Details for: ASAP1

Gene ID: 50807

Symbol: ASAP1

Ensembl ID: ENSG00000153317

Description: ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 544.4397
    Cell Significance Index: -84.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 361.1961
    Cell Significance Index: -91.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 200.2869
    Cell Significance Index: -94.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 187.5167
    Cell Significance Index: -76.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 169.0562
    Cell Significance Index: -86.9600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 140.9790
    Cell Significance Index: -94.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 79.9273
    Cell Significance Index: -76.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 73.8185
    Cell Significance Index: -91.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.3463
    Cell Significance Index: -89.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 31.5592
    Cell Significance Index: -69.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.6026
    Cell Significance Index: -84.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.4779
    Cell Significance Index: -92.6500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 5.7299
    Cell Significance Index: 82.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.9711
    Cell Significance Index: 304.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.6027
    Cell Significance Index: 96.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.3912
    Cell Significance Index: 672.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0241
    Cell Significance Index: 606.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.5922
    Cell Significance Index: 929.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.5485
    Cell Significance Index: 61.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.3559
    Cell Significance Index: 45.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.2792
    Cell Significance Index: 63.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.1277
    Cell Significance Index: 130.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.7192
    Cell Significance Index: 65.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.5642
    Cell Significance Index: 2126.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5148
    Cell Significance Index: 1047.7200
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.5071
    Cell Significance Index: 15.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4376
    Cell Significance Index: 63.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4079
    Cell Significance Index: 37.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8326
    Cell Significance Index: 23.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6915
    Cell Significance Index: 1301.9700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6796
    Cell Significance Index: 14.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6610
    Cell Significance Index: 37.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6092
    Cell Significance Index: 550.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4692
    Cell Significance Index: 57.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3688
    Cell Significance Index: 567.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2378
    Cell Significance Index: 438.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1958
    Cell Significance Index: 35.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1687
    Cell Significance Index: 107.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1662
    Cell Significance Index: 90.7700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1539
    Cell Significance Index: 0.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1507
    Cell Significance Index: 10.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1472
    Cell Significance Index: 23.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1399
    Cell Significance Index: 19.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1089
    Cell Significance Index: 5.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0989
    Cell Significance Index: 44.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0608
    Cell Significance Index: 26.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0430
    Cell Significance Index: -31.8600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0461
    Cell Significance Index: -0.6800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0773
    Cell Significance Index: -1.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0810
    Cell Significance Index: -11.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0890
    Cell Significance Index: -8.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0899
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1001
    Cell Significance Index: -62.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1040
    Cell Significance Index: -19.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1071
    Cell Significance Index: -78.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1212
    Cell Significance Index: -68.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1294
    Cell Significance Index: -97.9400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1373
    Cell Significance Index: -1.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1691
    Cell Significance Index: -18.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1824
    Cell Significance Index: -21.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2187
    Cell Significance Index: -28.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2279
    Cell Significance Index: -23.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2829
    Cell Significance Index: -59.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2837
    Cell Significance Index: -81.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3459
    Cell Significance Index: -59.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3658
    Cell Significance Index: -16.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4337
    Cell Significance Index: -50.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4918
    Cell Significance Index: -63.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5233
    Cell Significance Index: -53.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5596
    Cell Significance Index: -29.3800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.5721
    Cell Significance Index: -8.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5907
    Cell Significance Index: -40.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6030
    Cell Significance Index: -15.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6096
    Cell Significance Index: -21.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6450
    Cell Significance Index: -73.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6573
    Cell Significance Index: -16.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7199
    Cell Significance Index: -82.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7274
    Cell Significance Index: -20.8500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7482
    Cell Significance Index: -9.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8343
    Cell Significance Index: -18.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8491
    Cell Significance Index: -54.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8817
    Cell Significance Index: -15.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.9365
    Cell Significance Index: -69.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.9612
    Cell Significance Index: -45.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0443
    Cell Significance Index: -82.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0516
    Cell Significance Index: -64.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.0718
    Cell Significance Index: -75.8000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.1109
    Cell Significance Index: -16.9000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.1940
    Cell Significance Index: -15.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.2276
    Cell Significance Index: -63.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.3617
    Cell Significance Index: -28.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3766
    Cell Significance Index: -45.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.4222
    Cell Significance Index: -66.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.4353
    Cell Significance Index: -28.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4440
    Cell Significance Index: -45.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4645
    Cell Significance Index: -46.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.4650
    Cell Significance Index: -20.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.5500
    Cell Significance Index: -97.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.6112
    Cell Significance Index: -55.9900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -1.6414
    Cell Significance Index: -14.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ASAP1 is a multifunctional gene that exhibits distinct characteristics, including: 1. **Domain structure:** ASAP1 contains a unique domain arrangement, comprising an ArfGAP domain, an SH3 (Src homology 3) domain, an ANK (ankyrin repeat) domain, and a PH (phosphoinositide-binding) domain. 2. **Cellular localization:** ASAP1 is primarily localized to the cytosol, Golgi apparatus, and plasma membrane, where it regulates various cellular processes. 3. **Protein-protein interactions:** ASAP1 interacts with numerous proteins, including Arf proteins, SH3-containing proteins, and phosphoinositide-binding proteins, thereby modulating its functions. **Pathways and Functions:** ASAP1 is involved in a wide range of cellular pathways, including: 1. **Cargo trafficking to the periciliary membrane:** ASAP1 regulates the trafficking of cargo proteins to the periciliary membrane, a critical process in maintaining ciliary function and cellular homeostasis. 2. **Cilium assembly and maintenance:** ASAP1 plays a key role in regulating cilium assembly, a process essential for maintaining cellular polarity and function. 3. **Dendritic spine development and plasticity:** ASAP1 modulates dendritic spine development and plasticity, which are critical for synaptic function and learning. 4. **Golgi membrane and protein transport:** ASAP1 regulates the trafficking of proteins between the Golgi apparatus and the plasma membrane, ensuring proper cellular function. **Clinical Significance:** The dysregulation of ASAP1 has been implicated in various diseases, including: 1. **Immune disorders:** ASAP1 plays a crucial role in regulating immune cell function, and its dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** ASAP1 has been implicated in cancer progression, where its dysregulation can lead to uncontrolled cell proliferation and tumor formation. 3. **Neurological disorders:** ASAP1's role in regulating dendritic spine development and plasticity makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ASAP1 is a multifaceted gene that plays a critical role in regulating various cellular processes, including cargo trafficking, cilium assembly, and dendritic spine development. Its dysregulation has been implicated in various diseases, highlighting its importance as a therapeutic target for the treatment of immune disorders, cancer, and neurological diseases.

