Details for: IL21R

Gene ID: 50615

Symbol: IL21R

Ensembl ID: ENSG00000103522

Description: interleukin 21 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 24.7516
    Cell Significance Index: -3.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.3365
    Cell Significance Index: -3.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.9875
    Cell Significance Index: -4.8700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 10.1869
    Cell Significance Index: -5.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.1307
    Cell Significance Index: -3.8600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.3788
    Cell Significance Index: 5.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.6201
    Cell Significance Index: -4.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3433
    Cell Significance Index: -2.9400
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.3330
    Cell Significance Index: 4.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.2209
    Cell Significance Index: -3.7500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.9096
    Cell Significance Index: 9.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8015
    Cell Significance Index: 94.5200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.3631
    Cell Significance Index: 3.7700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.2854
    Cell Significance Index: 2.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2757
    Cell Significance Index: 7.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1594
    Cell Significance Index: 4.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1547
    Cell Significance Index: 22.4900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0743
    Cell Significance Index: 1.2800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.0742
    Cell Significance Index: 0.7900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0567
    Cell Significance Index: 1.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0505
    Cell Significance Index: 3.2600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0287
    Cell Significance Index: 0.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0274
    Cell Significance Index: 0.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0201
    Cell Significance Index: 4.0400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0165
    Cell Significance Index: 0.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0044
    Cell Significance Index: 1.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0033
    Cell Significance Index: 6.1300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0009
    Cell Significance Index: 1.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0014
    Cell Significance Index: -2.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0050
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0059
    Cell Significance Index: -3.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0064
    Cell Significance Index: -2.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0068
    Cell Significance Index: -1.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0069
    Cell Significance Index: -3.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0070
    Cell Significance Index: -1.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0071
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0138
    Cell Significance Index: -2.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0150
    Cell Significance Index: -2.7100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0168
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0189
    Cell Significance Index: -3.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0207
    Cell Significance Index: -2.6600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0264
    Cell Significance Index: -0.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0266
    Cell Significance Index: -3.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0303
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0313
    Cell Significance Index: -3.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0330
    Cell Significance Index: -3.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0346
    Cell Significance Index: -4.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0350
    Cell Significance Index: -3.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0351
    Cell Significance Index: -3.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0458
    Cell Significance Index: -3.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0469
    Cell Significance Index: -3.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0524
    Cell Significance Index: -0.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0535
    Cell Significance Index: -2.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0539
    Cell Significance Index: -2.5400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0548
    Cell Significance Index: -0.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0555
    Cell Significance Index: -2.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0562
    Cell Significance Index: -0.5400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0581
    Cell Significance Index: -0.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0597
    Cell Significance Index: -4.4500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0613
    Cell Significance Index: -1.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0616
    Cell Significance Index: -3.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0628
    Cell Significance Index: -2.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0643
    Cell Significance Index: -3.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0681
    Cell Significance Index: -2.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0684
    Cell Significance Index: -3.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0718
    Cell Significance Index: -4.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0744
    Cell Significance Index: -3.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0750
    Cell Significance Index: -2.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0803
    Cell Significance Index: -2.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0805
    Cell Significance Index: -2.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0813
    Cell Significance Index: -3.7900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0838
    Cell Significance Index: -1.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0908
    Cell Significance Index: -4.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0909
    Cell Significance Index: -2.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0918
    Cell Significance Index: -2.4600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0931
    Cell Significance Index: -1.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0996
    Cell Significance Index: -2.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1068
    Cell Significance Index: -3.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1134
    Cell Significance Index: -3.9900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1168
    Cell Significance Index: -1.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1227
    Cell Significance Index: -3.0600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1229
    Cell Significance Index: -2.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1233
    Cell Significance Index: -3.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1236
    Cell Significance Index: -2.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1267
    Cell Significance Index: -2.6900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1279
    Cell Significance Index: -1.5100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1292
    Cell Significance Index: -1.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1314
    Cell Significance Index: -3.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1315
    Cell Significance Index: -3.5800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1382
    Cell Significance Index: -1.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1386
    Cell Significance Index: -3.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1450
    Cell Significance Index: -2.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1499
    Cell Significance Index: -2.7700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1523
    Cell Significance Index: -3.8100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1525
    Cell Significance Index: -2.3600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1527
    Cell Significance Index: -3.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The IL21R gene encodes a transmembrane receptor that consists of two extracellular immunoglobulin-like domains and a cytoplasmic tail. 2. **Expression:** IL21R is highly expressed in hematopoietic cells, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and peripheral blood mononuclear cells. 3. **Signal Transduction:** Upon binding to IL-21, the IL21R receptor triggers a signaling cascade that activates downstream pathways, including the JAK/STAT and PI3K/AKT signaling pathways. 4. **Function:** IL21R plays a critical role in the regulation of immune responses, including the activation and proliferation of lymphocytes, the production of cytokines, and the modulation of immune cell function. **Pathways and Functions:** 1. **Cytokine-mediated signaling pathway:** IL21R is involved in the signaling of IL-21, a cytokine that regulates immune responses, including the activation and proliferation of lymphocytes. 2. **Cytokine receptor activity:** IL21R is a transmembrane receptor that binds to IL-21, triggering a signaling cascade that activates downstream pathways. 3. **Immune system:** IL21R plays a critical role in the regulation of immune responses, including the activation and proliferation of lymphocytes, the production of cytokines, and the modulation of immune cell function. 4. **Natural killer cell activation:** IL21R is expressed on natural killer cells, and its signaling pathway is involved in the activation of these cells. 5. **T cell activation:** IL21R is also expressed on T cells, and its signaling pathway is involved in the activation and proliferation of these cells. **Clinical Significance:** Dysregulation of the IL21R gene has been implicated in several autoimmune and inflammatory diseases, including: 1. **Rheumatoid arthritis:** IL21R has been shown to contribute to the pathogenesis of rheumatoid arthritis, a chronic autoimmune disease characterized by inflammation and joint damage. 2. **Multiple sclerosis:** IL21R has been implicated in the pathogenesis of multiple sclerosis, a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system. 3. **Type 1 diabetes:** IL21R has been shown to contribute to the pathogenesis of type 1 diabetes, an autoimmune disease characterized by the destruction of pancreatic beta cells. 4. **Cancer:** IL21R has been implicated in the pathogenesis of certain cancers, including multiple myeloma and lymphoma. In conclusion, the IL21R gene plays a critical role in the regulation of immune responses, and its dysregulation has been implicated in several autoimmune and inflammatory diseases. Further research is needed to fully understand the mechanisms by which IL21R contributes to disease pathogenesis and to develop effective therapeutic strategies.

