NFE2L2 | ENSG00000116044 | NCBI 4780

Details for: NFE2L2

Gene ID: 4780

Symbol: NFE2L2

Ensembl ID: ENSG00000116044

Description: NFE2 like bZIP transcription factor 2

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytoprotection by hmox1
(R-HSA-9707564)
Disease
(R-HSA-1643685)
Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
(R-HSA-9762114)
Heme signaling
(R-HSA-9707616)
Infectious disease
(R-HSA-5663205)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Nfe2l2 regulates pentose phosphate pathway genes
(R-HSA-9818028)
Nfe2l2 regulating anti-oxidant/detoxification enzymes
(R-HSA-9818027)
Nfe2l2 regulating er-stress associated genes
(R-HSA-9818035)
Nfe2l2 regulating inflammation associated genes
(R-HSA-9818026)
Nfe2l2 regulating mdr associated enzymes
(R-HSA-9818032)
Nfe2l2 regulating tca cycle genes
(R-HSA-9818025)
Nfe2l2 regulating tumorigenic genes
(R-HSA-9818030)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Post-translational protein modification
(R-HSA-597592)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of hmox1 expression and activity
(R-HSA-9707587)
Regulation of nfe2l2 gene expression
(R-HSA-9818749)
Sars-cov infections
(R-HSA-9679506)
Viral infection pathways
(R-HSA-9824446)
Aflatoxin catabolic process
(GO:0046223)
Cell redox homeostasis
(GO:0045454)
Cellular response to angiotensin
(GO:1904385)
Cellular response to copper ion
(GO:0071280)
Cellular response to fluid shear stress
(GO:0071498)
Cellular response to glucose starvation
(GO:0042149)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to hypoxia
(GO:0071456)
Cellular response to laminar fluid shear stress
(GO:0071499)
Cellular response to methionine
(GO:0061431)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to xenobiotic stimulus
(GO:0071466)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Golgi apparatus
(GO:0005794)
Inflammatory response
(GO:0006954)
Integrated stress response signaling
(GO:0140467)
Molecular condensate scaffold activity
(GO:0140693)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of cellular response to hypoxia
(GO:1900038)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Negative regulation of ferroptosis
(GO:0110076)
Negative regulation of hematopoietic stem cell differentiation
(GO:1902037)
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
(GO:1902176)
Negative regulation of vascular associated smooth muscle cell migration
(GO:1904753)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perk-mediated unfolded protein response
(GO:0036499)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood coagulation
(GO:0030194)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of d-glucose import
(GO:0046326)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erad pathway
(GO:1904294)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glutathione biosynthetic process
(GO:1903788)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of ubiquitin-dependent protein catabolic process
(GO:2000060)
Proteasomal ubiquitin-independent protein catabolic process
(GO:0010499)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein ubiquitination
(GO:0016567)
Reactive oxygen species metabolic process
(GO:0072593)
Regulation of cellular response to oxidative stress
(GO:1900407)
Regulation of embryonic development
(GO:0045995)
Regulation of innate immune response
(GO:0045088)
Regulation of removal of superoxide radicals
(GO:2000121)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to ischemia
(GO:0002931)
Response to oxidative stress
(GO:0006979)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 616.9267
Cell Significance Index: -95.9600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 373.6348
Cell Significance Index: -94.7700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 213.3768
Cell Significance Index: -100.7400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 203.1103
Cell Significance Index: -82.5200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 182.9174
Cell Significance Index: -94.0900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 150.9190
Cell Significance Index: -101.2700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 86.5626
Cell Significance Index: -82.6500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 80.1489
Cell Significance Index: -98.8200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 33.0924
Cell Significance Index: -88.6500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 28.2876
Cell Significance Index: -61.9100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 28.1398
Cell Significance Index: -86.4300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 25.4077
Cell Significance Index: -100.2600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 5.6841
Cell Significance Index: 158.8500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 5.1218
Cell Significance Index: 139.4100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.2447
Cell Significance Index: 521.9300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.2828
Cell Significance Index: 591.7800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.1622
Cell Significance Index: 84.4400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.0361
Cell Significance Index: 602.5300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.8447
Cell Significance Index: 81.5500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.3895
Cell Significance Index: 42.2300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.9597
Cell Significance Index: 138.6000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.9137
Cell Significance Index: 89.9400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.7252
Cell Significance Index: 128.5800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.7156
Cell Significance Index: 758.4900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.7084
Cell Significance Index: 234.6200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.6925
Cell Significance Index: 87.9200
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.4993
Cell Significance Index: 39.4300
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.3812
Cell Significance Index: 754.2800
Cell Name: lactocyte (CL0002325)
Fold Change: 1.2430
Cell Significance Index: 160.5900
Cell Name: preadipocyte (CL0002334)
Fold Change: 1.2256
Cell Significance Index: 23.9200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.2096
Cell Significance Index: 63.0100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.0824
Cell Significance Index: 31.1900
Cell Name: theca cell (CL0000503)
Fold Change: 0.8494
Cell Significance Index: 4.9900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.8386
Cell Significance Index: 107.5000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.8264
Cell Significance Index: 63.4200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4701
Cell Significance Index: 94.3000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.4268
Cell Significance Index: 3.9300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3349
Cell Significance Index: 120.1300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3249
Cell Significance Index: 15.1500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.3171
Cell Significance Index: 201.4000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2493
Cell Significance Index: 47.4400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2459
Cell Significance Index: 40.0000
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.2185
Cell Significance Index: 3.6800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.2051
Cell Significance Index: 10.3600
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.1866
