Details for: NFYC

Gene ID: 4802

Symbol: NFYC

Ensembl ID: ENSG00000066136

Description: nuclear transcription factor Y subunit gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 235.2370
    Cell Significance Index: -36.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 143.9423
    Cell Significance Index: -36.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.3412
    Cell Significance Index: -42.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.3677
    Cell Significance Index: -35.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.6667
    Cell Significance Index: -40.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.7274
    Cell Significance Index: -36.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.0507
    Cell Significance Index: -40.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.8637
    Cell Significance Index: -34.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.4712
    Cell Significance Index: -41.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4674
    Cell Significance Index: -32.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6311
    Cell Significance Index: -18.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8101
    Cell Significance Index: 138.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4138
    Cell Significance Index: 1276.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3279
    Cell Significance Index: 266.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2756
    Cell Significance Index: 253.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1685
    Cell Significance Index: 136.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8953
    Cell Significance Index: 25.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8626
    Cell Significance Index: 140.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8033
    Cell Significance Index: 10.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7756
    Cell Significance Index: 46.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7689
    Cell Significance Index: 90.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7196
    Cell Significance Index: 258.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6535
    Cell Significance Index: 36.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5145
    Cell Significance Index: 92.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4326
    Cell Significance Index: 299.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4141
    Cell Significance Index: 28.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4054
    Cell Significance Index: 49.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3917
    Cell Significance Index: 53.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3806
    Cell Significance Index: 10.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3279
    Cell Significance Index: 144.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2940
    Cell Significance Index: 4.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2936
    Cell Significance Index: 13.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2932
    Cell Significance Index: 160.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2735
    Cell Significance Index: 12.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2421
    Cell Significance Index: 23.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2196
    Cell Significance Index: 11.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1699
    Cell Significance Index: 8.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1681
    Cell Significance Index: 10.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1476
    Cell Significance Index: 3.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1383
    Cell Significance Index: 3.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1195
    Cell Significance Index: 3.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1164
    Cell Significance Index: 219.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1101
    Cell Significance Index: 2.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1090
    Cell Significance Index: 13.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1084
    Cell Significance Index: 18.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0970
    Cell Significance Index: 3.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0811
    Cell Significance Index: 5.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0775
    Cell Significance Index: 35.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0771
    Cell Significance Index: 3.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0686
    Cell Significance Index: 3.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0587
    Cell Significance Index: 37.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0464
    Cell Significance Index: 1.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0233
    Cell Significance Index: 1.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0205
    Cell Significance Index: 37.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0188
    Cell Significance Index: 28.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0045
    Cell Significance Index: 0.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0050
    Cell Significance Index: -6.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0107
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0182
    Cell Significance Index: -11.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0207
    Cell Significance Index: -15.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0250
    Cell Significance Index: -18.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0265
    Cell Significance Index: -20.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0329
    Cell Significance Index: -1.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0439
    Cell Significance Index: -0.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0524
    Cell Significance Index: -29.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0593
    Cell Significance Index: -3.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0619
    Cell Significance Index: -6.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0891
    Cell Significance Index: -16.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1058
    Cell Significance Index: -2.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1161
    Cell Significance Index: -1.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1213
    Cell Significance Index: -34.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1278
    Cell Significance Index: -18.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1304
    Cell Significance Index: -9.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1334
    Cell Significance Index: -28.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1629
    Cell Significance Index: -4.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1646
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1930
    Cell Significance Index: -22.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2981
    Cell Significance Index: -31.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3172
    Cell Significance Index: -36.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3439
    Cell Significance Index: -9.3600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4123
    Cell Significance Index: -5.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4136
    Cell Significance Index: -7.6500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4182
    Cell Significance Index: -6.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4592
    Cell Significance Index: -36.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4599
    Cell Significance Index: -5.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4932
    Cell Significance Index: -12.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5425
    Cell Significance Index: -13.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5457
    Cell Significance Index: -10.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5725
    Cell Significance Index: -14.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5919
    Cell Significance Index: -16.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6299
    Cell Significance Index: -20.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6375
    Cell Significance Index: -13.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6432
    Cell Significance Index: -17.2100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6651
    Cell Significance Index: -8.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6677
    Cell Significance Index: -14.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6733
    Cell Significance Index: -41.2800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6929
    Cell Significance Index: -14.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7414
    Cell Significance Index: -18.0900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7572
    Cell Significance Index: -11.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NFYC is a member of the NFY complex, which consists of three subunits: NFY-A, NFY-B, and NFY-C. NFYC is a DNA-binding transcription factor that interacts with RNA polymerase II to regulate gene expression. It is involved in the transcriptional regulation of genes involved in cellular stress response, lipid metabolism, and cholesterol biosynthesis. NFYC is also implicated in the regulation of ER stress response, with ATF6 (activating transcription factor 6) activating chaperone genes and Atf4 (activating transcription factor 4) activating genes in response to ER stress. **Pathways and Functions:** NFYC is involved in various cellular pathways, including: 1. **Activation of gene expression by SREBP (sterol regulatory element-binding protein):** NFYC collaborates with SREBP to regulate the transcription of genes involved in lipid metabolism and cholesterol biosynthesis. 2. **ER stress response:** NFYC is involved in the regulation of ER stress response, with ATF6 activating chaperone genes and Atf4 activating genes in response to ER stress. 3. **Cellular responses to stimuli:** NFYC is involved in the regulation of cellular responses to various stimuli, including oxidative stress, hypoxia, and nutrient deprivation. 4. **Gene expression (transcription):** NFYC regulates the transcription of genes involved in cellular stress response, lipid metabolism, and cholesterol biosynthesis. 5. **Metabolism:** NFYC is involved in the regulation of lipid metabolism and cholesterol biosynthesis. **Clinical Significance:** NFYC has significant implications for various diseases, including: 1. **Lipid metabolism disorders:** NFYC is involved in the regulation of lipid metabolism and cholesterol biosynthesis, making it a potential target for the treatment of lipid metabolism disorders, such as familial hypercholesterolemia. 2. **Cancer:** NFYC is overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis. 3. **Neurological disorders:** NFYC is involved in the regulation of gene expression in neural progenitor cells and GABAergic neurons, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular disease:** NFYC is involved in the regulation of gene expression in cardiac myocytes, making it a potential target for the treatment of cardiovascular disease. In conclusion, NFYC is a critical regulator of gene expression in response to cellular stress and metabolic pathways. Its dysregulation has significant implications for various diseases, including lipid metabolism disorders, cancer, neurological disorders, and cardiovascular disease. Further research is needed to fully elucidate the functions and clinical significance of NFYC.

