Details for: OGG1

Gene ID: 4968

Symbol: OGG1

Ensembl ID: ENSG00000114026

Description: 8-oxoguanine DNA glycosylase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.4782
    Cell Significance Index: -15.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.1702
    Cell Significance Index: -16.5300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 43.8163
    Cell Significance Index: -18.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.0239
    Cell Significance Index: -16.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.4612
    Cell Significance Index: -17.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.5322
    Cell Significance Index: -14.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6558
    Cell Significance Index: -14.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5945
    Cell Significance Index: -18.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3741
    Cell Significance Index: 162.0500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2024
    Cell Significance Index: 19.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1149
    Cell Significance Index: 66.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9685
    Cell Significance Index: 95.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7804
    Cell Significance Index: 84.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7441
    Cell Significance Index: 671.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6815
    Cell Significance Index: 135.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.6758
    Cell Significance Index: 11.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6002
    Cell Significance Index: 33.6800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5352
    Cell Significance Index: 11.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5316
    Cell Significance Index: 106.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5253
    Cell Significance Index: 15.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5098
    Cell Significance Index: 82.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4554
    Cell Significance Index: 20.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3834
    Cell Significance Index: 26.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3599
    Cell Significance Index: 22.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3598
    Cell Significance Index: 41.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3548
    Cell Significance Index: 22.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3501
    Cell Significance Index: 23.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3267
    Cell Significance Index: 44.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3163
    Cell Significance Index: 8.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2981
    Cell Significance Index: 53.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2868
    Cell Significance Index: 18.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2836
    Cell Significance Index: 101.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2804
    Cell Significance Index: 5.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2412
    Cell Significance Index: 10.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2407
    Cell Significance Index: 5.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1912
    Cell Significance Index: 7.2400
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.1822
    Cell Significance Index: 0.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1783
    Cell Significance Index: 2.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1655
    Cell Significance Index: 21.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1430
    Cell Significance Index: 3.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1376
    Cell Significance Index: 16.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1151
    Cell Significance Index: 1.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1125
    Cell Significance Index: 3.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0934
    Cell Significance Index: 17.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0919
    Cell Significance Index: 50.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0747
    Cell Significance Index: 1.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0669
    Cell Significance Index: 1.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0610
    Cell Significance Index: 2.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0578
    Cell Significance Index: 39.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0567
    Cell Significance Index: 1.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0567
    Cell Significance Index: 25.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0514
    Cell Significance Index: 3.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0282
    Cell Significance Index: 53.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0194
    Cell Significance Index: 29.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0126
    Cell Significance Index: 23.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0089
    Cell Significance Index: 0.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0077
    Cell Significance Index: 0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0068
    Cell Significance Index: 4.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0043
    Cell Significance Index: 5.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0053
    Cell Significance Index: -2.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0114
    Cell Significance Index: -0.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0131
    Cell Significance Index: -9.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0165
    Cell Significance Index: -12.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0204
    Cell Significance Index: -15.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0208
    Cell Significance Index: -3.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0214
    Cell Significance Index: -1.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0290
    Cell Significance Index: -16.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0311
    Cell Significance Index: -19.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0433
    Cell Significance Index: -4.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0553
    Cell Significance Index: -15.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0560
    Cell Significance Index: -9.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0680
    Cell Significance Index: -8.7800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0717
    Cell Significance Index: -0.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0905
    Cell Significance Index: -2.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0947
    Cell Significance Index: -19.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0973
    Cell Significance Index: -6.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1008
    Cell Significance Index: -5.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1115
    Cell Significance Index: -12.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1136
    Cell Significance Index: -5.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1246
    Cell Significance Index: -3.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1280
    Cell Significance Index: -3.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1374
    Cell Significance Index: -10.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1491
    Cell Significance Index: -15.5300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1604
    Cell Significance Index: -1.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1756
    Cell Significance Index: -4.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1831
    Cell Significance Index: -14.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1972
    Cell Significance Index: -10.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2149
    Cell Significance Index: -5.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2235
    Cell Significance Index: -3.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2421
    Cell Significance Index: -7.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2456
    Cell Significance Index: -7.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2463
    Cell Significance Index: -15.1000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2599
    Cell Significance Index: -2.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3051
    Cell Significance Index: -9.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3064
    Cell Significance Index: -9.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3088
    Cell Significance Index: -8.2600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3092
    Cell Significance Index: -3.9600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3591
    Cell Significance Index: -7.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3597
    Cell Significance Index: -5.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OGG1 is a DNA glycosylase enzyme that catalyzes the removal of 8-oxoguanine from DNA. It is a single-strand DNA endonuclease that recognizes and cleaves the phosphodiester bond between the 8-oxoguanine and the adjacent nucleotide, releasing the 8-oxoguanine and a uracil-containing oligonucleotide. OGG1 is a member of the AP-endonuclease family and is activated by the presence of 8-oxoguanine. **Pathways and Functions:** OGG1 is involved in several cellular processes, including: 1. **Base Excision Repair (BER):** OGG1 is a key enzyme in the BER pathway, responsible for repairing oxidative damage to DNA. 2. **Apex1-independent Resolution of Ap Sites:** OGG1 can also remove 8-oxoguanine from ap sites (apurinic/apyrimidinic sites) without the assistance of Apex1. 3. **Recognition and Association with Damaged DNA:** OGG1 recognizes and associates with damaged DNA, allowing it to access and repair the lesion. 4. **Negative Regulation of Apoptotic Process:** OGG1 can also regulate apoptosis by cleaving and inactivating pro-apoptotic proteins. **Clinical Significance:** Mutations in the OGG1 gene have been associated with several human diseases, including: 1. **Ataxia with Oculomotor Apraxia Type 1 (AOA1):** A rare genetic disorder characterized by progressive ataxia, oculomotor apraxia, and cerebellar degeneration. 2. **Neuropathy, Ataxia, and Dystonia (NAD):** A rare genetic disorder characterized by peripheral neuropathy, ataxia, and dystonia. 3. **Oxidative Stress and Cancer:** OGG1 mutations can increase the risk of cancer by allowing oxidative damage to accumulate in the genome. In conclusion, OGG1 is a critical enzyme that plays a vital role in maintaining genome integrity in response to oxidative stress. Mutations in the OGG1 gene can lead to various human diseases, highlighting the importance of this gene in human health. Further research is needed to fully understand the mechanisms of OGG1 and its role in human disease.