Cell Significance Index: 2.6800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1612
Cell Significance Index: 111.4600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1258
Cell Significance Index: 193.6900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1250
Cell Significance Index: 21.3500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1246
Cell Significance Index: 229.7200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1209
Cell Significance Index: 227.6700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0908
Cell Significance Index: 3.1900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0698
Cell Significance Index: 6.9000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0182
Cell Significance Index: 13.3500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0152
Cell Significance Index: 20.6700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0040
Cell Significance Index: 1.8300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0046
Cell Significance Index: -0.5000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0224
Cell Significance Index: -20.2600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0519
Cell Significance Index: -5.3000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0534
Cell Significance Index: -40.4200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0692
Cell Significance Index: -43.2300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0697
Cell Significance Index: -51.6100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0747
Cell Significance Index: -1.9200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1096
Cell Significance Index: -61.8000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2248
Cell Significance Index: -25.6700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2670
Cell Significance Index: -56.2400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2766
Cell Significance Index: -40.2000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2839
Cell Significance Index: -33.0900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2968
Cell Significance Index: -85.4000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3487
Cell Significance Index: -5.8300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3830
Cell Significance Index: -45.1700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4431
Cell Significance Index: -6.0500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4562
Cell Significance Index: -9.7200
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4819
Cell Significance Index: -31.0900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4965
Cell Significance Index: -56.8800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5049
Cell Significance Index: -12.6200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5859
Cell Significance Index: -32.8800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6074
Cell Significance Index: -3.6700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6279
Cell Significance Index: -42.2200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.6665
Cell Significance Index: -17.8600
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.7131
Cell Significance Index: -17.4000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7863
Cell Significance Index: -49.5600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.8134
Cell Significance Index: -84.6900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8241
Cell Significance Index: -65.2700
Cell Name: peg cell (CL4033014)
Fold Change: -0.8380
Cell Significance Index: -19.3600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.8619
Cell Significance Index: -15.9300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.0252
Cell Significance Index: -22.2100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.1031
Cell Significance Index: -67.8000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.1464
Cell Significance Index: -60.1900
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.2022
Cell Significance Index: -17.7500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.2487
Cell Significance Index: -56.6000
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.3056
Cell Significance Index: -19.2800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.3899
Cell Significance Index: -44.5200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.5522
Cell Significance Index: -53.9400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.6089
Cell Significance Index: -98.6400
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -1.6694
Cell Significance Index: -24.0100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.7522
Cell Significance Index: -51.6100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.7885
Cell Significance Index: -30.6500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -1.8828
Cell Significance Index: -21.3900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -2.0128
Cell Significance Index: -53.8400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.0279
Cell Significance Index: -89.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** Nrf2 is a transcription factor that belongs to the basic leucine zipper (bZIP) family. It is characterized by its ability to bind to specific DNA sequences, known as antioxidant response elements (ARE), which are present in the promoter regions of target genes. Nrf2 is also characterized by its ability to regulate the expression of genes involved in antioxidant defense, including those involved in the glutathione biosynthetic pathway, the pentose phosphate pathway, and the expression of anti-oxidant/detoxification enzymes. **Pathways and Functions** Nrf2 regulates a wide range of cellular processes, including: 1. **Antioxidant Defense**: Nrf2 regulates the expression of genes involved in antioxidant defense, including those involved in the glutathione biosynthetic pathway, the pentose phosphate pathway, and the expression of anti-oxidant/detoxification enzymes. 2. **Detoxification**: Nrf2 regulates the expression of genes involved in detoxification, including those involved in the metabolism of xenobiotics, such as cytochrome P450 enzymes. 3. **Cell Survival**: Nrf2 regulates the expression of genes involved in cell survival, including those involved in the regulation of apoptosis and cell cycle progression. 4. **Inflammation**: Nrf2 regulates the expression of genes involved in inflammation, including those involved in the regulation of inflammatory cytokines and chemokines. 5. **Cellular Redox Homeostasis**: Nrf2 regulates the expression of genes involved in maintaining cellular redox homeostasis, including those involved in the regulation of reactive oxygen species (ROS) production and antioxidant defenses. **Clinical Significance** Dysregulation of Nrf2 has been implicated in various diseases, including: 1. **Cancer**: Nrf2 dysregulation has been implicated in various types of cancer, including lung, breast, and colon cancer. 2. **Neurodegenerative Diseases**: Nrf2 dysregulation has been implicated in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Inflammatory Diseases**: Nrf2 dysregulation has been implicated in various inflammatory diseases, including atherosclerosis and rheumatoid arthritis. 4. **Metabolic Diseases**: Nrf2 dysregulation has been implicated in various metabolic diseases, including diabetes and obesity. In summary, Nrf2 is a critical transcription factor that plays a key role in maintaining cellular redox homeostasis and protecting cells against oxidative stress. Dysregulation of Nrf2 has been implicated in various diseases, highlighting the importance of Nrf2 in maintaining cellular homeostasis and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 985537206

