Details for: NMT1

Gene ID: 4836

Symbol: NMT1

Ensembl ID: ENSG00000136448

Description: N-myristoyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 332.9578
    Cell Significance Index: -51.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 222.3989
    Cell Significance Index: -56.4100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 152.6772
    Cell Significance Index: -62.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 124.0567
    Cell Significance Index: -58.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 119.0625
    Cell Significance Index: -48.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 106.2433
    Cell Significance Index: -54.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.8933
    Cell Significance Index: -48.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.7657
    Cell Significance Index: -57.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.3706
    Cell Significance Index: -54.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.2501
    Cell Significance Index: -46.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.8959
    Cell Significance Index: -58.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.1918
    Cell Significance Index: -31.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1670
    Cell Significance Index: 430.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1135
    Cell Significance Index: 259.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1099
    Cell Significance Index: 380.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5459
    Cell Significance Index: 310.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.4568
    Cell Significance Index: 91.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4494
    Cell Significance Index: 38.7000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.4236
    Cell Significance Index: 16.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4079
    Cell Significance Index: 12.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2958
    Cell Significance Index: 210.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9492
    Cell Significance Index: 24.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8370
    Cell Significance Index: 23.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7400
    Cell Significance Index: 511.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7215
    Cell Significance Index: 258.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7092
    Cell Significance Index: 97.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6801
    Cell Significance Index: 31.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6709
    Cell Significance Index: 18.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6681
    Cell Significance Index: 51.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6363
    Cell Significance Index: 28.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6355
    Cell Significance Index: 18.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6275
    Cell Significance Index: 277.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5993
    Cell Significance Index: 27.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5982
    Cell Significance Index: 76.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5817
    Cell Significance Index: 317.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4304
    Cell Significance Index: 42.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3873
    Cell Significance Index: 20.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2935
    Cell Significance Index: 20.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2816
    Cell Significance Index: 19.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1709
    Cell Significance Index: 315.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1646
    Cell Significance Index: 253.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1583
    Cell Significance Index: 3.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1581
    Cell Significance Index: 18.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1577
    Cell Significance Index: 9.7000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1262
    Cell Significance Index: 3.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1117
    Cell Significance Index: 5.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1050
    Cell Significance Index: 2.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1017
    Cell Significance Index: 17.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1015
    Cell Significance Index: 19.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0897
    Cell Significance Index: 2.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0897
    Cell Significance Index: 168.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0872
    Cell Significance Index: 78.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0606
    Cell Significance Index: 82.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0475
    Cell Significance Index: 3.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0360
    Cell Significance Index: 1.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0244
    Cell Significance Index: 1.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0003
    Cell Significance Index: 0.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0156
    Cell Significance Index: -7.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0172
    Cell Significance Index: -12.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0241
    Cell Significance Index: -17.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0252
    Cell Significance Index: -15.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0336
    Cell Significance Index: -25.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0771
    Cell Significance Index: -43.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0981
    Cell Significance Index: -12.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1366
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1605
    Cell Significance Index: -33.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1674
    Cell Significance Index: -4.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1718
    Cell Significance Index: -20.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1739
    Cell Significance Index: -11.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1772
    Cell Significance Index: -50.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1933
    Cell Significance Index: -22.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1947
    Cell Significance Index: -19.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2051
    Cell Significance Index: -29.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2090
    Cell Significance Index: -15.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2236
    Cell Significance Index: -24.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2789
    Cell Significance Index: -14.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3249
    Cell Significance Index: -14.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3574
    Cell Significance Index: -40.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3784
    Cell Significance Index: -6.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4219
    Cell Significance Index: -14.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4758
    Cell Significance Index: -49.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4881
    Cell Significance Index: -6.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4899
    Cell Significance Index: -18.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5250
    Cell Significance Index: -41.5800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5500
    Cell Significance Index: -11.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5742
    Cell Significance Index: -9.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8015
    Cell Significance Index: -49.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8265
    Cell Significance Index: -23.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8484
    Cell Significance Index: -12.5300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8646
    Cell Significance Index: -7.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8752
    Cell Significance Index: -20.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8909
    Cell Significance Index: -28.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9534
    Cell Significance Index: -25.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9549
    Cell Significance Index: -16.0900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0617
    Cell Significance Index: -22.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1131
    Cell Significance Index: -8.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.1254
    Cell Significance Index: -20.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.1597
    Cell Significance Index: -34.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1729
    Cell Significance Index: -24.5500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -1.1813
    Cell Significance Index: -19.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NMT1 is a member of the NMT family of enzymes, which are responsible for the N-myristoylation of proteins. This process involves the transfer of a myristoyl group (-C10-15-CH3) from Myristoyl-CoA to the N-terminus of target proteins. NMT1 is a cytosolic enzyme that exhibits high specificity for its substrate proteins, with a preference for N-terminally myristoylated proteins. The addition of a myristoyl group to proteins can influence their interaction with membranes, regulate their activity, and modulate their stability. **Pathways and Functions** NMT1 is involved in various cellular pathways, including: 1. **Apoptosis**: NMT1 has been shown to regulate the activity of pro-apoptotic proteins, such as Bid, which is involved in the intrinsic pathway of apoptosis. 2. **Cellular Metabolism**: NMT1 is involved in the regulation of cellular metabolism, including ketone body metabolism, which is essential for energy production in neurons. 3. **Viral Infection**: NMT1 has been implicated in the regulation of viral infection pathways, including the HIV life cycle, where it modulates the activity of viral proteins. 4. **Phototransduction**: NMT1 regulates the phototransduction cascade, which is essential for visual perception, by modifying the activity of rhodopsin, a key photoreceptor protein. 5. **Neurotransmission**: NMT1 is involved in the regulation of neurotransmission, including the activity of GABAergic interneurons, which play a critical role in neural circuitry. **Clinical Significance** Dysregulation of NMT1 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders**: NMT1 has been shown to play a role in the regulation of apoptosis and cellular metabolism in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: NMT1 has been implicated in the regulation of cancer cell metabolism and survival, making it a potential target for cancer therapy. 3. **Viral Infections**: NMT1 has been shown to play a role in the regulation of viral infections, including HIV, making it a potential target for antiviral therapy. 4. **Visual Impairment**: NMT1 has been implicated in the regulation of phototransduction, which is essential for visual perception, making it a potential target for the treatment of visual impairments. In conclusion, NMT1 is a critical enzyme involved in various cellular processes, including apoptosis, cellular metabolism, and viral infection pathways. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention. Further research is needed to fully understand the role of NMT1 in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 319081890

