NUP98 | ENSG00000110713 | NCBI 4928

Details for: NUP98

Gene ID: 4928

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: NUP98

Ensembl ID: ENSG00000110713

Description: nucleoporin 98 and 96 precursor

Cell Significance Landscape

Display Count:

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective tpr may confer susceptibility towards thyroid papillary carcinoma (tpc)
(R-HSA-5619107)
Disease
(R-HSA-1643685)
Disorders of transmembrane transporters
(R-HSA-5619115)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Export of viral ribonucleoproteins from nucleus
(R-HSA-168274)
Gene expression (transcription)
(R-HSA-74160)
Gene silencing by rna
(R-HSA-211000)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Interactions of rev with host cellular proteins
(R-HSA-177243)
Interactions of vpr with host cellular proteins
(R-HSA-176033)
Interferon signaling
(R-HSA-913531)
Isg15 antiviral mechanism
(R-HSA-1169408)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of non-coding rna
(R-HSA-194441)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic prophase
(R-HSA-68875)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Nep/ns2 interacts with the cellular export machinery
(R-HSA-168333)
Ns1 mediated effects on host pathways
(R-HSA-168276)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Nuclear envelope breakdown
(R-HSA-2980766)
Nuclear import of rev protein
(R-HSA-180746)
Nuclear pore complex (npc) disassembly
(R-HSA-3301854)
Post-translational protein modification
(R-HSA-597592)
Postmitotic nuclear pore complex (npc) reformation
(R-HSA-9615933)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Regulation of glucokinase by glucokinase regulatory protein
(R-HSA-170822)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rev-mediated nuclear export of hiv rna
(R-HSA-165054)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Slc transporter disorders
(R-HSA-5619102)
Snrnp assembly
(R-HSA-191859)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of chromatin organization proteins
(R-HSA-4551638)
Sumoylation of dna damage response and repair proteins
(R-HSA-3108214)
Sumoylation of dna replication proteins
(R-HSA-4615885)
Sumoylation of rna binding proteins
(R-HSA-4570464)
Sumoylation of sumoylation proteins
(R-HSA-4085377)
Sumoylation of ubiquitinylation proteins
(R-HSA-3232142)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transport of mature mrna derived from an intron-containing transcript
(R-HSA-159236)
Transport of mature mrna derived from an intronless transcript
(R-HSA-159231)
Transport of mature mrnas derived from intronless transcripts
(R-HSA-159234)
Transport of mature transcript to cytoplasm
(R-HSA-72202)
Transport of ribonucleoproteins into the host nucleus
(R-HSA-168271)
Transport of the slbp dependant mature mrna
(R-HSA-159230)
Transport of the slbp independent mature mrna
(R-HSA-159227)
Trna processing
(R-HSA-72306)
Trna processing in the nucleus
(R-HSA-6784531)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Vpr-mediated nuclear import of pics
(R-HSA-180910)
Cytosol
(GO:0005829)
Kinetochore
(GO:0000776)
Molecular condensate scaffold activity
(GO:0140693)
Mrna binding
(GO:0003729)
Mrna transport
(GO:0051028)
Nuclear body
(GO:0016604)
Nuclear envelope
(GO:0005635)
Nuclear inclusion body
(GO:0042405)
Nuclear localization sequence binding
(GO:0008139)
Nuclear membrane
(GO:0031965)
Nuclear periphery
(GO:0034399)
Nuclear pore
(GO:0005643)
Nuclear pore complex assembly
(GO:0051292)
Nuclear pore cytoplasmic filaments
(GO:0044614)
Nuclear pore nuclear basket
(GO:0044615)
Nuclear pore organization
(GO:0006999)
Nuclear pore outer ring
(GO:0031080)
Nucleocytoplasmic transport
(GO:0006913)
Nucleoplasm
(GO:0005654)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of mrna splicing, via spliceosome
(GO:0048026)
Post-transcriptional tethering of rna polymerase ii gene dna at nuclear periphery
(GO:0000973)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Proteolysis
(GO:0006508)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Rna export from nucleus
(GO:0006405)
Serine-type peptidase activity
(GO:0008236)
Structural constituent of nuclear pore
(GO:0017056)
Telomere tethering at nuclear periphery
(GO:0034398)
Transcription coactivator activity
(GO:0003713)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