Symbol: NF2L2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q16236 B2RBU2 B4E338 E9PGJ7 Q53RW6 Q59HH2 Q96F71

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 7937919

Title: Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

PubMed ID: 7937919

DOI: 10.1073/pnas.91.21.9926

PubMed ID: 11035812

Title: Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2.

PubMed ID: 11035812

DOI: 10.1073/pnas.220418997

PubMed ID: 11256947

Title: Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene.

PubMed ID: 11256947

DOI: 10.1042/0264-6021:3550045

PubMed ID: 15601839

Title: BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.

PubMed ID: 15601839

DOI: 10.1128/mcb.25.1.162-171.2005

PubMed ID: 15983046

Title: Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.

PubMed ID: 15983046

DOI: 10.1074/jbc.m501279200

PubMed ID: 19489739

Title: Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.

PubMed ID: 19489739

DOI: 10.1042/bj20090471

PubMed ID: 18387606

Title: PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria.

PubMed ID: 18387606

DOI: 10.1016/j.yexcr.2008.02.014

PubMed ID: 19424503

Title: Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.

PubMed ID: 19424503

DOI: 10.1371/journal.pone.0005492

PubMed ID: 20452972

Title: p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.

PubMed ID: 20452972

DOI: 10.1074/jbc.m110.118976

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21597468

Title: Transformation of eEF1Bdelta into heat-shock response transcription factor by alternative splicing.

PubMed ID: 21597468

DOI: 10.1038/embor.2011.82

PubMed ID: 21196497

Title: Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization.

