Details for: OAS2

Gene ID: 4939

Symbol: OAS2

Ensembl ID: ENSG00000111335

Description: 2'-5'-oligoadenylate synthetase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.59
    Marker Score: 4397
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 2.42
    Marker Score: 7764
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.59
    Marker Score: 438
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.36
    Marker Score: 358
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.31
    Marker Score: 1305
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.26
    Marker Score: 11046
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.22
    Marker Score: 68473
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.22
    Marker Score: 823
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.18
    Marker Score: 13773
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4762
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.13
    Marker Score: 467
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.1
    Marker Score: 737
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71764
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47989
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.98
    Marker Score: 1986
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.98
    Marker Score: 407
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.96
    Marker Score: 219
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.93
    Marker Score: 631
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.92
    Marker Score: 420
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 359
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4993
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5263
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.81
    Marker Score: 1078
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.81
    Marker Score: 20720
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.78
    Marker Score: 2691
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.77
    Marker Score: 748
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1231
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.76
    Marker Score: 1474
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.75
    Marker Score: 768.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.74
    Marker Score: 7319
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 671
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.73
    Marker Score: 1891
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.7
    Marker Score: 697
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.69
    Marker Score: 443
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.68
    Marker Score: 1342
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.67
    Marker Score: 487
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.66
    Marker Score: 478
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.65
    Marker Score: 1783
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.63
    Marker Score: 33445
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.61
    Marker Score: 3678
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.6
    Marker Score: 1895
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 359
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.59
    Marker Score: 155
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.58
    Marker Score: 202
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.58
    Marker Score: 3682
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.56
    Marker Score: 1374
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.56
    Marker Score: 257
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.56
    Marker Score: 488
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 367
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.55
    Marker Score: 1335
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 168
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.53
    Marker Score: 166
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.53
    Marker Score: 474
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.53
    Marker Score: 277
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.52
    Marker Score: 381
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.52
    Marker Score: 760
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.49
    Marker Score: 418
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.48
    Marker Score: 701
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.48
    Marker Score: 224
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.48
    Marker Score: 115
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.47
    Marker Score: 698
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.47
    Marker Score: 287
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.46
    Marker Score: 414
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.46
    Marker Score: 271.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.46
    Marker Score: 363
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.46
    Marker Score: 1881
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.45
    Marker Score: 435
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.45
    Marker Score: 495
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.45
    Marker Score: 338
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.45
    Marker Score: 714
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.44
    Marker Score: 468
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.44
    Marker Score: 418
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.44
    Marker Score: 790
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 117
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.44
    Marker Score: 392
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.44
    Marker Score: 341
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.43
    Marker Score: 6778
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.43
    Marker Score: 820
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.43
    Marker Score: 248
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.43
    Marker Score: 1208
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.43
    Marker Score: 185.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.43
    Marker Score: 351
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.42
    Marker Score: 126
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.42
    Marker Score: 459
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.41
    Marker Score: 3583
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.41
    Marker Score: 141
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.4
    Marker Score: 3007
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.4
    Marker Score: 442
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.4
    Marker Score: 2520.5

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Other Information

**Key characteristics:** - Gene name: OAS2 - Ensembl ID: ENSG00000111335 - Pathways/Ontology: 2'-5'-oligoadenylate synthetase activity, Antiviral mechanism by ifn-stimulated genes, Atp binding, Cytokine signaling in immune system, Disease - Significantly expressed cells: retina horizontal cell, amacrine cell, IgG plasmablast, IgA plasmablast, enterocyte of epithelium of large intestine, lung endothelial cell, CD14-positive, CD16-negative classical monocyte, intestinal crypt stem cell of small intestine, blood cell, enterocyte of epithelium of small intestine **Pathways and functions:** - The OAS2 gene is involved in the regulation of innate immunity. - It is a key player in the antiviral response, and it is activated by interferons. - Interferons are proteins that are produced by infected cells and that activate the immune system. - When interferons bind to OAS2, it triggers a signaling cascade that leads to the production of antiviral proteins. - These proteins include proteins that inhibit viral replication and proteins that help to destroy infected cells. **Clinical significance:** - Mutations in the OAS2 gene have been linked to the development of several diseases, including cancer and viral infections. - Targeting the OAS2 gene has been investigated as a therapy for these diseases. - In one study, for example, patients with cancer who received a drug that targeted the OAS2 gene had a better response to treatment than patients who received a drug that did not target the OAS2 gene.