IgG plasma cell CL0000985

CSI 27.89

rCSI 33.41%

PRS 42.53
mesodermal cell CL0000222

CSI 14.31

rCSI 17.17%

PRS 24.48
conjunctival epithelial cell CL1000432

CSI 12.75

rCSI 19.47%

PRS 25.35
elicited macrophage CL0000861

CSI 12.13

rCSI 11.14%

PRS 30.02
BEST4+ enteroycte CL4030026

CSI 8.51

rCSI 10.59%

PRS 26.95
alveolar macrophage CL0000583

CSI 7.74

rCSI 12.75%

PRS 29.65
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 7.23

rCSI 26.01%

PRS 14.39
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 6.96

rCSI 16.91%

PRS 14.91
transit amplifying cell of colon CL0009011

CSI 6.39

rCSI 7.5%

PRS 28.85
hematopoietic stem cell CL0000037

CSI 6.34

rCSI 4.21%

PRS 29.79
retinal cone cell CL0000573

CSI 6.27

rCSI 10.09%

PRS 19.31
radial glial cell CL0000681

CSI 6.17

rCSI 8.57%

PRS 25.48
Kupffer cell CL0000091

CSI 5.59

rCSI 12.79%

PRS 24.67
retinal pigment epithelial cell CL0002586

CSI 5.51

rCSI 10.94%

PRS 26.08
CD14-positive monocyte CL0001054

CSI 5.36

rCSI 6.67%

PRS 34.61
renal principal cell CL0005009

CSI 5.27

rCSI 13.68%

PRS 31.3
neural progenitor cell CL0011020

CSI 5.26

rCSI 23.13%

PRS 22.78
CD4-positive helper T cell CL0000492

CSI 5

rCSI 3.79%

PRS 34.45
CD14-low, CD16-positive monocyte CL0002396

CSI 4.98

rCSI 3.84%

PRS 23.67
basal cell of prostate epithelium CL0002341

CSI 4.81

rCSI 13.92%

PRS 48.41
T follicular helper cell CL0002038

CSI 4.8

rCSI 3.59%

PRS 38.87
myeloid dendritic cell CL0000782

CSI 4.78

rCSI 6.92%

PRS 37.74
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 4.6

rCSI 14.16%

PRS 36.32
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 4.4

rCSI 25.93%

PRS 15.98
amacrine cell CL0000561

CSI 4.3

rCSI 12.45%

PRS 19.69
intermediate monocyte CL0002393

CSI 4.15

rCSI 6.26%

PRS 25.84
lung pericyte CL0009089

CSI 4.12

rCSI 10.87%

PRS 30.01
paneth cell of epithelium of small intestine CL1000343

CSI 3.92

rCSI 10.97%

PRS 38.39
adventitial cell CL0002503

CSI 3.88

rCSI 9.27%

PRS 36.47
syncytiotrophoblast cell CL0000525

CSI 3.84

rCSI 11.06%

PRS 43.78
naive T cell CL0000898

CSI 3.81

rCSI 2.65%

PRS 35.33
Mueller cell CL0000636

CSI 3.66

rCSI 8.36%

PRS 21.54
Schwann cell CL0002573

CSI 3.63

rCSI 10.32%

PRS 27.52
myofibroblast cell CL0000186

CSI 3.6

rCSI 4.99%

PRS 33.58
mature B cell CL0000785

CSI 3.57

rCSI 3.1%

PRS 31.8
pulmonary alveolar type 1 cell CL0002062

CSI 3.51

rCSI 20.25%

PRS 30.53
dopaminergic neuron CL0000700

CSI 3.48

rCSI 19.64%

PRS 15.22
CD4-positive, alpha-beta memory T cell CL0000897

CSI 3.45

rCSI 2.48%

PRS 34.63
astrocyte of the cerebral cortex CL0002605

CSI 3.38

rCSI 7.59%

PRS 15.82
early lymphoid progenitor CL0000936

CSI 3.31

rCSI 2.91%

PRS 29.05
double-positive, alpha-beta thymocyte CL0000809

CSI 3.3

rCSI 3.37%

PRS 35.66
mononuclear phagocyte CL0000113

CSI 3.28

rCSI 7.23%

PRS 28.84
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 3.19

rCSI 8.25%

PRS 58.51
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 3.16

rCSI 5.57%

PRS 14.95
intestine goblet cell CL0019031

CSI 3.12

rCSI 2.77%

PRS 25.51
respiratory basal cell CL0002633

CSI 3.08

rCSI 3.19%

PRS 29.78
dendritic cell, human CL0001056

CSI 3.06

rCSI 4.7%

PRS 30.3
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 3.01

rCSI 9.41%

PRS 17.41
basal cell CL0000646

CSI 3

rCSI 4.01%

PRS 27.36
enteroglial cell CL4040002

CSI 2.89

rCSI 15.19%

PRS 38.8
ionocyte CL0005006

CSI 2.89

rCSI 3.1%

PRS 23.24
effector CD8-positive, alpha-beta T cell CL0001050

CSI 2.82

rCSI 2.15%

PRS 33.4
midzonal region hepatocyte CL0019028

CSI 2.81

rCSI 6.6%

PRS 35.03
retinal rod cell CL0000604

CSI 2.8

rCSI 4.94%

PRS 24.57
tissue-resident macrophage CL0000864

CSI 2.79

rCSI 13.06%

PRS 46.53
indirect pathway medium spiny neuron CL4023029

CSI 2.74

rCSI 66.11%

PRS 14.89
lung macrophage CL1001603

CSI 2.71

rCSI 6.06%

PRS 29.63
inhibitory interneuron CL0000498

CSI 2.68

rCSI 6.2%

PRS 20.37
direct pathway medium spiny neuron CL4023026

CSI 2.68

rCSI 64.07%

PRS 13.98
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 2.57

rCSI 2.97%

PRS 21.85
retinal bipolar neuron CL0000748

CSI 2.46

rCSI 4.61%

PRS 18.37
cardiac endothelial cell CL0010008

CSI 2.44

rCSI 9.84%

PRS 23.44
hepatic stellate cell CL0000632

CSI 2.42

rCSI 9.06%

PRS 21.18
pulmonary capillary endothelial cell CL4028001

CSI 2.41

rCSI 4.6%

PRS 39.2
lymphoid lineage restricted progenitor cell CL0000838

CSI 2.38