Genular Protein ID: 3935118996

Symbol: NFYC_HUMAN

Name: Nuclear transcription factor Y subunit gamma

UniProtKB Accession Codes:

Q13952 B4DUS6 B4DW63 D3DPV9 F8VWM3 Q59GY4 Q5T6K8 Q5T6K9 Q5T6L1 Q5TZR6 Q92869 Q9HBX1 Q9NXB5 Q9UM67 Q9UML0 Q9UMT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 20 Ensembl 10 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 5 RefSeq 18 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8910521

Title: Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox.

PubMed ID: 8910521

DOI: 10.1074/jbc.271.46.28784

PubMed ID: 9249075

Title: Cloning and expression of human NF-YC.

PubMed ID: 9249075

DOI: 10.1016/s0378-1119(97)00109-1

PubMed ID: 9332362

Title: Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor.

PubMed ID: 9332362

DOI: 10.1016/s0378-1119(97)00255-2

PubMed ID: 10446203

Title: Cell cycle-dependent switch of up- and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y.

PubMed ID: 10446203

DOI: 10.1074/jbc.274.34.24270

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 12401788

Title: The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y.

PubMed ID: 12401788

DOI: 10.1074/jbc.m209635200

PubMed ID: 23332751

Title: Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.

PubMed ID: 23332751

DOI: 10.1016/j.cell.2012.11.047

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 458
  • Mass: 50302
  • Checksum: B17B2C7F622653B9
  • Sequence:
    • MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKM 
ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND IAMAITKFDQ FDFLIDIVPR 
DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ QPTAVQVQGQ QQGQQTTSST TTIQPGQIII 
AQPQQGQTTP VTMQVGEGQQ VQIVQAQPQG QAQQAQSGTG QTMQVMQQII TNTGEIQQIP 
VQLNAGQLQY IRLAQPVSGT QVVQGQIQTL ATNAQQGQRN ASQGKPRRCL KETLQITQTE 
VQQGQQQFSQ FTDGQRNSVQ QARVSELTGE AEPREVKATG NSTPCTSSLP TTHPPSHRAG 
ASCVCCSQPQ QSSTSPPPSD ALQWVVVEVS GTPNQLETHR ELHAPLPGMT SLSPLHPSQQ 
LYQIQQVTMP AGQDLAQPMF IQSANQPSDG QAPQVTGD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.