Details for: OAS2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 68.0831
Cell Significance Index: -10.5900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 33.9847
Cell Significance Index: -8.6200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 27.0764
Cell Significance Index: -11.0000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 23.4649
Cell Significance Index: -12.0700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 11.6366
Cell Significance Index: -11.1100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 8.6216
Cell Significance Index: -10.6300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.6370
Cell Significance Index: 90.9200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 3.4940
Cell Significance Index: -9.3600 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 2.9784
Cell Significance Index: 46.0800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 2.9009
Cell Significance Index: -8.9100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.7116
Cell Significance Index: -10.7000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.8131
Cell Significance Index: 58.0700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.6723
Cell Significance Index: 87.1100 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.9566
Cell Significance Index: 8.2200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.9555
Cell Significance Index: 17.6600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.8691
Cell Significance Index: 165.4000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7872
Cell Significance Index: 10.7400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4526
Cell Significance Index: 408.6700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4204
Cell Significance Index: 21.8400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.4042
Cell Significance Index: 11.8700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2657
Cell Significance Index: 43.2200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2551
Cell Significance Index: 27.7500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2467
Cell Significance Index: 5.2600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.2465
Cell Significance Index: 28.7300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2152
Cell Significance Index: 13.8900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1955
Cell Significance Index: 24.0400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1919
Cell Significance Index: 18.9800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1765
Cell Significance Index: 31.8100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1725
Cell Significance Index: 1.9600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1694
Cell Significance Index: 10.1700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1307
Cell Significance Index: 9.0400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1286
Cell Significance Index: 16.4800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0689
Cell Significance Index: 8.1200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0601
Cell Significance Index: 2.8000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0300
Cell Significance Index: 0.6500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0215
Cell Significance Index: 0.9500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0182
Cell Significance Index: 0.5100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0108
Cell Significance Index: 0.3100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0106
Cell Significance Index: 1.4500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0034
Cell Significance Index: -2.3200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0053
Cell Significance Index: -9.9800 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0069
Cell Significance Index: -3.7600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0071
Cell Significance Index: -13.0700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0084
Cell Significance Index: -13.0000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0101
Cell Significance Index: -13.7900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0128
Cell Significance Index: -5.6600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0131
Cell Significance Index: -9.8800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0162
Cell Significance Index: -11.8800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0163
Cell Significance Index: -12.0500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0170
Cell Significance Index: -3.3700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0178
Cell Significance Index: -11.3300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0196
Cell Significance Index: -0.6900 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0208
Cell Significance Index: -0.1700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0215
Cell Significance Index: -7.7300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0220
Cell Significance Index: -12.3900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0226
Cell Significance Index: -14.1100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0232
Cell Significance Index: -0.1400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0243
Cell Significance Index: -1.4900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0258
Cell Significance Index: -7.4100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0267
Cell Significance Index: -12.1100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0306
Cell Significance Index: -1.3900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0346
Cell Significance Index: -1.3100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0380
Cell Significance Index: -7.6200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0385
Cell Significance Index: -3.9300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0473
Cell Significance Index: -1.2700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0554
Cell Significance Index: -11.6700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0716
Cell Significance Index: -12.2200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0755
Cell Significance Index: -1.9300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0761
Cell Significance Index: -11.0600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0834
Cell Significance Index: -10.7700 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0859
Cell Significance Index: -1.3000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1022
Cell Significance Index: -10.6400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1034
Cell Significance Index: -11.8500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1262
Cell Significance Index: -9.4100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1412
Cell Significance Index: -10.8300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1465
Cell Significance Index: -3.0400 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.1483
Cell Significance Index: -2.3800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1517
Cell Significance Index: -6.2200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1615
Cell Significance Index: -10.1800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1622
Cell Significance Index: -8.1900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1649
Cell Significance Index: -11.0900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1657
Cell Significance Index: -7.7900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1889
Cell Significance Index: -11.6100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.1975
Cell Significance Index: -3.4900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1996
Cell Significance Index: -5.1300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2099
Cell Significance Index: -11.7800 - Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: -0.2190
Cell Significance Index: -1.6900 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2228
Cell Significance Index: -9.6900 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.2423
Cell Significance Index: -1.5800 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.2440
Cell Significance Index: -3.5100 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2741
Cell Significance Index: -4.7300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2742
Cell Significance Index: -9.6100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2806
Cell Significance Index: -7.5200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2859
Cell Significance Index: -9.3600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2877
Cell Significance Index: -10.5600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2961
Cell Significance Index: -9.4300 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.2982
Cell Significance Index: -2.9900 - Cell Name: endothelial stalk cell (CL0002671)
Fold Change: -0.3132
Cell Significance Index: -3.5100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3268
Cell Significance Index: -4.6800 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.3356
Cell Significance Index: -1.8300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3097865151
Symbol: OAS2_HUMAN
Name: 2'-5'-oligoadenylate synthase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1577824
Title: The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains.