rCSI 9.28%

PRS 40.93
pvalb GABAergic cortical interneuron CL4023018

CSI 2.37

rCSI 2.95%

PRS 14.27
double negative thymocyte CL0002489

CSI 2.36

rCSI 1.64%

PRS 30.44
pancreatic D cell CL0000173

CSI 2.36

rCSI 2.32%

PRS 27.01
blood vessel endothelial cell CL0000071

CSI 2.32

rCSI 4.82%

PRS 24.95
alpha-beta T cell CL0000789

CSI 2.27

rCSI 2.66%

PRS 35.46
intestinal crypt stem cell of small intestine CL0009017

CSI 2.26

rCSI 6.08%

PRS 32.49
CD8-positive, alpha-beta memory T cell CL0000909

CSI 2.24

rCSI 2.34%

PRS 61.16
kidney connecting tubule epithelial cell CL1000768

CSI 2.21

rCSI 5.61%

PRS 19.24
bronchus fibroblast of lung CL2000093

CSI 2.19

rCSI 1.78%

PRS 26.35
promonocyte CL0000559

CSI 2.18

rCSI 3.74%

PRS 33.8
type B pancreatic cell CL0000169

CSI 2.18

rCSI 4.83%

PRS 23.3
GABAergic neuron CL0000617

CSI 2.15

rCSI 7.21%

PRS 18.2
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.15

rCSI 1.27%

PRS 35.48
epithelial cell of lung CL0000082

CSI 2.14

rCSI 1.78%

PRS 23.98
stromal cell of ovary CL0002132

CSI 2.14

rCSI 5.88%

PRS 40.16
mature T cell CL0002419

CSI 2.13

rCSI 1.65%

PRS 36.96
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 2.05

rCSI 4.08%

PRS 41.24
secretory cell CL0000151

CSI 2.04

rCSI 2.13%

PRS 25.85
endocardial cell CL0002350

CSI 2.03

rCSI 9.73%

PRS 29.85
hepatocyte CL0000182

CSI 2.02

rCSI 3.61%

PRS 23.38
extravillous trophoblast CL0008036

CSI 2.01

rCSI 2.49%

PRS 22.25
epicardial adipocyte CL1000309

CSI 2

rCSI 6.52%

PRS 29.8
activated CD4-positive, alpha-beta T cell CL0000896

CSI 1.99

rCSI 1.84%

PRS 44.07
choroid plexus epithelial cell CL0000706

CSI 1.97

rCSI 3.22%

PRS 19.47
keratinocyte CL0000312

CSI 1.96

rCSI 1.65%

PRS 29.79
precursor B cell CL0000817

CSI 1.9

rCSI 1.67%

PRS 33.19
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.89

rCSI 1.27%

PRS 31.37
interneuron CL0000099

CSI 1.88

rCSI 3.77%

PRS 18.7
cardiac neuron CL0010022

CSI 1.86

rCSI 5.95%

PRS 21.19
granulocyte CL0000094

CSI 1.85

rCSI 2.83%

PRS 32.55
melanocyte CL0000148

CSI 1.85

rCSI 1.37%

PRS 21.65
alveolar type 1 fibroblast cell CL4028004

CSI 1.84

rCSI 2.02%

PRS 28.16
hematopoietic multipotent progenitor cell CL0000837

CSI 1.81

rCSI 4.37%

PRS 39.3
helper T cell CL0000912

CSI 1.81

rCSI 2.57%

PRS 34.81
lung neuroendocrine cell CL1000223

CSI 1.81

rCSI 2.68%

PRS 28.68

kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.1

rCSI 1.5%

PRS 30.8%
cytotoxic T cell CL0000910

CSI 0.2

rCSI 1.0%

PRS 36.6%
OFF midget ganglion cell CL4033047

CSI 0.2

rCSI 4.0%

PRS 22.1%
luminal epithelial cell of mammary gland CL0002326

CSI 0.3

rCSI 0.5%

PRS 38.1%
blood vessel smooth muscle cell CL0019018

CSI 0.3

rCSI 2.3%

PRS 24.1%
respiratory goblet cell CL0002370

CSI 0.3

rCSI 3.1%

PRS 46.0%
erythroid progenitor cell CL0000038

CSI 0.3

rCSI 1.7%

PRS 36.1%
H2 horizontal cell CL0004218

CSI 0.3

rCSI 1.7%

PRS 26.9%
ON parasol ganglion cell CL4033052

CSI 0.4

rCSI 4.9%

PRS 20.1%
ON midget ganglion cell CL4033046

CSI 0.4

rCSI 7.1%

PRS 20.9%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.4

rCSI 0.8%

PRS 25.7%
GABAergic interneuron CL0011005

CSI 0.4

rCSI 5.9%

PRS 24.8%
Hofbauer cell CL3000001

CSI 0.4

rCSI 0.8%

PRS 32.1%
podocyte CL0000653

CSI 0.4

rCSI 1.9%

PRS 24.5%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.5

rCSI 2.4%

PRS 47.3%
pancreatic ductal cell CL0002079

CSI 0.5

rCSI 1.0%

PRS 25.9%
regular atrial cardiac myocyte CL0002129

CSI 0.5

rCSI 1.7%

PRS 25.9%
central nervous system neuron CL2000029

CSI 0.5

rCSI 4.0%

PRS 15.9%
colon macrophage CL0009038

CSI 0.5

rCSI 2.5%

PRS 48.7%
lung ciliated cell CL1000271

CSI 0.6

rCSI 0.7%

PRS 18.7%
pancreatic PP cell CL0002275

CSI 0.6

rCSI 2.4%

PRS 41.2%
intestinal crypt stem cell of colon CL0009043

CSI 0.6

rCSI 4.6%

PRS 44.4%
tendon cell CL0000388

CSI 0.6

rCSI 1.6%

PRS 55.8%
regular ventricular cardiac myocyte CL0002131

CSI 0.6

rCSI 4.0%

PRS 20.0%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.6

rCSI 2.1%

PRS 17.2%
pancreatic acinar cell CL0002064

CSI 0.6

rCSI 0.9%

PRS 27.7%
transit amplifying cell of small intestine CL0009012

CSI 0.7

rCSI 2.8%

PRS 44.5%
renal interstitial pericyte CL1001318

CSI 0.7

rCSI 1.8%

PRS 23.5%
squamous epithelial cell CL0000076

CSI 0.7

rCSI 1.6%

PRS 30.7%
mesenchymal stem cell of adipose tissue CL0002570

CSI 0.7

rCSI 3.8%

PRS 53.4%
mucus secreting cell CL0000319

CSI 0.7

