Details for: PDCL

Gene ID: 5082

Symbol: PDCL

Ensembl ID: ENSG00000136940

Description: phosducin like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 112.8289
    Cell Significance Index: -17.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.1592
    Cell Significance Index: -18.8100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 56.7548
    Cell Significance Index: -23.3800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.5591
    Cell Significance Index: -19.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.9056
    Cell Significance Index: -22.0700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 34.2314
    Cell Significance Index: -22.9700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.6862
    Cell Significance Index: -19.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.5351
    Cell Significance Index: -21.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4285
    Cell Significance Index: -19.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7779
    Cell Significance Index: -22.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1604
    Cell Significance Index: -15.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2090
    Cell Significance Index: 131.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1712
    Cell Significance Index: 70.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0721
    Cell Significance Index: 174.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0705
    Cell Significance Index: 67.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8667
    Cell Significance Index: 40.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4956
    Cell Significance Index: 5.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4939
    Cell Significance Index: 67.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4756
    Cell Significance Index: 24.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4723
    Cell Significance Index: 60.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4445
    Cell Significance Index: 6.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4299
    Cell Significance Index: 234.7800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.4113
    Cell Significance Index: 3.1700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3631
    Cell Significance Index: 3.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3209
    Cell Significance Index: 57.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3130
    Cell Significance Index: 20.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3125
    Cell Significance Index: 38.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3101
    Cell Significance Index: 8.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2868
    Cell Significance Index: 126.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2614
    Cell Significance Index: 93.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2483
    Cell Significance Index: 5.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2470
    Cell Significance Index: 49.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2150
    Cell Significance Index: 194.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1816
    Cell Significance Index: 6.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1715
    Cell Significance Index: 3.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1687
    Cell Significance Index: 8.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1448
    Cell Significance Index: 27.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1388
    Cell Significance Index: 16.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1282
    Cell Significance Index: 25.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1234
    Cell Significance Index: 5.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1163
    Cell Significance Index: 5.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1113
    Cell Significance Index: 3.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0858
    Cell Significance Index: 6.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0838
    Cell Significance Index: 5.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0776
    Cell Significance Index: 2.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0765
    Cell Significance Index: 7.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0522
    Cell Significance Index: 8.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0038
    Cell Significance Index: 7.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0033
    Cell Significance Index: 0.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0011
    Cell Significance Index: 0.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0017
    Cell Significance Index: -0.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0048
    Cell Significance Index: -0.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0070
    Cell Significance Index: -12.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0116
    Cell Significance Index: -17.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0139
    Cell Significance Index: -8.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0142
    Cell Significance Index: -19.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0145
    Cell Significance Index: -10.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0151
    Cell Significance Index: -11.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0183
    Cell Significance Index: -10.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0200
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0206
    Cell Significance Index: -12.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0311
    Cell Significance Index: -0.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0353
    Cell Significance Index: -16.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0422
    Cell Significance Index: -4.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0461
    Cell Significance Index: -13.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0476
    Cell Significance Index: -6.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0519
    Cell Significance Index: -3.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0536
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0587
    Cell Significance Index: -12.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0724
    Cell Significance Index: -8.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0740
    Cell Significance Index: -1.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0799
    Cell Significance Index: -1.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0925
    Cell Significance Index: -5.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1020
    Cell Significance Index: -14.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1089
    Cell Significance Index: -12.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1346
    Cell Significance Index: -15.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1570
    Cell Significance Index: -4.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1952
    Cell Significance Index: -10.1700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2060
    Cell Significance Index: -1.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2116
    Cell Significance Index: -22.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2118
    Cell Significance Index: -14.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2120
    Cell Significance Index: -16.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2258
    Cell Significance Index: -17.8800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2424
    Cell Significance Index: -2.8900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2439
    Cell Significance Index: -6.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2589
    Cell Significance Index: -15.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2921
    Cell Significance Index: -12.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3069
    Cell Significance Index: -7.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3514
    Cell Significance Index: -6.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3547
    Cell Significance Index: -9.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3673
    Cell Significance Index: -13.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3819
    Cell Significance Index: -10.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3846
    Cell Significance Index: -8.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3884
    Cell Significance Index: -5.8200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3971
    Cell Significance Index: -6.3000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.4363
    Cell Significance Index: -2.7400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4369
    Cell Significance Index: -2.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4612
    Cell Significance Index: -13.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4735
    Cell Significance Index: -12.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Sequence Homology:** PDCL exhibits high sequence homology to phosducin, a protein known for its role in G-protein coupled receptor signaling regulation. 2. **Cellular Expression:** PDCL is significantly expressed in various cell types, including alveolar macrophages, primordial germ cells, and cerebral cortex GABAergic interneurons. 3. **Protein Function:** PDCL is involved in protein folding, chaperone-mediated protein folding, and the regulation of signaling pathways, including the Smoothened signaling pathway and G-protein coupled receptor signaling pathways. 4. **Pathway Involvement:** PDCL is implicated in cell projection organization, cilium formation, and the cooperation of PDCL and TRIC/CCT in G-protein beta folding. **Pathways and Functions:** 1. **Protein Folding:** PDCL is involved in chaperone-mediated protein folding, a process critical for maintaining protein homeostasis and preventing protein misfolding. 2. **G-Protein Coupled Receptor Signaling Pathway:** PDCL regulates the activity of G-protein coupled receptors, which are essential for transmitting signals from the outside to the inside of the cell. 3. **Smoothened Signaling Pathway:** PDCL is involved in the regulation of the Smoothened signaling pathway, which plays a crucial role in development, cell growth, and differentiation. 4. **Cell Projection Organization:** PDCL is implicated in the organization of cell projections, which are essential for maintaining cellular structure and function. 5. **Cilium Formation:** PDCL is involved in the formation of cilia, which are critical for sensing the extracellular environment and regulating various cellular processes. **Clinical Significance:** 1. **Immunological Disorders:** Alterations in PDCL expression or function may contribute to the development of immunological disorders, such as autoimmune diseases or cancer. 2. **Neurological Disorders:** PDCL's role in regulating G-protein coupled receptor signaling pathways and the Smoothened signaling pathway may be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease or Parkinson's disease. 3. **Cancer:** PDCL's involvement in protein folding and chaperone-mediated protein folding may contribute to cancer development and progression. 4. **Visual Perception:** PDCL's role in regulating G-protein coupled receptor signaling pathways may be involved in visual perception and the development of visual disorders. In conclusion, the phosducin-like gene (PDCL) is a novel immunological player that has been implicated in various biological processes, including protein folding, chaperone-mediated protein folding, and the regulation of signaling pathways. Further studies are necessary to fully elucidate the molecular mechanisms and clinical implications of PDCL, which may lead to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 2349691992

