NMT1 | ENSG00000136448 | NCBI 4836

Details for: NMT1

Associated with

Activation, myristolyation of bid and translocation to mitochondria
(R-HSA-75108)
Apoptosis
(R-HSA-109581)
Disease
(R-HSA-1643685)
Enos activation
(R-HSA-203615)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Inactivation, recovery and regulation of the phototransduction cascade
(R-HSA-2514859)
Infectious disease
(R-HSA-5663205)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism
(R-HSA-1430728)
Metabolism of nitric oxide: nos3 activation and regulation
(R-HSA-202131)
Programmed cell death
(R-HSA-5357801)
Sensory perception
(R-HSA-9709957)
The phototransduction cascade
(R-HSA-2514856)
Viral infection pathways
(R-HSA-9824446)
Visual phototransduction
(R-HSA-2187338)
Cellular ketone metabolic process
(GO:0042180)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Glycylpeptide n-tetradecanoyltransferase activity
(GO:0004379)
In utero embryonic development
(GO:0001701)
Myristoyltransferase activity
(GO:0019107)
N-terminal peptidyl-glycine n-myristoylation
(GO:0018008)
Peptidyl-lysine n6-myristoyltransferase activity
(GO:0018030)
Plasma membrane
(GO:0005886)
Positive regulation of establishment of protein localization to mitochondrion
(GO:1903749)
Protein binding
(GO:0005515)
Protein localization to membrane
(GO:0072657)
Regulation of opsin-mediated signaling pathway
(GO:0022400)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

