Details for: PNPLA8

Gene ID: 50640

Symbol: PNPLA8

Ensembl ID: ENSG00000135241

Description: patatin like phospholipase domain containing 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 318.4926
    Cell Significance Index: -49.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 210.0981
    Cell Significance Index: -53.2900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 134.6530
    Cell Significance Index: -55.4700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 120.2654
    Cell Significance Index: -56.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 114.3365
    Cell Significance Index: -46.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 103.6188
    Cell Significance Index: -53.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.3431
    Cell Significance Index: -47.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.3673
    Cell Significance Index: -53.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.4915
    Cell Significance Index: -52.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.2345
    Cell Significance Index: -56.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.2678
    Cell Significance Index: -37.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6494
    Cell Significance Index: -18.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.6687
    Cell Significance Index: 105.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2830
    Cell Significance Index: 60.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8812
    Cell Significance Index: 186.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7143
    Cell Significance Index: 278.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6183
    Cell Significance Index: 22.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4007
    Cell Significance Index: 72.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3185
    Cell Significance Index: 264.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2425
    Cell Significance Index: 33.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2158
    Cell Significance Index: 26.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9145
    Cell Significance Index: 99.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8762
    Cell Significance Index: 41.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8408
    Cell Significance Index: 24.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7483
    Cell Significance Index: 92.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7447
    Cell Significance Index: 57.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6896
    Cell Significance Index: 476.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6854
    Cell Significance Index: 94.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6456
    Cell Significance Index: 38.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5877
    Cell Significance Index: 210.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5683
    Cell Significance Index: 102.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5644
    Cell Significance Index: 249.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5605
    Cell Significance Index: 25.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5376
    Cell Significance Index: 69.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4924
    Cell Significance Index: 31.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4922
    Cell Significance Index: 25.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4565
    Cell Significance Index: 34.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4543
    Cell Significance Index: 32.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4283
    Cell Significance Index: 84.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4266
    Cell Significance Index: 54.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4013
    Cell Significance Index: 219.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2991
    Cell Significance Index: 8.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2812
    Cell Significance Index: 33.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2735
    Cell Significance Index: 14.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1949
    Cell Significance Index: 11.9800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1864
    Cell Significance Index: 3.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1115
    Cell Significance Index: 70.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0968
    Cell Significance Index: 5.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0517
    Cell Significance Index: 97.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0514
    Cell Significance Index: 8.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0447
    Cell Significance Index: 8.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0332
    Cell Significance Index: 51.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0176
    Cell Significance Index: 8.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0162
    Cell Significance Index: 11.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0076
    Cell Significance Index: 13.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0203
    Cell Significance Index: -12.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0311
    Cell Significance Index: -4.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0427
    Cell Significance Index: -2.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0507
    Cell Significance Index: -38.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0558
    Cell Significance Index: -3.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0611
    Cell Significance Index: -34.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0710
    Cell Significance Index: -3.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0774
    Cell Significance Index: -7.9100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1101
    Cell Significance Index: -2.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1104
    Cell Significance Index: -3.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1170
    Cell Significance Index: -5.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1277
    Cell Significance Index: -14.5800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1288
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1324
    Cell Significance Index: -27.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1559
    Cell Significance Index: -44.8500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1799
    Cell Significance Index: -4.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1984
    Cell Significance Index: -13.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2142
    Cell Significance Index: -8.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2411
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2471
    Cell Significance Index: -28.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2529
    Cell Significance Index: -6.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2707
    Cell Significance Index: -31.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2927
    Cell Significance Index: -8.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3785
    Cell Significance Index: -8.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3792
    Cell Significance Index: -7.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4750
    Cell Significance Index: -8.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4828
    Cell Significance Index: -50.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4965
    Cell Significance Index: -39.3300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.5806
    Cell Significance Index: -4.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5830
    Cell Significance Index: -6.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5963
    Cell Significance Index: -19.1000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.6396
    Cell Significance Index: -4.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6582
    Cell Significance Index: -11.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6606
    Cell Significance Index: -14.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6636
    Cell Significance Index: -17.4500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7167
    Cell Significance Index: -12.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7352
    Cell Significance Index: -20.9800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7500
    Cell Significance Index: -11.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7574
    Cell Significance Index: -26.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7828
    Cell Significance Index: -47.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8060
    Cell Significance Index: -19.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8263
    Cell Significance Index: -19.0900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8322
    Cell Significance Index: -6.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PNPLA8 is a member of the patatin-like phospholipase domain-containing (PNPLA) family, characterized by its unique phospholipase domain, which enables it to hydrolyze various lipid molecules, including phospholipids, triglycerides, and fatty acids. This enzyme activity is crucial for regulating lipid metabolism, particularly in the context of inflammation and immune responses. PNPLA8 has been shown to exhibit a wide range of substrate specificity, allowing it to participate in various cellular processes, including the degradation of phospholipids, the regulation of fatty acid metabolism, and the modulation of immune responses. **Pathways and Functions:** PNPLA8 plays a pivotal role in multiple cellular pathways, including: 1. **Acyl chain remodeling of phospholipids (PC) and phosphatidylethanolamine (PE):** PNPLA8 is involved in the hydrolysis of phospholipid molecules, leading to the generation of lysophospholipids, which are potent signaling molecules that regulate cellular responses. 2. **Arachidonate metabolic process:** PNPLA8 participates in the degradation of arachidonic acid, a polyunsaturated fatty acid that plays a crucial role in inflammation and immune responses. 3. **Lipid homeostasis:** PNPLA8 helps regulate lipid metabolism by modulating the activity of enzymes involved in fatty acid synthesis and degradation. 4. **Intracellular signal transduction:** PNPLA8 can interact with various signaling molecules, including phospholipids, fatty acids, and other lipids, to regulate cellular responses to oxidative stress and inflammation. 5. **Mitochondrial membrane:** PNPLA8 is localized to the mitochondrial membrane, where it regulates mitochondrial function and lipid metabolism. **Clinical Significance:** The dysregulation of PNPLA8 has been implicated in various diseases, including: 1. **Atherosclerosis:** Elevated PNPLA8 expression has been linked to the development of atherosclerosis, a condition characterized by the buildup of lipids in the arteries. 2. **Inflammatory disorders:** PNPLA8 has been shown to play a role in the regulation of immune responses, and its dysregulation has been implicated in various inflammatory disorders, including asthma, rheumatoid arthritis, and multiple sclerosis. 3. **Cancer:** PNPLA8 has been identified as a potential biomarker for cancer, with elevated expression levels observed in various types of cancer, including lung, breast, and colon cancer. 4. **Neurological disorders:** PNPLA8 has been implicated in the regulation of lipid metabolism in the brain, and its dysregulation has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, PNPLA8 is a multifunctional gene that plays a critical role in lipid metabolism, immune regulation, and cellular signaling. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying PNPLA8 function and its potential as a therapeutic target.

