Details for: WRAP73

Gene ID: 49856

Symbol: WRAP73

Ensembl ID: ENSG00000116213

Description: WD repeat containing, antisense to TP73

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 100.2924
    Cell Significance Index: -15.6000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.3998
    Cell Significance Index: -15.3200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 40.2478
    Cell Significance Index: -16.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.2573
    Cell Significance Index: -17.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.7132
    Cell Significance Index: -14.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 33.6129
    Cell Significance Index: -17.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 26.2137
    Cell Significance Index: -17.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.6796
    Cell Significance Index: -14.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.8529
    Cell Significance Index: -17.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1962
    Cell Significance Index: -13.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4044
    Cell Significance Index: -17.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.4088
    Cell Significance Index: -10.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2709
    Cell Significance Index: -4.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1763
    Cell Significance Index: 1062.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9386
    Cell Significance Index: 102.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8181
    Cell Significance Index: 133.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6858
    Cell Significance Index: 79.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5315
    Cell Significance Index: 33.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4968
    Cell Significance Index: 34.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4544
    Cell Significance Index: 6.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3132
    Cell Significance Index: 9.0300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2689
    Cell Significance Index: 2.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2613
    Cell Significance Index: 16.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2510
    Cell Significance Index: 29.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2414
    Cell Significance Index: 5.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2324
    Cell Significance Index: 44.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2237
    Cell Significance Index: 122.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2190
    Cell Significance Index: 43.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2157
    Cell Significance Index: 6.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1896
    Cell Significance Index: 18.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1891
    Cell Significance Index: 34.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1791
    Cell Significance Index: 24.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1754
    Cell Significance Index: 9.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1667
    Cell Significance Index: 4.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1619
    Cell Significance Index: 7.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1569
    Cell Significance Index: 4.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1524
    Cell Significance Index: 43.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1483
    Cell Significance Index: 65.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1187
    Cell Significance Index: 23.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1002
    Cell Significance Index: 12.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0963
    Cell Significance Index: 12.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0796
    Cell Significance Index: 28.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0783
    Cell Significance Index: 3.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0555
    Cell Significance Index: 38.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0385
    Cell Significance Index: 0.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0264
    Cell Significance Index: 1.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0188
    Cell Significance Index: 0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 1.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0046
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0064
    Cell Significance Index: -1.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0086
    Cell Significance Index: -0.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0117
    Cell Significance Index: -15.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0131
    Cell Significance Index: -9.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0135
    Cell Significance Index: -9.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0143
    Cell Significance Index: -9.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0186
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0225
    Cell Significance Index: -16.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0240
    Cell Significance Index: -10.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0252
    Cell Significance Index: -0.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0258
    Cell Significance Index: -2.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0265
    Cell Significance Index: -0.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0299
    Cell Significance Index: -16.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0310
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0317
    Cell Significance Index: -19.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0331
    Cell Significance Index: -2.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0401
    Cell Significance Index: -2.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0419
    Cell Significance Index: -5.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0478
    Cell Significance Index: -2.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0533
    Cell Significance Index: -2.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0554
    Cell Significance Index: -8.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0597
    Cell Significance Index: -6.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0715
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0927
    Cell Significance Index: -19.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1089
    Cell Significance Index: -6.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1092
    Cell Significance Index: -8.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1127
    Cell Significance Index: -2.8800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1258
    Cell Significance Index: -1.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1496
    Cell Significance Index: -1.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1589
    Cell Significance Index: -16.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1744
    Cell Significance Index: -4.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1745
    Cell Significance Index: -5.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1752
    Cell Significance Index: -11.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1846
    Cell Significance Index: -14.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2008
    Cell Significance Index: -5.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2155
    Cell Significance Index: -5.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2179
    Cell Significance Index: -9.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2348
    Cell Significance Index: -4.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2368
    Cell Significance Index: -14.5200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2392
    Cell Significance Index: -2.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2616
    Cell Significance Index: -3.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2630
    Cell Significance Index: -9.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2630
    Cell Significance Index: -6.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2632
    Cell Significance Index: -4.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2874
    Cell Significance Index: -2.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2964
    Cell Significance Index: -6.4900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3096
    Cell Significance Index: -4.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3115
    Cell Significance Index: -8.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** WRAP73 is a WD repeat-containing protein that is antisense to the TP73 gene. The WD repeats are a conserved protein motif involved in protein-protein interactions, which are crucial for the regulation of various cellular processes. WRAP73 has been shown to be significantly expressed in several cell types, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and embryonic stem cells. Its expression is also observed in epithelial cells, including ileal goblet cells and ciliated cells of the bronchus. **Pathways and Functions:** WRAP73 has been implicated in multiple cellular pathways, including: 1. **Cell projection organization:** WRAP73 has been shown to regulate the organization of cell projections, including filopodia and lamellipodia, which are essential for cell migration, adhesion, and signaling. 2. **Centrosome function:** WRAP73 has been implicated in the regulation of centrosome function, including centriole duplication and centrosome maturation. 3. **Cilium assembly:** WRAP73 has been shown to regulate the assembly of non-motile cilia, which are essential for the maintenance of epithelial homeostasis. 4. **Microtubule organization:** WRAP73 has been implicated in the regulation of microtubule organization, including microtubule dynamics and microtubule-associated protein interactions. **Clinical Significance:** The dysregulation of WRAP73 has been implicated in various diseases, including: 1. **Hematological disorders:** WRAP73 has been shown to be mutated in patients with hematological disorders, including leukemia and lymphoma. 2. **Cancer:** WRAP73 has been implicated in the development and progression of various cancers, including colorectal cancer and lung cancer. 3. **Neurological disorders:** WRAP73 has been shown to be mutated in patients with neurological disorders, including Parkinson's disease and Alzheimer's disease. In conclusion, WRAP73 is a WD repeat-containing antisense gene that plays a crucial role in regulating various cellular processes, including cell projection organization, centrosome function, and cilium assembly. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying WRAP73 function and its role in human disease.