Bergmann glial cell CL0000644

CSI 15.38

rCSI 21.05%

PRS 22.92
type B pancreatic cell CL0000169

CSI 14

rCSI 31%

PRS 21.44
M cell of gut CL0000682

CSI 12.88

rCSI 13.69%

PRS 38.92
epithelial cell of lower respiratory tract CL0002632

CSI 10.9

rCSI 8.45%

PRS 22.42
retinal cone cell CL0000573

CSI 10.65

rCSI 17.14%

PRS 17.73
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 9.91

rCSI 6.68%

PRS 28.87
erythrocyte CL0000232

CSI 9.57

rCSI 21.7%

PRS 30.38
elicited macrophage CL0000861

CSI 8.61

rCSI 7.91%

PRS 27.57
intestine goblet cell CL0019031

CSI 8.39

rCSI 7.45%

PRS 23.42
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 8.36

rCSI 19.05%

PRS 23.81
cerebellar granule cell CL0001031

CSI 8.31

rCSI 12.21%

PRS 21.4
parietal epithelial cell CL1000452

CSI 6.99

rCSI 18.68%

PRS 19.25
luminal epithelial cell of mammary gland CL0002326

CSI 6.17

rCSI 11.21%

PRS 35.24
epithelial cell of lung CL0000082

CSI 5.91

rCSI 4.9%

PRS 22.06
dendritic cell, human CL0001056

CSI 5.88

rCSI 9.04%

PRS 27.98
hepatocyte CL0000182

CSI 5.31

rCSI 9.51%

PRS 21.5
transit amplifying cell CL0009010

CSI 5.17

rCSI 7.91%

PRS 37.23
lung ciliated cell CL1000271

CSI 4.93

rCSI 5.7%

PRS 17.16
innate lymphoid cell CL0001065

CSI 4.87

rCSI 10.05%

PRS 34
glioblast CL0000030

CSI 4.13

rCSI 6.58%

PRS 19.76
myeloid dendritic cell CL0000782

CSI 4.12

rCSI 5.97%

PRS 35.24
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.79

rCSI 3.03%

PRS 41.19
CD1c-positive myeloid dendritic cell CL0002399

CSI 3.77

rCSI 4.55%

PRS 28.17
renal interstitial pericyte CL1001318

CSI 3.75

rCSI 10.33%

PRS 21.62
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 3.51

rCSI 17.6%

PRS 30.72
syncytiotrophoblast cell CL0000525

CSI 3.42

rCSI 9.86%

PRS 41.51
erythroblast CL0000765

CSI 3.34

rCSI 8.86%

PRS 35.68
CD8-positive, alpha-beta thymocyte CL0000811

CSI 2.91

rCSI 4.54%

PRS 50.8
activated CD8-positive, alpha-beta T cell CL0000906

CSI 2.84

rCSI 2.79%

PRS 57.72
double negative thymocyte CL0002489

CSI 2.82

rCSI 1.96%

PRS 28.1
enteroendocrine cell CL0000164

CSI 2.82

rCSI 3.86%

PRS 25.81
respiratory hillock cell CL4030023

CSI 2.81

rCSI 5.01%

PRS 37.98
cytotoxic T cell CL0000910

CSI 2.79

rCSI 15.96%

PRS 34.19
brush cell of tracheobronchial tree CL0002075

CSI 2.78

rCSI 8.24%

PRS 32.32
interneuron CL0000099

CSI 2.73

rCSI 5.48%

PRS 17.13
mature alpha-beta T cell CL0000791

CSI 2.72

rCSI 9.84%

PRS 39.65
effector CD8-positive, alpha-beta T cell CL0001050

CSI 2.67

rCSI 2.03%

PRS 30.85
hematopoietic multipotent progenitor cell CL0000837

CSI 2.56

rCSI 6.16%

PRS 36.71
myoepithelial cell CL0000185

CSI 2.48

rCSI 6.27%

PRS 28.58
mesodermal cell CL0000222

CSI 2.43

rCSI 2.92%

PRS 22.61
fallopian tube secretory epithelial cell CL4030006

CSI 2.41

rCSI 2.32%

PRS 24.06
ionocyte CL0005006

CSI 2.4

rCSI 2.57%

PRS 21.4
pro-B cell CL0000826

CSI 2.38

rCSI 1.97%

PRS 23.65
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 2.32

rCSI 8.33%

PRS 13.03
unswitched memory B cell CL0000970

CSI 2.28

rCSI 1.92%

PRS 36.76
conjunctival epithelial cell CL1000432

CSI 2.27

rCSI 3.46%

PRS 23.42
ciliated cell CL0000064

CSI 2.25

rCSI 3.65%

PRS 23.33
melanocyte CL0000148

CSI 2.25

rCSI 1.66%

PRS 20
inflammatory macrophage CL0000863

CSI 2.2

rCSI 3.76%

PRS 46.31
corneal epithelial cell CL0000575

CSI 2.18

rCSI 6.23%

PRS 40.04
acinar cell CL0000622

CSI 2.17

rCSI 3.18%

PRS 30.4
pancreatic A cell CL0000171