Genular Protein ID: 1289284640

Symbol: PLPL8_HUMAN

Name: PNPLA-gamma

UniProtKB Accession Codes:

Q9NP80 A4D0S1 C9JZI4 O95035 Q8N3I3 Q9H7T5 Q9NR17 Q9NUN2 Q9NZ79

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 Ensembl 5 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 8 Rhea 44 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10833412

Title: A novel intracellular membrane-bound calcium-independent phospholipase A(2).

PubMed ID: 10833412

DOI: 10.1006/bbrc.2000.2776

PubMed ID: 10744668

Title: The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2).

PubMed ID: 10744668

DOI: 10.1074/jbc.275.14.9937

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15629460

Title: Identification and distribution of endoplasmic reticulum iPLA2.

PubMed ID: 15629460

DOI: 10.1016/j.bbrc.2004.12.016

PubMed ID: 15695510

Title: Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2.

PubMed ID: 15695510

DOI: 10.1074/jbc.m413766200

PubMed ID: 15908428

Title: The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling.

PubMed ID: 15908428

DOI: 10.1074/jbc.m502358200

PubMed ID: 17213206

Title: Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma.

PubMed ID: 17213206

DOI: 10.1074/jbc.m607307200

PubMed ID: 18171998

Title: Role of calcium-independent phospholipase A2 in complement-mediated glomerular epithelial cell injury.

PubMed ID: 18171998

DOI: 10.1152/ajprenal.00372.2007

PubMed ID: 25512002

Title: Loss of function variants in human PNPLA8 encoding calcium-independent phospholipase A2 gamma recapitulate the mitochondriopathy of the homologous null mouse.

PubMed ID: 25512002

DOI: 10.1002/humu.22743

PubMed ID: 28442572

Title: The phospholipase iPLA2gamma is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling.

PubMed ID: 28442572

DOI: 10.1074/jbc.m117.783068

Sequence Information:

  • Length: 782
  • Mass: 88477
  • Checksum: C66AD18A53AF649A
  • Sequence:
    • MSINLTVDIY IYLLSNARSV CGKQRSKQLY FLFSPKHYWR ISHISLQRGF HTNIIRCKWT 
KSEAHSCSKH CYSPSNHGLH IGILKLSTSA PKGLTKVNIC MSRIKSTLNS VSKAVFGNQN 
EMISRLAQFK PSSQILRKVS DSGWLKQKNI KQAIKSLKKY SDKSAEKSPF PEEKSHIIDK 
EEDIGKRSLF HYTSSITTKF GDSFYFLSNH INSYFKRKEK MSQQKENEHF RDKSELEDKK 
VEEGKLRSPD PGILAYKPGS ESVHTVDKPT SPSAIPDVLQ VSTKQSIANF LSRPTEGVQA 
LVGGYIGGLV PKLKYDSKSQ SEEQEEPAKT DQAVSKDRNA EEKKRLSLQR EKIIARVSID 
NRTRALVQAL RRTTDPKLCI TRVEELTFHL LEFPEGKGVA VKERIIPYLL RLRQIKDETL 
QAAVREILAL IGYVDPVKGR GIRILSIDGG GTRGVVALQT LRKLVELTQK PVHQLFDYIC 
GVSTGAILAF MLGLFHMPLD ECEELYRKLG SDVFSQNVIV GTVKMSWSHA FYDSQTWENI 
LKDRMGSALM IETARNPTCP KVAAVSTIVN RGITPKAFVF RNYGHFPGIN SHYLGGCQYK 
MWQAIRASSA APGYFAEYAL GNDLHQDGGL LLNNPSALAM HECKCLWPDV PLECIVSLGT 
GRYESDVRNT VTYTSLKTKL SNVINSATDT EEVHIMLDGL LPPDTYFRFN PVMCENIPLD 
ESRNEKLDQL QLEGLKYIER NEQKMKKVAK ILSQEKTTLQ KINDWIKLKT DMYEGLPFFS 
KL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.