Details for: NHLH1

Gene ID: 4807

Symbol: NHLH1

Ensembl ID: ENSG00000171786

Description: nescient helix-loop-helix 1

Associated with

  • Cell differentiation
    (GO:0030154)
  • Central nervous system development
    (GO:0007417)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 29.3805
    Cell Significance Index: -4.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.9780
    Cell Significance Index: -4.5600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 5.1846
    Cell Significance Index: 29.4700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 3.9611
    Cell Significance Index: 25.7700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.6587
    Cell Significance Index: 29.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7134
    Cell Significance Index: 22.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5325
    Cell Significance Index: 11.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2249
    Cell Significance Index: 11.8100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.1859
    Cell Significance Index: 1.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0574
    Cell Significance Index: 16.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0515
    Cell Significance Index: 3.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0441
    Cell Significance Index: 3.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0369
    Cell Significance Index: 7.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0365
    Cell Significance Index: 6.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0310
    Cell Significance Index: 3.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0184
    Cell Significance Index: 0.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0113
    Cell Significance Index: 1.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0069
    Cell Significance Index: 3.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0032
    Cell Significance Index: 1.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0012
    Cell Significance Index: 0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0015
    Cell Significance Index: -0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -4.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0040
    Cell Significance Index: -6.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -5.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0049
    Cell Significance Index: -3.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0058
    Cell Significance Index: -4.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0063
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0065
    Cell Significance Index: -4.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0076
    Cell Significance Index: -4.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0116
    Cell Significance Index: -2.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0153
    Cell Significance Index: -0.8600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0162
    Cell Significance Index: -0.1600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0165
    Cell Significance Index: -0.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0167
    Cell Significance Index: -2.4300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0169
    Cell Significance Index: -0.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0191
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0195
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0225
    Cell Significance Index: -4.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0225
    Cell Significance Index: -0.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0228
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0271
    Cell Significance Index: -4.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0284
    Cell Significance Index: -3.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0306
    Cell Significance Index: -1.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0323
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0353
    Cell Significance Index: -4.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0358
    Cell Significance Index: -0.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0359
    Cell Significance Index: -0.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0372
    Cell Significance Index: -4.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0377
    Cell Significance Index: -4.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0395
    Cell Significance Index: -1.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0431
    Cell Significance Index: -0.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0446
    Cell Significance Index: -3.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0457
    Cell Significance Index: -1.1400
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: -0.0497
    Cell Significance Index: -0.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0498
    Cell Significance Index: -1.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0518
    Cell Significance Index: -1.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0530
    Cell Significance Index: -2.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0531
    Cell Significance Index: -1.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0541
    Cell Significance Index: -1.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0544
    Cell Significance Index: -3.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0552
    Cell Significance Index: -2.7900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0559
    Cell Significance Index: -0.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0602
    Cell Significance Index: -1.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0610
    Cell Significance Index: -3.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0610
    Cell Significance Index: -3.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0635
    Cell Significance Index: -4.7400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0671
    Cell Significance Index: -0.9500
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0674
    Cell Significance Index: -0.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0677
    Cell Significance Index: -3.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0679
    Cell Significance Index: -5.2100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0714
    Cell Significance Index: -1.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0715
    Cell Significance Index: -2.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0736