CSI 2.17

rCSI 2.27%

PRS 24.63
pancreatic acinar cell CL0002064

CSI 2.14

rCSI 2.85%

PRS 25.46
midzonal region hepatocyte CL0019028

CSI 2.09

rCSI 4.89%

PRS 32.91
T-helper 17 cell CL0000899

CSI 2.08

rCSI 1.65%

PRS 41.23
rod bipolar cell CL0000751

CSI 2.02

rCSI 3.62%

PRS 19.19
cardiac neuron CL0010022

CSI 1.98

rCSI 6.33%

PRS 19.12
ependymal cell CL0000065

CSI 1.96

rCSI 3.98%

PRS 12.32
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 1.96

rCSI 11.52%

PRS 14.5
plasmacytoid dendritic cell, human CL0001058

CSI 1.95

rCSI 1.36%

PRS 24.88
blood vessel smooth muscle cell CL0019018

CSI 1.93

rCSI 15.72%

PRS 22.6
retina horizontal cell CL0000745

CSI 1.89

rCSI 2.89%

PRS 21.4
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.85

rCSI 3.11%

PRS 13.84
fibroblast of lung CL0002553

CSI 1.83

rCSI 1.71%

PRS 23.26
macroglial cell CL0000126

CSI 1.82

rCSI 4.68%

PRS 29.43
OFF-bipolar cell CL0000750

CSI 1.81

rCSI 2.48%

PRS 35
mature astrocyte CL0002627

CSI 1.81

rCSI 7.71%

PRS 26.67
pulmonary alveolar type 1 cell CL0002062

CSI 1.81

rCSI 10.41%

PRS 28.96
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.79

rCSI 3.25%

PRS 19.78
Hofbauer cell CL3000001

CSI 1.78

rCSI 3.37%

PRS 29.52
lung neuroendocrine cell CL1000223

CSI 1.72

rCSI 2.54%

PRS 26.47
common myeloid progenitor CL0000049

CSI 1.72

rCSI 1.39%

PRS 23.45
alternatively activated macrophage CL0000890

CSI 1.71

rCSI 2.16%

PRS 35.38
myeloid leukocyte CL0000766

CSI 1.69

rCSI 1.56%

PRS 24.32
keratinocyte CL0000312

CSI 1.69

rCSI 1.41%

PRS 27.5
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 1.67

rCSI 1.64%

PRS 36.02
stem cell CL0000034

CSI 1.65

rCSI 1.59%

PRS 16.98
CD4-positive helper T cell CL0000492

CSI 1.62

rCSI 1.22%

PRS 31.94
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 1.59

rCSI 7.31%

PRS 50.42
respiratory suprabasal cell CL4033048

CSI 1.58

rCSI 2.03%

PRS 26.84
pulmonary capillary endothelial cell CL4028001

CSI 1.57

rCSI 2.99%

PRS 36.33
lung endothelial cell CL1001567

CSI 1.57

rCSI 3.66%

PRS 51.33
intrahepatic cholangiocyte CL0002538

CSI 1.55

rCSI 3.72%

PRS 40.39
pancreatic D cell CL0000173

CSI 1.54

rCSI 1.52%

PRS 24.96
cerebral cortex GABAergic interneuron CL0010011

CSI 1.54

rCSI 4.54%

PRS 27.27
CD14-low, CD16-positive monocyte CL0002396

CSI 1.52

rCSI 1.17%

PRS 21.78
interstitial cell of Cajal CL0002088

CSI 1.52

rCSI 1.93%

PRS 26.82
pvalb GABAergic cortical interneuron CL4023018

CSI 1.52

rCSI 1.89%

PRS 12.96
indirect pathway medium spiny neuron CL4023029

CSI 1.5

rCSI 36.18%

PRS 13.36
activated type II NK T cell CL0000931

CSI 1.5

rCSI 1.69%

PRS 36.79
retinal pigment epithelial cell CL0002586

CSI 1.49

rCSI 2.96%

PRS 24.24
kidney epithelial cell CL0002518

CSI 1.49

rCSI 2.84%

PRS 47.99
direct pathway medium spiny neuron CL4023026

CSI 1.48

rCSI 35.36%

PRS 12.45
mature T cell CL0002419

CSI 1.46

rCSI 1.14%

PRS 34.17
neural crest cell CL0011012

CSI 1.46

rCSI 1.15%

PRS 15.95
Mueller cell CL0000636

CSI 1.46

rCSI 3.33%

PRS 19.9
plasmablast CL0000980

CSI 1.46

rCSI 1.15%

PRS 28.21
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.45

rCSI 2.06%

PRS 21.51
amacrine cell CL0000561

CSI 1.44

rCSI 4.18%

PRS 18
fibroblast of cardiac tissue CL0002548

CSI 1.44

rCSI 6.89%

PRS 19.09

OFF midget ganglion cell CL4033047

CSI 0.2

rCSI 3.4%

PRS 20.2%
pluripotent stem cell CL0002248

CSI 0.2

rCSI 5.5%

PRS 47.9%
enterocyte of epithelium of small intestine CL1000334

