P4HB | ENSG00000185624 | NCBI 5034

Details for: P4HB

Gene ID: 5034

Symbol: P4HB

Ensembl ID: ENSG00000185624

Description: prolyl 4-hydroxylase subunit beta

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Chylomicron assembly
(R-HSA-8963888)
Collagen biosynthesis and modifying enzymes
(R-HSA-1650814)
Collagen formation
(R-HSA-1474290)
Cytokine signaling in immune system
(R-HSA-1280215)
Detoxification of reactive oxygen species
(R-HSA-3299685)
Extracellular matrix organization
(R-HSA-1474244)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Immune system
(R-HSA-168256)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
Interleukin-23 signaling
(R-HSA-9020933)
Ldl remodeling
(R-HSA-8964041)
Metabolism of proteins
(R-HSA-392499)
Peptide hormone metabolism
(R-HSA-2980736)
Plasma lipoprotein assembly
(R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein remodeling
(R-HSA-8963899)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Transport of small molecules
(R-HSA-382551)
Vldl assembly
(R-HSA-8866423)
Actin binding
(GO:0003779)
Cellular response to hypoxia
(GO:0071456)
Cellular response to interleukin-7
(GO:0098761)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum-golgi intermediate compartment
(GO:0005793)
Endoplasmic reticulum chaperone complex
(GO:0034663)
Endoplasmic reticulum lumen
(GO:0005788)
Endoplasmic reticulum to golgi vesicle-mediated transport
(GO:0006888)
Enzyme binding
(GO:0019899)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Focal adhesion
(GO:0005925)
Insulin processing
(GO:0030070)
Integrin binding
(GO:0005178)
Interleukin-12-mediated signaling pathway
(GO:0035722)
Interleukin-23-mediated signaling pathway
(GO:0038155)
Lamellipodium
(GO:0030027)
Melanosome
(GO:0042470)
Peptidyl-proline hydroxylation to 4-hydroxy-l-proline
(GO:0018401)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Positive regulation of viral entry into host cell
(GO:0046598)
Procollagen-proline 4-dioxygenase activity
(GO:0004656)
Procollagen-proline 4-dioxygenase complex
(GO:0016222)
Protein-containing complex
(GO:0032991)
Protein-disulfide reductase activity
(GO:0015035)
Protein binding
(GO:0005515)
Protein disulfide isomerase activity
(GO:0003756)
Protein folding
(GO:0006457)
Protein folding in endoplasmic reticulum
(GO:0034975)
Protein heterodimerization activity
(GO:0046982)
Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
(GO:1902175)
Response to endoplasmic reticulum stress
(GO:0034976)
Rna binding
(GO:0003723)
Thiol oxidase activity
(GO:0016972)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 478.5103
Cell Significance Index: -74.4300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 311.0667
Cell Significance Index: -78.9000
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 236.9719
Cell Significance Index: -97.6200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 211.5901
Cell Significance Index: -85.9600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 204.6926
Cell Significance Index: -96.6400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 189.0023
Cell Significance Index: -97.2200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 144.7046
Cell Significance Index: -97.1000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 91.3021
Cell Significance Index: -87.1700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 71.0001
Cell Significance Index: -87.5400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 29.2065
Cell Significance Index: -78.2400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 24.5486
Cell Significance Index: -75.4000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 22.9647
Cell Significance Index: -90.6200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 14.2878
Cell Significance Index: -31.2700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 8.2010
Cell Significance Index: 382.3700
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 8.1604
Cell Significance Index: 170.1900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 6.8652
Cell Significance Index: 183.6400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 6.2392
Cell Significance Index: 1065.3800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 4.3384
Cell Significance Index: 90.8100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.6786
Cell Significance Index: 98.5700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.2700
Cell Significance Index: 153.6900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 3.1514
Cell Significance Index: 29.0200
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 3.0579
Cell Significance Index: 19.0000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 3.0341
Cell Significance Index: 2739.5300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.9013
Cell Significance Index: 77.4700
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.7595
Cell Significance Index: 1507.0200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.7557
Cell Significance Index: 378.4300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 2.5186
Cell Significance Index: 273.9500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.4976
Cell Significance Index: 495.6600
Cell Name: lactocyte (CL0002325)
Fold Change: 2.3846
Cell Significance Index: 308.0800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.2606
Cell Significance Index: 117.7500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.0556
Cell Significance Index: 153.2000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.9933
Cell Significance Index: 58.5400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.9063
Cell Significance Index: 54.9300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.7720
Cell Significance Index: 80.3200
Cell Name: epidermal cell (CL0000362)
Fold Change: 1.6234
Cell Significance Index: 3.6600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.4629
Cell Significance Index: 263.7100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.4466
Cell Significance Index: 639.5800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.3928
Cell Significance Index: 37.9100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.3195
Cell Significance Index: 93.3200
Cell Name: odontoblast (CL0000060)
Fold Change: 1.2871
Cell Significance Index: 165.0000
Cell Name: peg cell (CL4033014)
Fold Change: 1.2838
Cell Significance Index: 29.6600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2736
Cell Significance Index: 156.6000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.2033
Cell Significance Index: 18.0300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.0975
Cell Significance Index: 30.6700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0779
Cell Significance Index: 56.0000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8376
Cell Significance Index: 82.8600
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.7876
Cell Significance Index: 20.7100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7058
Cell Significance Index: 45.5300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.6707
Cell Significance Index: 8.5900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4945
Cell Significance Index: 94.1000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4843
Cell Significance Index: 97.1600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.4659
Cell Significance Index: 16.1900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.4533
