Details for: NONO

Gene ID: 4841

Symbol: NONO

Ensembl ID: ENSG00000147140

Description: non-POU domain containing octamer binding

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 385.8685
    Cell Significance Index: -60.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 192.0807
    Cell Significance Index: -48.7200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 178.3479
    Cell Significance Index: -73.4700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 155.7434
    Cell Significance Index: -73.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 152.1019
    Cell Significance Index: -61.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 140.0701
    Cell Significance Index: -72.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 110.1528
    Cell Significance Index: -73.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 65.4050
    Cell Significance Index: -62.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 55.1034
    Cell Significance Index: -67.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.7713
    Cell Significance Index: -63.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.8609
    Cell Significance Index: -70.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.8980
    Cell Significance Index: -48.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0613
    Cell Significance Index: -22.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.5710
    Cell Significance Index: 316.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.2294
    Cell Significance Index: 146.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.0989
    Cell Significance Index: 44.5600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.9979
    Cell Significance Index: 31.9200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.3385
    Cell Significance Index: 42.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.2406
    Cell Significance Index: 67.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.6663
    Cell Significance Index: 70.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.2419
    Cell Significance Index: 59.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1311
    Cell Significance Index: 137.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1038
    Cell Significance Index: 288.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0300
    Cell Significance Index: 1108.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7927
    Cell Significance Index: 220.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7610
    Cell Significance Index: 207.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5685
    Cell Significance Index: 282.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2570
    Cell Significance Index: 249.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2223
    Cell Significance Index: 33.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1757
    Cell Significance Index: 519.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1439
    Cell Significance Index: 147.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1193
    Cell Significance Index: 79.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0982
    Cell Significance Index: 51.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9832
    Cell Significance Index: 11.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9509
    Cell Significance Index: 25.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8806
    Cell Significance Index: 41.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8245
    Cell Significance Index: 42.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8068
    Cell Significance Index: 23.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7862
    Cell Significance Index: 134.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6981
    Cell Significance Index: 69.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6926
    Cell Significance Index: 51.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6892
    Cell Significance Index: 19.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6153
    Cell Significance Index: 13.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5696
    Cell Significance Index: 114.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5330
    Cell Significance Index: 27.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5311
    Cell Significance Index: 68.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4602
    Cell Significance Index: 20.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4481
    Cell Significance Index: 13.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4287
    Cell Significance Index: 22.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4283
    Cell Significance Index: 153.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4256
    Cell Significance Index: 23.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3743
    Cell Significance Index: 10.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2393
    Cell Significance Index: 216.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2064
    Cell Significance Index: 5.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1741
    Cell Significance Index: 28.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1328
    Cell Significance Index: 91.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1107
    Cell Significance Index: 3.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0747
    Cell Significance Index: 1.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0560
    Cell Significance Index: 105.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0244
    Cell Significance Index: 0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0174
    Cell Significance Index: 26.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0147
    Cell Significance Index: 2.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0108
    Cell Significance Index: 19.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0082
    Cell Significance Index: 0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0014
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0093
    Cell Significance Index: -6.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0134
    Cell Significance Index: -8.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0202
    Cell Significance Index: -1.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0302
    Cell Significance Index: -19.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0324
    Cell Significance Index: -23.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0346
    Cell Significance Index: -47.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0367
    Cell Significance Index: -3.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0739
    Cell Significance Index: -4.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0771
    Cell Significance Index: -35.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0880
    Cell Significance Index: -49.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1339
    Cell Significance Index: -28.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1964
    Cell Significance Index: -21.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1993
    Cell Significance Index: -57.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2582
    Cell Significance Index: -8.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2741
    Cell Significance Index: -39.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2760
    Cell Significance Index: -7.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2788
    Cell Significance Index: -31.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3268
    Cell Significance Index: -5.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3918
    Cell Significance Index: -44.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4012
    Cell Significance Index: -46.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4918
    Cell Significance Index: -6.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5192
    Cell Significance Index: -39.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5925
    Cell Significance Index: -14.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6095
    Cell Significance Index: -63.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6587
    Cell Significance Index: -3.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6751
    Cell Significance Index: -45.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7292
    Cell Significance Index: -57.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8479
    Cell Significance Index: -14.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9784
    Cell Significance Index: -17.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9905
    Cell Significance Index: -25.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0926
    Cell Significance Index: -23.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.1826
    Cell Significance Index: -17.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1873
    Cell Significance Index: -72.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2201
    Cell Significance Index: -53.9700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -1.3694
    Cell Significance Index: -14.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NONO is a protein-coding gene that belongs to the non-POU domain containing family. It is predominantly expressed in cells of mesodermal origin, including interstitial cells of the ovary, CD8-alpha-alpha-positive T cells, and epithelial cells of the nephron. NONO's primary function is to regulate the activation of innate immune response, which is essential for the early defense against pathogens. Additionally, NONO has been implicated in the regulation of circadian rhythm, DNA repair, and DNA recombination. **Pathways and Functions:** NONO's involvement in various cellular processes can be attributed to its ability to bind to specific DNA sequences, such as octamer-binding sites, and regulate the expression of target genes. The gene's functions can be broadly categorized into the following: 1. **Immune Response:** NONO plays a critical role in regulating the activation of innate immune response, which involves the recognition of pathogens and the initiation of an immune response. NONO's expression is upregulated in response to immune stimuli, such as lipopolysaccharide (LPS), and promotes the production of pro-inflammatory cytokines. 2. **Circadian Rhythm:** NONO's expression is also regulated by the circadian clock, which is essential for maintaining circadian homeostasis. NONO's protein levels are oscillatory, with peak expression during the day and decreased expression at night. 3. **DNA Repair:** NONO has been implicated in the regulation of DNA repair mechanisms, including non-homologous end joining (NHEJ) and homologous recombination (HR). NONO's expression is increased in response to DNA damage, and it promotes the recruitment of DNA repair proteins to damaged sites. 4. **Cellular Homeostasis:** NONO's expression is also regulated by cellular stress, including oxidative stress and hypoxia. NONO's protein levels are increased in response to these stressors, and it promotes the regulation of cellular homeostasis. **Clinical Significance:** The NONO gene's dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and neurodegenerative diseases. For example: 1. **Autoimmune Disorders:** NONO's dysregulation has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis, where NONO's expression is altered in response to immune stimuli. 2. **Cancer:** NONO's expression is often downregulated in cancer cells, where it is necessary for maintaining cellular homeostasis and preventing tumor progression. 3. **Neurodegenerative Diseases:** NONO's expression is altered in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where NONO's role in regulating circadian rhythm and cellular homeostasis is disrupted. In conclusion, the NONO gene plays a critical role in regulating immune response, circadian rhythm, and cellular homeostasis. Its dysregulation has significant implications in disease pathogenesis, highlighting the need for further research into the mechanisms underlying NONO's functions and its potential as a therapeutic target.