CSI 0.2

rCSI 3.1%

PRS 53.2%
mucus secreting cell CL0000319

CSI 0.2

rCSI 0.3%

PRS 29.8%
regular ventricular cardiac myocyte CL0002131

CSI 0.2

rCSI 1.3%

PRS 18.2%
ON midget ganglion cell CL4033046

CSI 0.2

rCSI 4.2%

PRS 19.1%
medium spiny neuron CL1001474

CSI 0.2

rCSI 1.8%

PRS 12.7%
paneth cell CL0000510

CSI 0.3

rCSI 0.4%

PRS 36.1%
type EC enteroendocrine cell CL0000577

CSI 0.3

rCSI 1.1%

PRS 37.2%
suprabasal keratinocyte CL4033013

CSI 0.3

rCSI 0.5%

PRS 13.9%
mesenchymal cell CL0008019

CSI 0.3

rCSI 0.8%

PRS 23.1%
endothelial cell of placenta CL0009092

CSI 0.3

rCSI 1.5%

PRS 31.3%
bronchial goblet cell CL1000312

CSI 0.3

rCSI 1.3%

PRS 46.8%
Cajal-Retzius cell CL0000695

CSI 0.3

rCSI 2.6%

PRS 43.8%
regular atrial cardiac myocyte CL0002129

CSI 0.3

rCSI 1.1%

PRS 24.0%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.3

rCSI 0.7%

PRS 38.6%
megakaryocyte CL0000556

CSI 0.4

rCSI 1.5%

PRS 39.4%
primitive red blood cell CL0002355

CSI 0.4

rCSI 1.9%

PRS 38.6%
pancreatic ductal cell CL0002079

CSI 0.4

rCSI 0.8%

PRS 23.9%
intermediate monocyte CL0002393

CSI 0.4

rCSI 0.6%

PRS 23.8%
enteroendocrine cell of colon CL0009042

CSI 0.4

rCSI 1.9%

PRS 53.8%
pancreatic epsilon cell CL0005019

CSI 0.4

rCSI 1.9%

PRS 48.5%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 0.4

rCSI 0.4%

PRS 21.1%
erythroid progenitor cell CL0000038

CSI 0.4

rCSI 2.6%

PRS 34.1%
IgG plasma cell CL0000985

CSI 0.5

rCSI 0.5%

PRS 39.9%
helper T cell CL0000912

CSI 0.5

rCSI 0.7%

PRS 32.5%
pancreatic stellate cell CL0002410

CSI 0.5

rCSI 2.7%

PRS 34.1%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.5

rCSI 1.3%

PRS 30.1%
retinal blood vessel endothelial cell CL0002585

CSI 0.5

rCSI 0.8%

PRS 25.5%
neural progenitor cell CL0011020

CSI 0.5

rCSI 2.2%

PRS 21.2%
paneth cell of epithelium of small intestine CL1000343

CSI 0.5

rCSI 1.4%

PRS 35.7%
myeloid dendritic cell, human CL0001057

CSI 0.5

rCSI 2.9%

PRS 62.8%
retinal bipolar neuron CL0000748

CSI 0.5

rCSI 1.0%

PRS 16.8%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.6

rCSI 0.7%

PRS 28.2%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.6

rCSI 1.9%

PRS 15.7%
transit amplifying cell of small intestine CL0009012

CSI 0.6

rCSI 2.7%

PRS 41.8%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.6

rCSI 1.5%

PRS 15.8%
keratocyte CL0002363

CSI 0.6

rCSI 1.5%

PRS 33.7%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.6

rCSI 2.4%

PRS 14.3%
podocyte CL0000653

CSI 0.6

rCSI 2.8%

PRS 22.6%
kidney connecting tubule epithelial cell CL1000768

CSI 0.7

rCSI 1.7%

PRS 17.6%
basal cell of epidermis CL0002187

CSI 0.7

rCSI 1.2%

PRS 18.1%
sncg GABAergic cortical interneuron CL4023015

CSI 0.7

rCSI 1.1%

PRS 15.1%
astrocyte of the cerebral cortex CL0002605

CSI 0.7

rCSI 1.5%

PRS 14.5%
alveolar adventitial fibroblast CL4028006

CSI 0.7

rCSI 1.1%

PRS 23.3%
glutamatergic neuron CL0000679

CSI 0.7

rCSI 1.4%

PRS 22.6%
granulocyte CL0000094

CSI 0.7

rCSI 1.1%

PRS 30.2%
dopaminergic neuron CL0000700

CSI 0.7

rCSI 4.0%

PRS 13.7%
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 0.7

rCSI 1.5%

PRS 17.2%
brush cell CL0002204

CSI 0.7

rCSI 1.4%

PRS 52.9%
mature B cell CL0000785

CSI 0.7

rCSI 0.6%

PRS 29.4%
BEST4+ enteroycte CL4030026

CSI 0.7

rCSI 0.9%

PRS 24.8%
tracheobronchial smooth muscle cell CL0019019

CSI 0.8

rCSI 1.4%

PRS 30.0%
respiratory basal cell CL0002633

CSI 0.8

rCSI 0.8%

PRS 27.5%
