Details for: HEBP1

Gene ID: 50865

Symbol: HEBP1

Ensembl ID: ENSG00000013583

Description: heme binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 76.3204
    Cell Significance Index: -31.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.4245
    Cell Significance Index: -18.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.3619
    Cell Significance Index: -26.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.0678
    Cell Significance Index: -30.7200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.7388
    Cell Significance Index: -29.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.3951
    Cell Significance Index: -27.1100
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 24.9124
    Cell Significance Index: -3.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.1329
    Cell Significance Index: -23.5900
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 17.8083
    Cell Significance Index: 8.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7135
    Cell Significance Index: -28.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1033
    Cell Significance Index: -28.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3553
    Cell Significance Index: -19.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3910
    Cell Significance Index: -9.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.7360
    Cell Significance Index: 25.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4114
    Cell Significance Index: 2177.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.3308
    Cell Significance Index: 29.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.1239
    Cell Significance Index: 17.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.9239
    Cell Significance Index: 40.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3696
    Cell Significance Index: 37.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2084
    Cell Significance Index: 154.9100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.1032
    Cell Significance Index: 6.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0915
    Cell Significance Index: 81.3500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0339
    Cell Significance Index: 18.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9889
    Cell Significance Index: 51.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9787
    Cell Significance Index: 45.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9753
    Cell Significance Index: 133.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9218
    Cell Significance Index: 19.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8769
    Cell Significance Index: 158.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8731
    Cell Significance Index: 6.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8331
    Cell Significance Index: 23.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7738
    Cell Significance Index: 20.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7733
    Cell Significance Index: 95.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7190
    Cell Significance Index: 20.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7001
    Cell Significance Index: 90.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6948
    Cell Significance Index: 118.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6603
    Cell Significance Index: 360.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6476
    Cell Significance Index: 30.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6128
    Cell Significance Index: 121.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5887
    Cell Significance Index: 10.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5668
    Cell Significance Index: 40.0900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4932
    Cell Significance Index: 3.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4288
    Cell Significance Index: 189.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4075
    Cell Significance Index: 10.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4058
    Cell Significance Index: 4.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3042
    Cell Significance Index: 13.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2734
    Cell Significance Index: 17.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1766
    Cell Significance Index: 1.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1736
    Cell Significance Index: 33.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1156
    Cell Significance Index: 3.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1001
    Cell Significance Index: 9.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0941
    Cell Significance Index: 1.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0818
    Cell Significance Index: 1.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0783
    Cell Significance Index: 2.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0779
    Cell Significance Index: 146.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0587
    Cell Significance Index: 1.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0553
    Cell Significance Index: 1.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0403
    Cell Significance Index: 2.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0381
    Cell Significance Index: 1.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0317
    Cell Significance Index: 11.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0241
    Cell Significance Index: 18.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0143
    Cell Significance Index: 10.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0086
    Cell Significance Index: 1.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0018
    Cell Significance Index: -0.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0065
    Cell Significance Index: -12.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0089
    Cell Significance Index: -6.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0093
    Cell Significance Index: -6.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0097
    Cell Significance Index: -6.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0149
    Cell Significance Index: -20.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0210
    Cell Significance Index: -13.3300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0220
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0386
    Cell Significance Index: -21.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0521
    Cell Significance Index: -23.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0534
    Cell Significance Index: -6.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0794
    Cell Significance Index: -22.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0818
    Cell Significance Index: -17.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0829
    Cell Significance Index: -9.6600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0863
    Cell Significance Index: -0.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1332
    Cell Significance Index: -19.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1580
    Cell Significance Index: -18.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1658
    Cell Significance Index: -8.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1710
    Cell Significance Index: -13.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1735
    Cell Significance Index: -20.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1782
    Cell Significance Index: -4.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2108
    Cell Significance Index: -5.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2176
    Cell Significance Index: -17.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2462
    Cell Significance Index: -6.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2469
    Cell Significance Index: -25.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2549
    Cell Significance Index: -1.5400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2887
    Cell Significance Index: -4.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3023
    Cell Significance Index: -15.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3242
    Cell Significance Index: -19.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3416
    Cell Significance Index: -4.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3502
    Cell Significance Index: -23.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3781
    Cell Significance Index: -23.2400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3790
    Cell Significance Index: -1.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3856
    Cell Significance Index: -21.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4314
    Cell Significance Index: -27.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4483
    Cell Significance Index: -19.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HEBP1 is a small, approximately 15-kDa protein that binds heme, a crucial component of hemoglobin, and other ligands. Its unique structure allows it to interact with various cellular components, including receptors, signaling pathways, and cytoskeletal elements. The protein's expression is widespread, with significant levels found in embryonic stem cells, hematopoietic cells, and immune cells, such as mast cells and T cells. HEBP1's ability to regulate heme binding and signaling pathways makes it an essential player in maintaining cellular function and responding to environmental changes. **Pathways and Functions:** HEBP1 is involved in several signaling pathways, including: 1. **G alpha (i) signaling events**: HEBP1 interacts with G protein-coupled receptors (GPCRs), influencing signaling cascades that regulate cell growth, differentiation, and survival. 2. **Gpcr downstream signaling**: HEBP1 modulates the activity of GPCRs, affecting downstream signaling pathways that control cellular responses to ligand binding. 3. **Formyl peptide receptors**: HEBP1 binds formyl peptides, which are involved in chemotaxis and immune cell migration. 4. **Mitochondrial function**: HEBP1 regulates mitochondrial function, influencing energy metabolism and oxidative stress responses. 5. **Heme binding**: HEBP1's interaction with heme modulates the activity of enzymes involved in heme metabolism and storage. **Clinical Significance:** The study of HEBP1 has significant implications for understanding and treating various diseases, including: 1. **Hematological disorders**: HEBP1's role in regulating heme binding and signaling pathways makes it a potential target for treating anemia, leukemia, and other blood disorders. 2. **Respiratory diseases**: HEBP1's involvement in GPCR signaling and mitochondrial function may contribute to the development of respiratory diseases, such as chronic obstructive pulmonary disease (COPD). 3. **Inflammatory disorders**: HEBP1's interaction with immune cells and GPCRs may influence the progression of inflammatory diseases, such as asthma and rheumatoid arthritis. In conclusion, HEBP1 is a multifunctional protein that plays a crucial role in immune response, cellular signaling, and hemoglobin regulation. Further research is necessary to fully understand the mechanisms by which HEBP1 influences cellular function and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1032213517

Symbol: HEBP1_HUMAN

Name: Heme-binding protein 1

UniProtKB Accession Codes:

Q9NRV9 A8K1G2 Q9Y5Z5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10640688

Title: Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches.

PubMed ID: 10640688

DOI: 10.1016/s0169-328x(99)00277-6

PubMed ID: 12413491

Title: Characterization of a human and mouse tetrapyrrole-binding protein.

PubMed ID: 12413491

DOI: 10.1016/s0003-9861(02)00471-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 189
  • Mass: 21097
  • Checksum: 6ED12EA91B101B02
  • Sequence:
    • MLGMIKNSLF GSVETWPWQV LSKGDKEEVA YEERACEGGK FATVEVTDKP VDEALREAMP 
KVAKYAGGTN DKGIGMGMTV PISFAVFPNE DGSLQKKLKV WFRIPNQFQS DPPAPSDKSV 
KIEEREGITV YSMQFGGYAK EADYVAQATR LRAALEGTAT YRGDIYFCTG YDPPMKPYGR 
RNEIWLLKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.