PubMed ID: 21196497

DOI: 10.1074/jbc.m110.208173

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25995248

Title: Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene Repression.

PubMed ID: 25995248

DOI: 10.1128/jvi.00895-15

PubMed ID: 29983246

Title: The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.

PubMed ID: 29983246

DOI: 10.1016/j.cmet.2018.06.008

PubMed ID: 29590092

Title: Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

PubMed ID: 29590092

DOI: 10.1038/nature25986

PubMed ID: 31398338

Title: The oncogenic action of NRF2 depends on de-glycation by fructosamine-3-kinase.

PubMed ID: 31398338

DOI: 10.1016/j.cell.2019.07.031

PubMed ID: 28842501

Title: Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.

PubMed ID: 28842501

DOI: 10.1074/jbc.r117.800169

PubMed ID: 30158636

Title: Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming.

PubMed ID: 30158636

DOI: 10.1038/s41467-018-05861-7

PubMed ID: 33009401

Title: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.

PubMed ID: 33009401

DOI: 10.1038/s41467-020-18764-3

PubMed ID: 33087717

Title: Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.

PubMed ID: 33087717

DOI: 10.1038/s41467-020-19363-y

PubMed ID: 16888629

Title: Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.

PubMed ID: 16888629

DOI: 10.1038/sj.emboj.7601243

PubMed ID: 29018201

Title: Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder.

PubMed ID: 29018201

DOI: 10.1038/s41467-017-00932-7

Sequence Information:

Length: 605
Mass: 67827
Checksum: 99FAFD811B6C1416
Sequence:

MMDLELPPPG LPSQQDMDLI DILWRQDIDL GVSREVFDFS QRRKEYELEK QKKLEKERQE 
QLQKEQEKAF FAQLQLDEET GEFLPIQPAQ HIQSETSGSA NYSQVAHIPK SDALYFDDCM 
QLLAQTFPFV DDNEVSSATF QSLVPDIPGH IESPVFIATN QAQSPETSVA QVAPVDLDGM 
QQDIEQVWEE LLSIPELQCL NIENDKLVET TMVPSPEAKL TEVDNYHFYS SIPSMEKEVG 
NCSPHFLNAF EDSFSSILST EDPNQLTVNS LNSDATVNTD FGDEFYSAFI AEPSISNSMP 
SPATLSHSLS ELLNGPIDVS DLSLCKAFNQ NHPESTAEFN DSDSGISLNT SPSVASPEHS 
VESSSYGDTL LGLSDSEVEE LDSAPGSVKQ NGPKTPVHSS GDMVQPLSPS QGQSTHVHDA 
QCENTPEKEL PVSPGHRKTP FTKDKHSSRL EAHLTRDELR AKALHIPFPV EKIINLPVVD 
FNEMMSKEQF NEAQLALIRD IRRRGKNKVA AQNCRKRKLE NIVELEQDLD HLKDEKEKLL 
KEKGENDKSL HLLKKQLSTL YLEVFSMLRD EDGKPYSPSE YSLQQTRDGN VFLVPKSKKP 
DVKKN

Genular Protein ID: 1167262893

Symbol: A0A8V8TPA8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TPA8

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

Length: 532
Mass: 59124
Checksum: 200249E9885F416E
Sequence:

MMDLELPPPG LPSQQDMDLI DILWRQDIDL GVAHIPKSDA LYFDDCMQLL AQTFPFVDDN 
EVSSATFQSL VPDIPGHIES PVFIATNQAQ SPETSVAQVA PVDLDGMQQD IEQVWEELLS 
IPELQCLNIE NDKLVETTMV PSPEAKLTEV DNYHFYSSIP SMEKEVGNCS PHFLNAFEDS 
FSSILSTEDP NQLTVNSLNS DATVNTDFGD EFYSAFIAEP SISNSMPSPA TLSHSLSELL 
NGPIDVSDLS LCKAFNQNHP ESTAEFNDSD SGISLNTSPS VASPEHSVES SSYGDTLLGL 
SDSEVEELDS APGSVKQNGP KTPVHSSGDM VQPLSPSQGQ STHVHDAQCE NTPEKELPVS 
PGHRKTPFTK DKHSSRLEAH LTRDELRAKA LHIPFPVEKI INLPVVDFNE MMSKEQFNEA 
QLALIRDIRR RGKNKVAAQN CRKRKLENIV ELEQDLDHLK DEKEKLLKEK GENDKSLHLL 
KKQLSTLYLE VFSMLRDEDG KPYSPSEYSL QQTRDGNVFL VPKSKKPDVK KN