intestinal epithelial cell CL0002563

CSI 0.8

rCSI 0.8%

PRS 24.2%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.8

rCSI 2.5%

PRS 15.9%
ciliated epithelial cell CL0000067

CSI 0.8

rCSI 0.7%

PRS 16.9%
alveolar macrophage CL0000583

CSI 0.8

rCSI 1.3%

PRS 27.5%
adventitial cell CL0002503

CSI 0.8

rCSI 2.0%

PRS 34.4%
inhibitory interneuron CL0000498

CSI 0.8

rCSI 1.9%

PRS 18.8%
mesenchymal stem cell CL0000134

CSI 0.9

rCSI 9.3%

PRS 40.1%
stromal cell of ovary CL0002132

CSI 0.9

rCSI 2.4%

PRS 37.6%
vascular associated smooth muscle cell CL0000359

CSI 0.9

rCSI 2.8%

PRS 27.7%
forebrain radial glial cell CL0013000

CSI 0.9

rCSI 2.8%

PRS 32.2%
cardiac endothelial cell CL0010008

CSI 0.9

rCSI 3.6%

PRS 21.4%
central nervous system neuron CL2000029

CSI 0.9

rCSI 6.5%

PRS 14.3%
basal-myoepithelial cell of mammary gland CL0002324

CSI 0.9

rCSI 1.7%

PRS 47.4%
T-helper 1 cell CL0000545

CSI 0.9

rCSI 1.6%

PRS 53.1%
foveolar cell of stomach CL0002179

CSI 0.9

rCSI 1.9%

PRS 36.5%
tendon cell CL0000388

CSI 0.9

rCSI 2.4%

PRS 54.4%
epithelial cell of proximal tubule CL0002306

CSI 0.9

rCSI 2.3%

PRS 22.5%
alveolar type 1 fibroblast cell CL4028004

CSI 1.0

rCSI 1.0%

PRS 26.0%
common dendritic progenitor CL0001029

CSI 1.0

rCSI 1.2%

PRS 30.2%
peripheral nervous system neuron CL2000032

CSI 1.0

rCSI 1.3%

PRS 20.3%
radial glial cell CL0000681

CSI 1.0

rCSI 1.3%

PRS 23.5%
choroid plexus epithelial cell CL0000706

CSI 1.0

rCSI 1.6%

PRS 17.8%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.0

rCSI 1.2%

PRS 40.0%
microcirculation associated smooth muscle cell CL0008035

CSI 1.0

rCSI 2.9%

PRS 26.1%
VIP GABAergic cortical interneuron CL4023016

CSI 1.0

rCSI 1.2%

PRS 13.7%
pulmonary alveolar type 2 cell CL0002063

CSI 1.0

rCSI 1.6%

PRS 34.1%
lung macrophage CL1001603

CSI 1.0

rCSI 2.2%

PRS 27.3%
class switched memory B cell CL0000972

CSI 1.0

rCSI 0.8%

PRS 38.8%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.0

rCSI 2.9%

PRS 35.1%
duct epithelial cell CL0000068

CSI 1.0

rCSI 1.5%

PRS 24.6%
retinal ganglion cell CL0000740

CSI 1.0

rCSI 2.3%

PRS 16.6%
chondrocyte CL0000138

CSI 1.0

rCSI 1.6%

PRS 19.6%
melanocyte of skin CL1000458

CSI 1.0

rCSI 1.4%

PRS 13.2%
retinal rod cell CL0000604

CSI 1.0

rCSI 1.8%

PRS 22.6%
contractile cell CL0000183

CSI 1.0

rCSI 3.0%

PRS 22.1%
basal cell CL0000646

CSI 1.0

rCSI 1.4%

PRS 25.3%
glandular epithelial cell CL0000150

CSI 1.0

rCSI 2.7%

PRS 44.3%
memory T cell CL0000813

CSI 1.1

rCSI 2.0%

PRS 51.3%
enteroendocrine cell of small intestine CL0009006

CSI 1.1

rCSI 2.3%

PRS 34.9%
L6b glutamatergic cortical neuron CL4023038

CSI 1.1

rCSI 3.3%

PRS 14.7%
cerebral cortex endothelial cell CL1001602

CSI 1.1

rCSI 1.9%

PRS 17.7%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 1.1

rCSI 2.6%

PRS 13.6%
promonocyte CL0000559

CSI 1.1

rCSI 1.9%

PRS 31.5%
extravillous trophoblast CL0008036

CSI 1.1

rCSI 1.3%

PRS 20.4%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.1

rCSI 1.3%

PRS 20.1%
lung pericyte CL0009089

CSI 1.1

rCSI 2.9%

