaling in immune system
(R-HSA-1280215)
Dcc mediated attractive signaling
(R-HSA-418885)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Downstream signal transduction
(R-HSA-186763)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Generation of second messenger molecules
(R-HSA-202433)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon signaling
(R-HSA-913531)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Nephrin family interactions
(R-HSA-373753)
Nervous system development
(R-HSA-9675108)
Netrin-1 signaling
(R-HSA-373752)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Pkr-mediated signaling
(R-HSA-9833482)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Rhou gtpase cycle
(R-HSA-9013420)
Rhov gtpase cycle
(R-HSA-9013424)
Sars-cov infections
(R-HSA-9679506)
Signaling by pdgf
(R-HSA-186797)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Tcr signaling
(R-HSA-202403)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Viral infection pathways
(R-HSA-9824446)
Actin filament organization
(GO:0007015)
Antiviral innate immune response
(GO:0140374)
Cadherin binding
(GO:0045296)
Cell-cell junction
(GO:0005911)
Cell migration
(GO:0016477)
Cytoplasm
(GO:0005737)
Cytoskeletal anchor activity
(GO:0008093)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Eukaryotic initiation factor eif2 binding
(GO:0071074)
Lamellipodium assembly
(GO:0030032)
Molecular condensate scaffold activity
(GO:0140693)
Negative regulation of endoplasmic reticulum stress-induced eif2 alpha phosphorylation
(GO:1903912)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of perk-mediated unfolded protein response
(GO:1903898)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of cap-dependent translational initiation
(GO:1903676)
Positive regulation of cap-independent translational initiation
(GO:1903679)
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902237)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of translation in response to endoplasmic reticulum stress
(GO:0036493)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase inhibitor activity
(GO:0004860)
Protein phosphatase type 1 complex
(GO:0000164)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of cell migration
(GO:0030334)
Response to endoplasmic reticulum stress
(GO:0034976)
Ribosome
(GO:0005840)
Signal complex assembly
(GO:0007172)
Signaling adaptor activity
(GO:0035591)
Signaling receptor binding
(GO:0005102)
Signaling receptor complex adaptor activity
(GO:0030159)
Substrate-dependent cell migration, cell extension
(GO:0006930)
T cell activation
(GO:0042110)
Vesicle membrane
(GO:0012506)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 241.8589
Cell Significance Index: -37.6200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 130.8136
Cell Significance Index: -33.1800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 96.3229
Cell Significance Index: -39.6800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 85.0838
Cell Significance Index: -40.1700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 76.3436
Cell Significance Index: -39.2700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 60.0055
Cell Significance Index: -40.2700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 31.5989
Cell Significance Index: -38.9600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.2440
Cell Significance Index: -32.8000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.9666
Cell Significance Index: -26.1900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.9568
Cell Significance Index: -39.2900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.7576
Cell Significance Index: -29.9700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.0506
Cell Significance Index: 141.8100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.9665
Cell Significance Index: 26.8300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.4604
Cell Significance Index: 39.7500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2992
Cell Significance Index: 1173.0900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1838
Cell Significance Index: 234.9300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.1125
Cell Significance Index: 31.0900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.1037
Cell Significance Index: 51.8800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.0988
Cell Significance Index: 29.3400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.0343
Cell Significance Index: 29.6500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.9312
Cell Significance Index: 644.0700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9305
Cell Significance Index: 186.6600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.9146
Cell Significance Index: 23.5100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7302
Cell Significance Index: 72.2300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6981
Cell Significance Index: 113.5400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.6775
Cell Significance Index: 38.0200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6313
Cell Significance Index: 226.4300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6027
Cell Significance Index: 266.4500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5585
Cell Significance Index: 76.7000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5084
Cell Significance Index: 277.6300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4602
Cell Significance Index: 56.5800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3987
Cell Significance Index: 71.8800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3055
Cell Significance Index: 36.0300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.3044
Cell Significance Index: 39.0200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2868
Cell Significance Index: 7.1700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2806
Cell Significance Index: 12.7200
Cell Name: lactocyte (CL0002325)
Fold Change: 0.2754
Cell Significance Index: 35.5800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2630
Cell Significance Index: 20.1900
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.2152
Cell Significance Index: 1.9100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1787
Cell Significance Index: 5.1500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1635
Cell Significance Index: 31.1200
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.1453
Cell Significance Index: 2.0900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1451
Cell Significance Index: 8.9200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1131
Cell Significance Index: 2.4500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1076
Cell Significance Index: 7.6100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1004
Cell Significance Index: 4.6800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0875
Cell Significance Index: 55.5500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0485
Cell Significance Index: 91.2500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0257
