Details for: ZFTRAF1

Gene ID: 50626

Symbol: ZFTRAF1

Ensembl ID: ENSG00000187954

Description: zinc finger TRAF-type containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 210.4211
    Cell Significance Index: -32.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.1186
    Cell Significance Index: -29.9600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 75.2037
    Cell Significance Index: -30.9800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.1064
    Cell Significance Index: -29.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 72.5447
    Cell Significance Index: -34.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 64.5236
    Cell Significance Index: -33.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.2126
    Cell Significance Index: -29.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.0789
    Cell Significance Index: -34.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.4433
    Cell Significance Index: -30.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9241
    Cell Significance Index: -35.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7623
    Cell Significance Index: -20.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3922
    Cell Significance Index: -13.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7308
    Cell Significance Index: 89.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6136
    Cell Significance Index: 96.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5393
    Cell Significance Index: 71.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2651
    Cell Significance Index: 34.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2402
    Cell Significance Index: 158.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1864
    Cell Significance Index: 213.8700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0726
    Cell Significance Index: 9.0100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.0468
    Cell Significance Index: 2.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0195
    Cell Significance Index: 204.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9857
    Cell Significance Index: 135.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9431
    Cell Significance Index: 8.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9100
    Cell Significance Index: 111.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8985
    Cell Significance Index: 25.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8278
    Cell Significance Index: 53.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7685
    Cell Significance Index: 419.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7629
    Cell Significance Index: 34.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6715
    Cell Significance Index: 35.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6515
    Cell Significance Index: 46.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6203
    Cell Significance Index: 14.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6097
    Cell Significance Index: 42.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6042
    Cell Significance Index: 13.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5226
    Cell Significance Index: 32.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5067
    Cell Significance Index: 224.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4723
    Cell Significance Index: 169.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4548
    Cell Significance Index: 13.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3824
    Cell Significance Index: 72.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3602
    Cell Significance Index: 16.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3441
    Cell Significance Index: 68.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2940
    Cell Significance Index: 3.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2918
    Cell Significance Index: 22.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2806
    Cell Significance Index: 253.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2645
    Cell Significance Index: 19.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2428
    Cell Significance Index: 31.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2383
    Cell Significance Index: 3.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1163
    Cell Significance Index: 4.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1042
    Cell Significance Index: 1.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0914
    Cell Significance Index: 15.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0884
    Cell Significance Index: 1.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0816
    Cell Significance Index: 51.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0797
    Cell Significance Index: 55.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0751
    Cell Significance Index: 141.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0612
    Cell Significance Index: 0.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0521
    Cell Significance Index: 1.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0316
    Cell Significance Index: 1.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0269
    Cell Significance Index: 19.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0248
    Cell Significance Index: 2.4500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0192
    Cell Significance Index: 0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0035
    Cell Significance Index: 5.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0060
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0074
    Cell Significance Index: -5.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0104
    Cell Significance Index: -0.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0187
    Cell Significance Index: -25.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0266
    Cell Significance Index: -1.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0316
    Cell Significance Index: -14.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0345
    Cell Significance Index: -3.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0422
    Cell Significance Index: -31.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0576
    Cell Significance Index: -32.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0644
    Cell Significance Index: -40.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0695
    Cell Significance Index: -7.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0877
    Cell Significance Index: -10.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0939
    Cell Significance Index: -15.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1048
    Cell Significance Index: -30.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1102
    Cell Significance Index: -5.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1126
    Cell Significance Index: -16.3700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1299
    Cell Significance Index: -1.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1473
    Cell Significance Index: -3.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1595
    Cell Significance Index: -5.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1845
    Cell Significance Index: -5.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1854
    Cell Significance Index: -4.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1862
    Cell Significance Index: -39.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1948
    Cell Significance Index: -10.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2249
    Cell Significance Index: -9.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2419
    Cell Significance Index: -6.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2441
    Cell Significance Index: -3.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2723
    Cell Significance Index: -4.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2741
    Cell Significance Index: -2.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2834
    Cell Significance Index: -10.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2923
    Cell Significance Index: -8.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2983
    Cell Significance Index: -31.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3148
    Cell Significance Index: -24.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3521
    Cell Significance Index: -14.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3660
    Cell Significance Index: -7.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4113
    Cell Significance Index: -11.0200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4816
    Cell Significance Index: -3.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4896
    Cell Significance Index: -30.0200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5449
    Cell Significance Index: -4.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ZFTRAF1 gene exhibits a distinct zinc finger TRAF-type motif, which is a characteristic feature of TRAF-domain containing proteins. These motifs are known to facilitate protein-protein interactions, thereby regulating signaling pathways. The expression of ZFTRAF1 is widespread, with significant expression observed in polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, embryonic stem cells, mucosal type mast cells, and peripheral blood mononuclear cells. This broad expression pattern suggests that ZFTRAF1 may play a multifaceted role in the regulation of various cellular processes. **Pathways and Functions:** The functional role of ZFTRAF1 remains poorly understood, but its expression in immune cells and stem cells suggests that it may be involved in the regulation of immune responses and cellular differentiation. The involvement of ZFTRAF1 in protein-protein interactions and signaling pathways, particularly those mediated by TRAF-domains, implies that it may regulate the activation of various signaling cascades, including those involved in inflammation and immune cell function. Furthermore, the expression of ZFTRAF1 in embryonic stem cells and hematopoietic cells suggests that it may play a role in the regulation of cellular differentiation and development. **Clinical Significance:** While the clinical significance of ZFTRAF1 remains unclear, its expression in immune cells and stem cells suggests that it may be involved in the regulation of immune responses and cellular differentiation. The identification of ZFTRAF1 as a potential regulator of immune responses may have significant implications for the treatment of immune-related disorders, such as autoimmune diseases and immunodeficiency syndromes. Additionally, the study of ZFTRAF1 may provide insights into the molecular mechanisms underlying cellular differentiation and development, with potential applications in regenerative medicine and tissue engineering. In conclusion, the ZFTRAF1 gene is a complex and multifaceted component of the human genome, with significant implications for our understanding of immune regulation and cellular differentiation. Further research is needed to fully elucidate the functional role of ZFTRAF1 and its clinical significance, but its unique expression pattern and involvement in protein-protein interactions suggest that it may be a key player in the regulation of immune responses and cellular development.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.