Details for: NDUFS6

Gene ID: 4726

Symbol: NDUFS6

Ensembl ID: ENSG00000145494

Description: NADH:ubiquinone oxidoreductase subunit S6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 415.6990
    Cell Significance Index: -64.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 260.6218
    Cell Significance Index: -66.1100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 207.1137
    Cell Significance Index: -85.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 179.5169
    Cell Significance Index: -72.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 174.5945
    Cell Significance Index: -82.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 156.1573
    Cell Significance Index: -80.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 123.3193
    Cell Significance Index: -82.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 77.2669
    Cell Significance Index: -73.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 63.9926
    Cell Significance Index: -78.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.8642
    Cell Significance Index: -61.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.2263
    Cell Significance Index: -83.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.1147
    Cell Significance Index: -58.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.6520
    Cell Significance Index: -27.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.5391
    Cell Significance Index: 165.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.0368
    Cell Significance Index: 27.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.8349
    Cell Significance Index: 170.1900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.8093
    Cell Significance Index: 22.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.7611
    Cell Significance Index: 63.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.7187
    Cell Significance Index: 123.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.6299
    Cell Significance Index: 474.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4796
    Cell Significance Index: 304.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.1477
    Cell Significance Index: 100.9400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.0179
    Cell Significance Index: 17.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9879
    Cell Significance Index: 140.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.9695
    Cell Significance Index: 56.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9649
    Cell Significance Index: 868.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9563
    Cell Significance Index: 1068.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5971
    Cell Significance Index: 219.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5687
    Cell Significance Index: 42.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.5498
    Cell Significance Index: 32.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.5293
    Cell Significance Index: 16.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5100
    Cell Significance Index: 178.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4045
    Cell Significance Index: 72.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3485
    Cell Significance Index: 87.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3469
    Cell Significance Index: 100.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3405
    Cell Significance Index: 39.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3077
    Cell Significance Index: 82.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1839
    Cell Significance Index: 13.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1824
    Cell Significance Index: 62.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1782
    Cell Significance Index: 30.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0704
    Cell Significance Index: 105.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0575
    Cell Significance Index: 172.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9492
    Cell Significance Index: 122.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9270
    Cell Significance Index: 836.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8625
    Cell Significance Index: 23.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7652
    Cell Significance Index: 98.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5762
    Cell Significance Index: 114.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5009
    Cell Significance Index: 95.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4998
    Cell Significance Index: 85.3500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4518
    Cell Significance Index: 6.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4394
    Cell Significance Index: 322.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3950
    Cell Significance Index: 7.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3805
    Cell Significance Index: 76.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3640
    Cell Significance Index: 12.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2901
    Cell Significance Index: 15.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2245
    Cell Significance Index: 7.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.2097
    Cell Significance Index: 16.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1794
    Cell Significance Index: 135.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1042
    Cell Significance Index: 2.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0496
    Cell Significance Index: 17.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0323
    Cell Significance Index: 0.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0211
    Cell Significance Index: -15.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0243
    Cell Significance Index: -45.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0411
    Cell Significance Index: -75.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0426
    Cell Significance Index: -4.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0500
    Cell Significance Index: -31.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0537
    Cell Significance Index: -82.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0694
    Cell Significance Index: -94.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0817
    Cell Significance Index: -51.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1016
    Cell Significance Index: -57.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1278
    Cell Significance Index: -58.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1685
    Cell Significance Index: -4.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1864
    Cell Significance Index: -39.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1925
    Cell Significance Index: -13.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2140
    Cell Significance Index: -16.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2184
    Cell Significance Index: -62.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2197
    Cell Significance Index: -25.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2847
    Cell Significance Index: -32.6200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3073
    Cell Significance Index: -7.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3407
    Cell Significance Index: -9.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3753
    Cell Significance Index: -12.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4328
    Cell Significance Index: -62.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5724
    Cell Significance Index: -7.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5751
    Cell Significance Index: -12.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5876
    Cell Significance Index: -3.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5964
    Cell Significance Index: -68.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7476
    Cell Significance Index: -45.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7611
    Cell Significance Index: -42.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7969
    Cell Significance Index: -82.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8001
    Cell Significance Index: -9.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9317
    Cell Significance Index: -23.2900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.9684
    Cell Significance Index: -5.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0074
    Cell Significance Index: -67.7400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0138
    Cell Significance Index: -10.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0449
    Cell Significance Index: -27.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1943
    Cell Significance Index: -73.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.3477
    Cell Significance Index: -11.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.3686
    Cell Significance Index: -24.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4538
    Cell Significance Index: -42.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.5721
    Cell Significance Index: -23.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of Complex I**: NDUFS6 is one of the 14 subunits that comprise Complex I, the first enzyme in the mitochondrial electron transport chain. 2. **Electron Transfer Activity**: This subunit is responsible for the transfer of electrons from NADH to ubiquinone, facilitating the generation of the proton motive force. 3. **Mitochondrial Inner Membrane**: NDUFS6 is primarily localized to the mitochondrial inner membrane, where it interacts with other subunits to form the functional Complex I. 4. **Highly Expressed in Various Tissues**: NDUFS6 is significantly expressed in multiple cell types, including kidney loop of Henle thick ascending limb epithelial cells, erythroid progenitor cells, and fetal cardiomyocytes. **Pathways and Functions:** The NDUFS6 gene is involved in several key pathways, including: 1. **Aerobic Respiration**: NDUFS6 plays a critical role in the electron transport chain, which is essential for the generation of ATP during aerobic respiration. 2. **Electron Transfer Activity**: This subunit facilitates the transfer of electrons from NADH to ubiquinone, generating the proton motive force necessary for ATP synthesis. 3. **Mitochondrial Electron Transport**: NDUFS6 is a key component of the mitochondrial electron transport chain, which is responsible for the production of ATP during oxidative phosphorylation. 4. **Heat Production by Uncoupling Proteins**: This subunit is also involved in the regulation of heat production by uncoupling proteins, which can influence cellular metabolism and energy homeostasis. **Clinical Significance:** Dysregulation of the NDUFS6 gene has been implicated in various diseases, including: 1. **Mitochondrial Myopathies**: Mutations in NDUFS6 have been associated with mitochondrial myopathies, such as MERRF syndrome and MNGIE syndrome. 2. **Neurodegenerative Disorders**: Alterations in NDUFS6 expression have been linked to neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer**: NDUFS6 has been identified as a potential oncogene, with altered expression levels observed in various types of cancer. 4. **Metabolic Disorders**: Dysregulation of NDUFS6 has also been implicated in metabolic disorders, such as diabetes and obesity. In conclusion, the NDUFS6 gene plays a critical role in maintaining mitochondrial function and overall cellular health. Alterations in NDUFS6 expression have been implicated in various diseases, highlighting the importance of this gene in understanding the pathogenesis of complex disorders. Further research is necessary to fully elucidate the mechanisms by which NDUFS6 influences disease progression and to develop effective therapeutic strategies for targeting this gene.