Genular Protein ID: 1782125753

Symbol: NONO_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q15233 B7Z4C2 D3DVV4 F5GYZ3 O00201 P30807 Q12786 Q9BQC5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 25 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 4 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8371983

Title: Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6.

PubMed ID: 8371983

DOI: 10.1093/nar/21.17.4085

PubMed ID: 9360842

Title: Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen receptor-negative human breast cancer.

PubMed ID: 9360842

DOI: 10.1097/00019606-199708000-00005

PubMed ID: 9341872

Title: AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism.

PubMed ID: 9341872

DOI: 10.1007/s004390050553

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8439294

Title: Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells.

PubMed ID: 8439294

DOI: 10.1042/bj2900267

PubMed ID: 9393982

Title: Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma.

PubMed ID: 9393982

DOI: 10.1038/sj.onc.1201394

PubMed ID: 9756848

Title: The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.

PubMed ID: 9756848

DOI: 10.1074/jbc.273.41.26261

PubMed ID: 10858305

Title: PSF/p54(nrb) stimulates 'jumping' of DNA topoisomerase I between separate DNA helices.

PubMed ID: 10858305

DOI: 10.1021/bi992898e

PubMed ID: 11525732

Title: The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs.

PubMed ID: 11525732

DOI: 10.1016/s0092-8674(01)00466-4

PubMed ID: 11897684

Title: Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription.

PubMed ID: 11897684

DOI: 10.1210/endo.143.4.8748

PubMed ID: 12403470

Title: PSF and p54nrb bind a conserved stem in U5 snRNA.

PubMed ID: 12403470

DOI: 10.1017/s1355838202022070

PubMed ID: 15590677

Title: Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor.

PubMed ID: 15590677

DOI: 10.1074/jbc.m412758200

PubMed ID: 16148043

Title: P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner.

PubMed ID: 16148043

DOI: 10.1091/mbc.e05-06-0587

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16767080

Title: Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners.

PubMed ID: 16767080

DOI: 10.1038/ncb1433

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18655028

Title: Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins.

PubMed ID: 18655028

DOI: 10.1002/pmic.200800083

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22002106

Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.

PubMed ID: 22002106

DOI: 10.1074/mcp.m111.013680

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28712728

Title: HEXIM1 and NEAT1 Long non-coding RNA form a multi-subunit complex that regulates DNA-mediated innate immune response.

PubMed ID: 28712728

DOI: 10.1016/j.molcel.2017.06.020

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30270045

Title: NONO detects the nuclear HIV capsid to promote cGAS-mediated innate immune activation.

PubMed ID: 30270045

DOI: 10.1016/j.cell.2018.08.062

PubMed ID: 22416126

Title: Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation.

PubMed ID: 22416126

DOI: 10.1073/pnas.1120792109

PubMed ID: 26571461

Title: Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects.

PubMed ID: 26571461

DOI: 10.1038/nn.4169

Sequence Information:

  • Length: 471
  • Mass: 54232
  • Checksum: 26BBD3828F5B9E49
  • Sequence:
    • MQSNKTFNLE KQNHTPRKHH QHHHQQQHHQ QQQQQPPPPP IPANGQQASS QNEGLTIDLK 
NFRKPGEKTF TQRSRLFVGN LPPDITEEEM RKLFEKYGKA GEVFIHKDKG FGFIRLETRT 
LAEIAKVELD NMPLRGKQLR VRFACHSASL TVRNLPQYVS NELLEEAFSV FGQVERAVVI 
VDDRGRPSGK GIVEFSGKPA ARKALDRCSE GSFLLTTFPR PVTVEPMDQL DDEEGLPEKL 
VIKNQQFHKE REQPPRFAQP GSFEYEYAMR WKALIEMEKQ QQDQVDRNIK EAREKLEMEM 
EAARHEHQVM LMRQDLMRRQ EELRRMEELH NQEVQKRKQL ELRQEEERRR REEEMRRQQE 
EMMRRQQEGF KGTFPDAREQ EIRMGQMAMG GAMGINNRGA MPPAPVPAGT PAPPGPATMM 
PDGTLGLTPP TTERFGQAAT MEGIGAIGGT PPAFNRAAPG AEFAPNKRRR Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.