Details for: P4HB
Gene ID: 5034
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: P4HB
Ensembl ID: ENSG00000185624
Description: prolyl 4-hydroxylase subunit beta
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 95.24rCSI 74.92%PRS 5.41
-
CSI 89.75rCSI 74.4%PRS 4.27
-
CSI 86.42rCSI 74.83%PRS 5.05
-
CSI 83.66rCSI 74.26%PRS 4.55
-
CSI 79.93rCSI 83.54%PRS 4.83
-
CSI 79.75rCSI 98.66%PRS 3.98
-
CSI 76.51rCSI 81.3%PRS 8.13
-
CSI 76.06rCSI 53.11%PRS 4.79
-
CSI 75.19rCSI 99.94%PRS 4.96
-
CSI 73.9rCSI 59.75%PRS 4.46
-
CSI 69.27rCSI 66.79%PRS 2.4
-
CSI 66.47rCSI 69.63%PRS 4.24
-
CSI 66.05rCSI 62.41%PRS 4.74
-
CSI 64.23rCSI 74.49%PRS 6.82
-
CSI 58.78rCSI 90.83%PRS 4.26
-
CSI 58.21rCSI 68.36%PRS 5.51
-
CSI 58.06rCSI 83.68%PRS 7.37
-
CSI 57.55rCSI 48.24%PRS 5.46
-
CSI 56.7rCSI 46.07%PRS 4.8
-
CSI 56.34rCSI 82.43%PRS 4.8
-
CSI 50.55rCSI 81.51%PRS 7.39
-
CSI 50.27rCSI 48.39%PRS 4.7
-
CSI 49.64rCSI 72.79%PRS 5.97
-
CSI 48.94rCSI 70.58%PRS 6.32
-
CSI 48.29rCSI 37.43%PRS 4.32
-
CSI 47.97rCSI 43.32%PRS 4
-
CSI 45.13rCSI 66.62%PRS 7.19
-
CSI 44.35rCSI 56.88%PRS 5.25
-
CSI 44.15rCSI 40.54%PRS 5.19
-
CSI 43.11rCSI 58.91%PRS 5.02
-
CSI 43.09rCSI 56.47%PRS 24.46
-
CSI 43.05rCSI 53.55%PRS 4.85
-
CSI 42.71rCSI 28.39%PRS 5.42
-
CSI 41.93rCSI 41.24%PRS 4.97
-
CSI 41.67rCSI 59.73%PRS 6.35
-
CSI 38.9rCSI 56.97%PRS 5.39
-
CSI 37.54rCSI 39.32%PRS 4.86
-
CSI 37.37rCSI 57.16%PRS 7.44
-
CSI 37.09rCSI 78.95%PRS 7.38
-
CSI 36.47rCSI 45.76%PRS 5.77
-
CSI 35.93rCSI 55.21%PRS 6.56
-
CSI 35.4rCSI 54.9%PRS 7.27
-
CSI 35.38rCSI 56.2%PRS 5.92
-
CSI 35.08rCSI 32.65%PRS 4.56
-
CSI 35.06rCSI 62.75%PRS 4.38
-
CSI 34.76rCSI 35.59%PRS 8.62
-
CSI 34.73rCSI 83.35%PRS 8.65
-
CSI 34rCSI 29.31%PRS 7.54
-
CSI 33.93rCSI 79.63%PRS 7.92
-
CSI 33.71rCSI 57.75%PRS 6.08
-
CSI 32.45rCSI 77.14%PRS 6.92
-
CSI 31.73rCSI 61.71%PRS 4.64
-
CSI 31rCSI 67.68%PRS 9.32
-
CSI 28.56rCSI 26.35%PRS 4.59
-
CSI 28.46rCSI 63%PRS 4.26
-
CSI 28.29rCSI 61.97%PRS 6.3
-
CSI 27.51rCSI 79.24%PRS 9.28
-
CSI 27.2rCSI 76.21%PRS 7.15
-
CSI 25.62rCSI 69.08%PRS 5.93
-
CSI 25.17rCSI 35.92%PRS 5.17
-
CSI 25.05rCSI 44.67%PRS 7.88
-
CSI 23.94rCSI 43.49%PRS 6.96
-
CSI 23.38rCSI 25.06%PRS 4.19
-
CSI 23.19rCSI 43.79%PRS 5.66
-
CSI 22.92rCSI 36.2%PRS 4.55
-
CSI 20.98rCSI 21.74%PRS 5.33
-
CSI 20.95rCSI 83.73%PRS 10.12
-
CSI 20.34rCSI 58.89%PRS 5.15
-
CSI 20rCSI 27.34%PRS 5.15
-
CSI 19.34rCSI 19.59%PRS 29.56
-
CSI 19.05rCSI 16.73%PRS 5.09
-
CSI 18.85rCSI 45.03%PRS 7.34
