Details for: DRG1

Gene ID: 4733

Symbol: DRG1

Ensembl ID: ENSG00000185721

Description: developmentally regulated GTP binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 202.8349
    Cell Significance Index: -31.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.8677
    Cell Significance Index: -30.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 85.3992
    Cell Significance Index: -35.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.3258
    Cell Significance Index: -39.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.7094
    Cell Significance Index: -31.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.1323
    Cell Significance Index: -36.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.3702
    Cell Significance Index: -31.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.6848
    Cell Significance Index: -36.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1279
    Cell Significance Index: -29.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5868
    Cell Significance Index: -37.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.2513
    Cell Significance Index: -15.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.2854
    Cell Significance Index: 226.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4608
    Cell Significance Index: 19.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1953
    Cell Significance Index: 71.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1789
    Cell Significance Index: 233.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0247
    Cell Significance Index: 925.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9658
    Cell Significance Index: 105.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8475
    Cell Significance Index: 22.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7702
    Cell Significance Index: 125.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6407
    Cell Significance Index: 128.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5740
    Cell Significance Index: 6.2400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5642
    Cell Significance Index: 4.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5444
    Cell Significance Index: 74.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5203
    Cell Significance Index: 10.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5083
    Cell Significance Index: 59.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4696
    Cell Significance Index: 168.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4631
    Cell Significance Index: 21.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4542
    Cell Significance Index: 248.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4332
    Cell Significance Index: 11.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4300
    Cell Significance Index: 33.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4184
    Cell Significance Index: 14.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4131
    Cell Significance Index: 23.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4051
    Cell Significance Index: 26.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4022
    Cell Significance Index: 72.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4011
    Cell Significance Index: 49.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3604
    Cell Significance Index: 159.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3464
    Cell Significance Index: 9.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3447
    Cell Significance Index: 16.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3429
    Cell Significance Index: 25.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3352
    Cell Significance Index: 231.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3269
    Cell Significance Index: 42.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3206
    Cell Significance Index: 8.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3177
    Cell Significance Index: 16.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3096
    Cell Significance Index: 8.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2984
    Cell Significance Index: 38.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2961
    Cell Significance Index: 50.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2756
    Cell Significance Index: 19.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2119
    Cell Significance Index: 4.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1737
    Cell Significance Index: 9.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1727
    Cell Significance Index: 7.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1485
    Cell Significance Index: 1.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1350
    Cell Significance Index: 3.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1144
    Cell Significance Index: 7.9100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0844
    Cell Significance Index: 0.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0817
    Cell Significance Index: 15.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0793
    Cell Significance Index: 2.5400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0726
    Cell Significance Index: 0.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0697
    Cell Significance Index: 128.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0674
    Cell Significance Index: 103.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0567
    Cell Significance Index: 1.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0523
    Cell Significance Index: 71.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0472
    Cell Significance Index: 88.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0356
    Cell Significance Index: 0.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0165
    Cell Significance Index: 10.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0001
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0156
    Cell Significance Index: -11.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0157
    Cell Significance Index: -9.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0217
    Cell Significance Index: -15.9000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0250
    Cell Significance Index: -0.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0266
    Cell Significance Index: -3.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0269
    Cell Significance Index: -0.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0371
    Cell Significance Index: -2.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0412
    Cell Significance Index: -23.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0416
    Cell Significance Index: -4.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0424
    Cell Significance Index: -2.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0522
    Cell Significance Index: -3.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0679
    Cell Significance Index: -2.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0884
    Cell Significance Index: -3.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0947
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1050
    Cell Significance Index: -22.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1097
    Cell Significance Index: -31.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1186
    Cell Significance Index: -13.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1291
    Cell Significance Index: -14.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1296
    Cell Significance Index: -2.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1854
    Cell Significance Index: -7.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2451
    Cell Significance Index: -27.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2923
    Cell Significance Index: -4.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3135
    Cell Significance Index: -19.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3206
    Cell Significance Index: -33.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3484
    Cell Significance Index: -7.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3678
    Cell Significance Index: -4.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3824
    Cell Significance Index: -30.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4214
    Cell Significance Index: -12.0800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4373
    Cell Significance Index: -10.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5040
    Cell Significance Index: -30.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5153
    Cell Significance Index: -12.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5408
    Cell Significance Index: -6.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5587
    Cell Significance Index: -14.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5933
    Cell Significance Index: -8.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GTP-binding protein**: DRG1 belongs to the GTP-binding protein family, which is involved in signal transduction and cellular regulation. 2. **Developmentally regulated**: DRG1 expression is tightly regulated during development, suggesting its involvement in specific cellular processes during embryonic development and tissue formation. 3. **Multiple cellular expressions**: DRG1 is expressed in various cell types, including erythroid progenitor cells, oogonial cells, and retinal ganglion cells, indicating its diverse roles in different cell types. 4. **Post-translational modifications**: DRG1 is involved in post-translational protein modification, including hydroxylation, hypusinylation, and arylsulfatase activation, which are crucial for protein function and cellular regulation. **Pathways and Functions:** 1. **GTPase activity**: DRG1's GTPase activity is essential for regulating microtubule polymerization and mitotic spindle assembly, which are critical for cell division and cellular organization. 2. **Microtubule polymerization**: DRG1's involvement in microtubule polymerization is mediated through its interaction with microtubule-associated proteins, which is essential for maintaining cellular structure and function. 3. **Mitotic spindle assembly**: DRG1's role in mitotic spindle assembly is crucial for proper cell division, as it regulates the formation of the mitotic spindle and ensures accurate chromosome segregation. 4. **Protein binding**: DRG1's ability to bind to various proteins, including microtubule-associated proteins and other GTP-binding proteins, enables it to regulate cellular processes and interact with other signaling molecules. **Clinical Significance:** The dysregulation of DRG1 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: DRG1's involvement in retinal ganglion cell function and mitotic spindle assembly makes it a potential target for the treatment of neurodegenerative disorders, such as glaucoma and Alzheimer's disease. 2. **Cancer**: DRG1's role in cell proliferation and differentiation makes it a potential biomarker for cancer diagnosis and a target for cancer therapy. 3. **Developmental disorders**: DRG1's involvement in embryonic development and tissue formation makes it a potential target for the treatment of developmental disorders, such as congenital heart defects and neural tube defects. In conclusion, DRG1 is a developmentally regulated GTP-binding protein that plays a crucial role in various cellular processes, including cell development, differentiation, and metabolism. Its dysregulation has been implicated in various diseases, making it a potential target for the diagnosis and treatment of these disorders. Further research is needed to fully elucidate the role of DRG1 in human disease and to explore its therapeutic potential.

