Details for: COPS7A

Gene ID: 50813

Symbol: COPS7A

Ensembl ID: ENSG00000111652

Description: COP9 signalosome subunit 7A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 133.2088
    Cell Significance Index: -20.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 80.0336
    Cell Significance Index: -20.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.9145
    Cell Significance Index: -24.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.8268
    Cell Significance Index: -21.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.6856
    Cell Significance Index: -23.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.2887
    Cell Significance Index: -21.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.7720
    Cell Significance Index: -23.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5629
    Cell Significance Index: -20.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2511
    Cell Significance Index: -19.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9452
    Cell Significance Index: -23.4600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.6939
    Cell Significance Index: 60.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5274
    Cell Significance Index: -7.7200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.0691
    Cell Significance Index: 17.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7338
    Cell Significance Index: 281.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4351
    Cell Significance Index: 19.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2177
    Cell Significance Index: 141.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1532
    Cell Significance Index: 60.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9598
    Cell Significance Index: 49.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7138
    Cell Significance Index: 44.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5692
    Cell Significance Index: 26.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5658
    Cell Significance Index: 15.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5432
    Cell Significance Index: 97.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5348
    Cell Significance Index: 73.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5083
    Cell Significance Index: 35.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4611
    Cell Significance Index: 56.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4409
    Cell Significance Index: 11.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3781
    Cell Significance Index: 206.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3773
    Cell Significance Index: 75.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3635
    Cell Significance Index: 7.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3541
    Cell Significance Index: 70.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3382
    Cell Significance Index: 43.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2997
    Cell Significance Index: 35.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2952
    Cell Significance Index: 130.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2904
    Cell Significance Index: 21.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2809
    Cell Significance Index: 253.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2638
    Cell Significance Index: 6.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2177
    Cell Significance Index: 2.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2142
    Cell Significance Index: 76.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1965
    Cell Significance Index: 37.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1845
    Cell Significance Index: 31.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1835
    Cell Significance Index: 9.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1730
    Cell Significance Index: 22.3500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1641
    Cell Significance Index: 1.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1366
    Cell Significance Index: 6.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1348
    Cell Significance Index: 3.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1291
    Cell Significance Index: 89.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1160
    Cell Significance Index: 5.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1096
    Cell Significance Index: 7.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0831
    Cell Significance Index: 5.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0441
    Cell Significance Index: 4.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0440
    Cell Significance Index: 1.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0161
    Cell Significance Index: 0.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0128
    Cell Significance Index: 0.2200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0125
    Cell Significance Index: 0.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0103
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0068
    Cell Significance Index: 12.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0065
    Cell Significance Index: 4.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0044
    Cell Significance Index: 3.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0099
    Cell Significance Index: -7.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0100
    Cell Significance Index: -15.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0128
    Cell Significance Index: -17.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0135
    Cell Significance Index: -8.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0137
    Cell Significance Index: -8.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0156
    Cell Significance Index: -1.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0225
    Cell Significance Index: -0.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0234
    Cell Significance Index: -13.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0342
    Cell Significance Index: -15.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0380
    Cell Significance Index: -0.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0478
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0489
    Cell Significance Index: -10.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0627
    Cell Significance Index: -1.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0672
    Cell Significance Index: -19.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0829
    Cell Significance Index: -9.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0831
    Cell Significance Index: -6.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0963
    Cell Significance Index: -1.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0984
    Cell Significance Index: -2.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1064
    Cell Significance Index: -3.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1124
    Cell Significance Index: -16.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1272
    Cell Significance Index: -2.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1360
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1496
    Cell Significance Index: -17.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1587
    Cell Significance Index: -10.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1949
    Cell Significance Index: -15.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2153
    Cell Significance Index: -22.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2425
    Cell Significance Index: -13.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2961
    Cell Significance Index: -7.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3157
    Cell Significance Index: -9.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3406
    Cell Significance Index: -20.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3445
    Cell Significance Index: -3.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3525
    Cell Significance Index: -10.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3599
    Cell Significance Index: -15.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3656
    Cell Significance Index: -9.3400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3738
    Cell Significance Index: -5.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3857
    Cell Significance Index: -5.7800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.3920
    Cell Significance Index: -2.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.4337
    Cell Significance Index: -3.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4400
    Cell Significance Index: -16.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4729
    Cell Significance Index: -4.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COPS7A is a highly conserved protein that is part of the COP9 signalosome complex. The CSN is a heterohexomer complex consisting of six subunits, with COPS7A being one of the subunits. COPS7A shares a high degree of sequence homology with other CSN subunits, suggesting a conserved functional role. The protein has a unique structure, with a C-terminal domain that is involved in neddylation recognition and a N-terminal domain that interacts with other CSN subunits. **Pathways and Functions:** COPS7A is involved in several critical cellular pathways, including: 1. **Clathrin-mediated endocytosis**: COPS7A recognizes cargo proteins and facilitates their internalization through clathrin-mediated endocytosis. 2. **DNA damage recognition and repair**: COPS7A is involved in the recognition and repair of DNA damage, particularly in the context of nucleotide excision repair (NER) and transcription-coupled NER (tc-NER). 3. **Protein neddylation regulation**: COPS7A regulates the neddylation of proteins, which affects their stability, localization, and function. 4. **Cell cycle regulation**: COPS7A is involved in the regulation of the cell cycle, particularly in the context of DNA damage response and repair. **Clinical Significance:** Dysregulation of COPS7A has been implicated in various diseases, including: 1. **Cancer**: Altered neddylation patterns and COPS7A expression have been observed in various types of cancer, suggesting a potential role in tumorigenesis. 2. **Neurodegenerative disorders**: COPS7A has been implicated in the regulation of protein neddylation and has been studied in the context of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. 3. **Inflammatory disorders**: COPS7A has been shown to regulate the neddylation of proteins involved in inflammation, suggesting a potential role in the pathogenesis of inflammatory disorders. In conclusion, COPS7A is a critical component of the COP9 signalosome complex that plays a pivotal role in regulating protein neddylation and other cellular processes. Further research is needed to fully elucidate the mechanisms by which COPS7A regulates cellular function and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 518219763