-
CSI 18.81rCSI 22.58%PRS 4.54
-
CSI 18.37rCSI 14.52%PRS 3.14
-
CSI 18.34rCSI 64.34%PRS 8.27
-
CSI 17.92rCSI 21.47%PRS 7.9
-
CSI 17.7rCSI 22.53%PRS 5.3
-
CSI 16.97rCSI 40.27%PRS 6.12
-
CSI 16.9rCSI 11.39%PRS 5.52
-
CSI 16.83rCSI 41.66%PRS 4.2
-
CSI 16.4rCSI 80.84%PRS 6.16
-
CSI 16.05rCSI 69.35%PRS 8.86
-
CSI 15.92rCSI 22.05%PRS 6.54
-
CSI 15.31rCSI 38.88%PRS 4.65
-
CSI 15.19rCSI 18.49%PRS 5.75
-
CSI 15.05rCSI 18.92%PRS 6.99
-
CSI 14.93rCSI 53.01%PRS 7.49
-
CSI 14.38rCSI 10.65%PRS 4.27
-
CSI 13.94rCSI 52.23%PRS 3.95
-
CSI 13.92rCSI 18.61%PRS 4.97
-
CSI 13.9rCSI 55.34%PRS 8.13
-
CSI 13.83rCSI 13.8%PRS 3.87
-
CSI 13.61rCSI 9.56%PRS 13.61
-
CSI 12.89rCSI 68.77%PRS 14.43
-
CSI 12.83rCSI 14.06%PRS 5.27
-
CSI 12.5rCSI 13.04%PRS 4.64
-
CSI 12.46rCSI 54.72%PRS 8.89
-
CSI 12.46rCSI 32.37%PRS 14.1
-
CSI 12.29rCSI 18.78%PRS 5.69
-
CSI 12.25rCSI 18.71%PRS 4.53
-
CSI -16.4rCSI -52.4%PRS 3.4%
-
CSI -6.9rCSI -15.4%PRS 2.9%
-
CSI -6.6rCSI -7.8%PRS 8.0%
-
CSI -4.3rCSI -7.7%PRS 6.2%
-
CSI -4.1rCSI -10.3%PRS 15.2%
-
CSI -4.1rCSI -42.3%PRS 4.3%
-
CSI -3.1rCSI -13.7%PRS 4.6%
-
CSI -2.8rCSI -2.3%PRS 4.5%
-
CSI -2.3rCSI -4.1%PRS 6.0%
-
CSI -2.1rCSI -10.1%PRS 2.6%
-
CSI -1.8rCSI -11.4%PRS 3.8%
-
CSI -1.7rCSI -2.2%PRS 6.4%
-
CSI -1.5rCSI -2.7%PRS 13.7%
-
CSI -1.4rCSI -4.2%PRS 3.2%
-
CSI -1.2rCSI -0.9%PRS 6.8%
-
CSI -1.1rCSI -18.2%PRS 23.4%
-
CSI -0.7rCSI -3.8%PRS 3.0%
-
CSI -0.6rCSI -0.6%PRS 6.2%
-
CSI -0.4rCSI -1.7%PRS 2.9%
-
CSI -0.3rCSI -0.6%PRS 1.6%
-
CSI -0.3rCSI -1.5%PRS 25.3%
-
CSI 0.1rCSI 0.2%PRS 20.8%
-
CSI 0.1rCSI 0.3%PRS 2.5%
-
CSI 0.1rCSI 0.6%PRS 7.2%
-
CSI 0.1rCSI 0.3%PRS 4.6%
-
CSI 0.2rCSI 4.0%PRS 26.2%
-
CSI 0.2rCSI 0.6%PRS 2.9%
-
CSI 0.2rCSI 3.5%PRS 66.7%
-
CSI 0.3rCSI 0.6%PRS 10.1%
-
CSI 0.3rCSI 7.4%PRS 16.2%
-
CSI 0.4rCSI 0.6%PRS 3.5%
-
CSI 0.4rCSI 9.2%PRS 17.3%
-
CSI 0.4rCSI 2.0%PRS 6.0%
-
CSI 0.4rCSI 1.9%PRS 7.5%
-
CSI 0.4rCSI 1.2%PRS 8.9%
-
CSI 0.4rCSI 2.5%PRS 14.6%
-
CSI 0.5rCSI 0.4%PRS 7.2%
-
CSI 0.5rCSI 1.6%PRS 7.9%
-
CSI 0.5rCSI 1.1%PRS 5.9%
-
CSI 0.5rCSI 1.0%PRS 3.5%
-
CSI 0.5rCSI 1.3%PRS 2.7%
-
CSI 0.5rCSI 0.5%PRS 5.6%
-
CSI 0.5rCSI 1.6%PRS 7.7%
-
CSI 0.6rCSI 1.7%PRS 4.0%
-
CSI 0.6rCSI 5.4%PRS 31.3%
-
CSI 0.6rCSI 6.9%PRS 30.9%
-
CSI 0.7rCSI 1.7%PRS 3.6%
-
CSI 0.7rCSI 1.8%PRS 5.2%
-
CSI 0.7rCSI 3.9%PRS 10.9%
-
CSI 0.7rCSI 11.0%PRS 13.2%
-
CSI 0.8rCSI 1.3%PRS 3.1%
-
CSI 0.8rCSI 1.1%PRS 5.0%
-
CSI 0.8rCSI 1.9%PRS 4.1%
-
CSI 0.8rCSI 1.2%PRS 4.4%
-
CSI 0.8rCSI 2.7%PRS 5.4%
-
