Details for: NRF1

Gene ID: 4899

Symbol: NRF1

Ensembl ID: ENSG00000106459

Description: nuclear respiratory factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 253.5275
    Cell Significance Index: -39.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 159.4759
    Cell Significance Index: -40.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.3125
    Cell Significance Index: -31.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.8844
    Cell Significance Index: -40.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.4328
    Cell Significance Index: -30.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.4091
    Cell Significance Index: -38.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.1781
    Cell Significance Index: -31.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1701
    Cell Significance Index: -37.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.3496
    Cell Significance Index: -40.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.1129
    Cell Significance Index: 105.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.2962
    Cell Significance Index: 128.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2817
    Cell Significance Index: 457.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.0071
    Cell Significance Index: 154.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6319
    Cell Significance Index: 323.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.5504
    Cell Significance Index: 58.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4861
    Cell Significance Index: 533.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4718
    Cell Significance Index: 65.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0249
    Cell Significance Index: 25.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.9525
    Cell Significance Index: 23.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9524
    Cell Significance Index: 658.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8285
    Cell Significance Index: 55.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8058
    Cell Significance Index: 22.5200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.7881
    Cell Significance Index: 5.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7824
    Cell Significance Index: 15.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6844
    Cell Significance Index: 16.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6784
    Cell Significance Index: 41.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6517
    Cell Significance Index: 588.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6055
    Cell Significance Index: 17.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3718
    Cell Significance Index: 60.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2699
    Cell Significance Index: 29.3600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2628
    Cell Significance Index: 3.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2448
    Cell Significance Index: 461.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2230
    Cell Significance Index: 141.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2010
    Cell Significance Index: 3.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1851
    Cell Significance Index: 84.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1621
    Cell Significance Index: 16.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1438
    Cell Significance Index: 221.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1326
    Cell Significance Index: 244.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1024
    Cell Significance Index: 2.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1011
    Cell Significance Index: 6.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0866
    Cell Significance Index: 117.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0820
    Cell Significance Index: 10.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0818
    Cell Significance Index: 15.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0693
    Cell Significance Index: 4.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0602
    Cell Significance Index: 7.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0539
    Cell Significance Index: 9.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0535
    Cell Significance Index: 1.1600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0468
    Cell Significance Index: 1.0000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0426
    Cell Significance Index: 0.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0318
    Cell Significance Index: 14.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0269
    Cell Significance Index: 0.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0208
    Cell Significance Index: 11.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0127
    Cell Significance Index: 0.8800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0035
    Cell Significance Index: 0.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0182
    Cell Significance Index: -2.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0205
    Cell Significance Index: -2.4200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0250
    Cell Significance Index: -0.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0278
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0403
    Cell Significance Index: -29.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0432
    Cell Significance Index: -31.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0557
    Cell Significance Index: -42.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0606
    Cell Significance Index: -2.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0683
    Cell Significance Index: -38.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0720
    Cell Significance Index: -44.9300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0799
    Cell Significance Index: -1.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1164
    Cell Significance Index: -15.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1184
    Cell Significance Index: -34.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1266
    Cell Significance Index: -21.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1669
    Cell Significance Index: -1.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2016
    Cell Significance Index: -20.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2044
    Cell Significance Index: -43.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2372
    Cell Significance Index: -27.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2395
    Cell Significance Index: -30.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2514
    Cell Significance Index: -25.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2575
    Cell Significance Index: -6.8800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2598
    Cell Significance Index: -3.2400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2760
    Cell Significance Index: -2.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2786
    Cell Significance Index: -35.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2862
    Cell Significance Index: -7.6700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3028
    Cell Significance Index: -4.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3098
    Cell Significance Index: -14.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3264
    Cell Significance Index: -6.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3455
    Cell Significance Index: -22.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3778
    Cell Significance Index: -19.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3910
    Cell Significance Index: -20.3100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.4084
    Cell Significance Index: -4.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4159
    Cell Significance Index: -25.5000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4168
    Cell Significance Index: -5.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4361
    Cell Significance Index: -34.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4412
    Cell Significance Index: -14.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4519
    Cell Significance Index: -33.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4702
    Cell Significance Index: -9.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4987
    Cell Significance Index: -23.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5226
    Cell Significance Index: -36.9600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.6155
    Cell Significance Index: -7.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6268
    Cell Significance Index: -32.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6289
    Cell Significance Index: -20.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6299
    Cell Significance Index: -20.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6759
    Cell Significance Index: -9.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7020
    Cell Significance Index: -13.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NRF1 is a member of the nuclear respiratory factor (NRF) family of transcription factors, which are known for their ability to regulate mitochondrial biogenesis and function. NRF1 is a dimeric transcription factor that binds to specific DNA sequences, known as cis-regulatory elements, to activate the transcription of target genes. NRF1 is highly expressed in various cell types, including astrocytes, neurons, and cardiac myocytes, where it plays a crucial role in maintaining cellular homeostasis. **Pathways and Functions:** NRF1 regulates various cellular processes, including: 1. **Mitochondrial Biogenesis:** NRF1 is a key regulator of mitochondrial biogenesis, promoting the expression of genes involved in energy metabolism and mitochondrial protein synthesis. 2. **Lipid Metabolism:** NRF1 regulates the expression of lipogenic enzymes, including those involved in fatty acid synthesis and beta-oxidation, thereby influencing lipid metabolism and energy homeostasis. 3. **Transcriptional Regulation:** NRF1 binds to specific DNA sequences, known as cis-regulatory elements, to activate the transcription of target genes involved in mitochondrial biogenesis, lipid metabolism, and cellular homeostasis. 4. **Cellular Stress Response:** NRF1 has been shown to regulate the expression of genes involved in the cellular stress response, including those involved in heat shock and oxidative stress. **Clinical Significance:** NRF1 dysregulation has been implicated in various disease states, including: 1. **Mitochondrial Diseases:** NRF1 mutations have been associated with mitochondrial diseases, including Kearns-Sayre syndrome and mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). 2. **Metabolic Disorders:** NRF1 dysregulation has been linked to metabolic disorders, including obesity, type 2 diabetes, and dyslipidemia. 3. **Neurodegenerative Diseases:** NRF1 has been shown to play a role in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction and dysregulation of lipid metabolism contribute to disease progression. 4. **Cancer:** NRF1 has been implicated in cancer, where its dysregulation can contribute to tumorigenesis and cancer progression. In conclusion, NRF1 is a crucial transcriptional regulator that plays a pivotal role in mitochondrial biogenesis, lipid metabolism, and cellular homeostasis. Its dysregulation has been implicated in various disease states, highlighting the importance of NRF1 in maintaining cellular homeostasis and preventing disease progression. Further research is needed to fully elucidate the mechanisms by which NRF1 regulates cellular processes and to explore its potential as a therapeutic target for various disease states.