PRS 27.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [NMT1](/details-gene/4836) (N-myristoyltransferase 1) is a protein-coding gene located on chromosome 17q21.31. It encodes a crucial enzyme responsible for the co-translational attachment of myristate, a 14-carbon saturated fatty acid, to the N-terminal glycine residue of a wide range of proteins. This modification, known as N-myristoylation ([GO:0018008](https://www.ebi.ac.uk/QuickGO/term/GO:0018008)), is vital for mediating protein-membrane interactions and is essential for the proper subcellular localization and function of its targets. Reflecting its fundamental role, [NMT1](/details-gene/4836) shows significant expression across a diverse array of functionally distinct cell types, including [Bergmann glial cells](/details-cell/CL0000644), [type B pancreatic cells](/details-cell/CL0000169), and various immune and epithelial cells, suggesting its broad importance in cellular signaling, metabolism, and structural integrity. Clinically, it is associated with OMIM entry [160993](https://omim.org/entry/160993). ## Cellular Roles and Expression Landscape The expression profile of [NMT1](/details-gene/4836) indicates its role as a fundamental enzyme with particularly high activity in cells with demanding signaling or metabolic functions. **Overall**, the gene exhibits its highest significance in highly specialized cells from disparate systems. It is a top marker in [Bergmann glial cells](/details-cell/CL0000644) of the cerebellum (CSI: 15.38), endocrine [type B pancreatic cells](/details-cell/CL0000169) (CSI: 14.00), and immunosurveillant [M cells of the gut](/details-cell/CL0000682) (CSI: 12.88). This diverse cellular landscape suggests that N-myristoylation is not a lineage-restricted process but rather a critical modification required by many cell types to execute their specialized functions. For instance, high expression is observed in sensory cells like [retinal cone cells](/details-cell/CL0000573) (CSI: 10.65), secretory cells such as [intestine goblet cells](/details-cell/CL0019031) (CSI: 8.39), and immune cells including [central memory CD8-positive, alpha-beta T cells](/details-cell/CL0000907) (CSI: 9.91) and [elicited macrophages](/details-cell/CL0000861) (CSI: 8.61). The consistent high significance across various epithelial cells, such as those of the lower respiratory tract ([CL0002632](/details-cell/CL0002632)) and lung ([CL0000082](/details-cell/CL0000082)), further underscores its importance in maintaining cellular structure and function at barrier surfaces. This pattern is consistent with a "housekeeping-plus" role, where [NMT1](/details-gene/4836) provides an essential enzymatic function that is upregulated in cells with high protein trafficking and signaling needs. ## Pathways and Molecular Function The primary molecular function of the [NMT1](/details-gene/4836) protein is glycylpeptide N-tetradecanoyltransferase activity ([GO:0004379](https://www.ebi.ac.uk/QuickGO/term/GO:0004379)), a process central to N-terminal protein myristoylation. This lipid modification is indispensable for localizing proteins to cellular membranes ([GO:0072657](https://www.ebi.ac.uk/QuickGO/term/GO:0072657)), including the plasma membrane ([GO:0005886](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)). The functional consequences of this activity are far-reaching, as reflected in the Reactome pathways where [NMT1](/details-gene/4836) is implicated. Its role in apoptosis ([R-HSA-109581](https://reactome.org/content/detail/R-HSA-109581)) is highlighted by its specific involvement in the myristoylation of the pro-apoptotic protein BID, which is required for its translocation to mitochondria ([R-HSA-75108](https://reactome.org/content/detail/R-HSA-75108)). This connects the gene directly to the intrinsic pathway for programmed cell death. Furthermore, its