Details for: P2RY11

Gene ID: 5032

Symbol: P2RY11

Ensembl ID: ENSG00000244165

Description: purinergic receptor P2Y11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.4682
    Cell Significance Index: -9.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.3198
    Cell Significance Index: -8.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.6483
    Cell Significance Index: -9.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4201
    Cell Significance Index: -9.5500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.9482
    Cell Significance Index: 2.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8901
    Cell Significance Index: 88.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7237
    Cell Significance Index: 20.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6213
    Cell Significance Index: 561.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4771
    Cell Significance Index: 77.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4481
    Cell Significance Index: 48.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3331
    Cell Significance Index: 15.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3255
    Cell Significance Index: 19.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2795
    Cell Significance Index: 80.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2790
    Cell Significance Index: 53.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2348
    Cell Significance Index: 47.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2166
    Cell Significance Index: 14.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1869
    Cell Significance Index: 4.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1836
    Cell Significance Index: 9.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1463
    Cell Significance Index: 3.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1282
    Cell Significance Index: 88.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1063
    Cell Significance Index: 2.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1041
    Cell Significance Index: 37.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0961
    Cell Significance Index: 1.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0824
    Cell Significance Index: 1.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0806
    Cell Significance Index: 9.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0654
    Cell Significance Index: 4.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0505
    Cell Significance Index: 27.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0347
    Cell Significance Index: 2.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0346
    Cell Significance Index: 15.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0320
    Cell Significance Index: 0.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0284
    Cell Significance Index: 5.1200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0161
    Cell Significance Index: 0.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0157
    Cell Significance Index: 3.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0111
    Cell Significance Index: 0.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0066
    Cell Significance Index: 0.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0008
    Cell Significance Index: -0.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0011
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0024
    Cell Significance Index: -0.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0066
    Cell Significance Index: -12.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0078
    Cell Significance Index: -11.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0088
    Cell Significance Index: -6.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0092
    Cell Significance Index: -12.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0113
    Cell Significance Index: -7.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0126
    Cell Significance Index: -0.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0130
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0163
    Cell Significance Index: -10.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0166
    Cell Significance Index: -9.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0189
    Cell Significance Index: -8.6000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0237
    Cell Significance Index: -0.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0247
    Cell Significance Index: -0.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0281
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0309
    Cell Significance Index: -5.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0310
    Cell Significance Index: -3.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0328
    Cell Significance Index: -4.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0330
    Cell Significance Index: -4.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0399
    Cell Significance Index: -5.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0440
    Cell Significance Index: -3.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0454
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0457
    Cell Significance Index: -5.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0466
    Cell Significance Index: -3.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0473
    Cell Significance Index: -2.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0496
    Cell Significance Index: -1.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0540
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0546
    Cell Significance Index: -11.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0572
    Cell Significance Index: -4.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0677
    Cell Significance Index: -1.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0708
    Cell Significance Index: -2.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0787
    Cell Significance Index: -2.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0860
    Cell Significance Index: -6.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0893
    Cell Significance Index: -9.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1014
    Cell Significance Index: -8.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1058
    Cell Significance Index: -2.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1094
    Cell Significance Index: -6.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1141
    Cell Significance Index: -3.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1168
    Cell Significance Index: -6.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1367
    Cell Significance Index: -3.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1548
    Cell Significance Index: -7.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1822
    Cell Significance Index: -7.4600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1823
    Cell Significance Index: -2.4600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1830
    Cell Significance Index: -2.6000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2068
    Cell Significance Index: -1.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2101
    Cell Significance Index: -6.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2104
    Cell Significance Index: -7.3100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2169
    Cell Significance Index: -5.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2324
    Cell Significance Index: -8.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2326
    Cell Significance Index: -5.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2352
    Cell Significance Index: -5.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2451
    Cell Significance Index: -7.2200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2453
    Cell Significance Index: -5.1200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2508
    Cell Significance Index: -3.4800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2573
    Cell Significance Index: -2.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2574
    Cell Significance Index: -9.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2608
    Cell Significance Index: -8.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2667
    Cell Significance Index: -8.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2672
    Cell Significance Index: -5.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2742
    Cell Significance Index: -7.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The P2RY11 gene encodes a purinergic receptor that is specifically activated by extracellular ATP. This receptor belongs to the class A/1 (rhodopsin-like receptors) family and is characterized by its high affinity for ATP. P2Y11 is widely expressed in various cell types, including intraepithelial lymphocytes, GABAergic interneurons, and epithelial cells of the small intestine. The receptor's expression is also observed in human tissues, including the cerebral cortex, forebrain radial glial cells, and intestinal crypt stem cells. **Pathways and Functions:** P2Y11 signaling involves the activation of adenylate cyclase activity, leading to the production of cAMP, a secondary messenger molecule. This cascade of events triggers various cellular responses, including calcium-mediated signaling, which regulates cellular processes such as proliferation, differentiation, and survival. P2Y11 is also implicated in the regulation of immune responses, particularly in the context of inflammation and tissue repair. The receptor's signaling pathways intersect with other G protein-coupled receptors, including those involved in neuronal signaling and neurotransmitter release. **Clinical Significance:** The P2RY11 gene has been implicated in various immunological disorders, including autoimmune diseases and inflammatory conditions. For instance, P2Y11 has been shown to play a role in the regulation of immune cell function, including the activation and proliferation of T cells. In the context of inflammatory diseases, P2Y11 has been implicated in the regulation of inflammatory responses, particularly in the context of tissue damage and repair. Furthermore, P2Y11 has been identified as a potential therapeutic target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. **Signaling by P2Y11:** The signaling by P2Y11 involves the activation of G proteins, which in turn regulate various downstream signaling pathways. The receptor's activation leads to the activation of adenylate cyclase, resulting in the production of cAMP. This secondary messenger molecule regulates various cellular processes, including calcium-mediated signaling, which triggers the activation of transcription factors and the regulation of gene expression. P2Y11 also intersects with other G protein-coupled receptors, including those involved in neuronal signaling and neurotransmitter release. **Conclusion:** In conclusion, the P2RY11 gene plays a crucial role in various cellular processes, including immune responses, neuronal signaling, and tissue homeostasis. Its signaling pathways involve the activation of adenylate cyclase activity, leading to the production of cAMP, a secondary messenger molecule that regulates various cellular responses. The clinical significance of P2Y11 has been implicated in various immunological disorders, including autoimmune diseases and inflammatory conditions. Further research is needed to fully elucidate the role of P2RY11 in human health and disease. **Future Directions:** Future studies should focus on the elucidation of P2Y11's signaling pathways and the regulation of its expression in different cell types. The development of specific P2Y11 agonists and antagonists may provide new therapeutic opportunities for the treatment of immunological disorders. Additionally, the study of P2Y11's role in tissue homeostasis and the regulation of immune responses may provide insights into the development of novel immunotherapeutic strategies.