Symbol: CSN7A_HUMAN

Name: COP9 signalosome complex subunit 7a

UniProtKB Accession Codes:

Q9UBW8 A8K9A6 Q9NVX3 Q9UJW4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 6 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12020345

Title: Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression.

PubMed ID: 12020345

DOI: 10.1042/bj20020211

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9535219

Title: A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.

PubMed ID: 9535219

DOI: 10.1096/fasebj.12.6.469

PubMed ID: 11285227

Title: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.

PubMed ID: 11285227

DOI: 10.1093/emboj/20.7.1630

PubMed ID: 11337588

Title: Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.

PubMed ID: 11337588

DOI: 10.1126/science.1059780

PubMed ID: 12220626

Title: Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome.

PubMed ID: 12220626

DOI: 10.1016/s0014-5793(02)03147-2

PubMed ID: 12732143

Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

PubMed ID: 12732143

DOI: 10.1016/s0092-8674(03)00316-7

PubMed ID: 12628923

Title: Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.

PubMed ID: 12628923

DOI: 10.1093/emboj/cdg127

PubMed ID: 18850735

Title: Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.

PubMed ID: 18850735

DOI: 10.1021/pr800574c

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26456823

Title: CSNAP is a stoichiometric subunit of the COP9 signalosome.

PubMed ID: 26456823

DOI: 10.1016/j.celrep.2015.09.021

PubMed ID: 29444943

Title: Vaccinia Virus C9 Ankyrin Repeat/F-Box Protein Is a Newly Identified Antagonist of the Type I Interferon-Induced Antiviral State.

PubMed ID: 29444943

DOI: 10.1128/jvi.00053-18

Sequence Information:

  • Length: 275
  • Mass: 30277
  • Checksum: 20888B35BFFF6326
  • Sequence:
    • MSAEVKVTGQ NQEQFLLLAK SAKGAALATL IHQVLEAPGV YVFGELLDMP NVRELAESDF 
ASTFRLLTVF AYGTYADYLA EARNLPPLTE AQKNKLRHLS VVTLAAKVKC IPYAVLLEAL 
ALRNVRQLED LVIEAVYADV LRGSLDQRNQ RLEVDYSIGR DIQRQDLSAI ARTLQEWCVG 
CEVVLSGIEE QVSRANQHKE QQLGLKQQIE SEVANLKKTI KVTTAAAAAA TSQDPEQHLT 
ELREPAPGTN QRQPSKKASK GKGLRGSAKI WSKSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.