rCSI 1.1%

PRS 32.4%
memory T cell CL0000813

CSI 0.7

rCSI 1.4%

PRS 54.1%
endothelial cell of arteriole CL1000412

CSI 0.7

rCSI 4.0%

PRS 55.9%
lung secretory cell CL1000272

CSI 0.7

rCSI 1.8%

PRS 23.5%
retinal ganglion cell CL0000740

CSI 0.7

rCSI 1.6%

PRS 18.1%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 0.8

rCSI 2.0%

PRS 23.3%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 0.8

rCSI 2.2%

PRS 37.7%
IgA plasma cell CL0000987

CSI 0.8

rCSI 0.8%

PRS 44.1%
tracheobronchial smooth muscle cell CL0019019

CSI 0.8

rCSI 1.4%

PRS 32.3%
glial cell CL0000125

CSI 0.8

rCSI 3.1%

PRS 23.5%
erythroid lineage cell CL0000764

CSI 0.8

rCSI 5.4%

PRS 49.4%
airway submucosal gland duct basal cell CL4033024

CSI 0.9

rCSI 5.4%

PRS 52.4%
CD1c-positive myeloid dendritic cell CL0002399

CSI 0.9

rCSI 1.0%

PRS 30.4%
rod bipolar cell CL0000751

CSI 0.9

rCSI 1.5%

PRS 20.9%
granulocyte monocyte progenitor cell CL0000557

CSI 0.9

rCSI 0.8%

PRS 28.3%
parietal epithelial cell CL1000452

CSI 0.9

rCSI 2.4%

PRS 20.9%
endothelial cell of placenta CL0009092

CSI 0.9

rCSI 4.5%

PRS 33.8%
skeletal muscle satellite stem cell CL0008011

CSI 1.0

rCSI 4.2%

PRS 55.3%
cerebellar granule cell CL0001031

CSI 1.0

rCSI 1.4%

PRS 23.2%
glutamatergic neuron CL0000679

CSI 1.0

rCSI 2.0%

PRS 24.0%
basophil CL0000767

CSI 1.0

rCSI 2.1%

PRS 47.4%
corneal epithelial cell CL0000575

CSI 1.0

rCSI 2.9%

PRS 42.5%
duct epithelial cell CL0000068

CSI 1.0

rCSI 1.5%

PRS 26.8%
near-projecting glutamatergic cortical neuron CL4023012

CSI 1.0

rCSI 3.9%

PRS 15.8%
class switched memory B cell CL0000972

CSI 1.1

rCSI 0.8%

PRS 41.3%
glandular epithelial cell CL0000150

CSI 1.1

rCSI 2.8%

PRS 46.7%
respiratory suprabasal cell CL4033048

CSI 1.1

rCSI 1.4%

PRS 29.1%
cardiac muscle cell CL0000746

CSI 1.1

rCSI 1.5%

PRS 19.7%
natural T-regulatory cell CL0000903

CSI 1.1

rCSI 2.1%

PRS 61.2%
group 3 innate lymphoid cell CL0001071

CSI 1.1

rCSI 0.8%

PRS 27.0%
basal-myoepithelial cell of mammary gland CL0002324

CSI 1.1

rCSI 2.1%

PRS 50.1%
pulmonary alveolar type 2 cell CL0002063

CSI 1.1

rCSI 1.8%

PRS 36.2%
keratocyte CL0002363

CSI 1.1

rCSI 2.7%

PRS 36.0%
vascular associated smooth muscle cell CL0000359

CSI 1.2

rCSI 3.7%

PRS 29.7%
T-helper 17 cell CL0000899

CSI 1.2

rCSI 0.9%

PRS 43.9%
sst GABAergic cortical interneuron CL4023017

CSI 1.2

rCSI 1.5%

PRS 15.9%
sncg GABAergic cortical interneuron CL4023015

CSI 1.2

rCSI 1.9%

PRS 16.6%
VIP GABAergic cortical interneuron CL4023016

CSI 1.3

rCSI 1.5%

PRS 15.0%
small intestine goblet cell CL1000495

CSI 1.3

rCSI 2.8%

PRS 33.3%
vascular leptomeningeal cell CL4023051

CSI 1.3

rCSI 2.3%

PRS 19.5%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.3

rCSI 2.3%

PRS 21.5%
cerebral cortex endothelial cell CL1001602

CSI 1.3

rCSI 2.2%

PRS 19.3%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.3

rCSI 1.6%

PRS 42.8%
kidney interstitial alternatively activated macrophage CL1000695

CSI 1.3

rCSI 3.5%

PRS 23.7%
fast muscle cell CL0000190

CSI 1.3

rCSI 5.2%

PRS 46.3%
ependymal cell CL0000065

CSI 1.3

rCSI 2.7%

PRS 13.8%
fibroblast of cardiac tissue CL0002548

CSI 1.3

rCSI 6.4%

PRS 21.4%
interstitial cell of Cajal CL0002088

CSI 1.3

rCSI 1.7%

PRS 29.0%
pancreatic A cell CL0000171

CSI 1.3

rCSI 1.4%

PRS 26.8%
renal beta-intercalated cell CL0002201

CSI 1.3

rCSI 3.2%

PRS 28.1%
neutrophil CL0000775

CSI 1.4

rCSI 7.5%

PRS 42.1%
intestinal tuft cell CL0019032

CSI 1.4

rCSI 2.1%

PRS 28.8%
myoepithelial cell CL0000185

CSI 1.4

rCSI 3.5%

PRS 30.9%
colon epithelial cell CL0011108

CSI 1.4

rCSI 1.5%

PRS 23.6%
common myeloid progenitor CL0000049

CSI 1.4

rCSI 1.1%

PRS 25.4%
activated CD8-positive, alpha-beta T cell CL0000906

CSI 1.4

rCSI 1.4%

PRS 59.4%
glioblast CL0000030

CSI 1.4

rCSI 2.2%

PRS 21.5%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.4

rCSI 1.3%

PRS 23.0%
adipocyte CL0000136

CSI 1.4

rCSI 1.8%

PRS 24.2%
erythrocyte CL0000232

CSI 1.4

rCSI 3.2%

PRS 32.4%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 1.4

rCSI 1.3%

PRS 37.9%
Bergmann glial cell CL0000644

CSI 1.4

rCSI 2.0%

PRS 24.6%
activated type II NK T cell CL0000931

CSI 1.5

rCSI 1.6%

PRS 39.6%
retinal blood vessel endothelial cell CL0002585

CSI 1.5

rCSI 2.3%

PRS 27.6%
goblet cell CL0000160

CSI 1.5

rCSI 1.4%

PRS 26.4%
innate lymphoid cell CL0001065

CSI 1.5

rCSI 3.1%

PRS 35.6%
stem cell CL0000034

CSI 1.5

rCSI 1.5%