Genular Protein ID: 4104832384

Symbol: DRG1_HUMAN

Name: Developmentally-regulated GTP-binding protein 1

UniProtKB Accession Codes:

Q9Y295 B2RDS8 Q6FGP8 Q8WW69 Q9UGF2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9824680

Title: SCL binds the human homologue of DRG in vivo.

PubMed ID: 9824680

DOI: 10.1016/s0167-4889(98)00129-3

PubMed ID: 10760581

Title: DRG represents a family of two closely related GTP-binding proteins.

PubMed ID: 10760581

DOI: 10.1016/s0167-4781(00)00025-7

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15676025

Title: Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2.

PubMed ID: 15676025

DOI: 10.1111/j.1365-2443.2005.00825.x

PubMed ID: 17709345

Title: Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.

PubMed ID: 17709345

DOI: 10.1093/nar/gkm617

PubMed ID: 18184589

Title: Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture.

PubMed ID: 18184589

DOI: 10.1016/j.str.2007.10.026

PubMed ID: 19819225

Title: Independent stabilizations of polysomal Drg1/Dfrp1 complex and non-polysomal Drg2/Dfrp2 complex in mammalian cells.

PubMed ID: 19819225

DOI: 10.1016/j.bbrc.2009.10.003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23711155

Title: Human Drg1 is a potassium-dependent GTPase enhanced by Lerepo4.

PubMed ID: 23711155

DOI: 10.1111/febs.12356

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28855639

Title: Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics.

PubMed ID: 28855639

DOI: 10.1038/s41598-017-10088-5

PubMed ID: 29915238

Title: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

PubMed ID: 29915238

DOI: 10.1038/s41589-018-0071-y

PubMed ID: 37179472

Title: Inactivation of DRG1, encoding a translation factor GTPase, causes a recessive neurodevelopmental disorder.

PubMed ID: 37179472

DOI: 10.1016/j.gim.2023.100893

Sequence Information:

  • Length: 367
  • Mass: 40542
  • Checksum: 4A177EA7C8E23005
  • Sequence:
    • MSSTLAKIAE IEAEMARTQK NKATAHHLGL LKARLAKLRR ELITPKGGGG GGPGEGFDVA 
KTGDARIGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT TVPGVIRYKG AKIQLLDLPG 
IIEGAKDGKG RGRQVIAVAR TCNLILIVLD VLKPLGHKKI IENELEGFGI RLNSKPPNIG 
FKKKDKGGIN LTATCPQSEL DAETVKSILA EYKIHNADVT LRSDATADDL IDVVEGNRVY 
IPCIYVLNKI DQISIEELDI IYKVPHCVPI SAHHRWNFDD LLEKIWDYLK LVRIYTKPKG 
QLPDYTSPVV LPYSRTTVED FCMKIHKNLI KEFKYALVWG LSVKHNPQKV GKDHTLEDED 
VIQIVKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.