Details for: NIT1

Gene ID: 4817

Symbol: NIT1

Ensembl ID: ENSG00000158793

Description: nitrilase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 135.5876
    Cell Significance Index: -21.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 77.3527
    Cell Significance Index: -19.6200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 55.8081
    Cell Significance Index: -22.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.1068
    Cell Significance Index: -19.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 48.4832
    Cell Significance Index: -22.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.5386
    Cell Significance Index: -22.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 34.1717
    Cell Significance Index: -22.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.3056
    Cell Significance Index: -22.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4659
    Cell Significance Index: -20.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8109
    Cell Significance Index: -22.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3126
    Cell Significance Index: -7.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9747
    Cell Significance Index: 321.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4232
    Cell Significance Index: 85.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.3478
    Cell Significance Index: 36.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3392
    Cell Significance Index: 156.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1214
    Cell Significance Index: 15.3000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8595
    Cell Significance Index: 7.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8437
    Cell Significance Index: 167.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8202
    Cell Significance Index: 17.7700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.7904
    Cell Significance Index: 4.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7354
    Cell Significance Index: 50.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7234
    Cell Significance Index: 37.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6353
    Cell Significance Index: 18.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6352
    Cell Significance Index: 16.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5348
    Cell Significance Index: 24.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3913
    Cell Significance Index: 70.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3875
    Cell Significance Index: 211.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3439
    Cell Significance Index: 16.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3377
    Cell Significance Index: 41.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3244
    Cell Significance Index: 8.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3131
    Cell Significance Index: 8.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2688
    Cell Significance Index: 36.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2591
    Cell Significance Index: 30.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2417
    Cell Significance Index: 45.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2245
    Cell Significance Index: 13.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2229
    Cell Significance Index: 14.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2178
    Cell Significance Index: 13.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1962
    Cell Significance Index: 39.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1938
    Cell Significance Index: 85.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1877
    Cell Significance Index: 24.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1546
    Cell Significance Index: 4.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1505
    Cell Significance Index: 3.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1390
    Cell Significance Index: 2.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1295
    Cell Significance Index: 4.5000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1165
    Cell Significance Index: 0.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1060
    Cell Significance Index: 7.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0943
    Cell Significance Index: 3.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0778
    Cell Significance Index: 27.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0711
    Cell Significance Index: 1.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0681
    Cell Significance Index: 1.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0634
    Cell Significance Index: 2.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0514
    Cell Significance Index: 46.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0497
    Cell Significance Index: 2.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0433
    Cell Significance Index: 3.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0432
    Cell Significance Index: 0.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0339
    Cell Significance Index: 63.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0334
    Cell Significance Index: 3.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0314
    Cell Significance Index: 5.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0299
    Cell Significance Index: 0.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0217
    Cell Significance Index: 33.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0180
    Cell Significance Index: 2.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0158
    Cell Significance Index: 29.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0138
    Cell Significance Index: 8.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0102
    Cell Significance Index: 0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0082
    Cell Significance Index: 11.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0077
    Cell Significance Index: 5.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0058
    Cell Significance Index: 0.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0068
    Cell Significance Index: -0.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0087
    Cell Significance Index: -6.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0094
    Cell Significance Index: -0.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0144
    Cell Significance Index: -6.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0155
    Cell Significance Index: -1.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0290
    Cell Significance Index: -21.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0365
    Cell Significance Index: -20.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0402
    Cell Significance Index: -25.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0403
    Cell Significance Index: -0.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0560
    Cell Significance Index: -4.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0585
    Cell Significance Index: -16.8200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0726
    Cell Significance Index: -0.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0794
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1136
    Cell Significance Index: -13.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1209
    Cell Significance Index: -25.4700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1556
    Cell Significance Index: -0.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1644
    Cell Significance Index: -4.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1666
    Cell Significance Index: -11.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1713
    Cell Significance Index: -9.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1933
    Cell Significance Index: -20.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1996
    Cell Significance Index: -3.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2183
    Cell Significance Index: -17.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2220
    Cell Significance Index: -9.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2285
    Cell Significance Index: -14.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2499
    Cell Significance Index: -3.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2658
    Cell Significance Index: -3.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2771
    Cell Significance Index: -6.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2852
    Cell Significance Index: -10.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2886
    Cell Significance Index: -7.7200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2897
    Cell Significance Index: -4.8800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3171
    Cell Significance Index: -3.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3308
    Cell Significance Index: -17.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The NIT1 gene is a pseudogene, meaning that it has undergone significant mutations and has lost its functional capabilities. Despite this, it remains significantly expressed in various cell types, including pulmonary interstitial fibroblasts, placental villous trophoblasts, and oogonial cells. The gene's expression patterns suggest that it plays a vital role in the regulation of cellular processes, particularly those involved in the metabolism of glutathione and other amino acids. **Pathways and Functions:** The NIT1 gene is involved in several key pathways, including: 1. **Amide catabolic process:** NIT1 is a deaminated glutathione amidase, which suggests that it plays a crucial role in the degradation of amides, a class of compounds that are involved in various cellular processes. 2. **Cytoplasmic localization:** The gene's expression in cytoplasmic cells suggests that it is involved in the regulation of cellular metabolism, particularly in the context of energy production and nutrient uptake. 3. **Mitochondrial localization:** The presence of NIT1 in mitochondrial cells indicates that it may play a role in the regulation of mitochondrial function and energy production. 4. **Nucleus:** The gene's expression in nucleus suggests that it may be involved in the regulation of gene expression and cellular differentiation. **Clinical Significance:** The NIT1 gene has been implicated in various diseases, including: 1. **Cancer:** Aberrant expression of NIT1 has been observed in several types of cancer, including lung, colon, and breast cancer. This suggests that the gene may play a role in the development and progression of these diseases. 2. **Neurological disorders:** NIT1 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. The gene's expression in GABAergic interneurons and radial glial cells suggests that it may play a role in the regulation of neuronal function and synaptic plasticity. 3. **Immune system:** The gene's expression in immune cells, including T cells and B cells, suggests that it may play a role in the regulation of immune function and the development of autoimmune diseases. In conclusion, the NIT1 gene is a complex and multifaceted gene that plays a crucial role in various cellular processes, including metabolism, gene expression, and immune function. Further research is needed to fully elucidate the gene's role in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 463524661