Genular Protein ID: 357725911

Symbol: A0A8V8TN14_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TN14

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

Length: 575
Mass: 64401
Checksum: 609EAAFD762BB381
Sequence:

MMDLELPPPG LPSQQDMDLI DILWRQDIDL GVSREVFDFS QRRKEYELEK QKKLEKERQE 
QLQKEQEKAF FAQLQLDEET GEFLPIQPAQ HIQSETSGSA NYSQVSSATF QSLVPDIPGH 
IESPVFIATN QAQSPETSVA QVAPVDLDGM QQDIEQVWEE LLSIPELQCL NIENDKLVET 
TMVPSPEAKL TEVDNYHFYS SIPSMEKEVG NCSPHFLNAF EDSFSSILST EDPNQLTVNS 
LNSDATVNTD FGDEFYSAFI AEPSISNSMP SPATLSHSLS ELLNGPIDVS DLSLCKAFNQ 
NHPESTAEFN DSDSGISLNT SPSVASPEHS VESSSYGDTL LGLSDSEVEE LDSAPGSVKQ 
NGPKTPVHSS GDMVQPLSPS QGQSTHVHDA QCENTPEKEL PVSPGHRKTP FTKDKHSSRL 
EAHLTRDELR AKALHIPFPV EKIINLPVVD FNEMMSKEQF NEAQLALIRD IRRRGKNKVA 
AQNCRKRKLE NIVELEQDLD HLKDEKEKLL KEKGENDKSL HLLKKQLSTL YLEVFSMLRD 
EDGKPYSPSE YSLQQTRDGN VFLVPKSKKP DVKKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NFE2L2

Associated with

Cells (max top 100)

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. PubMed ID: 7937919

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. PubMed ID: 11035812

Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene. PubMed ID: 11256947

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. PubMed ID: 15601839

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. PubMed ID: 15983046

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. PubMed ID: 19489739

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. PubMed ID: 18387606

Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. PubMed ID: 19424503

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. PubMed ID: 20452972

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Transformation of eEF1Bdelta into heat-shock response transcription factor by alternative splicing. PubMed ID: 21597468

Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. PubMed ID: 21196497

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene Repression. PubMed ID: 25995248

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. PubMed ID: 29983246

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. PubMed ID: 29590092

The oncogenic action of NRF2 depends on de-glycation by fructosamine-3-kinase. PubMed ID: 31398338

Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress. PubMed ID: 28842501

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming. PubMed ID: 30158636

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. PubMed ID: 33009401

Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. PubMed ID: 33087717

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. PubMed ID: 16888629

Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder. PubMed ID: 29018201

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Database document:

PubMed ID: 14702039

PubMed ID: 15815621

PubMed ID: 15489334

PubMed ID: 17974005

PubMed ID: 7937919

PubMed ID: 11035812

PubMed ID: 11256947

PubMed ID: 15601839

PubMed ID: 15983046

PubMed ID: 19489739

PubMed ID: 18387606

PubMed ID: 19424503

PubMed ID: 20452972

PubMed ID: 20068231

PubMed ID: 21597468

PubMed ID: 21196497

PubMed ID: 23186163

PubMed ID: 25995248

PubMed ID: 29983246

PubMed ID: 29590092

PubMed ID: 31398338

PubMed ID: 28842501

PubMed ID: 30158636

PubMed ID: 33009401

PubMed ID: 33087717

PubMed ID: 16888629

PubMed ID: 29018201

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 15815621

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 15815621