Symbol: NMT1_HUMAN

Name: Myristoyl-CoA:protein N-myristoyltransferase 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9353336

Title: Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction.

PubMed ID: 9353336

DOI: 10.1074/jbc.272.45.28680

PubMed ID: 9506952

Title: A second mammalian N-myristoyltransferase.

PubMed ID: 9506952

DOI: 10.1074/jbc.273.12.6595

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1570339

Title: Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae.

PubMed ID: 1570339

DOI: 10.1073/pnas.89.9.4129

PubMed ID: 9677304

Title: Characterization of human and rat brain myristoyl-CoA:protein N-myristoyltransferase: evidence for an alternative splice variant of the enzyme.

PubMed ID: 9677304

DOI: 10.1042/bj3330491

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22865860

Title: Identification and characterization of an extramitochondrial human 3-Hydroxy-3-methylglutaryl-CoA lyase.

PubMed ID: 22865860

DOI: 10.1074/jbc.m112.393231

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32686708

Title: N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells.

PubMed ID: 32686708

DOI: 10.1038/s41598-020-68615-w

PubMed ID: 34999170

Title: N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression.

PubMed ID: 34999170

DOI: 10.1016/j.canlet.2022.01.001

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 32103017

Title: NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle.

PubMed ID: 32103017

DOI: 10.1038/s41467-020-14893-x

PubMed ID: 32111831

Title: High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.

PubMed ID: 32111831

DOI: 10.1038/s41467-020-14847-3

Sequence Information:

  • Length: 496
  • Mass: 56806
  • Checksum: 7661140D3837BE7A
  • Sequence:
  • MADESETAVK PPAPPLPQMM EGNGNGHEHC SDCENEEDNS YNRGGLSPAN DTGAKKKKKK 
    QKKKKEKGSE TDSAQDQPVK MNSLPAERIQ EIQKAIELFS VGQGPAKTME EASKRSYQFW 
    DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY TLPQGFTWDA LDLGDRGVLK ELYTLLNENY 
    VEDDDNMFRF DYSPEFLLWA LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK 
    KMVEINFLCV HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS 
    LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP METKDIPVVH QLLTRYLKQF 
    HLTPVMSQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF YTLPSTIMNH PTHKSLKAAY 
    SFYNVHTQTP LLDLMSDALV LAKMKGFDVF NALDLMENKT FLEKLKFGIG DGNLQYYLYN 
    WKCPSMGAEK VGLVLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.