Genular Protein ID: 1451126645

Symbol: NDUS6_HUMAN

Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

UniProtKB Accession Codes:

O75380

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9647766

Title: cDNA sequence and chromosomal localization of the remaining three human nuclear encoded iron sulphur protein (IP) subunits of complex I: the human IP fraction is completed.

PubMed ID: 9647766

DOI: 10.1006/bbrc.1998.8882

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 15372108

Title: NDUFS6 mutations are a novel cause of lethal neonatal mitochondrial complex I deficiency.

PubMed ID: 15372108

DOI: 10.1172/jci20683

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27626371

Title: Accessory subunits are integral for assembly and function of human mitochondrial complex I.

PubMed ID: 27626371

DOI: 10.1038/nature19754

PubMed ID: 19259137

Title: Mutated NDUFS6 is the cause of fatal neonatal lactic acidemia in Caucasus Jews.

PubMed ID: 19259137

DOI: 10.1038/ejhg.2009.24

Sequence Information:

  • Length: 124
  • Mass: 13712
  • Checksum: 0A1465160BCA772D
  • Sequence:
    • MAAAMTFCRL LNRCGEAARS LPLGARCFGV RVSPTGEKVT HTGQVYDDKD YRRIRFVGRQ 
KEVNENFAID LIAEQPVSEV ETRVIACDGG GGALGHPKVY INLDKETKTG TCGYCGLQFR 
QHHH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.