Symbol: PHLP_HUMAN

Name: Phosducin-like protein

UniProtKB Accession Codes:

Q13371 Q4VXB6 Q96AF1 Q9UEW7 Q9UFL0 Q9UNX1 Q9UNX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 12 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10095058

Title: Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization.

PubMed ID: 10095058

DOI: 10.1016/s0167-4781(99)00006-8

PubMed ID: 15585822

Title: Identification of phosphorylation sites on phosducin-like protein by QTOF mass spectrometry.

PubMed ID: 15585822

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19376773

Title: Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity.

PubMed ID: 19376773

DOI: 10.1074/jbc.m900800200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23888055

Title: Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins.

PubMed ID: 23888055

DOI: 10.1074/jbc.m113.486258

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 301
  • Mass: 34282
  • Checksum: 717675FF869760D5
  • Sequence:
    • MTTLDDKLLG EKLQYYYSSS EDEDSDHEDK DRGRCAPASS SVPAEAELAG EGISVNTGPK 
GVINDWRRFK QLETEQREEQ CREMERLIKK LSMTCRSHLD EEEEQQKQKD LQEKISGKMT 
LKEFAIMNED QDDEEFLQQY RKQRMEEMRQ QLHKGPQFKQ VFEISSGEGF LDMIDKEQKS 
IVIMVHIYED GIPGTEAMNG CMICLAAEYP AVKFCKVKSS VIGASSQFTR NALPALLIYK 
GGELIGNFVR VTDQLGDDFF AVDLEAFLQE FGLLPEKEVL VLTSVRNSAT CHSEDSDLEI 
D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.