Details for: AK3

Gene ID: 50808

Symbol: AK3

Ensembl ID: ENSG00000147853

Description: adenylate kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 289.2085
    Cell Significance Index: -44.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 172.6440
    Cell Significance Index: -43.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 106.6884
    Cell Significance Index: -50.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 105.0320
    Cell Significance Index: -42.6700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.9265
    Cell Significance Index: -47.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.2881
    Cell Significance Index: -50.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.7031
    Cell Significance Index: -42.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.3518
    Cell Significance Index: -50.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.7086
    Cell Significance Index: -44.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.2771
    Cell Significance Index: -40.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.1955
    Cell Significance Index: -52.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0978
    Cell Significance Index: -22.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.5724
    Cell Significance Index: 581.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.6785
    Cell Significance Index: 71.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.4701
    Cell Significance Index: 148.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2278
    Cell Significance Index: 442.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6338
    Cell Significance Index: 294.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.5334
    Cell Significance Index: 25.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5073
    Cell Significance Index: 185.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2760
    Cell Significance Index: 35.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1569
    Cell Significance Index: 31.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0941
    Cell Significance Index: 392.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0848
    Cell Significance Index: 592.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9078
    Cell Significance Index: 47.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8997
    Cell Significance Index: 55.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8609
    Cell Significance Index: 66.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8579
    Cell Significance Index: 63.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8522
    Cell Significance Index: 23.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8428
    Cell Significance Index: 18.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8291
    Cell Significance Index: 7.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8149
    Cell Significance Index: 45.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7747
    Cell Significance Index: 54.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7650
    Cell Significance Index: 153.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7600
    Cell Significance Index: 336.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6852
    Cell Significance Index: 94.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6687
    Cell Significance Index: 30.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6375
    Cell Significance Index: 81.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5531
    Cell Significance Index: 15.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5464
    Cell Significance Index: 493.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4678
    Cell Significance Index: 21.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4033
    Cell Significance Index: 39.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3828
    Cell Significance Index: 65.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3588
    Cell Significance Index: 68.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1648
    Cell Significance Index: 5.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1426
    Cell Significance Index: 16.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1261
    Cell Significance Index: 16.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1193
    Cell Significance Index: 3.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1158
    Cell Significance Index: 3.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1065
    Cell Significance Index: 6.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1034
    Cell Significance Index: 194.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1032
    Cell Significance Index: 4.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0982
    Cell Significance Index: 3.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0835
    Cell Significance Index: 61.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0439
    Cell Significance Index: 27.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0317
    Cell Significance Index: 0.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0280
    Cell Significance Index: 43.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0224
    Cell Significance Index: 41.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0132
    Cell Significance Index: 5.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0107
    Cell Significance Index: 0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0124
    Cell Significance Index: -16.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0131
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0192
    Cell Significance Index: -14.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0205
    Cell Significance Index: -15.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0226
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0293
    Cell Significance Index: -18.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0420
    Cell Significance Index: -0.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0589
    Cell Significance Index: -33.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0636
    Cell Significance Index: -1.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0637
    Cell Significance Index: -6.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0650
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1046
    Cell Significance Index: -22.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1299
    Cell Significance Index: -4.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1389
    Cell Significance Index: -39.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1500
    Cell Significance Index: -21.8000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1809
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1860
    Cell Significance Index: -21.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1914
    Cell Significance Index: -21.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2295
    Cell Significance Index: -26.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2558
    Cell Significance Index: -3.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2624
    Cell Significance Index: -20.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3067
    Cell Significance Index: -20.6200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3284
    Cell Significance Index: -8.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3516
    Cell Significance Index: -8.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3836
    Cell Significance Index: -8.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3887
    Cell Significance Index: -8.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4018
    Cell Significance Index: -8.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4319
    Cell Significance Index: -8.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4392
    Cell Significance Index: -45.7300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4634
    Cell Significance Index: -3.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5720
    Cell Significance Index: -12.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6102
    Cell Significance Index: -32.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6582
    Cell Significance Index: -16.0600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6610
    Cell Significance Index: -5.3900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.6780
    Cell Significance Index: -6.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6883
    Cell Significance Index: -17.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6915
    Cell Significance Index: -43.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6927
    Cell Significance Index: -30.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7368
    Cell Significance Index: -38.3800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7860
    Cell Significance Index: -13.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8092
    Cell Significance Index: -49.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AK3 exhibits a unique combination of characteristics that distinguish it from other adenylate kinases. Its ability to bind ADP and ATP, as well as its capacity to phosphorylate nucleosides, positions it as a key regulator of energy metabolism and nucleotide synthesis. Additionally, AK3's involvement in the regulation of megakaryocyte development and platelet production underscores its role in hematopoiesis and blood coagulation. **Pathways and Functions:** AK3 is implicated in several key pathways, including: 1. **Adenylate kinase activity:** AK3 catalyzes the transfer of a phosphate group from ATP to ADP, generating AMP and ATP. This reaction is essential for maintaining the balance of NTPs in cells. 2. **Blood coagulation:** AK3 is involved in the regulation of platelet production and function, highlighting its role in maintaining hemostasis. 3. **DNA repair:** AK3's ability to phosphorylate nucleosides makes it a potential regulator of DNA repair mechanisms, such as base excision repair. 4. **Mitochondrial function:** AK3's expression in smooth muscle fibers and its involvement in energy metabolism suggest a role in maintaining mitochondrial function and homeostasis. **Clinical Significance:** The dysregulation of AK3 has been implicated in various diseases, including: 1. **Blood disorders:** Alterations in AK3 expression have been linked to conditions such as thrombocytopenia and platelet dysfunction. 2. **Cancer:** AK3's role in DNA repair and energy metabolism makes it a potential target for cancer therapy. 3. **Neurological disorders:** AK3's involvement in mitochondrial function and energy metabolism suggests a potential link to neurodegenerative diseases such as Alzheimer's and Parkinson's. In conclusion, AK3 is a multifaceted enzyme that plays a critical role in maintaining cellular homeostasis, regulating energy metabolism, and modulating immune responses. Further research into the functions and dysregulation of AK3 is necessary to fully appreciate its clinical significance and potential therapeutic applications. **References:** * [Insert references here] Note: The references section should include a list of credible sources that support the information presented in the article.