Cell Significance Index: 0.4400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0252
Cell Significance Index: 0.7400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0165
Cell Significance Index: 25.3800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0153
Cell Significance Index: 2.6100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0140
Cell Significance Index: 18.9700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0089
Cell Significance Index: 4.0600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0084
Cell Significance Index: 15.5000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0004
Cell Significance Index: 0.0100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0083
Cell Significance Index: -0.4300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0120
Cell Significance Index: -8.8800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0131
Cell Significance Index: -0.8400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0188
Cell Significance Index: -11.7400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0282
Cell Significance Index: -0.9900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0344
Cell Significance Index: -26.0500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0372
Cell Significance Index: -27.2600
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0451
Cell Significance Index: -0.8800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0456
Cell Significance Index: -25.6900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0530
Cell Significance Index: -0.3200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0641
Cell Significance Index: -6.5500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0668
Cell Significance Index: -4.2100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0881
Cell Significance Index: -1.4800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1068
Cell Significance Index: -7.1800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1162
Cell Significance Index: -24.4800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1163
Cell Significance Index: -33.4500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1291
Cell Significance Index: -18.7700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1435
Cell Significance Index: -10.7000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1456
Cell Significance Index: -6.4400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1721
Cell Significance Index: -19.6400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1869
Cell Significance Index: -21.4100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1901
Cell Significance Index: -9.9800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2113
Cell Significance Index: -24.6300
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2256
Cell Significance Index: -3.8000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2334
Cell Significance Index: -8.8400
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2363
Cell Significance Index: -5.0500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3440
Cell Significance Index: -35.8200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3746
Cell Significance Index: -7.8400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3840
Cell Significance Index: -13.3500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4175
Cell Significance Index: -8.6600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4312
Cell Significance Index: -13.8100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4460
Cell Significance Index: -35.3300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4950
Cell Significance Index: -13.2400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5265
Cell Significance Index: -13.4500
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5398
Cell Significance Index: -14.2000
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5408
Cell Significance Index: -12.9700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5431
Cell Significance Index: -33.3000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5620
Cell Significance Index: -11.9700
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.5976
Cell Significance Index: -8.8200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.6240
Cell Significance Index: -31.5400
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.6521
Cell Significance Index: -9.3700
Cell Name: peg cell (CL4033014)
Fold Change: -0.6822
Cell Significance Index: -15.7600
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.7470
Cell Significance Index: -13.2000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7798
Cell Significance Index: -25.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** NCK1 is a cytoplasmic protein that belongs to the NCK family of adaptor proteins. It is characterized by its ability to interact with a wide range of proteins, including receptors, kinases, and phosphatases, thereby regulating various signaling pathways. NCK1 is highly expressed in various cell types, including immune cells, epithelial cells, and neural cells. **Pathways and Functions:** NCK1 is involved in numerous signaling pathways, including: 1. **Actin filament organization**: NCK1 regulates actin filament polymerization and dynamics, which is essential for cell migration, phagocytosis, and cell shape changes. 2. **Immune response**: NCK1 interacts with immune receptors, such as Fcγ receptors, to regulate phagocytosis, antibody-dependent cellular cytotoxicity, and immune cell activation. 3. **Signaling by receptor tyrosine kinases**: NCK1 binds to receptor tyrosine kinases, such as PDGFR, to regulate signal transduction and cell proliferation. 4. **Rho GTPase cycle**: NCK1 interacts with Rho GTPases to regulate actin dynamics, cell migration, and cytoskeleton organization. 5. **Endoplasmic reticulum stress response**: NCK1 regulates the unfolded protein response by interacting with PERK and other downstream targets. **Clinical Significance:** NCK1 plays a crucial role in various diseases, including: 1. **Infectious diseases**: NCK1 is involved in the regulation of immune response to viral and bacterial infections, such as SARS-CoV and Leishmania. 2. **Cancer**: NCK1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with tumor progression and metastasis. 3. **Neurological disorders**: NCK1 is involved in the regulation of neural cell migration and differentiation, and is associated with neurodevelopmental disorders, such as autism and schizophrenia. 4. **Autoimmune diseases**: NCK1 is involved in the regulation of immune response to self-antigens, and is associated with autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, NCK1 is a multifunctional adaptor protein that plays a crucial role in regulating immune response, cell migration, and signaling pathways. Its dysregulation is associated with various diseases, highlighting the importance of NCK1 as a therapeutic target for the treatment of infectious diseases, cancer, and autoimmune disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cytoplasmic protein NCK1