Genular Protein ID: 3261044797

Symbol: P2Y11_HUMAN

Name: P2Y purinoceptor 11

UniProtKB Accession Codes:

Q96G91 B2R8X9 O43190 Q9BYU4 Q9H170

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 8 Ensembl 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11278528

Title: Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes.

PubMed ID: 11278528

DOI: 10.1074/jbc.m009609200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9405388

Title: Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase.

PubMed ID: 9405388

DOI: 10.1074/jbc.272.51.31969

Sequence Information:

  • Length: 374
  • Mass: 40345
  • Checksum: C02DF9B3B381D25E
  • Sequence:
    • MAANVSGAKS CPANFLAAAD DKLSGFQGDF LWPILVVEFL VAVASNGLAL YRFSIRKQRP 
WHPAVVFSVQ LAVSDLLCAL TLPPLAAYLY PPKHWRYGEA ACRLERFLFT CNLLGSVIFI 
TCISLNRYLG IVHPFFARSH LRPKHAWAVS AAGWVLAALL AMPTLSFSHL KRPQQGAGNC 
SVARPEACIK CLGTADHGLA AYRAYSLVLA GLGCGLPLLL TLAAYGALGR AVLRSPGMTV 
AEKLRVAALV ASGVALYASS YVPYHIMRVL NVDARRRWST RCPSFADIAQ ATAALELGPY 
VGYQVMRGLM PLAFCVHPLL YMAAVPSLGC CCRHCPGYRD SWNPEDAKST GQALPLNATA 
APKPSEPQSR ELSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.