Cell Significance Index: 343.0800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.4355
Cell Significance Index: 4.7400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.3972
Cell Significance Index: 11.3900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3801
Cell Significance Index: 44.8300
Cell Name: salivary gland glandular cell (CL1001596)
Fold Change: 0.3360
Cell Significance Index: 1.8700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3181
Cell Significance Index: 16.7000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2300
Cell Significance Index: 159.0700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2155
Cell Significance Index: 77.3000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1584
Cell Significance Index: 25.7600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1208
Cell Significance Index: 0.7300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1131
Cell Significance Index: 12.9100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0831
Cell Significance Index: 1.3900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.0595
Cell Significance Index: 1.1000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0194
Cell Significance Index: 0.2200
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0175
Cell Significance Index: 32.2900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0159
Cell Significance Index: 21.5700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0029
Cell Significance Index: 5.5400
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0092
Cell Significance Index: -0.1600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0146
Cell Significance Index: -22.4600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0275
Cell Significance Index: -20.1800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0280
Cell Significance Index: -2.8600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0296
Cell Significance Index: -21.9400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0840
Cell Significance Index: -52.4400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0872
Cell Significance Index: -55.3900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1162
Cell Significance Index: -65.5400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1278
Cell Significance Index: -58.0100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1348
Cell Significance Index: -4.7400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1856
Cell Significance Index: -39.0900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2075
Cell Significance Index: -4.4200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2819
Cell Significance Index: -81.1200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3608
Cell Significance Index: -41.3300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4176
Cell Significance Index: -10.4400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4446
Cell Significance Index: -14.2400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.5138
Cell Significance Index: -39.4300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.5155
Cell Significance Index: -74.9300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5395
Cell Significance Index: -62.8700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5966
Cell Significance Index: -15.2400
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.6619
Cell Significance Index: -9.7700
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.6875
Cell Significance Index: -7.1100
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.7962
Cell Significance Index: -4.9000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.8329
Cell Significance Index: -86.7200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.0230
Cell Significance Index: -57.4100
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.0418
Cell Significance Index: -10.7900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.0779
Cell Significance Index: -72.4800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1086
Cell Significance Index: -87.8000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.1354
Cell Significance Index: -69.7900
Cell Name: kidney cell (CL1000497)
Fold Change: -1.1560
Cell Significance Index: -9.2300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.1771
Cell Significance Index: -16.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** P4HB is a member of the PDIA family of proteins, which are known for their ability to facilitate disulfide bond formation and isomerization. P4HB is specifically involved in the prolyl 4-hydroxylase enzyme complex, which catalyzes the hydroxylation of proline residues in collagen. This process is essential for the formation of stable collagen triple helices. In addition to its role in collagen biosynthesis, P4HB has been shown to interact with a wide range of proteins, including integrins, cytokines, and growth factors, which highlights its involvement in various cellular processes. **Pathways and Functions:** P4HB is involved in several key cellular pathways, including: 1. **Collagen biosynthesis and modification**: P4HB plays a crucial role in the hydroxylation of proline residues in collagen, which is essential for the formation of stable collagen triple helices. 2. **Cell adhesion and migration**: P4HB has been shown to interact with integrins, which are key components of the cell adhesion machinery. This interaction is thought to regulate cell adhesion and migration. 3. **Immune responses**: P4HB has been implicated in the regulation of immune responses, including the activation of cytokines and the regulation of immune cell migration. 4. **Signaling by hedgehog and interleukins**: P4HB has been shown to interact with hedgehog and interleukin signaling pathways, which are involved in various cellular processes, including development and immune responses. 5. **Protein folding and quality control**: P4HB has been implicated in the regulation of protein folding and quality control, which is essential for maintaining protein homeostasis. **Clinical Significance:** Dysregulation of P4HB has been implicated in various diseases, including: 1. **Collagen-related disorders**: Mutations in the P4HB gene have been associated with collagen-related disorders, such as osteogenesis imperfecta and Ehlers-Danlos syndrome. 2. **Cancer**: P4HB has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer. This overexpression is thought to contribute to cancer progression and metastasis. 3. **Immune disorders**: P4HB has been implicated in the regulation of immune responses, and dysregulation of P4HB has been associated with various immune disorders, including rheumatoid arthritis and multiple sclerosis. 4. **Neurodegenerative disorders**: P4HB has been implicated in the regulation of protein folding and quality control, and dysregulation of P4HB has been associated with various neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, P4HB is a multifunctional protein that plays a crucial role in various cellular processes, including collagen biosynthesis, cell adhesion, and immune responses. Dysregulation of P4HB has been implicated in various diseases, highlighting the importance of this protein in maintaining cellular homeostasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein disulfide-isomerase