Genular Protein ID: 1149509138

Symbol: OGG1_HUMAN

Name: N-glycosylase/DNA lyase

UniProtKB Accession Codes:

O15527 A8K1E3 O00390 O00670 O00705 O14876 O95488 P78554 Q9BW42 Q9UIK0 Q9UIK1 Q9UIK2 Q9UL34 Q9Y2C0 Q9Y2C1 Q9Y6C3 Q9Y6C4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CDD 1 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 3 EMBL 22 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 33 PDBsum 33 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 9 RefSeq 8 Rhea 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9187114

Title: Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.

PubMed ID: 9187114

PubMed ID: 9207108

Title: Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.

PubMed ID: 9207108

DOI: 10.1073/pnas.94.14.7429

PubMed ID: 9223306

Title: Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase.

PubMed ID: 9223306

DOI: 10.1073/pnas.94.15.8016

PubMed ID: 9223305

Title: Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.

PubMed ID: 9223305

DOI: 10.1073/pnas.94.15.8010

PubMed ID: 9197244

Title: A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.

PubMed ID: 9197244

DOI: 10.1016/s0960-9822(06)00187-4

PubMed ID: 9190902

Title: Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage.

PubMed ID: 9190902

DOI: 10.1038/sj.onc.1201139

PubMed ID: 9348312

Title: Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers.

PubMed ID: 9348312

DOI: 10.1084/jem.186.9.1547

PubMed ID: 9321410

Title: Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites.

PubMed ID: 9321410

DOI: 10.1093/emboj/16.20.6314

PubMed ID: 10449904

Title: Structure and chromosome location of human OGG1.

PubMed ID: 10449904

DOI: 10.1159/000015299

PubMed ID: 10233168

Title: Expression and differential intracellular localization of two major forms of human 8-Oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs.

PubMed ID: 10233168

DOI: 10.1091/mbc.10.5.1637

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10775435

Title: The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis.

PubMed ID: 10775435

DOI: 10.1006/abbi.2000.1773

PubMed ID: 17148573

Title: UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles.

PubMed ID: 17148573

DOI: 10.1242/jcs.03312

PubMed ID: 10706276

Title: Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.

PubMed ID: 10706276

DOI: 10.1038/35002510

PubMed ID: 11902834

Title: Reciprocal 'flipping'; underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase.

PubMed ID: 11902834

DOI: 10.1006/jmbi.2002.5400

PubMed ID: 12578369

Title: Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase.

PubMed ID: 12578369

DOI: 10.1021/bi026823d

PubMed ID: 12592398

Title: Product-assisted catalysis in base-excision DNA repair.

PubMed ID: 12592398

DOI: 10.1038/nsb902

PubMed ID: 15610848

Title: Structures of end products resulting from lesion processing by a DNA glycosylase/lyase.

PubMed ID: 15610848

DOI: 10.1016/j.chembiol.2004.09.014

PubMed ID: 17114185

Title: Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations.

PubMed ID: 17114185

DOI: 10.1074/jbc.m608989200

PubMed ID: 9765618

Title: Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer.

