Details for: CNOT3

Gene ID: 4849

Symbol: CNOT3

Ensembl ID: ENSG00000088038

Description: CCR4-NOT transcription complex subunit 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.8652
    Cell Significance Index: -18.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.1485
    Cell Significance Index: -18.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.2669
    Cell Significance Index: -23.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.7500
    Cell Significance Index: -18.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.3418
    Cell Significance Index: -21.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 34.6188
    Cell Significance Index: -23.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.2198
    Cell Significance Index: -18.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.6673
    Cell Significance Index: -20.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5443
    Cell Significance Index: -20.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3471
    Cell Significance Index: -21.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.6639
    Cell Significance Index: 115.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6326
    Cell Significance Index: 161.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5345
    Cell Significance Index: 249.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3475
    Cell Significance Index: 1216.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9519
    Cell Significance Index: 103.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8299
    Cell Significance Index: 49.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7588
    Cell Significance Index: 20.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5305
    Cell Significance Index: 15.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4810
    Cell Significance Index: 21.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4680
    Cell Significance Index: 24.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4049
    Cell Significance Index: 21.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3420
    Cell Significance Index: 7.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3251
    Cell Significance Index: 58.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3187
    Cell Significance Index: 63.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3185
    Cell Significance Index: 43.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3105
    Cell Significance Index: 169.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2867
    Cell Significance Index: 35.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2702
    Cell Significance Index: 51.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2604
    Cell Significance Index: 30.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2516
    Cell Significance Index: 15.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2465
    Cell Significance Index: 8.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2370
    Cell Significance Index: 15.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1997
    Cell Significance Index: 88.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1894
    Cell Significance Index: 8.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1719
    Cell Significance Index: 4.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1712
    Cell Significance Index: 61.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1657
    Cell Significance Index: 32.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1572
    Cell Significance Index: 3.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1346
    Cell Significance Index: 93.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1291
    Cell Significance Index: 6.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1199
    Cell Significance Index: 3.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1172
    Cell Significance Index: 8.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0888
    Cell Significance Index: 11.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0822
    Cell Significance Index: 2.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0660
    Cell Significance Index: 3.1000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0653
    Cell Significance Index: 0.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0502
    Cell Significance Index: 6.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0456
    Cell Significance Index: 1.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0418
    Cell Significance Index: 0.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0417
    Cell Significance Index: 3.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0344
    Cell Significance Index: 5.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0201
    Cell Significance Index: 1.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0012
    Cell Significance Index: 2.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0078
    Cell Significance Index: -11.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0128
    Cell Significance Index: -9.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0136
    Cell Significance Index: -9.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0138
    Cell Significance Index: -18.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0168
    Cell Significance Index: -10.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0188
    Cell Significance Index: -0.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0206
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0221
    Cell Significance Index: -16.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0301
    Cell Significance Index: -16.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0335
    Cell Significance Index: -15.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0346
    Cell Significance Index: -3.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0397
    Cell Significance Index: -24.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0533
    Cell Significance Index: -6.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0765
    Cell Significance Index: -22.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0894
    Cell Significance Index: -10.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0971
    Cell Significance Index: -14.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1090
    Cell Significance Index: -8.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1099
    Cell Significance Index: -23.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1255
    Cell Significance Index: -7.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1312
    Cell Significance Index: -1.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1379
    Cell Significance Index: -3.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1402
    Cell Significance Index: -4.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1747
    Cell Significance Index: -5.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1940
    Cell Significance Index: -4.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2012
    Cell Significance Index: -20.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2016
    Cell Significance Index: -2.7500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2287
    Cell Significance Index: -3.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2359
    Cell Significance Index: -18.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2436
    Cell Significance Index: -9.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2988
    Cell Significance Index: -7.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2995
    Cell Significance Index: -3.5700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.3016
    Cell Significance Index: -0.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3280
    Cell Significance Index: -14.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3657
    Cell Significance Index: -22.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3772
    Cell Significance Index: -11.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3871
    Cell Significance Index: -10.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4032
    Cell Significance Index: -15.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4166
    Cell Significance Index: -14.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4462
    Cell Significance Index: -14.6100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4463
    Cell Significance Index: -4.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4499
    Cell Significance Index: -14.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4740
    Cell Significance Index: -8.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4741
    Cell Significance Index: -6.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4819
    Cell Significance Index: -17.6900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4835
    Cell Significance Index: -3.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CNOT3 is a 34-kDa protein that is highly conserved across species. It is a subunit of the CCR4-NOT complex, which is composed of five subunits: CNOT1, CNOT2, CNOT3, CNOT4, and CNOT6. The CCR4-NOT complex is a polycomb-like transcriptional repressor complex that is involved in regulating gene expression through the degradation of mRNA and the repression of transcription. CNOT3 is essential for the assembly and function of the CCR4-NOT complex and is required for the regulation of various cellular processes, including cell cycle control, differentiation, and development. **Pathways and Functions:** CNOT3 is involved in several key pathways, including: 1. **Deadenylation-dependent mRNA decay**: CNOT3 is required for the regulation of mRNA decay through the CCR4-NOT complex. 2. **Transcriptional regulation**: CNOT3 is involved in the repression of transcription through the CCR4-NOT complex. 3. **Cell cycle control**: CNOT3 is required for the regulation of cell cycle progression through the CCR4-NOT complex. 4. **Differentiation and development**: CNOT3 is involved in the regulation of cellular differentiation and development through the CCR4-NOT complex. 5. **Regulation of stem cell population maintenance**: CNOT3 is required for the maintenance of stem cell populations through the CCR4-NOT complex. **Clinical Significance:** The dysregulation of CNOT3 has been implicated in various diseases, including: 1. **Cancer**: CNOT3 is often downregulated in cancer cells, leading to the dysregulation of cell cycle control and the promotion of tumorigenesis. 2. **Neurological disorders**: CNOT3 has been implicated in the regulation of gene expression in the brain, and its dysregulation has been linked to neurological disorders, such as schizophrenia and autism. 3. **Immune system dysregulation**: CNOT3 is involved in the regulation of immune cell function, and its dysregulation has been linked to immune system dysregulation and autoimmune diseases. In conclusion, CNOT3 is a multifaceted protein that plays a crucial role in regulating gene expression and cellular processes. Its dysregulation has significant implications for our understanding of disease and the development of novel therapeutic strategies. Further research is needed to fully elucidate the role of CNOT3 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2786379093