PRS 18.7%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 1.6

rCSI 7.8%

PRS 33.3%
plasmacytoid dendritic cell, human CL0001058

CSI 1.6

rCSI 1.1%

PRS 26.9%
placental villous trophoblast CL2000060

CSI 1.6

rCSI 2.4%

PRS 23.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [NUP98](/details-gene/4928) is a protein-coding gene that encodes a precursor protein which is proteolytically cleaved into two distinct nucleoporins, Nup98 and Nup96. As integral components of the nuclear pore complex (NPC), these proteins play a central role in mediating the transport of molecules between the nucleus and the cytoplasm, including the export of mRNA and the import of proteins ([Link](https://doi.org/10.1083/jcb.144.6.1097)). Beyond its structural role, [NUP98](/details-gene/4928) is also implicated in transcriptional regulation and cell cycle control. Expression data indicates its high significance in metabolically active and secretory cells, particularly [IgG plasma cell](/details-cell/CL0000985), suggesting a critical function in managing high-volume molecular transport. Clinically, [NUP98](/details-gene/4928) is well-known for its involvement in chromosomal translocations that generate oncogenic fusion proteins, particularly in acute myeloid leukemia (AML) ([Link](https://doi.org/10.1038/ng0296-159)), highlighting its importance in both normal cellular homeostasis and disease. ## Cellular Roles and Expression Landscape The expression profile of [NUP98](/details-gene/4928) underscores its fundamental role in nucleocytoplasmic transport, with its significance scaling with the cell's transcriptional and secretory demands. **Overall**, the gene shows its highest significance in [IgG plasma cell](/details-cell/CL0000985) (CSI: 27.89), a cell type dedicated to the massive production and secretion of antibodies, a process that necessitates highly efficient mRNA export from the nucleus. Its prominence extends to other functionally active cell types, including various immune cells such as [elicited macrophage](/details-cell/CL0000861), [alveolar macrophage](/details-cell/CL0000583), [Kupffer cell](/details-cell/CL0000091), and [CD14-positive monocyte](/details-cell/CL0001054). This pattern suggests a vital role in supporting the dynamic transcriptional programs that govern immune cell activation, differentiation, and effector functions. Furthermore, its notable significance in [hematopoietic stem cell](/details-cell/CL0000037) is consistent with its role in developmental processes and provides a cellular context for its involvement in leukemia. The broad, albeit varied, significance in diverse cell types like [conjunctival epithelial cell](/details-cell/CL1000432) and glutamatergic neurons highlights its essential housekeeping function in maintaining the integrity of the nuclear transport machinery across multiple tissues. ## Pathways and Molecular Function Functional annotation confirms that [NUP98](/details-gene/4928) is a multifunctional protein primarily associated with the nuclear pore. It serves as a `structural constituent of the nuclear pore` ([GO:0017056](https://www.ebi.ac.uk/QuickGO/term/GO:0017056)) and is essential for `nuclear pore complex assembly` ([GO:0051292](https://www.ebi.ac.uk/QuickGO/term/GO:0051292)) and organization. Its core function involves mediating `nucleocytoplasmic transport` ([GO:0006913](https://www.ebi.ac.uk/QuickGO/term/GO:0006913)), including `mRNA transport` ([GO:0051028](https://www.ebi.ac.uk/QuickGO/term/GO:0051028)) and `protein import into nucleus` ([GO:0006606](https://www.ebi.ac.uk/QuickGO/term/GO:0006606)). Beyond these canonical roles, [NUP98](/details-gene/4928) is also involved in gene regulation, evidenced by its association with `positive regulation of dna-templated transcription` ([GO:0045893](https://www.ebi.ac.uk/QuickGO/term/GO:0045893)) and `transcription coactivator activity` ([GO:0003713](https://www.ebi.ac.uk/QuickGO/term/GO:0003713)). This dual role in transport and transcription suggests it acts as a gatekeeper that links gene expression events in the nucleoplasm with the export of their products to the cytoplasm. Reactome pathway analysis further broadens the functional scope of [NUP98](/details-gene/4928), implicating it in fundamental cellular processes such as the `cell cycle` ([R-HSA-1640170](https://reactome.org/content/detail/R-HSA-1640170)) and `immune system` ([R-HSA-168256](https://reactome.org/content/detail/R-HSA-168256)). Notably, [NUP98](/details-gene/4928) is