role in sensory perception ([R-HSA-9709957](https://reactome.org/content/detail/R-HSA-9709957)) is exemplified by its participation in the visual phototransduction cascade ([R-HSA-2187338](https://reactome.org/content/detail/R-HSA-2187338)), consistent with its high expression in [retinal cone cells](/details-cell/CL0000573). The enzyme is also co-opted during infectious diseases ([R-HSA-5663205](https://reactome.org/content/detail/R-HSA-5663205)), as it is essential for the myristoylation of viral proteins, such as those involved in the HIV life cycle ([R-HSA-162587](https://reactome.org/content/detail/R-HSA-162587)). ## Research Directions Given the fundamental and widespread role of [NMT1](/details-gene/4836)-mediated myristoylation, future research should focus on its context-specific functions and vulnerabilities in disease. **Proposed Hypotheses:** 1. Given the exceptionally high CSI of [NMT1](/details-gene/4836) in [Bergmann glial cells](/details-cell/CL0000644), it is hypothesized that [NMT1](/details-gene/4836) is essential for cerebellar function by myristoylating key proteins involved in neurotransmitter receptor trafficking or glutamate uptake, thereby modulating synaptic integrity and plasticity. 2. The enzyme's involvement in the HIV life cycle ([R-HSA-162587](https://reactome.org/content/detail/R-HSA-162587)) and high expression in key immune cells like [CD8-positive, alpha-beta T cells](/details-cell/CL0000907) suggests that partial inhibition of [NMT1](/details-gene/4836) could serve as a host-directed antiviral strategy, disrupting the viral life cycle while potentially preserving essential host cell functions. 3. Based on its high significance in [type B pancreatic cells](/details-cell/CL0000169), it is proposed that [NMT1](/details-gene/4836) activity is critical for the proper processing, membrane targeting, and regulated secretion of insulin, and its dysregulation could contribute to metabolic disorders. **Experimental Approach:** To test the hypothesis regarding its role in pancreatic beta cells (Hypothesis 3), one could utilize a beta cell-specific conditional knockout of [NMT1](/details-gene/4836) in a mouse model. Glucose tolerance tests and insulin secretion assays (in vivo and ex vivo from isolated islets) would reveal functional defects. Subcellular fractionation followed by mass spectrometry could identify myristoylated proteins whose localization to secretory granules or the plasma membrane is disrupted upon [NMT1](/details-gene/4836) deletion, thereby pinpointing the specific molecular mechanisms responsible for impaired insulin secretion. **Therapeutic Potential:** [NMT1](/details-gene/4836) represents a complex but promising therapeutic target. Its essential role in a wide variety of cells suggests that systemic **inhibition** would likely lead to significant toxicity. However, its crucial function in the life cycles of pathogens like HIV and its potential role in hyperproliferative diseases like cancer make it an attractive target for context-specific therapies. The development of NMT inhibitors is an active area of research for cancer and infectious diseases. The therapeutic challenge lies in achieving a sufficient therapeutic window, possibly through targeted drug delivery systems or by developing inhibitors that preferentially target the enzyme in diseased cells over healthy ones.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Myristoyl-CoA:protein N-myristoyltransferase 1