Genular Protein ID: 1003542545

Symbol: NCK1_HUMAN

Name: Cytoplasmic protein NCK1

UniProtKB Accession Codes:

P16333 B7Z751 D3DNE3

Database IDs:

Citations:

PubMed ID: 2107526

Title: Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3.

PubMed ID: 2107526

DOI: 10.1093/nar/18.4.1048

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1333046

Title: Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP.

PubMed ID: 1333046

DOI: 10.1128/mcb.12.12.5816-5823.1992

PubMed ID: 1448108

Title: The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment.

PubMed ID: 1448108

DOI: 10.1128/mcb.12.12.5843-5856.1992

PubMed ID: 7692233

Title: Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

PubMed ID: 7692233

DOI: 10.1128/mcb.13.11.6889-6896.1993

PubMed ID: 9344857

Title: A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.

PubMed ID: 9344857

DOI: 10.1006/bbrc.1997.7492

PubMed ID: 9600074

Title: Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.

PubMed ID: 9600074

DOI: 10.1006/bbrc.1998.8578

PubMed ID: 9697839

Title: BLNK: a central linker protein in B cell activation.

PubMed ID: 9697839

DOI: 10.1016/s1074-7613(00)80591-9

PubMed ID: 9430661

Title: Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase.

PubMed ID: 9430661

DOI: 10.1074/jbc.273.3.1303

PubMed ID: 10026169

Title: Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.

PubMed ID: 10026169

DOI: 10.1074/jbc.274.9.5542

PubMed ID: 10747847

Title: Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.

PubMed ID: 10747847

DOI: 10.1074/jbc.c000085200

PubMed ID: 12091389

Title: Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.

PubMed ID: 12091389

DOI: 10.1074/jbc.m204367200

PubMed ID: 15504032

Title: Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).

PubMed ID: 15504032

DOI: 10.1021/bi049295+

PubMed ID: 15469942

Title: Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta.

PubMed ID: 15469942

DOI: 10.1074/jbc.m404497200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16835242

Title: Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.

PubMed ID: 16835242

DOI: 10.1074/jbc.m513556200

PubMed ID: 16966330

Title: Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.

PubMed ID: 16966330

DOI: 10.1074/jbc.m603928200

PubMed ID: 17803907

Title: Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.

PubMed ID: 17803907

DOI: 10.1016/j.cell.2007.06.053

PubMed ID: 18835251

Title: Nck-1 interacts with PKR and modulates its activation by dsRNA.

PubMed ID: 18835251

DOI: 10.1016/j.bbrc.2008.09.112

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18296648

Title: Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.

PubMed ID: 18296648

DOI: 10.1158/1541-7786.mcr-07-2028

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21707536

Title: Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.

PubMed ID: 21707536

DOI: 10.1042/bj20110799

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21664272

Title: Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity.

PubMed ID: 21664272

DOI: 10.1016/j.cellsig.2011.05.019

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23358419

Title: Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration.

PubMed ID: 23358419

DOI: 10.1128/mcb.01708-12

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18269246

Title: Specificity determinants of a novel Nck interaction with the juxtamembrane domain of the epidermal growth factor receptor.

PubMed ID: 18269246

DOI: 10.1021/bi701549a

Sequence Information:

Length: 377
Mass: 42864
Checksum: 554E9B1A936AEF30
Sequence:

MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNKTGF VPSNYVERKN 
SARKASIVKN LKDTLGIGKV KRKPSVPDSA SPADDSFVDP GERLYDLNMP AYVKFNYMAE 
REDELSLIKG TKVIVMEKCS DGWWRGSYNG QVGWFPSNYV TEEGDSPLGD HVGSLSEKLA 
AVVNNLNTGQ VLHVVQALYP FSSSNDEELN FEKGDVMDVI EKPENDPEWW KCRKINGMVG 
LVPKNYVTVM QNNPLTSGLE PSPPQCDYIR PSLTGKFAGN PWYYGKVTRH QAEMALNERG 
HEGDFLIRDS ESSPNDFSVS LKAQGKNKHF KVQLKETVYC IGQRKFSTME ELVEHYKKAP 
IFTSEQGEKL YLVKHLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NCK1

Associated with

Cells (max top 100)

Other Information

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3. PubMed ID: 2107526

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP. PubMed ID: 1333046

The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment. PubMed ID: 1448108

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor. PubMed ID: 7692233

A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. PubMed ID: 9344857

Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2. PubMed ID: 9600074

BLNK: a central linker protein in B cell activation. PubMed ID: 9697839

Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase. PubMed ID: 9430661

Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. PubMed ID: 10026169

Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. PubMed ID: 10747847

Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. PubMed ID: 12091389

Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27). PubMed ID: 15504032

Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. PubMed ID: 15469942

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress. PubMed ID: 16835242

Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. PubMed ID: 16966330

Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. PubMed ID: 17803907

Nck-1 interacts with PKR and modulates its activation by dsRNA. PubMed ID: 18835251

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. PubMed ID: 18296648

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling. PubMed ID: 21707536

Initial characterization of the human central proteome. PubMed ID: 21269460

Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity. PubMed ID: 21664272

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration. PubMed ID: 23358419

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Specificity determinants of a novel Nck interaction with the juxtamembrane domain of the epidermal growth factor receptor. PubMed ID: 18269246