Details for: NDUFB1

Gene ID: 4707

Symbol: NDUFB1

Ensembl ID: ENSG00000183648

Description: NADH:ubiquinone oxidoreductase subunit B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 473.1421
    Cell Significance Index: -73.6000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 332.0410
    Cell Significance Index: -84.2200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 250.6872
    Cell Significance Index: -103.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 217.5716
    Cell Significance Index: -88.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 214.5629
    Cell Significance Index: -101.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 191.0436
    Cell Significance Index: -98.2700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 151.5151
    Cell Significance Index: -101.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 92.9779
    Cell Significance Index: -88.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 78.4051
    Cell Significance Index: -96.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 32.0024
    Cell Significance Index: -85.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 26.1198
    Cell Significance Index: -103.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.6277
    Cell Significance Index: -69.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.5978
    Cell Significance Index: -29.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.5281
    Cell Significance Index: 164.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.2947
    Cell Significance Index: 405.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.9018
    Cell Significance Index: 523.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5533
    Cell Significance Index: 350.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1946
    Cell Significance Index: 1198.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.0538
    Cell Significance Index: 145.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0082
    Cell Significance Index: 887.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0034
    Cell Significance Index: 236.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9312
    Cell Significance Index: 247.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8721
    Cell Significance Index: 17.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7392
    Cell Significance Index: 81.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6424
    Cell Significance Index: 86.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6393
    Cell Significance Index: 44.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6387
    Cell Significance Index: 34.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.6263
    Cell Significance Index: 12.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5426
    Cell Significance Index: 152.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4652
    Cell Significance Index: 27.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4317
    Cell Significance Index: 41.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.3966
    Cell Significance Index: 401.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3283
    Cell Significance Index: 99.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3020
    Cell Significance Index: 82.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2130
    Cell Significance Index: 54.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1506
    Cell Significance Index: 148.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9005
    Cell Significance Index: 10.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6713
    Cell Significance Index: 134.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5587
    Cell Significance Index: 14.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5491
    Cell Significance Index: 104.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4865
    Cell Significance Index: 25.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4136
    Cell Significance Index: 70.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3222
    Cell Significance Index: 243.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2960
    Cell Significance Index: 17.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2891
    Cell Significance Index: 57.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2567
    Cell Significance Index: 92.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2528
    Cell Significance Index: 185.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0393
    Cell Significance Index: 1.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0285
    Cell Significance Index: 2.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0027
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0065
    Cell Significance Index: -12.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0178
    Cell Significance Index: -1.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0496
    Cell Significance Index: -91.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0530
    Cell Significance Index: -33.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0624
    Cell Significance Index: -96.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0808
    Cell Significance Index: -51.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0827
    Cell Significance Index: -112.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0841
    Cell Significance Index: -2.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0916
    Cell Significance Index: -41.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1124
    Cell Significance Index: -63.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1230
    Cell Significance Index: -12.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1989
    Cell Significance Index: -41.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2039
    Cell Significance Index: -4.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2125
    Cell Significance Index: -2.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2201
    Cell Significance Index: -23.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2202
    Cell Significance Index: -5.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2206
    Cell Significance Index: -7.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2623
    Cell Significance Index: -30.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3471
    Cell Significance Index: -9.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3723
    Cell Significance Index: -2.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3831
    Cell Significance Index: -29.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3959
    Cell Significance Index: -12.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4561
    Cell Significance Index: -66.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5499
    Cell Significance Index: -8.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5502
    Cell Significance Index: -64.1200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6467
    Cell Significance Index: -3.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6901
    Cell Significance Index: -14.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7151
    Cell Significance Index: -37.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7540
    Cell Significance Index: -21.6200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7934
    Cell Significance Index: -20.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8194
    Cell Significance Index: -11.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8239
    Cell Significance Index: -28.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8484
    Cell Significance Index: -96.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9531
    Cell Significance Index: -99.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0620
    Cell Significance Index: -12.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1034
    Cell Significance Index: -74.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.1111
    Cell Significance Index: -19.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1141
    Cell Significance Index: -62.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1778
    Cell Significance Index: -72.4000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.2512
    Cell Significance Index: -10.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3949
    Cell Significance Index: -41.0900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.5546
    Cell Significance Index: -26.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6381
    Cell Significance Index: -100.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.6834
    Cell Significance Index: -35.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8642
    Cell Significance Index: -82.4600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.9570
    Cell Significance Index: -27.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.0488
    Cell Significance Index: -35.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.0733
    Cell Significance Index: -55.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.1786
    Cell Significance Index: -56.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NDUFB1 is a mitochondrial protein encoded by the ENSG00000183648 gene. It is a subunit of the NADH dehydrogenase complex, which is the largest enzyme in the mitochondrial electron transport chain. NDUFB1 is a beta-subunit, and it interacts with other subunits to form the functional Complex I. The protein is characterized by its ability to bind to NADH and ubiquinone, facilitating the transfer of electrons and the generation of the proton motive force. **Pathways and Functions:** NDUFB1 is a crucial component of the following pathways: 1. **Aerobic Respiration**: NDUFB1 plays a central role in the aerobic respiratory chain, where it facilitates the transfer of electrons from NADH to ubiquinone, generating the proton motive force that drives ATP synthesis. 2. **Complex I Biogenesis**: NDUFB1 is essential for the biogenesis of Complex I, which is the first enzyme in the mitochondrial electron transport chain. The protein interacts with other subunits to form the functional Complex I. 3. **Mitochondrial Electron Transport**: NDUFB1 is involved in the mitochondrial electron transport chain, where it facilitates the transfer of electrons and the generation of the proton motive force. 4. **ATP Synthesis**: NDUFB1 is critical for the synthesis of ATP through the chemiosmotic coupling mechanism, where the proton motive force drives the production of ATP. **Clinical Significance:** Dysregulation of NDUFB1 has been implicated in various mitochondrial disorders, including: 1. **Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS)**: Mutations in the NDUFB1 gene have been associated with MELAS, a rare genetic disorder characterized by mitochondrial dysfunction and neurological symptoms. 2. **Leber's Hereditary Optic Neuropathy (LHON)**: NDUFB1 mutations have also been linked to LHON, a rare genetic disorder that affects the optic nerve and causes blindness. 3. **Mitochondrial Myopathies**: NDUFB1 mutations have been associated with mitochondrial myopathies, a group of disorders characterized by muscle weakness and fatigue. In conclusion, NDUFB1 is a critical component of the mitochondrial respiratory chain complex I, and its dysregulation has significant implications for mitochondrial function and disease. Further research is needed to fully understand the role of NDUFB1 in human health and disease, and to develop effective therapeutic strategies for mitochondrial disorders.

Genular Protein ID: 3649603766

Symbol: NDUB1_HUMAN

Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

UniProtKB Accession Codes:

O75438 A0AV68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27626371

Title: Accessory subunits are integral for assembly and function of human mitochondrial complex I.

PubMed ID: 27626371

DOI: 10.1038/nature19754

Sequence Information:

  • Length: 58
  • Mass: 6961
  • Checksum: 2281D89AAE61EA52
  • Sequence:
    • MVNLLQIVRD HWVHVLVPMG FVIGCYLDRK SDERLTAFRN KSMLFKRELQ PSEEVTWK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.