Symbol: NIT1_HUMAN

Name: Deaminated glutathione amidase

UniProtKB Accession Codes:

Q86X76 B1AQP3 D3DVF4 O76091

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 4 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 5 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9671749

Title: Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans.

PubMed ID: 9671749

DOI: 10.1073/pnas.95.15.8744

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 327
  • Mass: 35896
  • Checksum: 90F7FB9D4BA627B1
  • Sequence:
    • MLGFITRPPH RFLSLLCPGL RIPQLSVLCA QPRPRAMAIS SSSCELPLVA VCQVTSTPDK 
QQNFKTCAEL VREAARLGAC LAFLPEAFDF IARDPAETLH LSEPLGGKLL EEYTQLAREC 
GLWLSLGGFH ERGQDWEQTQ KIYNCHVLLN SKGAVVATYR KTHLCDVEIP GQGPMCESNS 
TMPGPSLESP VSTPAGKIGL AVCYDMRFPE LSLALAQAGA EILTYPSAFG SITGPAHWEV 
LLRARAIETQ CYVVAAAQCG RHHEKRASYG HSMVVDPWGT VVARCSEGPG LCLARIDLNY 
LRQLRRHLPV FQHRRPDLYG NLGHPLS

Genular Protein ID: 495638524

Symbol: B7Z410_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z410

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 312
  • Mass: 34265
  • Checksum: A26FFF9B75D24EE0
  • Sequence:
    • MTFGLRKRLS EERGFSLMPR AMAISSSSCE LPLVAVCQVT STPDKQQNFK TCAELVREAA 
RLGACLAFLP EAFDFIARDP AETLHLSEPL GGKLLEEYTQ LARECGLWLS LGGFHERGQD 
WEQTQKIYNC HVLLNSKGAV VATYRKTHLC DVEIPGQGPM CESNSTMPGP SLESPVSTPA 
GKIGLAVCYG MRFPELSLAL AQAGAEILTY PSAFGSITGP AHWEVLLRAR AIETQCYVVA 
AAQCGRHHEK RASYGHSMVV DPWGTVVARC SEGPGLCLAR IDLNYLRQLR RHLPVFQHRR 
PDLYGNLGHP LS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.