Symbol: CNOT3_HUMAN

Name: CCR4-associated factor 3

UniProtKB Accession Codes:

O75175 Q9NZN7 Q9UF76

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 20 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10637334

Title: Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.

PubMed ID: 10637334

DOI: 10.1093/nar/28.3.809

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12207886

Title: TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3.

PubMed ID: 12207886

DOI: 10.1016/s0006-291x(02)02031-4

PubMed ID: 14707134

Title: Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex.

PubMed ID: 14707134

DOI: 10.1074/jbc.m311747200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19558367

Title: Human Ccr4-Not complexes contain variable deadenylase subunits.

PubMed ID: 19558367

DOI: 10.1042/bj20090500

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21299754

Title: CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death.

PubMed ID: 21299754

DOI: 10.1111/j.1365-2443.2011.01492.x

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22342980

Title: Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression.

PubMed ID: 22342980

DOI: 10.1016/j.bbrc.2012.02.007

PubMed ID: 22367759

Title: Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.

PubMed ID: 22367759

DOI: 10.1002/stem.1070

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27807034

Title: Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis.

PubMed ID: 27807034

DOI: 10.1101/gad.285452.116

PubMed ID: 31201375

Title: De novo variants in CNOT3 cause a variable neurodevelopmental disorder.

PubMed ID: 31201375

DOI: 10.1038/s41431-019-0413-6

Sequence Information:

  • Length: 753
  • Mass: 81872
  • Checksum: C9D4F8B9FEF6CD90
  • Sequence:
    • MADKRKLQGE IDRCLKKVSE GVEQFEDIWQ KLHNAANANQ KEKYEADLKK EIKKLQRLRD 
QIKTWVASNE IKDKRQLIDN RKLIETQMER FKVVERETKT KAYSKEGLGL AQKVDPAQKE 
KEEVGQWLTN TIDTLNMQVD QFESEVESLS VQTRKKKGDK DKQDRIEGLK RHIEKHRYHV 
RMLETILRML DNDSILVDAI RKIKDDVEYY VDSSQDPDFE ENEFLYDDLD LEDIPQALVA 
TSPPSHSHME DEIFNQSSST PTSTTSSSPI PPSPANCTTE NSEDDKKRGR STDSEVSQSP 
AKNGSKPVHS NQHPQSPAVP PTYPSGPPPA ASALSTTPGN NGVPAPAAPP SALGPKASPA 
PSHNSGTPAP YAQAVAPPAP SGPSTTQPRP PSVQPSGGGG GGSGGGGSSS SSNSSAGGGA 
GKQNGATSYS SVVADSPAEV ALSSSGGNNA SSQALGPPSG PHNPPPSTSK EPSAAAPTGA 
GGVAPGSGNN SGGPSLLVPL PVNPPSSPTP SFSDAKAAGA LLNGPPQFST APEIKAPEPL 
SSLKSMAERA AISSGIEDPV PTLHLTERDI ILSSTSAPPA SAQPPLQLSE VNIPLSLGVC 
PLGPVPLTKE QLYQQAMEEA AWHHMPHPSD SERIRQYLPR NPCPTPPYHH QMPPPHSDTV 
EFYQRLSTET LFFIFYYLEG TKAQYLAAKA LKKQSWRFHT KYMMWFQRHE EPKTITDEFE 
QGTYIYFDYE KWGQRKKEGF TFEYRYLEDR DLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.