Details for: OAS2

Gene ID: 4939

Symbol: OAS2

Ensembl ID: ENSG00000111335

Description: 2'-5'-oligoadenylate synthetase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 68.0831
    Cell Significance Index: -10.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 33.9847
    Cell Significance Index: -8.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.0764
    Cell Significance Index: -11.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 23.4649
    Cell Significance Index: -12.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.6366
    Cell Significance Index: -11.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6216
    Cell Significance Index: -10.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.6370
    Cell Significance Index: 90.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4940
    Cell Significance Index: -9.3600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.9784
    Cell Significance Index: 46.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9009
    Cell Significance Index: -8.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7116
    Cell Significance Index: -10.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8131
    Cell Significance Index: 58.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6723
    Cell Significance Index: 87.1100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.9566
    Cell Significance Index: 8.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.9555
    Cell Significance Index: 17.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8691
    Cell Significance Index: 165.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7872
    Cell Significance Index: 10.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4526
    Cell Significance Index: 408.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4204
    Cell Significance Index: 21.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4042
    Cell Significance Index: 11.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2657
    Cell Significance Index: 43.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2551
    Cell Significance Index: 27.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2467
    Cell Significance Index: 5.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2465
    Cell Significance Index: 28.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2152
    Cell Significance Index: 13.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1955
    Cell Significance Index: 24.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1919
    Cell Significance Index: 18.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1765
    Cell Significance Index: 31.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1725
    Cell Significance Index: 1.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1694
    Cell Significance Index: 10.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1307
    Cell Significance Index: 9.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1286
    Cell Significance Index: 16.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0689
    Cell Significance Index: 8.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0601
    Cell Significance Index: 2.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0300
    Cell Significance Index: 0.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0215
    Cell Significance Index: 0.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0182
    Cell Significance Index: 0.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0108
    Cell Significance Index: 0.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0106
    Cell Significance Index: 1.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0034
    Cell Significance Index: -2.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0053
    Cell Significance Index: -9.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0069
    Cell Significance Index: -3.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0084
    Cell Significance Index: -13.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0101
    Cell Significance Index: -13.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0128
    Cell Significance Index: -5.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0131
    Cell Significance Index: -9.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0162
    Cell Significance Index: -11.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0163
    Cell Significance Index: -12.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0170
    Cell Significance Index: -3.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0178
    Cell Significance Index: -11.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0196
    Cell Significance Index: -0.6900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0208
    Cell Significance Index: -0.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0215
    Cell Significance Index: -7.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0220
    Cell Significance Index: -12.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0226
    Cell Significance Index: -14.1100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0232
    Cell Significance Index: -0.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0243
    Cell Significance Index: -1.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0258
    Cell Significance Index: -7.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0267
    Cell Significance Index: -12.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0306
    Cell Significance Index: -1.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0346
    Cell Significance Index: -1.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0380
    Cell Significance Index: -7.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0385
    Cell Significance Index: -3.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0473
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0554
    Cell Significance Index: -11.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0716
    Cell Significance Index: -12.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0755
    Cell Significance Index: -1.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0761
    Cell Significance Index: -11.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0834
    Cell Significance Index: -10.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0859
    Cell Significance Index: -1.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1022
    Cell Significance Index: -10.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1034
    Cell Significance Index: -11.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1262
    Cell Significance Index: -9.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1412
    Cell Significance Index: -10.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1465
    Cell Significance Index: -3.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1483
    Cell Significance Index: -2.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1517
    Cell Significance Index: -6.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1615
    Cell Significance Index: -10.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1622
    Cell Significance Index: -8.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1649
    Cell Significance Index: -11.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1657
    Cell Significance Index: -7.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1889
    Cell Significance Index: -11.6100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1975
    Cell Significance Index: -3.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1996
    Cell Significance Index: -5.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2099
    Cell Significance Index: -11.7800
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: -0.2190
    Cell Significance Index: -1.6900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2228
    Cell Significance Index: -9.6900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2423
    Cell Significance Index: -1.5800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2440
    Cell Significance Index: -3.5100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2741
    Cell Significance Index: -4.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2742
    Cell Significance Index: -9.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2806
    Cell Significance Index: -7.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2859
    Cell Significance Index: -9.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2877
    Cell Significance Index: -10.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2961
    Cell Significance Index: -9.4300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2982
    Cell Significance Index: -2.9900
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.3132
    Cell Significance Index: -3.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3268
    Cell Significance Index: -4.6800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3356
    Cell Significance Index: -1.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** OAS2 is a 2'-5'-oligoadenylate synthetase, which is responsible for the production of 2'-5'-oligoadenylates from ATP and GTP. 2. **Antiviral Mechanism:** OAS2 plays a crucial role in the antiviral response by activating PKR, leading to the phosphorylation and inhibition of viral RNA-dependent RNA polymerase. 3. **Cellular Expression:** OAS2 is expressed in various cell types, including retina horizontal cells, amacrine cells, IgG plasmablasts, IgA plasmablasts, enterocytes, lung endothelial cells, and immune cells. 4. **Regulatory Functions:** OAS2 is involved in the regulation of lactation, ribonuclease activity, and the production of interferon-beta and tumor necrosis factor. **Pathways and Functions:** 1. **Interferon Signaling Pathway:** OAS2 is a key component of the interferon signaling pathway, which is essential for the induction of antiviral genes. 2. **Antiviral Response:** OAS2 is involved in the activation of PKR, leading to the inhibition of viral RNA-dependent RNA polymerase and the induction of antiviral genes. 3. **Cytokine Signaling:** OAS2 is involved in the regulation of cytokine signaling, including the production of interferon-alpha, interferon-beta, and tumor necrosis factor. 4. **Immune Cell Function:** OAS2 is expressed in immune cells, including classical monocytes, and plays a crucial role in the regulation of immune responses. **Clinical Significance:** 1. **Viral Infections:** OAS2 is involved in the response to viral infections, including respiratory syncytial virus (RSV) and influenza. 2. **Autoimmune Diseases:** OAS2 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** OAS2 has been shown to play a role in the regulation of tumor necrosis factor production and the suppression of tumor growth. 4. **Neurological Disorders:** OAS2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the OAS2 gene plays a crucial role in the antiviral immune response and is involved in various cellular processes, including cytokine signaling and immune cell function. Further research is needed to fully elucidate the role of OAS2 in human disease and to explore its potential as a therapeutic target for viral infections and autoimmune diseases.