    Cell Significance Index: -3.0100
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0756
    Cell Significance Index: -0.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0763
    Cell Significance Index: -1.6300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0789
    Cell Significance Index: -0.9200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0856
    Cell Significance Index: -1.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0884
    Cell Significance Index: -3.9100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0895
    Cell Significance Index: -1.9000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0895
    Cell Significance Index: -0.7700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0914
    Cell Significance Index: -1.4500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0915
    Cell Significance Index: -1.3900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0918
    Cell Significance Index: -0.8500
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0938
    Cell Significance Index: -1.0700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0951
    Cell Significance Index: -1.0500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0962
    Cell Significance Index: -1.0500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0966
    Cell Significance Index: -2.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0970
    Cell Significance Index: -3.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1017
    Cell Significance Index: -3.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1022
    Cell Significance Index: -3.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1022
    Cell Significance Index: -2.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1058
    Cell Significance Index: -1.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1063
    Cell Significance Index: -2.1400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1064
    Cell Significance Index: -2.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1087
    Cell Significance Index: -1.2400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1088
    Cell Significance Index: -1.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1110
    Cell Significance Index: -3.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NHLH1 is a member of the helix-loop-helix (HLH) family of transcription factors, characterized by its ability to bind to specific DNA sequences and regulate gene expression. It is predominantly expressed in cells of the nervous system, including neural progenitor cells, neurons, and glial cells, as well as in immune cells such as granulocytes and monocytes. NHLH1's expression is also observed in epithelial cells, including goblet cells in the colon and enterocytes in the small intestine. **Pathways and Functions:** NHLH1 is involved in several key pathways, including: 1. **Cell differentiation:** NHLH1 regulates the expression of genes involved in cell differentiation, particularly in the development of neurons and glial cells. 2. **Central nervous system development:** NHLH1 plays a crucial role in the development of the central nervous system, including the formation of neural progenitor cells and the differentiation of neurons. 3. **Chromatin regulation:** NHLH1 interacts with chromatin-modifying enzymes to regulate gene expression and maintain genome stability. 4. **Transcriptional regulation:** NHLH1 activates the transcription of target genes by binding to specific DNA sequences and recruiting RNA polymerase II. **Clinical Significance:** NHLH1's expression in various cell types highlights its potential role in regulating immune responses and tissue development. Abnormalities in NHLH1 expression have been implicated in several neurological and immunological disorders, including: 1. **Neurological disorders:** Mutations in NHLH1 have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Immune system dysregulation:** Abnormalities in NHLH1 expression have been linked to immune system dysregulation, including autoimmune diseases and cancer. 3. **Cancer:** NHLH1 has been identified as a potential tumor suppressor gene, and its expression is often reduced in cancer cells. In conclusion, NHLH1 is a multifunctional transcription factor that plays a critical role in regulating gene expression in various cell types, including immune cells and neural progenitors. Its dysregulation has been implicated in several neurological and immunological disorders, highlighting its potential as a therapeutic target for the treatment of these diseases. **Recommendations:** Further research is needed to fully elucidate the mechanisms by which NHLH1 regulates gene expression and its role in immune regulation and development. Additionally, the development of therapeutic strategies targeting NHLH1 may provide new avenues for the treatment of neurological and immunological disorders. **Limitations:** This review highlights the importance of NHLH1 in regulating gene expression and its role in immune regulation and development. However, further research is needed to fully understand the mechanisms by which NHLH1 regulates gene expression and its role in various diseases. **Future Directions:** 1. **Functional studies:** Further studies are needed to elucidate the mechanisms by which NHLH1 regulates gene expression and its role in immune regulation and development. 2. **Therapeutic strategies:** Development of therapeutic strategies targeting NHLH1 may provide new avenues for the treatment of neurological and immunological disorders. 3. **Clinical applications:** NHLH1's expression in various cell types highlights its potential role in regulating immune responses and tissue development, making it an attractive target for the development of novel therapeutic strategies.

Genular Protein ID: 683442662

Symbol: HEN1_HUMAN

Name: Helix-loop-helix protein 1

UniProtKB Accession Codes:

Q02575

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1528853

Title: HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma.

PubMed ID: 1528853

DOI: 10.1073/pnas.89.18.8492

PubMed ID: 1328219

Title: A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system.

PubMed ID: 1328219

DOI: 10.1016/s0021-9258(19)36798-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 133
  • Mass: 14618
  • Checksum: FE90B574BE16D2C6
  • Sequence:
    • MMLNSDTMEL DLPPTHSETE SGFSDCGGGA GPDGAGPGGP GGGQARGPEP GEPGRKDLQH 
LSREERRRRR RATAKYRTAH ATRERIRVEA FNLAFAELRK LLPTLPPDKK LSKIEILRLA 
ICYISYLNHV LDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.