a component of numerous pathways related to `infectious disease` ([R-HSA-5663205](https://reactome.org/content/detail/R-HSA-5663205)), including `influenza infection` ([R-HSA-168255](https://reactome.org/content/detail/R-HSA-168255)), `HIV infection` ([R-HSA-162906](https://reactome.org/content/detail/R-HSA-162906)), and `SARS-CoV-2 infection` ([R-HSA-9694516](https://reactome.org/content/detail/R-HSA-9694516)). This suggests that the NUP98-mediated transport machinery is a common target co-opted by viruses to facilitate the nuclear export of their own ribonucleoproteins, a conclusion supported by research showing viral proteins directly targeting Nup98 ([Link](https://doi.org/10.1016/s1097-2765(00)00120-9)). ## Research Directions The diverse roles of [NUP98](/details-gene/4928) in cellular homeostasis and pathology present several avenues for future research. Its established involvement in leukemogenesis through gene fusions offers a clear link between the disruption of its normal function and disease. The oncogenic NUP98 fusion proteins, such as NUP98-HOXA9, are known to act as aberrant transcription factors, but they may also disrupt the architecture and function of the nuclear pore, leading to global defects in molecular transport that contribute to the malignant phenotype ([Link](https://doi.org/10.1038/ng0296-159)). Based on the available data, several testable hypotheses can be proposed: 1. The exceptionally high CSI of [NUP98](/details-gene/4928) in [IgG plasma cell](/details-cell/CL0000985) suggests that its expression level is a rate-limiting factor for antibody production. Therefore, partial knockdown of [NUP98](/details-gene/4928) in these cells will disproportionately reduce the secretion of immunoglobulins compared to the export of housekeeping transcripts. 2. Given its role in numerous viral infection pathways, [NUP98](/details-gene/4928) is a critical host dependency factor for a broad range of viruses that replicate in the nucleus. Its depletion in target cells (e.g., macrophages) will confer resistance to infection by viruses like influenza and HIV by trapping viral ribonucleoproteins within the nucleus. 3. The oncogenic activity of NUP98 fusion proteins in AML stems from a dual mechanism: aberrant transcriptional activation of target genes (e.g., HOX family) and a dominant-negative disruption of normal nuclear pore complex function, leading to a global mislocalization of proteins and RNAs that locks hematopoietic progenitors in an undifferentiated state. **Experimental Proposal:** To test the second hypothesis regarding NUP98's role as a pan-viral host factor, one could perform a CRISPR-Cas9-mediated knockout of [NUP98](/details-gene/4928) in an A549 lung epithelial cell line. Wild-type and knockout cells would then be infected in parallel with a panel of clinically relevant respiratory viruses that utilize the nucleus, such as influenza A virus and respiratory syncytial virus (RSV). Viral replication kinetics would be assessed over time by quantifying viral titers in the supernatant using plaque assays or TCID50. Concurrently, subcellular fractionation followed by RT-qPCR for viral genomes could be used to determine if viral RNA is retained in the nucleus of knockout cells. A significant reduction in viral progeny and a corresponding nuclear accumulation of viral RNA in [NUP98](/details-gene/4928)-deficient cells would validate its role as a critical host factor. **Therapeutic Potential:** As a ubiquitous and essential component of the nuclear pore complex, [NUP98](/details-gene/4928) itself is a poor direct therapeutic target; its systemic inhibition would likely cause unacceptable toxicity. However, the NUP98 fusion proteins found in cancers like AML ([OMIM:601021](https://omim.org/entry/601021)) represent highly specific and attractive targets. These fusions create neomorphic functions that are unique to the cancer cell. Therefore, therapeutic strategies should focus on inhibiting the specific activities of these fusion proteins, such as their protein-protein interactions or their binding to chromatin. Small molecules designed to disrupt the function of the fusion partner (e.g., the HOXA9 domain) or the unique interface created by the fusion could offer a targeted and effective treatment for these malignancies.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Nuclear pore complex protein Nup98