Genular Protein ID: 961013342

Symbol: PDIA1_HUMAN

Name: Protein disulfide-isomerase

UniProtKB Accession Codes:

P07237 B2RDQ2 P30037 P32079 Q15205 Q6LDE5

Database IDs:

Citations:

PubMed ID: 3034602

Title: Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene.

PubMed ID: 3034602

DOI: 10.1002/j.1460-2075.1987.tb04803.x

PubMed ID: 3611107

Title: The nucleotide sequence of a human cellular thyroid hormone binding protein present in endoplasmic reticulum.

PubMed ID: 3611107

DOI: 10.1016/s0021-9258(18)60947-0

PubMed ID: 2846539

Title: Characterization of the human gene for a polypeptide that acts both as the beta subunit of prolyl 4-hydroxylase and as protein disulfide isomerase.

PubMed ID: 2846539

DOI: 10.1016/s0021-9258(18)37581-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1597478

Title: Promoter of the gene for the multifunctional protein disulfide isomerase polypeptide. Functional significance of the six CCAAT boxes and other promoter elements.

PubMed ID: 1597478

DOI: 10.1016/s0021-9258(19)49940-7

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 2079031

Title: Development of a database of amino acid sequences for human colon carcinoma proteins separated by two-dimensional polyacrylamide gel electrophoresis.

PubMed ID: 2079031

DOI: 10.1002/elps.1150111019

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 9399589

Title: Functions of characteristic Cys-Gly-His-Cys (CGHC) and Gln-Glu-Asp-Leu (QEDL) motifs of microsomal ER-60 protease.

PubMed ID: 9399589

DOI: 10.1093/oxfordjournals.jbchem.a021830

PubMed ID: 3342239

Title: Characterization of a cDNA for human glutathione-insulin transhydrogenase (protein-disulfide isomerase/oxidoreductase).

PubMed ID: 3342239

DOI: 10.1016/0167-4781(88)90080-2

PubMed ID: 1699755

Title: Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes.

PubMed ID: 1699755

DOI: 10.1002/elps.1150110703

PubMed ID: 7753822

Title: Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit.