Genular Protein ID: 3097865151

Symbol: OAS2_HUMAN

Name: 2'-5'-oligoadenylate synthase 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1577824

Title: The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains.

PubMed ID: 1577824

DOI: 10.1016/s0021-9258(19)50182-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11986302

Title: Identification of the substrate-binding sites of 2'-5'-oligoadenylate synthetase.

PubMed ID: 11986302

DOI: 10.1074/jbc.m110202200

PubMed ID: 2211721

Title: Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon.

PubMed ID: 2211721

DOI: 10.1016/s0021-9258(17)44794-6

PubMed ID: 9880569

Title: Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase.

PubMed ID: 9880569

DOI: 10.1074/jbc.274.3.1848

PubMed ID: 10464285

Title: The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases.

PubMed ID: 10464285

DOI: 10.1074/jbc.274.36.25535

PubMed ID: 11682059

Title: Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions.

PubMed ID: 11682059

DOI: 10.1016/s0014-5793(01)02918-0

PubMed ID: 17408844

Title: The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.

PubMed ID: 17408844

DOI: 10.1016/j.biochi.2007.02.003

PubMed ID: 19923450

Title: Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection.

PubMed ID: 19923450

DOI: 10.4049/jimmunol.0902728

PubMed ID: 19904482

Title: Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria.

PubMed ID: 19904482

DOI: 10.1007/s00239-009-9299-1

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21142819

Title: The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.

PubMed ID: 21142819

DOI: 10.1089/jir.2010.0107

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 719
  • Mass: 82431
  • Checksum: 1B680D397D5EDB78
  • Sequence:
  • MGNGESQLSS VPAQKLGWFI QEYLKPYEEC QTLIDEMVNT ICDVLQEPEQ FPLVQGVAIG 
    GSYGRKTVLR GNSDGTLVLF FSDLKQFQDQ KRSQRDILDK TGDKLKFCLF TKWLKNNFEI 
    QKSLDGFTIQ VFTKNQRISF EVLAAFNALS LNDNPSPWIY RELKRSLDKT NASPGEFAVC 
    FTELQQKFFD NRPGKLKDLI LLIKHWHQQC QKKIKDLPSL SPYALELLTV YAWEQGCRKD 
    NFDIAEGVRT VLELIKCQEK LCIYWMVNYN FEDETIRNIL LHQLQSARPV ILDPVDPTNN 
    VSGDKICWQW LKKEAQTWLT SPNLDNELPA PSWNVLPAPL FTTPGHLLDK FIKEFLQPNK 
    CFLEQIDSAV NIIRTFLKEN CFRQSTAKIQ IVRGGSTAKG TALKTGSDAD LVVFHNSLKS 
    YTSQKNERHK IVKEIHEQLK AFWREKEEEL EVSFEPPKWK APRVLSFSLK SKVLNESVSF 
    DVLPAFNALG QLSSGSTPSP EVYAGLIDLY KSSDLPGGEF STCFTVLQRN FIRSRPTKLK 
    DLIRLVKHWY KECERKLKPK GSLPPKYALE LLTIYAWEQG SGVPDFDTAE GFRTVLELVT 
    QYQQLCIFWK VNYNFEDETV RKFLLSQLQK TRPVILDPAE PTGDVGGGDR WCWHLLAKEA 
    KEWLSSPCFK DGTGNPIPPW KVPTMQTPGS CGARIHPIVN EMFSSRSHRI LNNNSKRNF

Genular Protein ID: 2027178608

Symbol: Q7Z6D0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 172
  • Mass: 19586
  • Checksum: 8CF485C9EE9850A9
  • Sequence:
  • MGNGESQLSS VPAQKLGWFI QEYLKPYEEC QTLIDEMVNT ICDVLQEPEQ FPLVQGVAIG 
    GSYGRKTVLR GNSDGTLVLF FSDLKQFQDQ KRSQRDILDK TGDKLKFCLF TKWLKNNFEI 
    QKSLDGFTIQ VFTKNQRISF EVLAAFNALS KHCWVSGEKS QRRGCQTALC NL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.