Genular Protein ID: 3200082497

Symbol: NUP98_HUMAN

Name: Nuclear pore complex protein Nup98

UniProtKB Accession Codes:

P52948 Q8IUT2 Q8WYB0 Q96E54 Q9H3Q4 Q9NT02 Q9UF57 Q9UHX0 Q9Y6J4 Q9Y6J5

Database IDs:

Citations:

PubMed ID: 8563754

Title: The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.

PubMed ID: 8563754

DOI: 10.1038/ng0296-159

PubMed ID: 10087256

Title: A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.

PubMed ID: 10087256

DOI: 10.1083/jcb.144.6.1097

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10556215

Title: The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion.

PubMed ID: 10556215

PubMed ID: 10209021

Title: RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains.

PubMed ID: 10209021

DOI: 10.1083/jcb.145.2.237

PubMed ID: 11106761

Title: Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98.

PubMed ID: 11106761

DOI: 10.1016/s1097-2765(00)00120-9

PubMed ID: 11493482

Title: A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.

PubMed ID: 11493482

DOI: 10.1182/blood.v98.4.1264

PubMed ID: 11684705

Title: Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export.

PubMed ID: 11684705

DOI: 10.1083/jcb.200108007

PubMed ID: 11986249

Title: NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15).

PubMed ID: 11986249

DOI: 10.1182/blood.v99.10.3857

PubMed ID: 11839768

Title: Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export.

PubMed ID: 11839768

DOI: 10.1083/jcb.200106046

PubMed ID: 12802065

Title: Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex.

PubMed ID: 12802065

DOI: 10.1091/mbc.e02-09-0620

PubMed ID: 15229283

Title: Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket.

PubMed ID: 15229283

DOI: 10.1091/mbc.e04-03-0165

PubMed ID: 16028218

Title: Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in a NUP98-C6orf80 fusion in a case of acute megakaryoblastic leukemia.

PubMed ID: 16028218

DOI: 10.1002/gcc.20233

PubMed ID: 15725483

Title: t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia.

PubMed ID: 15725483

DOI: 10.1016/j.leukres.2004.09.002

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16467868

Title: NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogenetique Hematologique.

PubMed ID: 16467868

DOI: 10.1038/sj.leu.2404130

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17287853

Title: A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia.

PubMed ID: 17287853

DOI: 10.1038/sj.leu.2404579

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20407419

Title: Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion.

PubMed ID: 20407419

DOI: 10.1038/emboj.2010.54

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22058212

Title: Functional analysis of the NUP98-CCDC28A fusion protein.

PubMed ID: 22058212

DOI: 10.3324/haematol.2011.047969

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23523133

Title: Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication.

PubMed ID: 23523133

DOI: 10.1016/j.virol.2013.02.008

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28221134

Title: Human Nup98 regulates the localization and activity of DExH/D-box helicase DHX9.

PubMed ID: 28221134

DOI: 10.7554/elife.18825

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30543681

Title: Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.

PubMed ID: 30543681

DOI: 10.1371/journal.pgen.1007845

PubMed ID: 33097660

Title: SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.

PubMed ID: 33097660

DOI: 10.1073/pnas.2016650117

PubMed ID: 33360543

Title: Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.

PubMed ID: 33360543

DOI: 10.1016/j.bbrc.2020.11.115

PubMed ID: 33849972

Title: SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98.

PubMed ID: 33849972

DOI: 10.1128/mbio.00065-21

PubMed ID: 12191480

Title: The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98.

PubMed ID: 12191480

DOI: 10.1016/s1097-2765(02)00589-0

PubMed ID: 18287282

Title: Structural constraints on autoprocessing of the human nucleoporin Nup98.

PubMed ID: 18287282

DOI: 10.1110/ps.073311808

PubMed ID: 20498086

Title: Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1.

