Details for: NDN

Gene ID: 4692

Symbol: NDN

Ensembl ID: ENSG00000182636

Description: necdin, MAGE family member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 213.0570
    Cell Significance Index: -33.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.9285
    Cell Significance Index: -31.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 86.8800
    Cell Significance Index: -35.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.1558
    Cell Significance Index: -32.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.9515
    Cell Significance Index: -33.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.2090
    Cell Significance Index: -35.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3552
    Cell Significance Index: -32.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 7.5465
    Cell Significance Index: 96.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.1181
    Cell Significance Index: 107.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.9725
    Cell Significance Index: 106.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.6251
    Cell Significance Index: 39.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.1147
    Cell Significance Index: 108.2400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.0388
    Cell Significance Index: 18.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.9644
    Cell Significance Index: 345.4700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.6059
    Cell Significance Index: 15.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1524
    Cell Significance Index: 295.5900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1.7998
    Cell Significance Index: 10.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7387
    Cell Significance Index: 91.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5562
    Cell Significance Index: 40.9200
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.3450
    Cell Significance Index: 6.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2179
    Cell Significance Index: 156.1300
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.1626
    Cell Significance Index: 5.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8595
    Cell Significance Index: 54.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.6026
    Cell Significance Index: 9.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5888
    Cell Significance Index: 35.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4631
    Cell Significance Index: 45.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4241
    Cell Significance Index: 382.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3828
    Cell Significance Index: 41.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2960
    Cell Significance Index: 59.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2709
    Cell Significance Index: 97.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2171
    Cell Significance Index: 95.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2101
    Cell Significance Index: 34.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1784
    Cell Significance Index: 2.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1695
    Cell Significance Index: 2.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1592
    Cell Significance Index: 28.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1501
    Cell Significance Index: 29.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1471
    Cell Significance Index: 10.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1294
    Cell Significance Index: 15.9100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.1216
    Cell Significance Index: 0.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0753
    Cell Significance Index: 1.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0715
    Cell Significance Index: 1.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0644
    Cell Significance Index: 12.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0159
    Cell Significance Index: 0.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0068
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0095
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0113
    Cell Significance Index: -8.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0216
    Cell Significance Index: -16.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0238
    Cell Significance Index: -17.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0250
    Cell Significance Index: -46.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0297
    Cell Significance Index: -45.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0308
    Cell Significance Index: -1.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0342
    Cell Significance Index: -46.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0381
    Cell Significance Index: -21.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0394
    Cell Significance Index: -0.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0406
    Cell Significance Index: -25.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0472
    Cell Significance Index: -25.7800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0479
    Cell Significance Index: -0.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0500
    Cell Significance Index: -2.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0506
    Cell Significance Index: -10.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0632
    Cell Significance Index: -28.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0685
    Cell Significance Index: -2.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0960
    Cell Significance Index: -27.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1254
    Cell Significance Index: -14.3700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1435
    Cell Significance Index: -1.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1488
    Cell Significance Index: -5.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1526
    Cell Significance Index: -10.7900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1557
    Cell Significance Index: -1.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1706
    Cell Significance Index: -24.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1925
    Cell Significance Index: -4.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1957
    Cell Significance Index: -5.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2226
    Cell Significance Index: -1.8700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2293
    Cell Significance Index: -1.4400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2376
    Cell Significance Index: -1.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2376
    Cell Significance Index: -7.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2393
    Cell Significance Index: -30.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2634
    Cell Significance Index: -26.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2724
    Cell Significance Index: -6.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2839
    Cell Significance Index: -33.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2850
    Cell Significance Index: -32.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2945
    Cell Significance Index: -15.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3091
    Cell Significance Index: -8.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3166
    Cell Significance Index: -32.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3204
    Cell Significance Index: -19.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3368
    Cell Significance Index: -9.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3376
    Cell Significance Index: -7.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3402
    Cell Significance Index: -15.8600
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3461
    Cell Significance Index: -2.1200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3498
    Cell Significance Index: -2.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3696
    Cell Significance Index: -29.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4050
    Cell Significance Index: -6.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4220
    Cell Significance Index: -31.4500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4242
    Cell Significance Index: -2.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4494
    Cell Significance Index: -21.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4583
    Cell Significance Index: -35.1700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5035
    Cell Significance Index: -4.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5052
    Cell Significance Index: -13.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5250
    Cell Significance Index: -33.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5266
    Cell Significance Index: -27.4300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.5346
    Cell Significance Index: -2.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Necdin exhibits several distinct characteristics that are relevant to its function and potential role in the immune system. These include: 1. **Cellular localization**: Necdin is primarily localized in the cytosol and nucleus, suggesting its involvement in regulating cellular processes at multiple levels. 2. **Gamma-tubulin binding**: Necdin interacts with gamma-tubulin, a protein essential for microtubule formation and dynamics, indicating its role in regulating microtubule organization and cell migration. 3. **DNA binding**: Necdin has been shown to bind to DNA, which may contribute to its regulatory functions in gene expression. 4. **Protein binding**: Necdin interacts with various proteins, including transcription factors and signaling molecules, which may modulate its activity and influence cellular processes. **Pathways and Functions** Necdin is involved in several cellular pathways and processes, including: 1. **Axonal fasciculation and extension**: Necdin plays a role in regulating axon extension and fasciculation, which are critical for neuronal development and function. 2. **Central nervous system development**: Necdin is involved in the development of the central nervous system, including neuron migration and differentiation. 3. **Immune system regulation**: Necdin has been implicated in regulating immune system function, including cytokine signaling and immune cell migration. 4. **Cytokine signaling**: Necdin interacts with cytokines, such as interleukin-4 and interleukin-13, which are essential for immune system function and regulation. **Clinical Significance** The clinical significance of Necdin is an area of active research, and its dysregulation has been implicated in various diseases, including: 1. **Neurological disorders**: Necdin's role in axonal fasciculation and neuronal development suggests its potential involvement in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). 2. **Immune system disorders**: Necdin's regulation of immune system function and cytokine signaling may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: Necdin's expression in cancer cells and its potential role in regulating cell migration and differentiation may contribute to cancer progression and metastasis. In conclusion, Necdin is a multifunctional protein involved in various cellular processes, including cell migration, differentiation, and survival. Its dysregulation has been implicated in various diseases, including neurological and immune system disorders. Further research is needed to fully understand the clinical significance of Necdin and its potential role in disease prevention and treatment.

