Details for: OXT

Gene ID: 5020

Symbol: OXT

Ensembl ID: ENSG00000101405

Description: oxytocin/neurophysin I prepropeptide

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 13.7581
    Cell Significance Index: -2.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.1504
    Cell Significance Index: -1.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 4.3209
    Cell Significance Index: -2.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.3935
    Cell Significance Index: 76.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.7357
    Cell Significance Index: -2.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2964
    Cell Significance Index: 246.7200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.9636
    Cell Significance Index: 15.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8049
    Cell Significance Index: 23.1900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.7742
    Cell Significance Index: 6.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7564
    Cell Significance Index: 45.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5683
    Cell Significance Index: 92.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5529
    Cell Significance Index: 54.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.5474
    Cell Significance Index: -2.1600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.5376
    Cell Significance Index: 5.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5358
    Cell Significance Index: 58.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5245
    Cell Significance Index: 473.5500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3271
    Cell Significance Index: 2.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3103
    Cell Significance Index: 21.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3102
    Cell Significance Index: 6.7200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2685
    Cell Significance Index: 4.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2280
    Cell Significance Index: 6.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1873
    Cell Significance Index: 9.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1293
    Cell Significance Index: 25.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1230
    Cell Significance Index: 2.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0821
    Cell Significance Index: 10.5200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0688
    Cell Significance Index: 0.7100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0688
    Cell Significance Index: 0.9700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0537
    Cell Significance Index: 0.7700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0341
    Cell Significance Index: 0.0800
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.0329
    Cell Significance Index: 0.1900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0275
    Cell Significance Index: 0.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0234
    Cell Significance Index: 1.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0172
    Cell Significance Index: 0.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0153
    Cell Significance Index: 0.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0145
    Cell Significance Index: 0.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0136
    Cell Significance Index: 1.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0111
    Cell Significance Index: 0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0106
    Cell Significance Index: 1.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0079
    Cell Significance Index: 0.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0062
    Cell Significance Index: 2.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0022
    Cell Significance Index: 0.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0009
    Cell Significance Index: -0.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0020
    Cell Significance Index: -0.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0024
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0025
    Cell Significance Index: -1.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0025
    Cell Significance Index: -1.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0031
    Cell Significance Index: -1.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0032
    Cell Significance Index: -0.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0040
    Cell Significance Index: -0.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0044
    Cell Significance Index: -0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0045
    Cell Significance Index: -2.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0048
    Cell Significance Index: -1.7200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0052
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0061
    Cell Significance Index: -0.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0071
    Cell Significance Index: -0.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0071
    Cell Significance Index: -0.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0081
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0097
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0097
    Cell Significance Index: -1.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0108
    Cell Significance Index: -1.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0110
    Cell Significance Index: -0.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0112
    Cell Significance Index: -1.4500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0112
    Cell Significance Index: -0.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0119
    Cell Significance Index: -0.5600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0139
    Cell Significance Index: -0.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0152
    Cell Significance Index: -1.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0153
    Cell Significance Index: -1.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0167
    Cell Significance Index: -1.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0200
    Cell Significance Index: -2.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0220
    Cell Significance Index: -1.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0221
    Cell Significance Index: -1.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0239
    Cell Significance Index: -1.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0244
    Cell Significance Index: -0.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0252
    Cell Significance Index: -0.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0261
    Cell Significance Index: -0.7000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0270
    Cell Significance Index: -0.2600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0271
    Cell Significance Index: -0.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0271
    Cell Significance Index: -0.3100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0273
    Cell Significance Index: -0.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0280
    Cell Significance Index: -2.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0306
    Cell Significance Index: -1.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0317
    Cell Significance Index: -2.1300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0325
    Cell Significance Index: -0.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0343
    Cell Significance Index: -0.6700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0347
    Cell Significance Index: -0.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0363
    Cell Significance Index: -1.8900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0373
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0381
    Cell Significance Index: -0.4800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0383
    Cell Significance Index: -0.4200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0395
    Cell Significance Index: -0.4100
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0402
    Cell Significance Index: -0.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0406
    Cell Significance Index: -2.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0422
    Cell Significance Index: -2.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0428
    Cell Significance Index: -1.5000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0449
    Cell Significance Index: -0.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** The OXT gene is highly expressed in enterocytes of the colon, early T lineage precursors, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and other cell types involved in neuroendocrine signaling. 2. **Protein Structure:** The OXT gene encodes for a preproprotein that consists of the oxytocin peptide and the neurophysin I protein. The oxytocin peptide is a 9-amino acid hormone that plays a key role in social behavior, reproduction, and lactation, while the neurophysin I protein is a carrier protein that facilitates the transport of oxytocin across cell membranes. 3. **Regulation:** The OXT gene is regulated by various transcription factors, including those involved in the hypothalamic-pituitary-adrenal axis and the hypothalamic-pituitary-ovarian axis. **Pathways and Functions:** 1. **Neurohypophyseal Hormone Activity:** Oxytocin, produced from the OXT gene, plays a crucial role in the regulation of neurohypophyseal hormone activity, including the release of vasopressin and oxytocin from the hypothalamus. 2. **G Protein-Coupled Receptor Signaling:** Oxytocin binds to G protein-coupled receptors (GPCRs) on various cell types, triggering signaling cascades that regulate thermogenesis, social behavior, and other physiological processes. 3. **Thermogenesis:** Oxytocin has been shown to stimulate cold-induced thermogenesis, a process by which the body generates heat in response to cold exposure. 4. **Neuroprotection:** Oxytocin has neuroprotective effects, including the promotion of neuronal survival and the regulation of neuronal excitability. **Clinical Significance:** 1. **Thermogenic Disorders:** Abnormalities in OXT gene expression have been implicated in thermogenic disorders, such as obesity and metabolic syndrome. 2. **Neurological Disorders:** Alterations in oxytocin signaling have been linked to various neurological disorders, including autism, schizophrenia, and Alzheimer's disease. 3. **Reproductive Disorders:** Oxytocin plays a critical role in reproductive processes, including lactation and parturition. Abnormalities in OXT gene expression may contribute to reproductive disorders, such as infertility and miscarriage. 4. **Psychiatric Disorders:** Oxytocin has been shown to have anxiolytic and antidepressant effects, suggesting its potential role in the treatment of psychiatric disorders, such as anxiety and depression. In conclusion, the oxytocin/neurophysin I prepropeptide (OXT) gene is a critical component of neuroendocrine signaling and thermogenesis. Its dysregulation has been implicated in various physiological and pathological processes, highlighting the need for further research into the molecular mechanisms underlying OXT gene function and its clinical significance.