PubMed ID: 20498086

DOI: 10.1073/pnas.1005389107

PubMed ID: 8563753

Title: Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia.

PubMed ID: 8563753

DOI: 10.1038/ng0296-154

PubMed ID: 10477737

Title: The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia.

PubMed ID: 10477737

PubMed ID: 10929031

Title: t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of a new subset of T acute lymphoblastic leukaemia.

PubMed ID: 10929031

DOI: 10.1046/j.1365-2141.2000.02106.x

PubMed ID: 16419055

Title: Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene.

PubMed ID: 16419055

DOI: 10.1002/gcc.20308

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23531517

Title: NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern.

PubMed ID: 23531517

DOI: 10.1038/leu.2013.87

PubMed ID: 34163069

Title: Phase separation drives aberrant chromatin looping and cancer development.

PubMed ID: 34163069

DOI: 10.1038/s41586-021-03662-5

Sequence Information:

Length: 1817
Mass: 197579
Checksum: BC60E5456B936C79
Sequence:

MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 
GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 
GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 
NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 
FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 
SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 
GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNTSGNSIF 
GSKPAPGTLG TGLGAGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTTTATLGFG 
APQAPVALTD PNASAAQQAV LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA 
QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL 
VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD EDSLVSHFYT 
NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE 
EIENNSYHMH PAGIILTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD 
VNLTNLNLDD IVHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP 
DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS 
TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD 
TMLEESMPED QEPVSASTHI ASSLGINPHV LQIMKASLLT DEEDVDMALD QRFSRLPSKA 
DTSQEICSPR LPISASHSSK TRSLVGGLLQ SKFTSGAFLS PSVSVQECRT PRAASLMNIP 
STSSWSVPPP LTSVFTMPSP APEVPLKTVG TRRQLGLVPR EKSVTYGKGK LLMDMALFMG 
RSFRVGWGPN WTLANSGEQL NGSHELENHQ IADSMEFGFL PNPVAVKPLT ESPFKVHLEK 
LSLRQRKPDE DMKLYQTPLE LKLKHSTVHV DELCPLIVPN LGVAVIHDYA DWVKEASGDL 
PEAQIVKHWS LTWTLCEALW GHLKELDSQL NEPREYIQIL ERRRAFSRWL SCTATPQIEE 
EVSLTQKNSP VEAVFSYLTG KRISEACSLA QQSGDHRLAL LLSQFVGSQS VRELLTMQLV 
DWHQLQADSF IQDERLRIFA LLAGKPVWQL SEKKQINVCS QLDWKRSLAI HLWYLLPPTA 
SISRALSMYE EAFQNTSDSD RYACSPLPSY LEGSGCVIAE EQNSQTPLRD VCFHLLKLYS 
DRHYDLNQLL EPRSITADPL DYRLSWHLWE VLRALNYTHL SAQCEGVLQA SYAGQLESEG 
LWEWAIFVLL HIDNSGIREK AVRELLTRHC QLLETPESWA KETFLTQKLR VPAKWIHEAK 
AVRAHMESDK HLEALCLFKA EHWNRCHKLI IRHLASDAII NENYDYLKGF LEDLAPPERS 
SLIQDWETSG LVYLDYIRVI EMLRHIQQVD CSGNDLEQLH IKVTSLCSRI EQIQCYSAKD 
RLAQSDMAKR VANLLRVVLS LHHPPDRTSD STPDPQRVPL RLLAPHIGRL PMPEDYAMDE 
LRSLTQSYLR ELAVGSL

Details for: NUP98

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. PubMed ID: 8563754

A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96. PubMed ID: 10087256

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion. PubMed ID: 10556215

RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains. PubMed ID: 10209021

Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98. PubMed ID: 11106761

A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia. PubMed ID: 11493482

Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. PubMed ID: 11684705

NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). PubMed ID: 11986249

Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. PubMed ID: 11839768

Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. PubMed ID: 12802065

Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. PubMed ID: 15229283

Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in a NUP98-C6orf80 fusion in a case of acute megakaryoblastic leukemia. PubMed ID: 16028218

t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia. PubMed ID: 15725483

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogenetique Hematologique. PubMed ID: 16467868

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia. PubMed ID: 17287853

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. PubMed ID: 18318008

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion. PubMed ID: 20407419

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Functional analysis of the NUP98-CCDC28A fusion protein. PubMed ID: 22058212

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication. PubMed ID: 23523133

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Human Nup98 regulates the localization and activity of DExH/D-box helicase DHX9. PubMed ID: 28221134

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence. PubMed ID: 30543681

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling. PubMed ID: 33097660

Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex. PubMed ID: 33360543

SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98. PubMed ID: 33849972

The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98. PubMed ID: 12191480

Structural constraints on autoprocessing of the human nucleoporin Nup98. PubMed ID: 18287282

Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. PubMed ID: 20498086

Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. PubMed ID: 8563753

The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia. PubMed ID: 10477737

t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of a new subset of T acute lymphoblastic leukaemia. PubMed ID: 10929031

Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene. PubMed ID: 16419055

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern. PubMed ID: 23531517

Phase separation drives aberrant chromatin looping and cancer development. PubMed ID: 34163069