Genular Protein ID: 934166782

Symbol: NECD_HUMAN

Name: Necdin

UniProtKB Accession Codes:

Q99608 B2R6Z5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9354807

Title: The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region.

PubMed ID: 9354807

DOI: 10.1038/ng1197-357

PubMed ID: 9630521

Title: The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region.

PubMed ID: 9630521

DOI: 10.1016/s0378-1119(98)00206-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21543378

Title: Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism.

PubMed ID: 21543378

DOI: 10.1530/eje-11-0199

Sequence Information:

  • Length: 321
  • Mass: 36086
  • Checksum: 5068FE121308BFAF
  • Sequence:
    • MSEQSKDLSD PNFAAEAPNS EVHSSPGVSE GVPPSATLAE PQSPPLGPTA APQAAPPPQA 
PNDEGDPKAL QQAAEEGRAH QAPSAAQPGP APPAPAQLVQ KAHELMWYVL VKDQKKMIIW 
FPDMVKDVIG SYKKWCRSIL RRTSLILARV FGLHLRLTSL HTMEFALVKA LEPEELDRVA 
LSNRMPMTGL LLMILSLIYV KGRGARESAV WNVLRILGLR PWKKHSTFGD VRKLITEEFV 
QMNYLKYQRV PYVEPPEYEF FWGSRASREI TKMQIMEFLA RVFKKDPQAW PSRYREALEE 
ARALREANPT AHYPRSSVSE D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.