Genular Protein ID: 2510214409

Symbol: NEU1_HUMAN

Name: Oxytocin-neurophysin 1

UniProtKB Accession Codes:

P01178 Q3MIG0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 EMDB 2 Ensembl 1 ExpressionAtlas 1 GO 49 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 3768139

Title: The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation.

PubMed ID: 3768139

DOI: 10.1515/bchm3.1986.367.2.695

PubMed ID: 2991279

Title: The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.

PubMed ID: 2991279

DOI: 10.1016/s0021-9258(17)39236-0

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2249637

Title: Expression of the oxytocin and vasopressin genes in human and baboon gonadal tissues.

PubMed ID: 2249637

DOI: 10.1210/endo-127-6-2990

PubMed ID: 4065330

Title: Expression of the vasopressin and oxytocin genes in human hypothalami.

PubMed ID: 4065330

DOI: 10.1016/0014-5793(85)80069-7

PubMed ID: 6574452

Title: Identification of human neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins.

PubMed ID: 6574452

DOI: 10.1073/pnas.80.10.2839

PubMed ID: 7262323

Title: A comparative study of mammalian neurophysin protein sequences.

PubMed ID: 7262323

DOI: 10.1016/0014-5793(81)80109-3

PubMed ID: 13591312

Title: On the nature of oxytocin and vasopressin from human pituitary.

PubMed ID: 13591312

DOI: 10.3181/00379727-98-24154

PubMed ID: 18174156

Title: Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides.

PubMed ID: 18174156

DOI: 10.1074/jbc.m706477200

Sequence Information:

  • Length: 125
  • Mass: 12722
  • Checksum: C65BB544731A0E7C
  • Sequence:
    • MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG RCFGPNICCA 
EELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAV LGLCCSPDGC HADPACDAEA 
TFSQR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.