Genular Protein ID: 537468722

Symbol: NRF1_HUMAN

Name: Nuclear respiratory factor 1

UniProtKB Accession Codes:

Q16656 A8K4C6 B4DDV6 Q15305 Q96AN2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 19 Ensembl 5 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8253388

Title: NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators.

PubMed ID: 8253388

DOI: 10.1101/gad.7.12a.2431

PubMed ID: 8034649

Title: A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development.

PubMed ID: 8034649

DOI: 10.1016/s0021-9258(17)32255-x

PubMed ID: 7629110

Title: Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1.

PubMed ID: 7629110

DOI: 10.1074/jbc.270.30.18019

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8541844

Title: The pre-mRNA of nuclear respiratory factor 1, a regulator of mitochondrial biogenesis, is alternatively spliced in human tissues and cell lines.

PubMed ID: 8541844

DOI: 10.1093/hmg/4.9.1591

PubMed ID: 9228045

Title: Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding.

PubMed ID: 9228045

DOI: 10.1074/jbc.272.30.18732

PubMed ID: 11340167

Title: Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells.

PubMed ID: 11340167

DOI: 10.1128/mcb.21.11.3738-3749.2001

PubMed ID: 16908542

Title: PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth.

PubMed ID: 16908542

DOI: 10.1128/mcb.00585-06

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 503
  • Mass: 53541
  • Checksum: F31C358278371929
  • Sequence:
    • MEEHGVTQTE HMATIEAHAV AQQVQQVHVA TYTEHSMLSA DEDSPSSPED TSYDDSDILN 
STAADEVTAH LAAAGPVGMA AAAAVATGKK RKRPHVFESN PSIRKRQQTR LLRKLRATLD 
EYTTRVGQQA IVLCISPSKP NPVFKVFGAA PLENVVRKYK SMILEDLESA LAEHAPAPQE 
VNSELPPLTI DGIPVSVDKM TQAQLRAFIP EMLKYSTGRG KPGWGKESCK PIWWPEDIPW 
ANVRSDVRTE EQKQRVSWTQ ALRTIVKNCY KQHGREDLLY AFEDQQTQTQ ATATHSIAHL 
VPSQTVVQTF SNPDGTVSLI QVGTGATVAT LADASELPTT VTVAQVNYSA VADGEVEQNW 
ATLQGGEMTI QTTQASEATQ AVASLAEAAV AASQEMQQGA TVTMALNSEA AAHAVATLAE 
ATLQGGGQIV LSGETAAAVG ALTGVQDANG LVQIPVSMYQ TVVTSLAQGN GPVQVAMAPV 
TTRISDSAVT MDGQAVEVVT LEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.