PubMed ID: 1577824
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11986302
Title: Identification of the substrate-binding sites of 2'-5'-oligoadenylate synthetase.
PubMed ID: 11986302
PubMed ID: 2211721
Title: Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon.
PubMed ID: 2211721
PubMed ID: 9880569
Title: Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase.
PubMed ID: 9880569
PubMed ID: 10464285
Title: The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases.
PubMed ID: 10464285
PubMed ID: 11682059
Title: Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions.
PubMed ID: 11682059
PubMed ID: 17408844
Title: The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.
PubMed ID: 17408844
PubMed ID: 19923450
Title: Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection.
PubMed ID: 19923450
PubMed ID: 19904482
Title: Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria.
PubMed ID: 19904482
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21142819
Title: The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.
PubMed ID: 21142819
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 719
- Mass: 82431
- Checksum: 1B680D397D5EDB78
- Sequence:
MGNGESQLSS VPAQKLGWFI QEYLKPYEEC QTLIDEMVNT ICDVLQEPEQ FPLVQGVAIG GSYGRKTVLR GNSDGTLVLF FSDLKQFQDQ KRSQRDILDK TGDKLKFCLF TKWLKNNFEI QKSLDGFTIQ VFTKNQRISF EVLAAFNALS LNDNPSPWIY RELKRSLDKT NASPGEFAVC FTELQQKFFD NRPGKLKDLI LLIKHWHQQC QKKIKDLPSL SPYALELLTV YAWEQGCRKD NFDIAEGVRT VLELIKCQEK LCIYWMVNYN FEDETIRNIL LHQLQSARPV ILDPVDPTNN VSGDKICWQW LKKEAQTWLT SPNLDNELPA PSWNVLPAPL FTTPGHLLDK FIKEFLQPNK CFLEQIDSAV NIIRTFLKEN CFRQSTAKIQ IVRGGSTAKG TALKTGSDAD LVVFHNSLKS YTSQKNERHK IVKEIHEQLK AFWREKEEEL EVSFEPPKWK APRVLSFSLK SKVLNESVSF DVLPAFNALG QLSSGSTPSP EVYAGLIDLY KSSDLPGGEF STCFTVLQRN FIRSRPTKLK DLIRLVKHWY KECERKLKPK GSLPPKYALE LLTIYAWEQG SGVPDFDTAE GFRTVLELVT QYQQLCIFWK VNYNFEDETV RKFLLSQLQK TRPVILDPAE PTGDVGGGDR WCWHLLAKEA KEWLSSPCFK DGTGNPIPPW KVPTMQTPGS CGARIHPIVN EMFSSRSHRI LNNNSKRNF
Genular Protein ID: 2027178608
Symbol: Q7Z6D0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 172
- Mass: 19586
- Checksum: 8CF485C9EE9850A9
- Sequence:
MGNGESQLSS VPAQKLGWFI QEYLKPYEEC QTLIDEMVNT ICDVLQEPEQ FPLVQGVAIG GSYGRKTVLR GNSDGTLVLF FSDLKQFQDQ KRSQRDILDK TGDKLKFCLF TKWLKNNFEI QKSLDGFTIQ VFTKNQRISF EVLAAFNALS KHCWVSGEKS QRRGCQTALC NL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.