Genular Protein ID: 3252945127

Symbol: IL21R_HUMAN

Name: Interleukin-21 receptor

UniProtKB Accession Codes:

Q9HBE5 A8K9E8 D3DWF7 Q96HZ1 Q9HB91

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 Ensembl 3 EvolutionaryTrace 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11081504

Title: Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.

PubMed ID: 11081504

DOI: 10.1038/35040504

PubMed ID: 11016959

Title: Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain.

PubMed ID: 11016959

DOI: 10.1073/pnas.200360997

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11821949

Title: The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma.

PubMed ID: 11821949

DOI: 10.1038/sj.onc.1205099

PubMed ID: 22235133

Title: Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R.

PubMed ID: 22235133

DOI: 10.1074/jbc.m111.311084

PubMed ID: 23440042

Title: Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome.

PubMed ID: 23440042

DOI: 10.1084/jem.20111229

Sequence Information:

  • Length: 538
  • Mass: 59130
  • Checksum: 414079CCB974850A
  • Sequence:
    • MPRGWAAPLL LLLLQGGWGC PDLVCYTDYL QTVICILEMW NLHPSTLTLT WQDQYEELKD 
EATSCSLHRS AHNATHATYT CHMDVFHFMA DDIFSVNITD QSGNYSQECG SFLLAESIKP 
APPFNVTVTF SGQYNISWRS DYEDPAFYML KGKLQYELQY RNRGDPWAVS PRRKLISVDS 
RSVSLLPLEF RKDSSYELQV RAGPMPGSSY QGTWSEWSDP VIFQTQSEEL KEGWNPHLLL 
LLLLVIVFIP AFWSLKTHPL WRLWKKIWAV PSPERFFMPL YKGCSGDFKK WVGAPFTGSS 
LELGPWSPEV PSTLEVYSCH PPRSPAKRLQ LTELQEPAEL VESDGVPKPS FWPTAQNSGG 
SAYSEERDRP YGLVSIDTVT VLDAEGPCTW PCSCEDDGYP ALDLDAGLEP SPGLEDPLLD 
AGTTVLSCGC VSAGSPGLGG PLGSLLDRLK PPLADGEDWA GGLPWGGRSP GGVSESEAGS 
PLAGLDMDTF DSGFVGSDCS SPVECDFTSP GDEGPPRSYL RQWVVIPPPL SSPGPQAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.