Genular Protein ID: 827716100

Symbol: ASAP1_HUMAN

Name: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

UniProtKB Accession Codes:

Q9ULH1 B2RNV3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 9819391

Title: ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.

PubMed ID: 9819391

DOI: 10.1128/mcb.18.12.7038

PubMed ID: 12149250

Title: Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.

PubMed ID: 12149250

DOI: 10.1074/jbc.m203453200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20393563

Title: Functional genomic screen for modulators of ciliogenesis and cilium length.

PubMed ID: 20393563

DOI: 10.1038/nature08895

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25673879

Title: The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting.

PubMed ID: 25673879

DOI: 10.1242/jcs.162925

PubMed ID: 16636290

Title: Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.

PubMed ID: 16636290

DOI: 10.1073/pnas.0509166103

PubMed ID: 20509626

Title: Structural basis of the recognition of the SAMP motif of adenomatous polyposis coli by the Src-homology 3 domain.

PubMed ID: 20509626

DOI: 10.1021/bi100563z

Sequence Information:

  • Length: 1129
  • Mass: 125498
  • Checksum: 7F54B22015638D55
  • Sequence:
    • MRSSASRLSS FSSRDSLWNR MPDQISVSEF IAETTEDYNS PTTSSFTTRL HNCRNTVTLL 
EEALDQDRTA LQKVKKSVKA IYNSGQDHVQ NEENYAQVLD KFGSNFLSRD NPDLGTAFVK 
FSTLTKELST LLKNLLQGLS HNVIFTLDSL LKGDLKGVKG DLKKPFDKAW KDYETKFTKI 
EKEKREHAKQ HGMIRTEITG AEIAEEMEKE RRLFQLQMCE YLIKVNEIKT KKGVDLLQNL 
IKYYHAQCNF FQDGLKTADK LKQYIEKLAA DLYNIKQTQD EEKKQLTALR DLIKSSLQLD 
QKEDSQSRQG GYSMHQLQGN KEYGSEKKGY LLKKSDGIRK VWQRRKCSVK NGILTISHAT 
SNRQPAKLNL LTCQVKPNAE DKKSFDLISH NRTYHFQAED EQDYVAWISV LTNSKEEALT 
MAFRGEQSAG ENSLEDLTKA IIEDVQRLPG NDICCDCGSS EPTWLSTNLG ILTCIECSGI 
HREMGVHISR IQSLELDKLG TSELLLAKNV GNNSFNDIME ANLPSPSPKP TPSSDMTVRK 
EYITAKYVDH RFSRKTCSTS SAKLNELLEA IKSRDLLALI QVYAEGVELM EPLLEPGQEL 
GETALHLAVR TADQTSLHLV DFLVQNCGNL DKQTALGNTV LHYCSMYSKP ECLKLLLRSK 
PTVDIVNQAG ETALDIAKRL KATQCEDLLS QAKSGKFNPH VHVEYEWNLR QEEIDESDDD 
LDDKPSPIKK ERSPRPQSFC HSSSISPQDK LALPGFSTPR DKQRLSYGAF TNQIFVSTST 
DSPTSPTTEA PPLPPRNAGK GPTGPPSTLP LSTQTSSGSS TLSKKRPPPP PPGHKRTLSD 
PPSPLPHGPP NKGAVPWGND GGPSSSSKTT NKFEGLSQQS STSSAKTALG PRVLPKLPQK 
VALRKTDHLS LDKATIPPEI FQKSSQLAEL PQKPPPGDLP PKPTELAPKP QIGDLPPKPG 
ELPPKPQLGD LPPKPQLSDL PPKPQMKDLP PKPQLGDLLA KSQTGDVSPK AQQPSEVTLK 
SHPLDLSPNV QSRDAIQKQA SEDSNDLTPT LPETPVPLPR KINTGKNKVR RVKTIYDCQA 
DNDDELTFIE GEVIIVTGEE DQEWWIGHIE GQPERKGVFP VSFVHILSD