PubMed ID: 7753822

DOI: 10.1073/pnas.92.10.4427

PubMed ID: 10636893

Title: Protein-disulfide isomerase (PDI) in FRTL5 cells. pH-dependent thyroglobulin/PDI interactions determine a novel PDI function in the post-endoplasmic reticulum of thyrocytes.

PubMed ID: 10636893

DOI: 10.1074/jbc.275.3.1920

PubMed ID: 11707400

Title: Manipulation of oxidative protein folding and PDI redox state in mammalian cells.

PubMed ID: 11707400

DOI: 10.1093/emboj/20.22.6288

PubMed ID: 11181151

Title: The catalytic activity of protein disulfide isomerase is involved in human immunodeficiency virus envelope-mediated membrane fusion after CD4 cell binding.

PubMed ID: 11181151

DOI: 10.1086/318823

PubMed ID: 12485997

Title: Is protein disulfide isomerase a redox-dependent molecular chaperone?

PubMed ID: 12485997

DOI: 10.1093/emboj/cdf685

PubMed ID: 12095988

Title: Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death.

PubMed ID: 12095988

DOI: 10.1074/jbc.m203412200

PubMed ID: 12218051

Title: Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry.

PubMed ID: 12218051

DOI: 10.1074/jbc.m204547200

PubMed ID: 12218052

Title: Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusion.

PubMed ID: 12218052

DOI: 10.1074/jbc.m205467200

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 15158710

Title: Protein disulfide isomerase.

PubMed ID: 15158710

DOI: 10.1016/j.bbapap.2004.02.017

PubMed ID: 14592831

Title: Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry.

PubMed ID: 14592831

DOI: 10.1182/blood-2003-05-1390

PubMed ID: 15644496

Title: Glycosaminoglycans and protein disulfide isomerase-mediated reduction of HIV Env.

PubMed ID: 15644496

DOI: 10.1124/mol.104.008276

PubMed ID: 16478722

Title: Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins.

PubMed ID: 16478722

DOI: 10.1074/jbc.m512823200

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21670307

Title: Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry.

PubMed ID: 21670307

DOI: 10.1073/pnas.1017954108

PubMed ID: 23475612

Title: Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia.

PubMed ID: 23475612

DOI: 10.1194/jlr.m031658

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25683117

Title: Cole-Carpenter syndrome is caused by a heterozygous missense mutation in P4HB.

PubMed ID: 25683117

DOI: 10.1016/j.ajhg.2014.12.027

PubMed ID: 26224785

Title: A novel abetalipoproteinemia missense mutation highlights the importance of N-Terminal beta-barrel in microsomal triglyceride transfer protein function.

PubMed ID: 26224785

DOI: 10.1161/circgenetics.115.001106

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32149426

Title: Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.

PubMed ID: 32149426

DOI: 10.15252/embj.2019103841

PubMed ID: 8580850

Title: Nuclear magnetic resonance characterization of the N-terminal thioredoxin-like domain of protein disulfide isomerase.

PubMed ID: 8580850

DOI: 10.1002/pro.5560041216

PubMed ID: 8672469

Title: Structure determination of the N-terminal thioredoxin-like domain of protein disulfide isomerase using multidimensional heteronuclear 13C/15N NMR spectroscopy.

PubMed ID: 8672469

DOI: 10.1021/bi960335m

PubMed ID: 10383197

Title: The structure in solution of the B domain of protein disulfide isomerase.

PubMed ID: 10383197

DOI: 10.1023/a:1008341820489

Sequence Information:

Length: 508
Mass: 57116
Checksum: 906CE6D9900B8FCE
Sequence:

MLRRALLCLA VAALVRADAP EEEDHVLVLR KSNFAEALAA HKYLLVEFYA PWCGHCKALA 
PEYAKAAGKL KAEGSEIRLA KVDATEESDL AQQYGVRGYP TIKFFRNGDT ASPKEYTAGR 
EADDIVNWLK KRTGPAATTL PDGAAAESLV ESSEVAVIGF FKDVESDSAK QFLQAAEAID 
DIPFGITSNS DVFSKYQLDK DGVVLFKKFD EGRNNFEGEV TKENLLDFIK HNQLPLVIEF 
TEQTAPKIFG GEIKTHILLF LPKSVSDYDG KLSNFKTAAE SFKGKILFIF IDSDHTDNQR 
ILEFFGLKKE ECPAVRLITL EEEMTKYKPE SEELTAERIT EFCHRFLEGK IKPHLMSQEL 
PEDWDKQPVK VLVGKNFEDV AFDEKKNVFV EFYAPWCGHC KQLAPIWDKL GETYKDHENI 
VIAKMDSTAN EVEAVKVHSF PTLKFFPASA DRTVIDYNGE RTLDGFKKFL ESGGQDGAGD 
DDDLEDLEEA EEPDMEEDDD QKAVKDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: P4HB

Associated with

Cells (max top 100)

Other Information

Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene. PubMed ID: 3034602

The nucleotide sequence of a human cellular thyroid hormone binding protein present in endoplasmic reticulum. PubMed ID: 3611107

Characterization of the human gene for a polypeptide that acts both as the beta subunit of prolyl 4-hydroxylase and as protein disulfide isomerase. PubMed ID: 2846539

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Promoter of the gene for the multifunctional protein disulfide isomerase polypeptide. Functional significance of the six CCAAT boxes and other promoter elements. PubMed ID: 1597478

A two-dimensional gel database of human colon carcinoma proteins. PubMed ID: 9150948

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Development of a database of amino acid sequences for human colon carcinoma proteins separated by two-dimensional polyacrylamide gel electrophoresis. PubMed ID: 2079031

Human liver protein map: a reference database established by microsequencing and gel comparison. PubMed ID: 1286669

Functions of characteristic Cys-Gly-His-Cys (CGHC) and Gln-Glu-Asp-Leu (QEDL) motifs of microsomal ER-60 protease. PubMed ID: 9399589

Characterization of a cDNA for human glutathione-insulin transhydrogenase (protein-disulfide isomerase/oxidoreductase). PubMed ID: 3342239

Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes. PubMed ID: 1699755

Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit. PubMed ID: 7753822

Protein-disulfide isomerase (PDI) in FRTL5 cells. pH-dependent thyroglobulin/PDI interactions determine a novel PDI function in the post-endoplasmic reticulum of thyrocytes. PubMed ID: 10636893

Manipulation of oxidative protein folding and PDI redox state in mammalian cells. PubMed ID: 11707400

The catalytic activity of protein disulfide isomerase is involved in human immunodeficiency virus envelope-mediated membrane fusion after CD4 cell binding. PubMed ID: 11181151

Is protein disulfide isomerase a redox-dependent molecular chaperone? PubMed ID: 12485997

Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death. PubMed ID: 12095988

Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry. PubMed ID: 12218051

Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusion. PubMed ID: 12218052

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. PubMed ID: 12643545

Protein disulfide isomerase. PubMed ID: 15158710

Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry. PubMed ID: 14592831

Glycosaminoglycans and protein disulfide isomerase-mediated reduction of HIV Env. PubMed ID: 15644496

Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins. PubMed ID: 16478722

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Initial characterization of the human central proteome. PubMed ID: 21269460

Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry. PubMed ID: 21670307

Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia. PubMed ID: 23475612

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

A single kinase generates the majority of the secreted phosphoproteome. PubMed ID: 26091039

Cole-Carpenter syndrome is caused by a heterozygous missense mutation in P4HB. PubMed ID: 25683117

A novel abetalipoproteinemia missense mutation highlights the importance of N-Terminal beta-barrel in microsomal triglyceride transfer protein function. PubMed ID: 26224785

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. PubMed ID: 32149426

Nuclear magnetic resonance characterization of the N-terminal thioredoxin-like domain of protein disulfide isomerase. PubMed ID: 8580850

Structure determination of the N-terminal thioredoxin-like domain of protein disulfide isomerase using multidimensional heteronuclear 13C/15N NMR spectroscopy. PubMed ID: 8672469

The structure in solution of the B domain of protein disulfide isomerase. PubMed ID: 10383197