CSI 0.9rCSI 2.4%PRS 6.6%
-
CSI 0.9rCSI 2.8%PRS 7.1%
-
CSI 0.9rCSI 2.5%PRS 7.6%
-
CSI 0.9rCSI 2.8%PRS 12.4%
-
CSI 1.0rCSI 1.6%PRS 3.5%
-
CSI 1.0rCSI 2.4%PRS 11.1%
-
CSI 1.0rCSI 2.2%PRS 3.3%
-
CSI 1.1rCSI 1.7%PRS 5.0%
-
CSI 1.1rCSI 1.6%PRS 3.8%
-
CSI 1.1rCSI 1.4%PRS 2.9%
-
CSI 1.1rCSI 11.4%PRS 40.8%
-
CSI 1.2rCSI 1.4%PRS 7.3%
-
CSI 1.2rCSI 4.6%PRS 7.6%
-
CSI 1.2rCSI 4.6%PRS 9.9%
-
CSI 1.3rCSI 10.0%PRS 20.8%
-
CSI 1.3rCSI 1.8%PRS 6.8%
-
CSI 1.4rCSI 5.8%PRS 13.5%
-
CSI 1.4rCSI 1.7%PRS 2.7%
-
CSI 1.4rCSI 2.3%PRS 11.7%
-
CSI 1.5rCSI 2.9%PRS 3.4%
-
CSI 1.5rCSI 24.3%PRS 30.2%
-
CSI 1.6rCSI 1.5%PRS 9.9%
-
CSI 1.7rCSI 3.0%PRS 2.7%
-
CSI 1.7rCSI 2.6%PRS 4.3%
-
CSI 1.8rCSI 2.2%PRS 2.5%
-
CSI 1.8rCSI 11.3%PRS 21.4%
-
CSI 1.9rCSI 7.6%PRS 7.5%
-
CSI 1.9rCSI 15.7%PRS 4.8%
-
CSI 2.0rCSI 3.6%PRS 4.5%
-
CSI 2.0rCSI 22.0%PRS 22.7%
-
CSI 2.0rCSI 11.4%PRS 17.1%
-
CSI 2.1rCSI 5.2%PRS 5.7%
-
CSI 2.1rCSI 3.3%PRS 15.0%
-
CSI 2.1rCSI 12.5%PRS 9.3%
-
CSI 2.1rCSI 49.0%PRS 33.6%
-
CSI 2.1rCSI 5.5%PRS 5.4%
-
CSI 2.1rCSI 9.9%PRS 12.7%
-
CSI 2.1rCSI 20.1%PRS 20.5%
-
CSI 2.1rCSI 2.9%PRS 8.7%
-
CSI 2.2rCSI 3.6%PRS 2.7%
-
CSI 2.2rCSI 12.4%PRS 7.1%
-
CSI 2.2rCSI 3.7%PRS 9.9%
-
CSI 2.2rCSI 17.1%PRS 25.8%
-
CSI 2.3rCSI 8.6%PRS 5.0%
-
CSI 2.3rCSI 24.9%PRS 8.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 961013342
Symbol: PDIA1_HUMAN
Name: Protein disulfide-isomerase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3034602
Title: Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene.
PubMed ID: 3034602
PubMed ID: 3611107
Title: The nucleotide sequence of a human cellular thyroid hormone binding protein present in endoplasmic reticulum.
PubMed ID: 3611107
PubMed ID: 2846539
Title: Characterization of the human gene for a polypeptide that acts both as the beta subunit of prolyl 4-hydroxylase and as protein disulfide isomerase.
PubMed ID: 2846539
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1597478
Title: Promoter of the gene for the multifunctional protein disulfide isomerase polypeptide. Functional significance of the six CCAAT boxes and other promoter elements.
PubMed ID: 1597478
PubMed ID: 9150948
Title: A two-dimensional gel database of human colon carcinoma proteins.
PubMed ID: 9150948
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 2079031
Title: Development of a database of amino acid sequences for human colon carcinoma proteins separated by two-dimensional polyacrylamide gel electrophoresis.