Genular Protein ID: 1622529225

Symbol: WRP73_HUMAN

Name: WD repeat-containing protein WRAP73

UniProtKB Accession Codes:

Q9P2S5 Q5T0D6 Q9BUH7 Q9NTK7 Q9NX56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11401440

Title: Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family.

PubMed ID: 11401440

DOI: 10.1006/geno.2000.6475

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26545777

Title: The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation.

PubMed ID: 26545777

DOI: 10.1016/j.bbrc.2015.10.169

PubMed ID: 26675238

Title: WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis.

PubMed ID: 26675238

DOI: 10.1242/jcs.179713

Sequence Information:

  • Length: 460
  • Mass: 51588
  • Checksum: C2E318B1F06F79BF
  • Sequence:
    • MNFSEVFKLS SLLCKFSPDG KYLASCVQYR LVVRDVNTLQ ILQLYTCLDQ IQHIEWSADS 
LFILCAMYKR GLVQVWSLEQ PEWHCKIDEG SAGLVASCWS PDGRHILNTT EFHLRITVWS 
LCTKSVSYIK YPKACLQGIT FTRDGRYMAL AERRDCKDYV SIFVCSDWQL LRHFDTDTQD 
LTGIEWAPNG CVLAVWDTCL EYKILLYSLD GRLLSTYSAY EWSLGIKSVA WSPSSQFLAV 
GSYDGKVRIL NHVTWKMITE FGHPAAINDP KIVVYKEAEK SPQLGLGCLS FPPPRAGAGP 
LPSSESKYEI ASVPVSLQTL KPVTDRANPK IGIGMLAFSP DSYFLATRND NIPNAVWVWD 
IQKLRLFAVL EQLSPVRAFQ WDPQQPRLAI CTGGSRLYLW SPAGCMSVQV PGEGDFAVLS 
LCWHLSGDSM ALLSKDHFCL CFLETEAVVG TACRQLGGHT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.