PubMed ID: 9765618

DOI: 10.1111/j.1349-7006.1998.tb00635.x

PubMed ID: 9662341

Title: Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours.

PubMed ID: 9662341

DOI: 10.1038/sj.onc.1202096

PubMed ID: 10497264

Title: Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations.

PubMed ID: 10497264

DOI: 10.1093/nar/27.20.4001

PubMed ID: 10908322

Title: Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the ogg1 protein.

PubMed ID: 10908322

DOI: 10.1093/nar/28.14.2672

PubMed ID: 12509224

Title: Mitochondrial targeting of human 8-oxoguanine DNA glycosylase hOGG1 is impaired by a somatic mutation found in kidney cancer.

PubMed ID: 12509224

DOI: 10.1016/s1568-7864(02)00034-4

Sequence Information:

  • Length: 345
  • Mass: 38782
  • Checksum: C284106ADEEC1FDD
  • Sequence:
    • MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA 
DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF 
QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG 
FPSLQALAGP EVEAHLRKLG LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL 
CILPGVGTKV ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG 
NFFRSLWGPY AGWAQAVLFS ADLRQSRHAQ EPPAKRRKGS KGPEG

Genular Protein ID: 2105439087

Symbol: E5KPM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5KPM5

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 43 ExpressionAtlas 1 GO 6 Gene3D 2 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 Rhea 4 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 424
  • Mass: 47237
  • Checksum: 0013B0F2D51FD316
  • Sequence:
    • MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA 
DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF 
QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG 
FPSLQALAGP EVEAHLRKLG LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL 
CILPGVGTKV ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG 
NFFRSLWGPY AGWAQAGLLG NAFDGHQLLR PLIFCQDHLR EGPPIGRGDS QGEELEPQLP 
SSLSSIPYGF CDHCWTKDVD DPPLVTHPSP GSRDGHMTQA WPVKVVSPLA TVIGHVMQAS 
LLAL

Genular Protein ID: 2862971990

Symbol: E5KPM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5KPM7

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 43 ExpressionAtlas 1 GO 6 Gene3D 2 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 Rhea 4 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 356
  • Mass: 40095
  • Checksum: 40D1E4783F042C8F
  • Sequence:
    • MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA 
DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF 
QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG 
FPSLQALAGP EVEAHLRKLG LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL 
CILPGVGTKV ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG 
NFFRSLWGPY AGWAQALCQV ITTFMTFLGP HRLDQMPPEE LQTSSSRLGG PPWQCI

Genular Protein ID: 3052771716

Symbol: E5KPM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5KPM8

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 43 ExpressionAtlas 1 GO 6 Gene3D 2 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 195
  • Mass: 22210
  • Checksum: 16628F612964E282
  • Sequence:
    • MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA 
DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF 
QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG 
FPSLQALAGP PWQCI

Genular Protein ID: 496136545

Symbol: E5KPN0_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5KPN0

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 39 ExpressionAtlas 1 GO 6 Gene3D 2 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 Rhea 4 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 410
  • Mass: 45761
  • Checksum: CA01660C056A09F0
  • Sequence:
    • MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA 
DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF 
QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG 
FPSLQALAGP EVEAHLRKLG LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL 
CILPGVGTKV ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG 
NFFRSLWGPY AGWAQATPPS YRCCSVPTCA NPAMLRSHQQ SAERVPKGRK ARWGTLDKEI 
PQAPSPPFPT SLSPSPPSLM LGRGLPVTTS KARHPQIKQS VCTTRWGGGY

Genular Protein ID: 1902220322

Symbol: E5KPM9_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5KPM9

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 43 ExpressionAtlas 1 GO 6 Gene3D 2 HOGENOM 1 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 Rhea 4 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 322
  • Mass: 36085
  • Checksum: E47B3CA5AE8CFABB
  • Sequence:
    • MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA 
DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF 
QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG 
FPSLQALAGP EVEAHLRKLG LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL 
CILPGVGTKV ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG 
NFFRSLWGPY AGWAQAAGSD AS

Genular Protein ID: 2340311919

Symbol: E5KPM6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5KPM6

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 43 ExpressionAtlas 1 GO 6 Gene3D 2 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 Rhea 4 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 357
  • Mass: 39729
  • Checksum: 0FAA63310FC13ADB
  • Sequence:
    • MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA 
DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF 
QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG 
FPSLQALAGP EVEAHLRKLG LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL 
CILPGVGTKG LLGNAFDGHQ LLRPLIFCQD HLREGPPIGR GDSQGEELEP QLPSSLSSIP 
YGFCDHCWTK DVDDPPLVTH PSPGSRDGHM TQAWPVKVVS PLATVIGHVM QASLLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.