PubMed ID: 2079031
PubMed ID: 1286669
Title: Human liver protein map: a reference database established by microsequencing and gel comparison.
PubMed ID: 1286669
PubMed ID: 9399589
Title: Functions of characteristic Cys-Gly-His-Cys (CGHC) and Gln-Glu-Asp-Leu (QEDL) motifs of microsomal ER-60 protease.
PubMed ID: 9399589
PubMed ID: 3342239
Title: Characterization of a cDNA for human glutathione-insulin transhydrogenase (protein-disulfide isomerase/oxidoreductase).
PubMed ID: 3342239
PubMed ID: 1699755
Title: Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes.
PubMed ID: 1699755
PubMed ID: 7753822
Title: Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit.
PubMed ID: 7753822
PubMed ID: 10636893
Title: Protein-disulfide isomerase (PDI) in FRTL5 cells. pH-dependent thyroglobulin/PDI interactions determine a novel PDI function in the post-endoplasmic reticulum of thyrocytes.
PubMed ID: 10636893
PubMed ID: 11707400
Title: Manipulation of oxidative protein folding and PDI redox state in mammalian cells.
PubMed ID: 11707400
PubMed ID: 11181151
Title: The catalytic activity of protein disulfide isomerase is involved in human immunodeficiency virus envelope-mediated membrane fusion after CD4 cell binding.
PubMed ID: 11181151
DOI: 10.1086/318823
PubMed ID: 12485997
Title: Is protein disulfide isomerase a redox-dependent molecular chaperone?
PubMed ID: 12485997
DOI: 10.1093/emboj/cdf685
PubMed ID: 12095988
Title: Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death.
PubMed ID: 12095988
PubMed ID: 12218051
Title: Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry.
PubMed ID: 12218051
PubMed ID: 12218052
Title: Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusion.
PubMed ID: 12218052
PubMed ID: 12643545
Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
PubMed ID: 12643545
DOI: 10.1021/pr025562r
PubMed ID: 15158710
PubMed ID: 14592831
Title: Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry.
PubMed ID: 14592831
PubMed ID: 15644496
Title: Glycosaminoglycans and protein disulfide isomerase-mediated reduction of HIV Env.
PubMed ID: 15644496
PubMed ID: 16478722
Title: Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins.
PubMed ID: 16478722
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21670307
Title: Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry.
PubMed ID: 21670307
PubMed ID: 23475612
Title: Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia.
PubMed ID: 23475612
DOI: 10.1194/jlr.m031658
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
PubMed ID: 25683117
Title: Cole-Carpenter syndrome is caused by a heterozygous missense mutation in P4HB.
PubMed ID: 25683117
PubMed ID: 26224785
Title: A novel abetalipoproteinemia missense mutation highlights the importance of N-Terminal beta-barrel in microsomal triglyceride transfer protein function.
PubMed ID: 26224785
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 32149426
Title: Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.
PubMed ID: 32149426
PubMed ID: 8580850
Title: Nuclear magnetic resonance characterization of the N-terminal thioredoxin-like domain of protein disulfide isomerase.
PubMed ID: 8580850
PubMed ID: 8672469
Title: Structure determination of the N-terminal thioredoxin-like domain of protein disulfide isomerase using multidimensional heteronuclear 13C/15N NMR spectroscopy.
PubMed ID: 8672469
DOI: 10.1021/bi960335m
PubMed ID: 10383197
Title: The structure in solution of the B domain of protein disulfide isomerase.
PubMed ID: 10383197
Sequence Information:
- Length: 508
- Mass: 57116
- Checksum: 906CE6D9900B8FCE
- Sequence:
MLRRALLCLA VAALVRADAP EEEDHVLVLR KSNFAEALAA HKYLLVEFYA PWCGHCKALA PEYAKAAGKL KAEGSEIRLA KVDATEESDL AQQYGVRGYP TIKFFRNGDT ASPKEYTAGR EADDIVNWLK KRTGPAATTL PDGAAAESLV ESSEVAVIGF FKDVESDSAK QFLQAAEAID DIPFGITSNS DVFSKYQLDK DGVVLFKKFD EGRNNFEGEV TKENLLDFIK HNQLPLVIEF TEQTAPKIFG GEIKTHILLF LPKSVSDYDG KLSNFKTAAE SFKGKILFIF IDSDHTDNQR ILEFFGLKKE ECPAVRLITL EEEMTKYKPE SEELTAERIT EFCHRFLEGK IKPHLMSQEL PEDWDKQPVK VLVGKNFEDV AFDEKKNVFV EFYAPWCGHC KQLAPIWDKL GETYKDHENI VIAKMDSTAN EVEAVKVHSF PTLKFFPASA DRTVIDYNGE RTLDGFKKFL ESGGQDGAGD DDDLEDLEEA EEPDMEEDDD QKAVKDEL