Genular Protein ID: 3097865151

Symbol: OAS2_HUMAN

Name: 2'-5'-oligoadenylate synthase 2

UniProtKB Accession Codes:

P29728 A8K9T1 Q6PJ33 Q86XX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 3 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1577824

Title: The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains.

PubMed ID: 1577824

DOI: 10.1016/s0021-9258(19)50182-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11986302

Title: Identification of the substrate-binding sites of 2'-5'-oligoadenylate synthetase.

PubMed ID: 11986302

DOI: 10.1074/jbc.m110202200

PubMed ID: 2211721

Title: Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon.

PubMed ID: 2211721

DOI: 10.1016/s0021-9258(17)44794-6

PubMed ID: 9880569

Title: Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase.

PubMed ID: 9880569

DOI: 10.1074/jbc.274.3.1848

PubMed ID: 10464285

Title: The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases.

PubMed ID: 10464285

DOI: 10.1074/jbc.274.36.25535

PubMed ID: 11682059

Title: Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions.

PubMed ID: 11682059

DOI: 10.1016/s0014-5793(01)02918-0

PubMed ID: 17408844

Title: The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.

PubMed ID: 17408844

DOI: 10.1016/j.biochi.2007.02.003

PubMed ID: 19923450

Title: Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection.

PubMed ID: 19923450

DOI: 10.4049/jimmunol.0902728

PubMed ID: 19904482

Title: Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria.

PubMed ID: 19904482

DOI: 10.1007/s00239-009-9299-1

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21142819

Title: The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.

PubMed ID: 21142819

DOI: 10.1089/jir.2010.0107

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 719
  • Mass: 82431
  • Checksum: 1B680D397D5EDB78
  • Sequence:
    • MGNGESQLSS VPAQKLGWFI QEYLKPYEEC QTLIDEMVNT ICDVLQEPEQ FPLVQGVAIG 
GSYGRKTVLR GNSDGTLVLF FSDLKQFQDQ KRSQRDILDK TGDKLKFCLF TKWLKNNFEI 
QKSLDGFTIQ VFTKNQRISF EVLAAFNALS LNDNPSPWIY RELKRSLDKT NASPGEFAVC 
FTELQQKFFD NRPGKLKDLI LLIKHWHQQC QKKIKDLPSL SPYALELLTV YAWEQGCRKD 
NFDIAEGVRT VLELIKCQEK LCIYWMVNYN FEDETIRNIL LHQLQSARPV ILDPVDPTNN 
VSGDKICWQW LKKEAQTWLT SPNLDNELPA PSWNVLPAPL FTTPGHLLDK FIKEFLQPNK 
CFLEQIDSAV NIIRTFLKEN CFRQSTAKIQ IVRGGSTAKG TALKTGSDAD LVVFHNSLKS 
YTSQKNERHK IVKEIHEQLK AFWREKEEEL EVSFEPPKWK APRVLSFSLK SKVLNESVSF 
DVLPAFNALG QLSSGSTPSP EVYAGLIDLY KSSDLPGGEF STCFTVLQRN FIRSRPTKLK 
DLIRLVKHWY KECERKLKPK GSLPPKYALE LLTIYAWEQG SGVPDFDTAE GFRTVLELVT 
QYQQLCIFWK VNYNFEDETV RKFLLSQLQK TRPVILDPAE PTGDVGGGDR WCWHLLAKEA 
KEWLSSPCFK DGTGNPIPPW KVPTMQTPGS CGARIHPIVN EMFSSRSHRI LNNNSKRNF

Genular Protein ID: 2027178608

Symbol: Q7Z6D0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z6D0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 172
  • Mass: 19586
  • Checksum: 8CF485C9EE9850A9
  • Sequence:
    • MGNGESQLSS VPAQKLGWFI QEYLKPYEEC QTLIDEMVNT ICDVLQEPEQ FPLVQGVAIG 
GSYGRKTVLR GNSDGTLVLF FSDLKQFQDQ KRSQRDILDK TGDKLKFCLF TKWLKNNFEI 
QKSLDGFTIQ VFTKNQRISF EVLAAFNALS KHCWVSGEKS QRRGCQTALC NL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.