Genular Protein ID: 319081890

Symbol: NMT1_HUMAN

Name: Myristoyl-CoA:protein N-myristoyltransferase 1

UniProtKB Accession Codes:

P30419 A8K7C1 Q9UE09

Database IDs:

Citations:

PubMed ID: 9353336

Title: Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction.

PubMed ID: 9353336

DOI: 10.1074/jbc.272.45.28680

PubMed ID: 9506952

Title: A second mammalian N-myristoyltransferase.

PubMed ID: 9506952

DOI: 10.1074/jbc.273.12.6595

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1570339

Title: Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae.

PubMed ID: 1570339

DOI: 10.1073/pnas.89.9.4129

PubMed ID: 9677304

Title: Characterization of human and rat brain myristoyl-CoA:protein N-myristoyltransferase: evidence for an alternative splice variant of the enzyme.

PubMed ID: 9677304

DOI: 10.1042/bj3330491

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22865860

Title: Identification and characterization of an extramitochondrial human 3-Hydroxy-3-methylglutaryl-CoA lyase.

PubMed ID: 22865860

DOI: 10.1074/jbc.m112.393231

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32686708

Title: N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells.

PubMed ID: 32686708

DOI: 10.1038/s41598-020-68615-w

PubMed ID: 34999170

Title: N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression.

PubMed ID: 34999170

DOI: 10.1016/j.canlet.2022.01.001

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 32103017

Title: NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle.

PubMed ID: 32103017

DOI: 10.1038/s41467-020-14893-x

PubMed ID: 32111831

Title: High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.

PubMed ID: 32111831

DOI: 10.1038/s41467-020-14847-3

Sequence Information:

Length: 496
Mass: 56806
Checksum: 7661140D3837BE7A
Sequence:

MADESETAVK PPAPPLPQMM EGNGNGHEHC SDCENEEDNS YNRGGLSPAN DTGAKKKKKK 
QKKKKEKGSE TDSAQDQPVK MNSLPAERIQ EIQKAIELFS VGQGPAKTME EASKRSYQFW 
DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY TLPQGFTWDA LDLGDRGVLK ELYTLLNENY 
VEDDDNMFRF DYSPEFLLWA LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK 
KMVEINFLCV HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS 
LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP METKDIPVVH QLLTRYLKQF 
HLTPVMSQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF YTLPSTIMNH PTHKSLKAAY 
SFYNVHTQTP LLDLMSDALV LAKMKGFDVF NALDLMENKT FLEKLKFGIG DGNLQYYLYN 
WKCPSMGAEK VGLVLQ

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	\|— Prefrontal cortex Healthy UBERON0000451_PATO0000461
	Primary motor cortex UBERON0001384
	\|— Primary motor cortex Healthy UBERON0001384_PATO0000461
	Primary visual cortex UBERON0002436
	Renal medulla UBERON0000362
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Right cardiac atrium UBERON0002078
	\|— Right cardiac atrium Healthy UBERON0002078_PATO0000461
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: NMT1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction. PubMed ID: 9353336

A second mammalian N-myristoyltransferase. PubMed ID: 9506952

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae. PubMed ID: 1570339

Characterization of human and rat brain myristoyl-CoA:protein N-myristoyltransferase: evidence for an alternative splice variant of the enzyme. PubMed ID: 9677304

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Identification and characterization of an extramitochondrial human 3-Hydroxy-3-methylglutaryl-CoA lyase. PubMed ID: 22865860

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells. PubMed ID: 32686708

N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression. PubMed ID: 34999170

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. PubMed ID: 25255805

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. PubMed ID: 32103017

High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. PubMed ID: 32111831