Genular Protein ID: 2247658034

Symbol: KAD3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UIJ7 B4DP58 D3DRI1 E7ET30 Q5VYW6 Q9H576 Q9HC01 Q9NPB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 CarbonylDB 1 ChEBI 29 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 Ensembl 4 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 2 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11485571

Title: Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix.

PubMed ID: 11485571

DOI: 10.1042/0264-6021:3580225

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 35457131

Title: Adenylate Kinase Isozyme 3 Regulates Mitochondrial Energy Metabolism and Knockout Alters HeLa Cell Metabolism.

PubMed ID: 35457131

DOI: 10.3390/ijms23084316

PubMed ID: 32822537

Title: Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3.

PubMed ID: 32822537

DOI: 10.1021/acs.biochem.0c00549

Sequence Information:

  • Length: 227
  • Mass: 25565
  • Checksum: 98A0EDF4FD9C9CEF
  • Sequence:
    • MGASARLLRA VIMGAPGSGK GTVSSRITTH FELKHLSSGD LLRDNMLRGT EIGVLAKAFI 
DQGKLIPDDV MTRLALHELK NLTQYSWLLD GFPRTLPQAE ALDRAYQIDT VINLNVPFEV 
IKQRLTARWI HPASGRVYNI EFNPPKTVGI DDLTGEPLIQ REDDKPETVI KRLKAYEDQT 
KPVLEYYQKK GVLETFSGTE TNKIWPYVYA FLQTKVPQRS QKASVTP

Genular Protein ID: 3165301332

Symbol: Q7Z4Y4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z4Y4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 15 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 9 Gene3D 1 HAMAP 2 HAMAP-Rule 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 3 RefSeq 5 Rhea 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 227
  • Mass: 25620
  • Checksum: 2AB7977F152213D0
  • Sequence:
    • MGAGRRLLRA VIMGAPGSGK GTVSSRITTH FELKHLSSGD LLRDNMLRGT EIGVLAKAFI 
DQGKLIPDDV MTRLALHELK NLTQYSWLLD GFPRTLPQAE ALDRAYQIDT VINLNVPFEV 
IKQRLTARWI HPASGRVYNI EFNPPKTVGI DDLTGEPLIQ REDDKPETVI KRLKAYEDQT 
KPVLEYYQKK GVLETFSGTE TNKIWPYVYA FLQTKVPQRS QKASVTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.