Genular Protein ID: 2534336773

Symbol: A0A0A0MRE5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MRE5

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 GO 3 Gene3D 6 GeneTree 1 HGNC 1 InterPro 15 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 4 SUPFAM 5 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1122
  • Mass: 124772
  • Checksum: 5E0177B20D7F107D
  • Sequence:
    • MVSNLKRIMA QKWMPDQISV SEFIAETTED YNSPTTSSFT TRLHNCRNTV TLLEEALDQD 
RTALQKVKKS VKAIYNSGQD HVQNEENYAQ VLDKFGSNFL SRDNPDLGTA FVKFSTLTKE 
LSTLLKNLLQ GLSHNVIFTL DSLLKGDLKG VKGDLKKPFD KAWKDYETKF TKIEKEKREH 
AKQHGMIRTE ITGAEIAEEM EKERRLFQLQ MCEYLIKVNE IKTKKGVDLL QNLIKYYHAQ 
CNFFQDGLKT ADKLKQYIEK LAADLYNIKQ TQDEEKKQLT ALRDLIKSSL QLDQKEDSQS 
RQGGYSMHQL QGNKEYGSEK KGYLLKKSDG IRKVWQRRKC SVKNGILTIS HATSNRQPAK 
LNLLTCQVKP NAEDKKSFDL ISHNRTYHFQ AEDEQDYVAW ISVLTNSKEE ALTMAFRGEQ 
SAGENSLEDL TKAIIEDVQR LPGNDICCDC GSSEPTWLST NLGILTCIEC SGIHREMGVH 
ISRIQSLELD KLGTSELLLA KNVGNNSFND IMEANLPSPS PKPTPSSDMT VRKEYITAKY 
VDHRFSRKTC STSSAKLNEL LEAIKSRDLL ALIQVYAEGV ELMEPLLEPG QELGETALHL 
AVRTADQTSL HLVDFLVQNC GNLDKQTALG NTVLHYCSMY SKPECLKLLL RSKPTVDIVN 
QAGETALDIA KRLKATQCED LLSQAKSGKF NPHVHVEYEW NLRQEEIDES DDDLDDKPSP 
IKKERSPRPQ SFCHSSSISP QDKLALPGFS TPRDKQRLSY GAFTNQIFVS TSTDSPTSPT 
TEAPPLPPRN AGKGPTGPPS TLPLSTQTSS GSSTLSKKRP PPPPPGHKRT LSDPPSPLPH 
GPPNKGAVPW GNDGGPSSSS KTTNKFEGLS QQSSTSSAKT ALGPRVLPKL PQKVALRKTD 
HLSLDKATIP PEIFQKSSQL AELPQKPPPG DLPPKPTELA PKPQIGDLPP KPGELPPKPQ 
LGDLPPKPQL SDLPPKPQMK DLPPKPQLGD LLAKSQTGDV SPKAQQPSEV TLKSHPLDLS 
PNVQSRDAIQ KQASEDSNDL TPTLPETPVP LPRKINTGKN KVRRVKTIYD CQADNDDELT 
FIEGEVIIVT GEEDQEWWIG HIEGQPERKG VFPVSFVHIL SD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.